CN104258221A - 一种治疗血瘀阻络型脑栓塞的中药组合物及其制备方法 - Google Patents
一种治疗血瘀阻络型脑栓塞的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗血瘀阻络型脑栓塞的中药组合物及其制备方法,中药组合物包括以下原料药材:熟地黄、龙眼肉、楮实子、夜交藤、珍珠母、刺蒺藜、钩藤、地龙、蜈蚣、夏天无、鸡血藤、凌霄花、禹白附、稻芽、鸡矢藤、威灵仙、乌梢蛇、伸筋草、丁公藤、路路通、土牛膝、叶上珠根、八角莲、秋海棠根、蝤蛑、三棱、泽兰、牛马藤、红曲、多刺绿绒蒿、红娘子、牡丹皮、花榈木、波缘楤木、琼越线蕨、麦饭石、萱藻、叶上花、金丝木通、马蔺子、漏芦、蝇虎、铜罗伞。本发明具有活血化瘀、通达脉络的功效,主治脑栓塞血瘀阻络证。辨证论治,针对性较强,可及时控制病情,疗效显著,安全有效,制作工艺简单,给药方便,价格低廉,病人易于接受。
Description
技术领域
本发明涉及含有来源于植物、动物或矿物原料的医用配制品,特别涉及一种治疗血瘀阻络型脑栓塞的中药组合物及其制备方法。
背景技术
脑栓塞(cerebral embolism)又称为栓塞性脑梗死(embolic infarction)。是指人体血液循环中某些异常的固体、液体或气体等栓子物质,随血流进入脑动脉或供应脑的颈部动脉,使血管腔急性闭塞,引起局部脑血流中断,造成局部脑组织缺血、缺氧甚至软化、坏死,故而出现急性脑功能障碍的临床表现。脑栓塞常发生于颈内动脉系统,椎-基底动脉系统相对少见。
病因病理:根据栓子来源,病因可分为:①心源性,占脑栓塞的60%~75%;②非心源性;非心源性栓子引起的脑栓塞有明确病因,证明栓子是来自心脏以外。常见的非心源栓主要有以下几种。(1)动脉粥样硬化斑块脱落 (2)细菌性栓子 (3)脂肪栓子 (4)空气栓子 (5)其他栓子。③来源不明,约30%的脑栓塞不能明确原因。还有部分脑栓塞利用现代手段和方法,虽经仔细检查也未能找到栓子来源称为栓子来源不明者。
症状体征: 1.(1)关于发病年龄:由于栓子来源不同,脑栓塞发病年龄也不同。如风湿性心脏病引起者,发病年龄以中青年为主。若为冠心病、心肌梗死、心律失常、动脉粥样硬化者多见于老年人。(2)常有引起栓子来源的原发病的症状和体征,甚至可伴有脑以外器官栓塞的症状或体征,如风湿性冠心病伴心房纤维颤动有心肌缺血的临床表现,亚急性感染性心内膜炎可有发热、关节疼痛、胸闷的表现,心肌梗死有胸痛等表现,脂肪栓塞可有长骨骨折的表现等。2.发病情况:急骤起病是主要特点,是发病最急的疾病之一,大多数患者病前无任何前驱症状,活动中突然起病,绝大多数症状在数秒或数分钟内病情发展到最高峰。少数患者在数天内呈阶梯样或进行性恶化。约半数患者起病时有意识障碍,但持续时间短暂。3.神经系统定位体征:脑栓塞多数发生在颈内动脉系统,特别是大脑中动脉最常见。栓塞引起的神经功能障碍,取决于栓子数目、范围和部位。急性起病时可有头痛、头晕或局限性疼痛。(1)大脑中动脉栓塞:最常见,其临床表现为主干栓塞时引起病灶对侧偏瘫、偏身感觉障碍和偏盲。优势半球动脉主干栓塞可有失语、失写、失读。 (2)大脑前动脉栓塞时可产生病灶对侧下肢的感觉及运动障碍,对侧中枢性面瘫、舌肌瘫及上肢瘫痪,亦可发生情感淡漠、欣快等精神障碍及强握反射,可伴有尿潴留。(3)大脑后动脉栓塞可引起病灶对侧同向偏盲或上象限盲,病灶对侧半身感觉减退伴丘脑性疼痛。病灶对侧肢体舞蹈样徐动症,各种眼肌麻痹等。(4)基底动脉栓塞最常见症状为眩晕、眼球震颤、复视、交叉性瘫痪或交叉性感觉障碍、肢体共济失调。若基底动脉主干栓塞可出现四肢瘫痪、眼肌麻痹、瞳孔缩小,常伴有面神经、展神经、三叉神经、迷走神经及舌下神经的麻痹及小脑症状等,严重者可迅速昏迷、四肢瘫痪、中枢性高热、消化道出血甚至死亡。
并发症:1.由于栓子顺血流流动,根据流动的部位不同,可以引起相应器官的梗死,所以临床上常有其他部位栓塞的征象。如肺栓塞(气急、发绀、胸痛、咯血和胸膜摩擦音等),肾栓塞(腰痛、血尿等),肠系膜栓塞(腹痛,便血等),皮肤栓塞(出血点或淤斑)等症状、体征。2.大多数病人还伴有风心病、冠心病和严重心律失常等,或心脏手术、长骨骨折、血管内介入治疗后等临床表现。
中医学认为,脑栓塞属于祖国医学“中风”、“真头痛”、“眩晕”等范畴。中风病是由于正气亏虚,饮食、情志、劳倦内伤等引起气血逆乱,产生风、火、痰、瘀,导致脑脉痹阻或血溢脑脉之外为基本病机,以突然昏仆、半身不遂、口舌歪斜、言语謇涩或不语、偏身麻木为主要临床表现的病证。病因病机:1.积损正衰“年四十而阴气自半,起居衰矣”。年老体弱,或久病气血亏损,脑脉失养。气虚则运血无力,血流不畅,而致脑脉瘀滞不通;阴血亏虚则阴不制阳,内风动越,携痰浊、瘀血止扰清窍,突发本病。2.劳倦内伤烦劳过度,伤耗阴精,阴虚而火旺,或阴不制阳易使阳气鸱张,引动风阳,内风旋动,则气火俱浮,或兼挟痰浊、瘀血上壅清窍脉络。3.脾失健运过食肥甘醇酒,致使脾胃受伤,脾失运化,痰浊内生,郁久化热,痰热互结,壅滞经脉,上蒙清窍;或素体肝旺,气机郁结,克伐脾土,痰浊内生;或肝郁化火,烁津成痰,痰郁互结,携风阳之邪,窜扰经脉,发为本病。4.情志过极七情所伤,肝失条达,气机郁滞,血行不畅,瘀结脑脉;暴怒伤肝,则肝阳暴张,或心火暴盛,风火相煽,血随气逆,上冲犯脑。凡此种种,均易引起气血逆乱,上扰脑窍而发为中风。尤以暴怒引发本病者最为多见。
辨证论治:1、风痰瘀血,痹阻脉络,血瘀阻络症状:半身不遂,口舌歪斜,舌强言謇或不语,偏身麻木,头晕目眩,舌质暗淡,舌苔薄白或白腻,脉弦滑。2、肝阳暴亢,风火上扰症状:半身不遂,偏身麻木,舌强言謇或不语,或口舌歪斜,眩晕头痛,面红目赤,口苦咽干,心烦易怒,尿赤便干,舌质红或红绛,脉弦有力。3、痰热腑实,风痰上扰症状:半身不遂,口舌歪斜,言语謇涩或不语,偏身麻木,腹胀便干便秘,头晕目眩,咯痰或痰多,舌质暗红或暗淡,苔黄或黄腻,脉弦滑或偏瘫侧脉弦滑而大。4、气虚血瘀症状:半身不遂,口舌歪斜,口角流涎,言语謇涩或不语,偏身麻木,面色觥白,气短乏力,心悸,自汗,便溏,手足肿胀,舌质暗淡,舌苔薄白或白腻,脉沉细、细缓或细弦。5、肝阳上亢症状:半身不遂,口舌歪斜,舌强言謇或不语,偏身麻木,烦躁失眠,眩晕耳鸣,手足心热,舌质红绛或暗红,少苔或无苔,脉细弦或细弦数。6、痰热内闭清窍(阳闭)症状:起病骤急,神昏或昏愦,半身不遂,鼻鼾痰鸣,肢体强痉拘急,项背身热,躁扰不宁,甚则手足厥冷,频繁抽搐,偶见呕血,舌质红绛,舌苔黄腻或干腻,脉弦滑数。7、痰湿蒙塞心神(阴闭)症状:素体阳虚,突发神昏,半身不遂,肢体松懈,瘫软不温,甚则四肢逆冷,面白唇暗,痰涎壅盛,舌质暗淡,舌苔白腻,脉沉滑或沉缓。8、元气败脱,神明散乱(脱证)症状:突然神昏或昏愦,肢体瘫软,手撤肢冷汗多,重则周身湿冷,二便失禁,舌痿,舌质紫暗,苔白腻,脉沉缓、沉微。
西医治疗脑栓塞脱水降低颅内压,常用的是高渗脱水剂、利尿药和肾上腺皮质激素。高渗脱水剂以20%的甘露醇为最常用;扩张血管,如常用的有罂粟碱、烟酸、碳酸氢钠或山莨菪碱(654-2)静滴,二氧化碳气体间断吸入和口服桂利嗪(脑益嗪)、双氢麦角碱(海特琴)或桂利嗪(肉桂哌嗪)等,以促进侧支循环,增加缺血区的局部血容量;抗血小板聚集剂,通常可选用阿司匹林、双嘧达莫(潘生丁)、磺吡酮(苯磺唑酮)等;抗凝及溶栓治疗;颈星状交感神经节封闭 ;神经保护剂等。但是,西医治疗脑栓塞用药适应症严格,可出现反跳现象,加重心脏负担,加重病情;副作用较多,如引起电解质紊乱,胃肠道反应等。
中医药治疗脑栓塞利用传统中医理论,重视整体观念:通过调节机体气血正常运行,营养肌肤,调节肢体关节的正常功能活动,防止血小板病理性聚集,化痰开窍,扩张血管,降低颅内压,减少并发症;;辨证论治,针对性较强,可及时控制病情,疗效显著,提高治愈率,减少复发率;安全有效,制作工艺简单,给药方便,价格低廉,病人易于接受,可明显提高患者的生活质量等。
发明内容
本发明所要解决的技术问题在于,提供了一种具有活血化瘀、通达脉络的功效,主治血瘀阻络型脑栓塞的中药组合物。本发明利用传统中医理论,重视整体观念:通过调节机体气血正常运行,营养肌肤,调节肢体关节的正常功能活动,防止血小板病理性聚集,化痰开窍,扩张血管,降低颅内压,减少并发症;辨证论治,针对性较强,可及时控制病情,疗效显著,提高治愈率,减少复发率;安全有效,制作工艺简单,给药方便,价格低廉,病人易于接受,可明显提高患者的生活质量等。
为解决上述技术问题,本发明提供一种治疗血瘀阻络型脑栓塞的中药组合物,包括以下原料药材:熟地黄、龙眼肉、楮实子、夜交藤、珍珠母、刺蒺藜、钩藤、地龙、蜈蚣、夏天无、鸡血藤、凌霄花、禹白附、稻芽、鸡矢藤、威灵仙、乌梢蛇、伸筋草、丁公藤、路路通、土牛膝、叶上珠根、八角莲、秋海棠根、蝤蛑、三棱、泽兰、牛马藤、红曲、多刺绿绒蒿、红娘子、牡丹皮、花榈木、波缘楤木、琼越线蕨、麦饭石、萱藻、叶上花、金丝木通、马蔺子、漏芦、蝇虎和铜罗伞。
所述中药组合物中各原料药材的重量份数比为:熟地黄10-20重量份、龙眼肉12-29重量份、楮实子10-25重量份、夜交藤13-24重量份、珍珠母10-24重量份、刺蒺藜10-20重量份、钩藤15-25重量份、地龙10-20重量份、蜈蚣3-5重量份、夏天无10-20重量份、鸡血藤10-22重量份、凌霄花14-25重量份、禹白附3-5重量份、稻芽12-28重量份、鸡矢藤15-29重量份、威灵仙1-3重量份、乌梢蛇10-20重量份、伸筋草14-27重量份、丁公藤2-4重量份、路路通10-25重量份、土牛膝12-27重量份、叶上珠根15-29重量份、八角莲2-4重量份、秋海棠根10-20重量份、蝤蛑10-27重量份、三棱15-22重量份、泽兰12-27重量份、牛马藤10-28重量份、红曲10-20重量份、多刺绿绒蒿14-26重量份、红娘子3-5重量份、牡丹皮15-30重量份、花榈木12-29重量份、波缘楤木10-25重量份、琼越线蕨14-26重量份、麦饭石10-20重量份、萱藻15-25重量份、叶上花10-20重量份、金丝木通13-29重量份、马蔺子10-20、漏芦3-5、蝇虎10-20重量份和铜罗伞13-24重量份。
所述中药组合物中各原料药材的重量份数比为:熟地黄15-20重量份、龙眼肉12-20重量份、楮实子15-25重量份、夜交藤13-20重量份、珍珠母15-24重量份、刺蒺藜15-20重量份、钩藤15-20重量份、地龙15-20重量份、蜈蚣3-4重量份、夏天无15-20重量份、鸡血藤15-22重量份、凌霄花14-20重量份、禹白附3-4重量份、稻芽12-20重量份、鸡矢藤15-20重量份、威灵仙1-2重量份、乌梢蛇15-20重量份、伸筋草14-20重量份、丁公藤2-3重量份、路路通15-25重量份、土牛膝12-20重量份、叶上珠根15-20重量份、八角莲3-4重量份、秋海棠根15-20重量份、蝤蛑10-20重量份、三棱18-22重量份、泽兰12-20重量份、牛马藤15-28重量份、红曲15-20重量份、多刺绿绒蒿14-20重量份、红娘子4-5重量份、牡丹皮15-20重量份、花榈木12-20重量份、波缘楤木15-25重量份、琼越线蕨14-20重量份、麦饭石15-20重量份、萱藻15-20重量份、叶上花15-20重量份、金丝木通13-20重量份、马蔺子15-20重量份、漏芦4-5重量份、蝇虎15-20重量份和铜罗伞18-24重量份。
所述中药组合物中各原料药材的重量份数比为:熟地黄14重量份、龙眼肉22重量份、楮实子14重量份、夜交藤24重量份、珍珠母14重量份、刺蒺藜13重量份、钩藤25重量份、地龙12重量份、蜈蚣5重量份、夏天无14重量份、鸡血藤14重量份、凌霄花25重量份、禹白附5重量份、稻芽28重量份、鸡矢藤25重量份、威灵仙4重量份、乌梢蛇13重量份、伸筋草27重量份、丁公藤1重量份、路路通14重量份、土牛膝27重量份、叶上珠根29重量份、八角莲2重量份、秋海棠根12重量份、蝤蛑27重量份、三棱15重量份、泽兰27重量份、牛马藤13重量份、红曲12重量份、多刺绿绒蒿26重量份、红娘子3重量份、牡丹皮30重量份、花榈木24重量份、波缘楤木14重量份、琼越线蕨26重量份、麦饭石13重量份、萱藻25重量份、叶上花12重量份、金丝木通29重量份、马蔺子13重量份、漏芦3重量份、蝇虎14重量份和铜罗伞15重量份。
所述中药组合物中各原料药材的重量份数比为:熟地黄20重量份、龙眼肉20重量份、楮实子20重量份、夜交藤18重量份、珍珠母20重量份、刺蒺藜17重量份、钩藤18重量份、地龙18重量份、蜈蚣3重量份、夏天无20重量份、鸡血藤20重量份、凌霄花18重量份、禹白附3重量份、稻芽18重量份、鸡矢藤16重量份、威灵仙2重量份、乌梢蛇16重量份、伸筋草18重量份、丁公藤3重量份、路路通20重量份、土牛膝18重量份、叶上珠根16重量份、八角莲3重量份、秋海棠根16重量份、蝤蛑15重量份、三棱18重量份、泽兰15重量份、牛马藤28重量份、红曲15重量份、多刺绿绒蒿16重量份、红娘子4重量份、牡丹皮18重量份、花榈木17重量份、波缘楤木18重量份、琼越线蕨18重量份、麦饭石20重量份、萱藻20重量份、叶上花18重量份、金丝木通20重量份、马蔺子20重量份、漏芦5重量份、蝇虎20重量份和铜罗伞24重量份。
为了解决上述技术问题,本发明还提供了一种所述中药组合物的制备方法,其中,所述中药组合物的剂型为蜜炼丸剂时,其制备方法为:
第一步,将所述原料药材加1-3倍量的水浸泡30分钟-1小时,加热煮沸30-50分钟,过滤,滤液备用;
第二步,将所述第一步得到的所述滤渣加入1-3倍量的水,第二次加热,煮沸30-50分钟,再过滤,滤液备用;
第三步,将所述第二步得到的滤渣再加1-3倍量的水,第三次加热煮沸30-40分钟,过滤;
第四步,将三次滤液合在一起,加热浓缩至糊状,放入烘箱,控制在75℃-80℃,烘干后冷却成粉末状与蜂蜜适量混和在一起搓成细条;以每5g为一丸腊封包装。
所述中药组合物的剂型为片剂时,其制备方法为:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉;
第三步,将第二步获得的超微细粉,加入相对于其质量0.1~0.3倍的微晶纤维素、0.05~0.15倍乳糖、0.1~0.3倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.005~0.05倍硬脂酸镁,整粒,压片,制成。
所述中药组合物的剂型为:片剂、胶囊剂、蜜炼丸剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂、糖浆剂、散剂、擦剂、灌肠剂和贴剂。
本发明的有益效果是:本发明具有活血化瘀、通达脉络的功效,主治血瘀阻络型脑栓塞。本发明利用传统中医理论,重视整体观念:通过调节机体气血正常运行,营养肌肤,调节肢体关节的正常功能活动,防止血小板病理性聚集,化痰开窍,扩张血管,降低颅内压,减少并发症;辨证论治,针对性较强,可及时控制病情,疗效显著,提高治愈率,减少复发率;安全有效,制作工艺简单,给药方便,价格低廉,病人易于接受,可明显提高患者的生活质量等。
具体实施方式
中医学认为,本病由于患者脏腑功能失调,气血素虚或痰浊、瘀血内生,加之劳倦内伤、忧思恼怒、饮酒饱食、用力过度、气候骤变等诱因,而致瘀血阻滞、痰热内蕴,或阳化风动、血随气逆,导致脑脉痹阻或血溢脉外,引起昏仆不遂,发为中风。其病位在脑,与心、肾、肝、脾密切相关。其病机有虚(阴虚、气虚)、火(肝火、心火)、风(肝风)、痰(风痰、湿痰)、气(气逆)、血(血瘀)六端,此六端多在一定条件下相互影响,相互作用。病性多为本虚标实,上盛下虚。在本为肝肾阴虚,气血衰少,在标为风火相煽,痰湿壅盛,瘀血阻滞,气血逆乱。而其基本病机为气血逆乱,上犯于脑,脑之神明失用。
因此,本发明治疗脑栓血瘀阻络证,以活血化瘀、通达脉络为主要治疗原则,选用方剂:熟地黄、龙眼肉、楮实子、夜交藤、珍珠母、刺蒺藜、钩藤、地龙、蜈蚣、夏天无、鸡血藤、凌霄花、禹白附、稻芽、鸡矢藤、威灵仙、乌梢蛇、伸筋草、丁公藤、路路通、土牛膝、叶上珠根、八角莲、秋海棠根、蝤蛑、三棱、泽兰、牛马藤、红曲、多刺绿绒蒿、红娘子、牡丹皮、花榈木、波缘楤木、琼越线蕨、麦饭石、萱藻、叶上花、金丝木通、马蔺子、漏芦、蝇虎和铜罗伞。
其中,熟地黄、龙眼肉、楮实子补血和营;夜交藤、珍珠母、刺蒺藜、钩藤、地龙、蜈蚣、夏天无、鸡血藤、凌霄花、禹白附祛风通络;稻芽、鸡矢藤理气健脾消食;威灵仙、乌梢蛇、伸筋草、丁公藤、路路通祛风活络通经土牛膝、叶上珠根、八角莲、秋海棠根、蝤蛑、三棱、泽兰、牛马藤、红曲、多刺绿绒蒿、红娘子、牡丹皮、花榈木、波缘楤木、琼越线蕨、麦饭石、萱藻、叶上花、金丝木通、马蔺子活血化瘀;漏芦、蝇虎和铜罗伞通化脉络。
现将各味药的药理性质作用分述如下:
熟地黄:味甘,性微温,入肝、肾经,《本草纲目》:“填骨髓,长肌肉,生精血。补五脏内伤不足,通血脉,利耳目,黑须发,男子五劳七伤,女子伤中胞漏,经候不调,胎产百病。”具有补血滋阴,益精填髓的作用,用于血虚萎黄;眩晕,心悸,失眠,月经不调,崩不止;肝肾阴亏,盗汗,足膝疼痛,腰膝酸软,耳鸣耳聋,头目昏花,遗精阳痿,不育不孕,月经不调,崩漏下血,须发早白,消渴,肾虚喘促等证。
龙眼肉:《滇南本草》:“养血安神,长智敛汗,开胃益脾。”《泉州本草》:“壮阳益气,补脾胃。治妇人产后浮肿,气虚水肿,脾虚泄泻。补益心脾,”养血安神。用于气血不足、心悸怔忡、健忘失眠、血虚萎黄。龙眼所含糖分量很高,为易消化吸收的单糖,可以被人体直接吸收,故体弱贫血,年老体衰,久病体虚,经常吃些龙眼是很有补益作用;妇女产后,龙眼也是重要的调补食品。因含铁及维生素B2很丰富,可以减轻子宫收缩及宫体下垂感。
楮实子:甘,寒。入肝,脾、肾经。《日华子本草》:"壮筋骨,助阳气,补虚劳,助腰膝,益颜色。"《大名本草》:“壮筋骨、助阳气、补虚劳、助腰膝、益颜色。”补肾清肝,明目,利尿。用于腰膝酸软、虚劳骨蒸、砂晕目昏、目生翳膜、水肿胀满。
夜交藤:味甘、微苦,性平;归心、肝经,具有能养心安神、祛风通络的功效,主治失眠多梦,血虚身痛,风湿痹痛;皮肤瘙痒等证,夜交藤能够活血、通经、扩张血管、促进血液循环、下乳消肿。具有促进造血功能,增强免疫功能,降血脂与抗动脉粥样硬化,保肝,何首乌含有大黄酚、大黄素、大黄酸、大黄素甲醚、脂肪油、淀粉、糖类、土大黄甙、卵磷脂等有效成分。药理研究证明,何首乌能促进人体淋巴母细胞的转化。尚有降低血清胆固醇、抗动脉硬化、抗光毒等作用。
珍珠母:咸、寒。归肝、心经。《中国医学大辞典》:“滋肝阴,清肝火。治癫狂惊痫,头眩,耳鸣,心跳,胸腹膜胀,妇女血热,血崩,小儿惊搐发痉。”平肝,潜阳,定惊,止血。治头眩,耳鸣,心悸,失眠,癫狂,惊痫,吐血,衄血,妇女血崩。
刺蒺藜:《别录》:“主身体风痒,头痛、咳逆伤肺,肺痿,止烦、下气;小儿头疮,痈肿阴癀,可作摩粉。”散风,明目,下气,行血。治头痛,身痒,目赤肿翳,胸满,咳逆,症瘕,乳难,痈疽,瘰疬。
钩藤:甘,苦,微寒;入肝经,心经。《纲目》:“大人头旋目眩,平肝风,除心热,小儿内钓腹痛,发斑疹。”《唐本草》:“钩藤,出梁州。叶细长,茎间有刺,形若钓钩者。”功用清热平肝,熄风止痉。主治小儿惊风,夜啼,热盛动风,子痫,肝阳眩晕,肝火头胀痛。
地龙:清热,镇痉,利尿,解毒。用于热病惊狂、小儿惊风、咳喘、头痛目赤、咽喉肿痛、小便不通、风湿关节疼痛,半身不遂地龙菜等症。外用涂丹毒、漆疮等症。预先腹腔注射地龙注射液10g/kg,对蒙古沙土鼠一测预总动脉结扎造成的缺血性脑卒中具有一定的预防作用,可减轻缺血性脑卒中的症状;小鼠每日灌服地龙提取物l1mg/只,连续58d,对移植的肉瘤S180。有明显的抑制作用,不仅瘤体明显减少,且可延长小鼠的生存期。
蜈蚣:辛,温。归肝经。《本草纲目》:“治小儿惊厥风搐,脐风口噤,丹毒,秃疮,瘰疠,便毒,痔漏,蛇伤。”息风镇痉,攻毒散结,通络止痛。用于小儿惊风,抽搐痉挛,中风口歪,半身不遂,破伤风,风湿顽痹,疮疡,瘰疬,毒蛇咬伤。
夏天无:苦、微辛,温。归肝经。《全国中草药汇编》:“祛风湿,降血压。主治风湿性关节炎、腰肌劳损,高血压病,脑血管意外引起偏瘫。”功能活血通络,行气止痛。用于中风偏瘫,跌扑损伤,风湿性关节炎,坐骨神经痛。夏天无生物碱可使麻醉犬脑与下肢血流量增加,血管阻力减低(经统计学处理均有显著差异),血压轻度下降,提示其有扩张脑血管和下肢血管的作用。1%夏大无注射液0.3ml加入15ml平滑肌溶液中肠管节律性收缩增强,张力增强,甚至是痉挛性收缩,提示对大白鼠离体平滑肌有兴奋作用。对于坐骨神经痛、风湿性关节炎、骨折及扭伤、小儿麻痹症等,有止痛,消肿,缓解关节僵硬,促进患肢功能恢复,加速骨折愈合等效果。
鸡血藤:味苦、甘,性温,入肝、肾经,《现代实用中药》:“为强壮性之补血药,适用于贫血性之神经麻痹症,如肢体及腰膝酸痛,麻木不仁等。又用于妇女月经不调,月经闭止等,有活血镇痛之效。”有扩张血管,补血活血,调经,舒筋活络的功效,对血小板聚集有明显的抑制作用,促进动物肾脏及子宫总磷代谢,主要用于治疗血虚有淤之月经不调,四肢疼痛不仁,腰膝酸软、疼痛等证。
凌霄花:甘、酸,寒;归肝、心包经。《本草纲目》:“凌雷花及根,甘酸而寒,茎叶带苦,行血分,能去血中伏火,故主产乳崩漏诸疾及血热生风之证也。”《本经逢原》:“凌雪花,额痛血闭,血气刺痛,厉风恶疮多用之,皆取其散恶血之功也。”《神农本草经》:“主妇人产乳余疾,崩中,症瘕,血闭,寒热羸瘦。”行血去瘀,凉血祛风。用于经闭癓瘕,产后乳肿,风疹发红,皮肤瘙痒,痤疮。
禹白附:味辛、甘,性温。归胃、肝经。燥湿化痰,祛风止痉,解毒散结止痛。主治风痰所致中风口眼斜、中风痰壅、半身不遂、破伤风、头痛、风湿痹痛、肢体麻木、瘰疬结核、阴疽肿毒辣,毒蛇咬伤、惊风癫痫、痈疽肿毒。禹白附粉混悬液或煎剂给大鼠腹腔注射, 结果显示其均能显著降低蛋清所致炎症的肿胀度,生禹白附或制禹白附提取物给小鼠腹腔注射, 均有显著祛痰作用。禹白附蛋白预防和治疗用药, 对小鼠肌肉注射破伤风毒素引起的破伤风均有对抗作用, 能使动物存活率显著增加。
稻芽:性味甘,平。归脾、胃经、肝经。《日华子本草》:“温中,下气,开胃,止霍乱,除烦,消痰,破症结,能催生落胎。”《滇南本草》:“宽中,下气,止呕吐,消宿食,止吞酸吐酸,止泻,消胃宽膈,并治妇人奶乳不收,乳汁不止。”具有行气消食,健脾开胃,退乳消胀的功效。主治食积不消,脘腹胀痛,脾虚食少,乳汗郁积,乳房胀痛,妇女断乳。
鸡矢藤:性平,味甘、微苦。《生草药性备要》:“其头治新内伤,煲肉食,补虚益肾,除火补血;洗疮止痛,消热散毒。其叶擂米加糖食,止痢。”《植物名实图考》:“为洗药,解毒,去风,清热,散寒。敷无名肿毒,并补筋骨。”祛风活血,止痛解毒,消食导滞,除湿消肿。治风湿疼痛,腹泻痢疾,肮腹疼痛,气虚浮肿,头昏食少,肝脾肿大,瘰疬,肠痈,无名肿毒,跌打损伤。鸡矢藤总生物碱腹腔注射能抑制小鼠自发性活动,延长戊巴比妥钠睡眠时间,有一定的镇静作用。鸡矢藤总生物碱能抑制肠肌收缩,并能拮抗乙酰胆碱所致的肠肌挛缩。鸡矢藤煎剂对体外金黄色葡萄球菌和褔氏痢疾杆菌有抑制作用,浸膏对金黄色葡萄球菌及肺炎链球菌也有抑菌作用。
威灵仙:辛,咸,温。归膀胱经。《开宝本草》:“主诸风,宣通五藏,去腹内冷滞,心隔痰水久积,症瘕痃癣气块,膀胱宿脓恶水,腰膝冷疼及疗折伤。”《本经逢原》:“痘疹毒壅于上不能下达,腰下胫膝起灌迟者,用为下引。”具有祛风除湿,通络止痛,消痰水,散癖积的功效,主治痛风顽痹、风湿痹痛,肢体麻木,腰膝冷痛,筋脉拘挛,屈伸不利,脚气,疟疾,症瘕积聚,破伤风,扁桃体炎,诸骨鲠咽等证。
乌梢蛇:味甘,性平;归肝、脾经。具有祛风湿,通经络,熄风止痉,止痒解毒的功效。主治风湿顽痹,麻木拘挛,中风口眼歪斜,半身不遂,小儿惊风,抽搐痉挛,破伤风,麻风疥癣,瘰疬恶疮。蛇血清(包括乌梢蛇、松花蛇及五步蛇血清)对小白鼠次全致死量或二倍致死量五步蛇毒的注入均有明显的保护作用;对注射五步蛇毒的小白鼠给予蛇血清后,可使其凝血时间正常;每毫升五步蛇血清可灭活五步蛇毒5毫克;注射后10分钟再注射蛇血清,对小白鼠亦有保护作用。
伸筋草:苦、辛、温,入肝经。《本草拾遗》:“主人久患风痹,脚膝疼冷,皮肤不仁,气力衰弱。”《湖南药物志》:“舒筋活血,补气通络。治腰痛,关节痛,闭经。”祛风散寒,除湿消肿,舒筋活络。用于风寒湿痹,筋脉拘挛疼痈。外用治跌打扭伤肿痛。本品水浸剂对实验家兔有降温作用。30毫克/公斤静脉注射石松碱可使麻醉猫、兔血压骤降,中毒剂量可增加动物呼吸振幅而减少频率。体外对福氏痢疾杆菌、宋内氏痢疾杆菌高度敏感,对志贺氏痢疾杆菌中度敏感。石松碱对蛙心收缩力有增强作用。对离体大鼠、豚鼠、家兔小肠平滑肌有兴奋作用。对兔、大鼠及豚鼠子宫有兴奋作用。
丁公藤:辛、温;归肝,脾,胃经。《常用中草药手册》:“解表发汗,驱风湿,除痹痛,消肿止痛。治风湿痹痛,半身不遂,跌打肿痛。”有祛风除湿,消肿止痛的作用。可用于风湿性关节炎,类风湿性关节炎,坐骨神经痛,半身不遂,跌打肿痛。丁公藤所含黄酮乙可使离体兔心的冠状动脉血流量增加,血管阻力下降,作用随剂量加大而增加,黄酮乙为治疗冠心病的有效成分。
路路通:苦,平;归肝、肾经。《纲目拾遗》:“枫果,树似白杨,内圆如蜂窝,即路路通。其性大能通行十二经穴,故《救生苦海》治水肿胀用之,以其能搜逐伏水也。”《现代实用中药》:“烧灰外用于皮肤湿癣、痔漏等,有收敛、消炎、消毒作用。”祛风活络,利水通经。用于关节痹痛,麻木拘挛,水肿胀满,乳少经闭。
土牛膝:性味苦酸,平。①《福建民间草药》:"苦酸,平,无毒。"②《广西中草药》:"味微苦酸,性寒,无毒。"③《云南中草药》:"甘微酸,凉。"功能主治活血散瘀,祛湿利民,清热解毒。治淋病,尿血,妇女经闭,症瘕,风湿关节痛,脚气,水肿,痢疾,疟疾,白喉,痈肿,跌打损伤。①《本草图经》:"治妇人血块。"②《纲目拾遗》:"活血化瘀,宽筋,理跌打损伤。治破伤风,七十二般恶疾。功胜川产。又:善能理疮,并箭入肉。"③《岭南采药录》:"为收敛药及利小便药,清血消毒。治喉症捣汁含漱;又散血止痛,理脚气,煎酒服。"④《福建民间草药》:"散瘀血,强足膝,引药下行。"⑤《南宁市药物志,:"清热,散血止痛。治疟疾、痔疮及红白痢;外用治跌打损伤。"⑥《江西草药》:"治竹木刺伤,毒蜂咬伤等症;并可引产。"⑦《上海常用中草药手册》:"通经利尿,清热解毒,活血止痛。治脚气肿胀,关节炎,风湿痛,白喉,急慢性咽炎。"⑧《贵州草药》:"生用可破血利湿,炒用补肝肾,强筋骨。"⑨《云南中草药》:"活血祛瘀,清热除湿,治咳血,鼻衄,尿血,尿路感染,湿热带下。"
叶上珠根: 性味苦辛,平。①《贵州草药》:"性平,味辛微甘。"②《云南中草药》:"苦微涩,凉。"功能主治平喘止咳,活血化瘀。治咳喘,风湿,劳伤,月经不调,跌打损伤。①《贵州草药》:"补虚,止咳,止痛,固脱。"②《云南中草药》:"活血祛瘀,接骨,截疟。"③《昆明民间常用草药》:"祛风湿,祛瘀活血。治风湿疼痛,跌打损伤。"
八角莲:性味苦辛,平。①《分类草药性》:"味苦,无毒。"②《福建民间草药》:"甘微辛,温。"③《贵阳民间药草》:"辛微苦,平,无毒。"④《广西中药志》:"甘苦微辛,性凉,无毒。"归经《广西中药志》:"入肺经。"功能主治清热解毒,化痰散结,祛瘀消肿。治痈肿,疔疮,瘰疬,喉蛾,跌打损伤,蛇咬伤。①《纲目拾遗》:"治一切毒蛇伤。"②《贵州民间方药集》:"治虚弱脱肛;外用消伤肿,并治蛇咬伤,疔疮。"③《福建民间草药》:"散结活瘀,消瘿解毒。"④《广西中药志》:"清热化痰,解蛇虫毒。治肺热痰咳,虫蛇咬伤,单双蛾喉痛,疮疖。"⑤《四川中药志》:"治劳伤吐血、腰痛,疥癣白秃。"⑥广州部队《常用中草药手册》:"清热解毒,燥湿泻火。治淋巴结炎,腮腺炎,痈疮。"⑦《江西草药》:"治肾虚,劳伤,中暑,胃痛。"
秋海棠根:性味①《贵州草药》:"性平,味酸涩。"②《陕西中草药》:"味苦涩酸,性寒。"功能主治活血化瘀,止血,清热。治跌打损伤,吐血、咯血,痢疾,月经不调,崩漏,带下,淋浊,喉痛。①《分类草药性》:"治吐血,跌打损伤。"②《贵州民间方药集》:"止吐血、咯血、刀伤出血。"③《贵州草药》:"活血化瘀,凉血止血。"④《陕西中草药》:"活血散瘀,清热,止血止痛。治跌打损伤,吐血,衄血,胃溃疡,痢疾,肺痈,崩漏,白带,月经不调。"⑤江西《草药手册》:"行气行血,消肿止痛,镇痉,治瘰疬。"
蝤蛑:生态环境:生活于低潮线10m的水深内,有海藻的泥沙质水底或石隙间。每年5-6间为产卵期。资源分布:全国沿海均有分布。性味咸;微辛;性温。归经脾;胃经。功能主治活血化瘀;消食;通乳。主血瘀经闭;产后瘀滞腹痛;消化不良;食积痞满;乳法不足。
三棱:性味苦辛,平。①《本草拾遗》:"甘平,温。"②《日华子本草》:"味甘涩,凉。"③《开宝本草》:"味苦,平,无毒。"④《本草衍义补遗》:"辛苦。"归经入肝。脾经。①《雷公炮制药性解">雷公炮制药性解》:"入肺、脾二经。"②《本草经疏》:"入足厥阴、太阴。"功能主治破血,行气,消积,止痛。治症瘕积聚,气血凝滞,心腹疼痛,胁下胀疼,经闭,产后瘀血腹痛,跌打损伤。疮肿坚硬。①《日华子本草》:"治妇人血脉不调,心腹痛,落胎,消恶血,补劳,通月经,治气胀,消扑损瘀血,产后腹痛、血运并宿血不下。"②《开宝本草》:"主老癖症瘕结块。"③《医学启源》:"主心膈痛,饮食不消,破气。"④王好古:"通肝经积血。治疮肿坚硬。"
泽兰:性味苦辛,微温。①《本经》:"味苦,微温。"②《吴普本草》:"神农、黄帝、岐伯、桐君:酸,无毒。李氏:温。"③《别录》:"甘,无毒。"④《药性论》:"味苦辛。"归经入肝、脾经。①《滇南本草》:"行肝、脾二经。"②《雷公炮制药性解》:"入小肠经。"功能主治活血,行水。治经闭,症瘕,产后瘀滞腹痛,身面浮肿,跌扑损伤,金疮,痈肿。①《本经》:"主乳妇内衄,中风余疾,大腹水肿,身面四肢浮肿,骨节中水,金疮,痈肿疮脓。"②《雷公炮炙论》:"能破血,通久积。"③《别录》:"产后、金疮内塞。"④《药性论》:"主产后腹痛,频产血气衰冷成劳,瘦羸,又治通身面目大肿,主妇人血沥腰痛。"⑤《日华子本草》:"通九窍,利关脉,养血气,破宿血,消症瘕,产前产后百病,通小肠,长肉生肌,消扑损瘀血,治鼻洪吐血,头风目痛,妇人劳瘦,丈夫面黄。"⑥《医林纂要》:"补肝泻脾,和气血,利筋脉。主治妇人血分,调经去瘀。"⑦《岭南采药录》:"治蛇伤,散毒疮。"
牛马藤:性味 ①《四川中药志》:"甘,温,无毒。"②《中药鉴别手册》:"性温,味苦。"功能主治行血补血,通经活络。治风湿疼痛,四肢麻木,贫血,月经不调。①《草木便方》:"活血化瘀,舒筋,利关节。治腰脊痛。"②《分类草药性》:"治寒脾风,风湿麻木,筋骨疼痛,消肿。"③江西《草药手册》:"治妇女经闭,膝盖骨痛。"
红曲:性味甘,温。①《饮膳正要》:"味甘,平,无毒。"②《纲目》:"甘,温,无毒。"③《本经逢源》:"甘微苦辛,平。"归经入肝、脾、大肠经。①《本草经解》:"入足厥阴肝经,足太阴脾经。"②《得配本草》:"入足阳明、太阴经血分。"③《要药分剂》:"入脾、胃、大肠三经。"功能主治活血化瘀,健脾消食。治产后恶露不净,瘀滞腹痛,食积饱胀,赤白下痢,跌打损伤。①《饮膳正要》:"健脾,益气,温中。"②《本草衍义补遗》:"活血消食,健脾暖胃,赤白痢下水谷。"③《纲目》:"治女人血气痛及产后恶血不尽,擂酒饮之良。"④《本草备要》:"入营而破血,燥胃消食,活血和血。治赤白下痢,跌打损伤。"⑤《医林纂要》:"解生冷物毒。"
多刺绿绒蒿:生境分布生高山峡谷或山坡草地。分布西藏、云南、四川、青海、甘肃等地。性味性寒,味苦,有小毒。功能主治活血化瘀,镇痛。治跌打损伤。
红娘子:性味苦辛,平。归经《纲目》:"厥阴经。"功能主治攻毒,通瘀,破积。外用治瘰疬,癣疮;内服治血瘀经闭,狂犬咬伤。①《本经》:"主心腹邪气,阴痿。"②《别录》:"疗腰痛,下气。"③《本草衍义》:"行瘀血、月闭。"④《纲目》:"主瘰疬,散目中结翳,疗猘犬伤。"⑤《药材资料汇编》:"效用与斑蝥同。"⑥《山西中药志》:"外用治疮癣。"
牡丹皮:性味辛苦,凉。①《本经》:"味辛,寒。"②《滇南本草》:"性寒,味酸辛。"③《本草备要》:"辛甘,微寒。"归经入心、肝、肾经。①《珍珠囊》:"手厥阴、足少阴。"②《纲目》:"手足少阴、厥阴四经。"③《雷公炮制药性解》:"入肺经。"功能主治清热,凉血,和血,消瘀。治热入血分,发斑,惊痫,吐、衄、便血,骨蒸劳热,经闭,症瘕,痈疡,扑损。①《本经》:"主寒热,中风瘈疭、痉、惊痫邪气,除症坚瘀血留舍肠胃,安五脏,疗痈疮。"②《别录》:"除时气头痛,客热五劳,劳气头腰痛,风噤,癫疾。"③《药性论》:"治冷气,散诸痛,治女子经脉不通,血沥腰疼。"④《日华子本草》:"除邪气,悦色,通关腠血脉,排脓,通月经,消扑损瘀血,续筋骨,除风痹,落胎下胞,产后一切冷热血气。"⑤《珍珠囊》:"治肠胃积血、衄血、吐血,无汗骨蒸。"⑥《滇南本草》:"破血,行(血),消癥瘕之疾,除血分之热。"⑦《医学入门》:"泻伏火,养真血气,破结蓄。"⑧《纲目》:"和血,生血,凉血。治血中伏火,除烦热。"
花榈木:别名三钱三[江西]、青竹蛇、牛屎樵。来源豆科红豆树属植物花榈木Ormosia henryi Prain,以根、根皮、茎及叶入药。全年可采,鲜用或晒干。性味辛,温。有毒。功能主治活血化瘀,祛风消肿。用于跌打损伤,腰肌劳损,风湿关节痛,产后血瘀疼痛,白带,流行性腮腺炎,丝虫病;根皮外用治骨折;叶外用治烧烫伤。
波缘楤木:生态环境:生于海拔1000m左右的山中密林或山谷疏林下。资源分布:分布于湖南、广东、广西、四川、贵翻译片等地。性味苦;辛;性凉。功能主治活血化瘀;通经止痛;祛风除湿。主跌打损伤;骨折;痞块;经闭;痛经;劳伤疼痛;风湿痛。
琼越线蕨: 生态环境:生于密林下溪沟边的潮湿岩石上。资源分布:分布于海南、广西等地。性味微苦;涩;凉。归经入肝、肾、膀胱三经。功能主治活血化瘀;清热利尿。主跌打损伤;小例淋沥涩痛。
麦饭石:性味甘;温;无毒.归经肝;胃;肾经。功能主治解毒散结;去腐生肌;除寒祛湿;益肝健胃;活血化瘀;利尿化石;延年益寿。主痈疽发背;痤疮;湿疹;脚气;痱子;手指皲裂;黄褐斑;牙痛;口腔溃疡;风湿痹痛;腰背痛;慢性肝炎;胃炎;痢疾;糖尿病;神经衰弱;外伤红肿;高血压;老年性血管硬化;肿瘤;尿路结石。
萱藻:药理作用1.明显增加离体豚鼠心脏冠脉流量及麻醉犬的冠脉流量。2.提取液能明显增强常压下和预先给予肾上腺素的小白鼠减压下的缺氧耐力。3.岩藻甾醇有雌激素样作用及降低血胆固醇的作用。性味咸;寒。归经入肝、肺经功能主治化痰软坚;清热解毒。主咳嗽;喉炎;甲状腺肿;颈淋巴结肿。各家论述《新华本草纲要》:全藻味咸、性寒。有清热解毒、活血化瘀功能。用于喉炎、干咳、甲状腺肿及颈淋巴结肿。
叶上花: 山茱萸科青荚叶属植物西南青荚叶Hewingia himalaica Clarke和青荚叶H. japonica (Thunb.)Dietr.,以全株及根入药。夏秋采,晒干。性味苦、微涩,凉。功能主治活血化瘀,清热解毒。用于跌打损伤,骨折,风湿性关节炎,胃痛,痢疾,月经不调;外用治烧烫伤,疮疖痈肿,毒蛇咬伤。
金丝木通: 生态环境:生于海拔1000-3200m的山坡、山谷的灌木丛中、林下或林边,或河谷旁。资源分布:分布于四川南部和西部、贵州西部、云南。性味甘;淡;性平。归经归肝;肾;膀胱经。功能主治清热利水;活血通经;祛风除湿。主小便不利;水肿;湿热淋证;风湿痹痛;跌打损伤;风火上炎;眼赤疼痛;闭经;疥癞。
马蔺子:性味甘,平。①《本经》:"味甘,平。"②《别录》:"无毒。"③《蜀本草》:"寒。"归经①《得配本草》:"入阳明经血分。"②《本草再新》:"入脾、肺二经。"功能主治清热,利湿,止血,解毒。治黄疸,泻痢,吐血,衄血,血崩,白带,喉痹,痈肿。①《本经》:"主皮肤寒热,胃冲热气,风寒湿痹,坚筋骨,令人嗜食。"②《别录》:"止心烦满,利大小便,长肌肤。"③《唐本草》:"疗金疮血内流、痈肿等病有效。"④《日华子本草》:"治妇人血气烦闷,产后血运并经脉不止,崩中带下,消一切疮疖肿毒,止鼻洪吐血,通小肠,消酒毒,治黄病,敷蛇虫咬,杀草毒。"⑤《纲目》:、"治小腹疝痛、腹内冷积、水痢诸病。"⑥《医林纂要》:"破血,软坚。"
漏芦:性味苦咸,寒。①《本经》:"味苦咸,寒。"②《别录》:"大寒,无毒。’③《本草正》:"味微咸,性寒。"归经入胃、大肠经。①李杲:"手、足阳明。"②《木草从新》:"入胃、大肠,通肺、小肠。"③《玉楸药解》:"入足少阴肾、足厥阴肝经。"功能主治清热解毒,消肿排脓,下乳,通筋脉。治痈疽发背,乳房肿痛。乳汁不通,瘰疬恶疮,湿痹筋脉拘牵,骨节疼痛,热毒血痢,痔疮出血。①《本经》:"主皮肤热,恶疮疽痔,湿痹,下乳汁。"②《别录》:"止遗溺,热气疮痒如麻豆,可作浴汤。"③陶弘景:"疗诸瘘疥。"④《药性论t》:"治身上热毒风生恶疮,皮肌瘙痒瘾疹。"⑤《本草拾遗》:"杀虫,洗疮疥用之。"⑥《日华子本草》:"治小儿壮热,通小肠,(治)泄精,尿血,风赤眼,乳痈,发背,瘰疬,肠风,排脓,补血,治扑损,续筋骨,敷金疮,止血长肉,通经脉。"⑦《山西中药志》:"清热凉血,治热毒血痢,鼻衄,血痔,温疫等症。"
蝇虎:生态环境:生活于稻区,捕食农田害虫及蝇类。资源分布:分布于吉林、河北、山西、陕西、山东、江苏、台湾、河南、湖北、湖南等地。性味辛;温。归经肝;脾经。功能主治活血通脉。主跌打损伤
铜罗伞:生态环境:生于海拔200-1000m的沟谷旁及杂木林或灌丛中。资源分布:分布于安徽、浙江、福建、广东、广西、贵州等地。栽培生物学特性 喜温暖、向阳,不耐寒。对土壤不甚选择,在华北地区宜盆栽。栽培技术 用种子每秒殖。春3-4月播种。田间管理 苗高10cm左右,即可栽入盆中,夏季追肥2-3次。生长地盛枝条,可剪短一半,在北方栽培,冬季要移入冷室越冬。性味辛;酸;性平。归经肝;肾经。功能主治续筋接骨;散瘀止痛。主跌打损伤;痛经;血瘀经闭;风湿痹痛。
为解决上述技术问题,本发明提供一种治疗血瘀阻络型脑栓塞的中药组合物,包括以下原料药材:熟地黄、龙眼肉、楮实子、夜交藤、珍珠母、刺蒺藜、钩藤、地龙、蜈蚣、夏天无、鸡血藤、凌霄花、禹白附、稻芽、鸡矢藤、威灵仙、乌梢蛇、伸筋草、丁公藤、路路通、土牛膝、叶上珠根、八角莲、秋海棠根、蝤蛑、三棱、泽兰、牛马藤、红曲、多刺绿绒蒿、红娘子、牡丹皮、花榈木、波缘楤木、琼越线蕨、麦饭石、萱藻、叶上花、金丝木通、马蔺子、漏芦、蝇虎和铜罗伞。
所述中药组合物中各原料药材的重量份数比为:熟地黄10-20重量份、龙眼肉12-29重量份、楮实子10-25重量份、夜交藤13-24重量份、珍珠母10-24重量份、刺蒺藜10-20重量份、钩藤15-25重量份、地龙10-20重量份、蜈蚣3-5重量份、夏天无10-20重量份、鸡血藤10-22重量份、凌霄花14-25重量份、禹白附3-5重量份、稻芽12-28重量份、鸡矢藤15-29重量份、威灵仙1-3重量份、乌梢蛇10-20重量份、伸筋草14-27重量份、丁公藤2-4重量份、路路通10-25重量份、土牛膝12-27重量份、叶上珠根15-29重量份、八角莲2-4重量份、秋海棠根10-20重量份、蝤蛑10-27重量份、三棱15-22重量份、泽兰12-27重量份、牛马藤10-28重量份、红曲10-20重量份、多刺绿绒蒿14-26重量份、红娘子3-5重量份、牡丹皮15-30重量份、花榈木12-29重量份、波缘楤木10-25重量份、琼越线蕨14-26重量份、麦饭石10-20重量份、萱藻15-25重量份、叶上花10-20重量份、金丝木通13-29重量份、马蔺子10-20、漏芦3-5、蝇虎10-20重量份和铜罗伞13-24重量份。
所述中药组合物中各原料药材的重量份数比为:熟地黄15-20重量份、龙眼肉12-20重量份、楮实子15-25重量份、夜交藤13-20重量份、珍珠母15-24重量份、刺蒺藜15-20重量份、钩藤15-20重量份、地龙15-20重量份、蜈蚣3-4重量份、夏天无15-20重量份、鸡血藤15-22重量份、凌霄花14-20重量份、禹白附3-4重量份、稻芽12-20重量份、鸡矢藤15-20重量份、威灵仙1-2重量份、乌梢蛇15-20重量份、伸筋草14-20重量份、丁公藤2-3重量份、路路通15-25重量份、土牛膝12-20重量份、叶上珠根15-20重量份、八角莲3-4重量份、秋海棠根15-20重量份、蝤蛑10-20重量份、三棱18-22重量份、泽兰12-20重量份、牛马藤15-28重量份、红曲15-20重量份、多刺绿绒蒿14-20重量份、红娘子4-5重量份、牡丹皮15-20重量份、花榈木12-20重量份、波缘楤木15-25重量份、琼越线蕨14-20重量份、麦饭石15-20重量份、萱藻15-20重量份、叶上花15-20重量份、金丝木通13-20重量份、马蔺子15-20重量份、漏芦4-5重量份、蝇虎15-20重量份和铜罗伞18-24重量份。
所述中药组合物中各原料药材的重量份数比为:熟地黄14重量份、龙眼肉22重量份、楮实子14重量份、夜交藤24重量份、珍珠母14重量份、刺蒺藜13重量份、钩藤25重量份、地龙12重量份、蜈蚣5重量份、夏天无14重量份、鸡血藤14重量份、凌霄花25重量份、禹白附5重量份、稻芽28重量份、鸡矢藤25重量份、威灵仙4重量份、乌梢蛇13重量份、伸筋草27重量份、丁公藤1重量份、路路通14重量份、土牛膝27重量份、叶上珠根29重量份、八角莲2重量份、秋海棠根12重量份、蝤蛑27重量份、三棱15重量份、泽兰27重量份、牛马藤13重量份、红曲12重量份、多刺绿绒蒿26重量份、红娘子3重量份、牡丹皮30重量份、花榈木24重量份、波缘楤木14重量份、琼越线蕨26重量份、麦饭石13重量份、萱藻25重量份、叶上花12重量份、金丝木通29重量份、马蔺子13重量份、漏芦3重量份、蝇虎14重量份和铜罗伞15重量份。
所述中药组合物中各原料药材的重量份数比为:熟地黄20重量份、龙眼肉20重量份、楮实子20重量份、夜交藤18重量份、珍珠母20重量份、刺蒺藜17重量份、钩藤18重量份、地龙18重量份、蜈蚣3重量份、夏天无20重量份、鸡血藤20重量份、凌霄花18重量份、禹白附3重量份、稻芽18重量份、鸡矢藤16重量份、威灵仙2重量份、乌梢蛇16重量份、伸筋草18重量份、丁公藤3重量份、路路通20重量份、土牛膝18重量份、叶上珠根16重量份、八角莲3重量份、秋海棠根16重量份、蝤蛑15重量份、三棱18重量份、泽兰15重量份、牛马藤28重量份、红曲15重量份、多刺绿绒蒿16重量份、红娘子4重量份、牡丹皮18重量份、花榈木17重量份、波缘楤木18重量份、琼越线蕨18重量份、麦饭石20重量份、萱藻20重量份、叶上花18重量份、金丝木通20重量份、马蔺子20重量份、漏芦5重量份、蝇虎20重量份和铜罗伞24重量份。
为了解决上述技术问题,本发明还提供了一种所述中药组合物的制备方法,其中,所述中药组合物的剂型为蜜炼丸剂时,其制备方法为:
第一步,将所述原料药材加1-3倍量的水浸泡30分钟-1小时,加热煮沸30-50分钟,过滤,滤液备用;
第二步,将所述第一步得到的所述滤渣加入1-3倍量的水,第二次加热,煮沸30-50分钟,再过滤,滤液备用;
第三步,将所述第二步得到的滤渣再加1-3倍量的水,第三次加热煮沸30-40分钟,过滤;
第四步,将三次滤液合在一起,加热浓缩至糊状,放入烘箱,控制在75℃-80℃,烘干后冷却成粉末状与蜂蜜适量混和在一起搓成细条;以每5g为一丸腊封包装。
所述中药组合物的剂型为片剂时,其制备方法为:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉;
第三步,将第二步获得的超微细粉,加入相对于其质量0.1~0.3倍的微晶纤维素、0.05~0.15倍乳糖、0.1~0.3倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.005~0.05倍硬脂酸镁,整粒,压片,制成。
所述中药组合物的剂型为:片剂、胶囊剂、蜜炼丸剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂、糖浆剂、散剂、擦剂、灌肠剂和贴剂。
以下采用实施例来详细说明本发明的实施方式,借此对本发明如何应用技术手段来解决技术问题,并达成技术效果的实现过程能充分理解并据以实施。
实施例1 蜜炼丸剂
熟地黄14重量份、龙眼肉22重量份、楮实子14重量份、夜交藤24重量份、珍珠母14重量份、刺蒺藜13重量份、钩藤25重量份、地龙12重量份、蜈蚣5重量份、夏天无14重量份、鸡血藤14重量份、凌霄花25重量份、禹白附5重量份、稻芽28重量份、鸡矢藤25重量份、威灵仙4重量份、乌梢蛇13重量份、伸筋草27重量份、丁公藤1重量份、路路通14重量份、土牛膝27重量份、叶上珠根29重量份、八角莲2重量份、秋海棠根12重量份、蝤蛑27重量份、三棱15重量份、泽兰27重量份、牛马藤13重量份、红曲12重量份、多刺绿绒蒿26重量份、红娘子3重量份、牡丹皮30重量份、花榈木24重量份、波缘楤木14重量份、琼越线蕨26重量份、麦饭石13重量份、萱藻25重量份、叶上花12重量份、金丝木通29重量份、马蔺子13重量份、漏芦3重量份、蝇虎14重量份和铜罗伞15重量份。
其制备方法包括以下步骤:
第一步,将所述原料药材加3倍量的水浸泡1小时,加热煮沸50分钟,过滤,滤液备用;
第二步,将所述第一步得到的所述滤渣加入2倍量的水,第二次加热,煮沸30分钟,再过滤,滤液备用;
第三步,将所述第二步得到的滤渣再加1倍量的水,第三次加热煮沸40分钟,过滤;
第四步,将三次滤液合在一起,加热浓缩至糊状,放入烘箱,控制在80℃,烘干后冷却成粉末状与蜂蜜适量混和在一起搓成细条;以每5g为一丸腊封包装。
实施例2 片剂
熟地黄20重量份、龙眼肉20重量份、楮实子20重量份、夜交藤18重量份、珍珠母20重量份、刺蒺藜17重量份、钩藤18重量份、地龙18重量份、蜈蚣3重量份、夏天无20重量份、鸡血藤20重量份、凌霄花18重量份、禹白附3重量份、稻芽18重量份、鸡矢藤16重量份、威灵仙2重量份、乌梢蛇16重量份、伸筋草18重量份、丁公藤3重量份、路路通20重量份、土牛膝18重量份、叶上珠根16重量份、八角莲3重量份、秋海棠根16重量份、蝤蛑15重量份、三棱18重量份、泽兰15重量份、牛马藤28重量份、红曲15重量份、多刺绿绒蒿16重量份、红娘子4重量份、牡丹皮18重量份、花榈木17重量份、波缘楤木18重量份、琼越线蕨18重量份、麦饭石20重量份、萱藻20重量份、叶上花18重量份、金丝木通20重量份、马蔺子20重量份、漏芦5重量份、蝇虎20重量份和铜罗伞24重量份。
其制备方法包括以下步骤:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量4倍的醇浓度为95%的乙醇,加热回流3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1倍的醇浓度为95%的乙醇,加热回流3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎2小时,粉碎,过筛,获得300目的超微细粉;
第三步,将第二步获得的超微细粉,加入相对于其质量0.1倍的微晶纤维素、0.05倍乳糖、0.1倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.005倍硬脂酸镁,整粒,压片,制成。
实施例3 汤剂
熟地黄20g、龙眼肉20g、楮实子20g、夜交藤18g、珍珠母20g、刺蒺藜17g、钩藤18g、地龙18g、蜈蚣3g、夏天无20g、鸡血藤20g、凌霄花18g、禹白附3g、稻芽18g、鸡矢藤16g、威灵仙2g、乌梢蛇16g、伸筋草18g、丁公藤3g、路路通20g、土牛膝18g、叶上珠根16g、八角莲3g、秋海棠根16g、蝤蛑15g、三棱18g、泽兰15g、牛马藤28g、红曲15g、多刺绿绒蒿16g、红娘子4g、牡丹皮18g、花榈木17g、波缘楤木18g、琼越线蕨18g、麦饭石20g、萱藻20g、叶上花18g、金丝木通20g、马蔺子20g、漏芦5g、蝇虎20g和铜罗伞24g。
其制备方法包括以下步骤:
将所述原料药材混合放入紫砂锅中,加入清水,至清水浸过药材上表面3cm,浸泡4小时;将紫砂锅置于火上,武火煮沸后,改用文火慢煎50分钟至药液的剂量为100ml,过滤,得滤液a,备用;将剩余药渣再次加入清水,至清水浸过药材上表面2cm,浸泡3小时;将紫砂锅置于火上,武火煮沸后,改用文火慢煎25分钟至药液的剂量为100-300ml,过滤,得滤液b,将滤液a和滤液b混合即可。
药物的毒性试验
急性毒性试验:取15只白鼠进行试验,以本发明实施例1的蜜炼丸剂为对象,临床日用量的150倍给白鼠大肠内投药,观察7日。结果所有动物健存,其活动、饮食、毛发、排泄物未发现异常,未见毒性反应。对白鼠阴道和破损皮肤进行刺激性试验,未见有刺激性反应和其它不良反应。毒性试验证明,该中药组合物没有毒性作用和不良反应,临床应用安全可靠。
长期毒性试验:本发明实施例2的片剂对小鼠按10.78、20.35和33.48g生药/kg连续用药16周(1.0ml/100g体重,每天2次)及停药4周后,结果表明:本发明中药对小鼠的毛发、行为、大小便、体重、脏器重量、血象、肝肾功能、血糖、血脂等指标均无明显影响,脏器肉眼没有发现异样变化和组织学检查结果表明,用药16周及停药4周后,小鼠各脏器均无明显改变。说明本发明中药组合物对小鼠长期用药后毒性小,停药后也没有异样反应,应用安全。
临床试验
资料与方法
选择2010年2月-2012年2月期间,我院接收的血瘀阻络型脑栓塞患者共计600例。其中,600例患者中,年龄30-50岁以下的病例患者有80例,年龄50-60岁的病例患者290例,年龄60岁以上的病例患者有230例。将该600例患者随机分为治疗一组、治疗二组、治疗三组和西药治疗组,来进行治疗对比。四组患者在年龄、性别、病情轻重方面比较差异无统计学意义,具有可比性,并根据病情的轻重门诊治疗。
诊断标准
均符合中华神经科学会《各类脑血管疾病诊断要点》中关于脑栓塞的诊断标准:①突然起病,局灶性神经功能障碍迅速达高峰;②有栓子来源;③脑梗死经CT 和MRI 检查证实。
症状:半身不遂,口舌歪斜,舌强言謇或不语,偏身麻木,头晕目眩,舌质暗淡,舌苔薄白或白腻,脉弦滑。
治疗方法
治疗一组:本组150例患者采用本发明的实施例1的蜜炼丸剂进行治疗。每日1次,每次1丸,5g/丸,10天为一个疗程,治疗进行3个疗程。跟进半年观察复发。
治疗二组:本组150例患者采用本发明的实施例2的片剂进行治疗。每日4次,0.4g/片,10天为一个疗程,治疗进行3个疗程。跟进半年观察复发。
治疗三组:本组150例患者采用本发明的实施例2的汤剂进行治疗。每日2次,每次15ml,10天为一个疗程,治疗进行3个疗程。跟进半年观察复发。
西药治疗组:本组150例患者采用瑞科林进行治疗。每次80mg~120mg,静脉滴注,一日一至两次,10天为1疗程,治疗进行3个疗程。跟进半年观察复发。
疗效标准
按照全国第四届脑血管病学术会议制定的评分标准进行评定:基本痊愈,功能缺损评分减少91%~100%,病残程度为0级;显著进步,功能缺损评分减少46%~90%,病残程度为1~3 级;进步:功能缺损评分减少18%~ 45%; 无变化:功能缺损评分减少或增多17%左右;恶化:功能缺损评分增多18%以上;死亡。有效=基本痊愈+显著进步+进步;无效=无变化+恶化+死亡。
治疗结果
表1为各组的治疗效果对比
组别 | 人数 | 基本痊愈 | 显著进步 | 进步 | 无变化 | 恶化 | 死亡 | 有效率 |
治疗一组 | 150 | 130(86.67%) | 10(6.67%) | 5(3.33%) | 5(3.33%) | 0(0%) | 0(0%) | 96.67% |
治疗二组 | 150 | 132(88%) | 8(5.33%) | 6(4%) | 4(2.67%) | 0(0%) | 0(0%) | 97.33% |
治疗三组 | 150 | 131(87.33%) | 8(5.33%) | 7(4.67%) | 4(2.67%) | 0(0%) | 0(0%) | 97.33% |
西药治疗组 | 150 | 70(46.67%) | 20(13.33%) | 6(4%) | 24(16%) | 30(20%) | 0(0%) | 64% |
由表1可以看出,三个治疗组的治疗有效率要高于西药治疗组。说明本发明的中药组合物,治疗血瘀阻络型脑栓塞,效果好,疗效确切。
表2为各组的有效人数的治疗时间对比
组别 | 有效人数 | 第一个疗程 | 第二个疗程 | 第三个疗程 |
治疗一组 | 145 | 70(48.28%) | 50(34.48%) | 25(17.24%) |
治疗二组 | 146 | 68(46.58%) | 53(36.3%) | 25(17.12%) |
治疗三组 | 146 | 71(48.63%) | 49(33.56%) | 26(17.81%) |
西药治疗组 | 96 | 20(20.83%) | 30(31.25%) | 46(47.92%) |
由表2可以看出,三个治疗组的治疗有效人数,在治疗短时间内就出现很好的治疗效果。说明本发明的中药组合物,治疗血瘀阻络型脑栓塞,治疗快速,见效快。
表3为各组治疗前后的平均神经功能缺损评分对比
组别 | 人数 | 治疗前 | 治疗后 |
治疗一组 | 150 | 20.03±7.8 | 7.2±6.5 |
治疗二组 | 150 | 20.04±7.7 | 7.17±6.5 |
治疗三组 | 150 | 20.04±7.75 | 7.21±6.5 |
西药治疗组 | 150 | 20.12±8.11 | 15.24±6.2 |
由表3可以看出,三个治疗组的患者治疗前后的平均神经功能缺损评分要明显优于西药治疗组,由此可知,本发明的中药组合物,治疗血瘀阻络型脑栓塞,治疗后有很大的改善。
综上所述,本发明的中药组合物,治疗血瘀阻络型脑栓塞,治疗效果好,疗效确切,见效快,能很好的应用于血瘀阻络型脑栓塞的治疗。
典型病例:孙某,女,50岁,患血瘀阻络型脑栓塞,症状表现为半身不遂,口舌歪斜,不语,偏身麻木,头晕目眩,使用本发明实施例2的片剂进行治疗。每日4次,0.4g/片,10天为一个疗程,治疗进行3个疗程。治疗后,基本痊愈,无副作用。跟近半年,没有复发。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种治疗血瘀阻络型脑栓塞的中药组合物,其特征在于,包括以下原料药材:熟地黄、龙眼肉、楮实子、夜交藤、珍珠母、刺蒺藜、钩藤、地龙、蜈蚣、夏天无、鸡血藤、凌霄花、禹白附、稻芽、鸡矢藤、威灵仙、乌梢蛇、伸筋草、丁公藤、路路通、土牛膝、叶上珠根、八角莲、秋海棠根、蝤蛑、三棱、泽兰、牛马藤、红曲、多刺绿绒蒿、红娘子、牡丹皮、花榈木、波缘楤木、琼越线蕨、麦饭石、萱藻、叶上花、金丝木通、马蔺子、漏芦、蝇虎和铜罗伞。
2.如权利要求1所述的中药组合物,其特征在于,所述中药组合物中各原料药材的重量份数比为:熟地黄10-20重量份、龙眼肉12-29重量份、楮实子10-25重量份、夜交藤13-24重量份、珍珠母10-24重量份、刺蒺藜10-20重量份、钩藤15-25重量份、地龙10-20重量份、蜈蚣3-5重量份、夏天无10-20重量份、鸡血藤10-22重量份、凌霄花14-25重量份、禹白附3-5重量份、稻芽12-28重量份、鸡矢藤15-29重量份、威灵仙1-3重量份、乌梢蛇10-20重量份、伸筋草14-27重量份、丁公藤2-4重量份、路路通10-25重量份、土牛膝12-27重量份、叶上珠根15-29重量份、八角莲2-4重量份、秋海棠根10-20重量份、蝤蛑10-27重量份、三棱15-22重量份、泽兰12-27重量份、牛马藤10-28重量份、红曲10-20重量份、多刺绿绒蒿14-26重量份、红娘子3-5重量份、牡丹皮15-30重量份、花榈木12-29重量份、波缘楤木10-25重量份、琼越线蕨14-26重量份、麦饭石10-20重量份、萱藻15-25重量份、叶上花10-20重量份、金丝木通13-29重量份、马蔺子10-20、漏芦3-5、蝇虎10-20重量份和铜罗伞13-24重量份。
3.如权利要求1或2所述的中药组合物,其特征在于,所述中药组合物中各原料药材的重量份数比为:熟地黄15-20重量份、龙眼肉12-20重量份、楮实子15-25重量份、夜交藤13-20重量份、珍珠母15-24重量份、刺蒺藜15-20重量份、钩藤15-20重量份、地龙15-20重量份、蜈蚣3-4重量份、夏天无15-20重量份、鸡血藤15-22重量份、凌霄花14-20重量份、禹白附3-4重量份、稻芽12-20重量份、鸡矢藤15-20重量份、威灵仙1-2重量份、乌梢蛇15-20重量份、伸筋草14-20重量份、丁公藤2-3重量份、路路通15-25重量份、土牛膝12-20重量份、叶上珠根15-20重量份、八角莲3-4重量份、秋海棠根15-20重量份、蝤蛑10-20重量份、三棱18-22重量份、泽兰12-20重量份、牛马藤15-28重量份、红曲15-20重量份、多刺绿绒蒿14-20重量份、红娘子4-5重量份、牡丹皮15-20重量份、花榈木12-20重量份、波缘楤木15-25重量份、琼越线蕨14-20重量份、麦饭石15-20重量份、萱藻15-20重量份、叶上花15-20重量份、金丝木通13-20重量份、马蔺子15-20重量份、漏芦4-5重量份、蝇虎15-20重量份和铜罗伞18-24重量份。
4.如权利要求1至3任一项所述的中药组合物,其特征在于,所述中药组合物中各原料药材的重量份数比为:熟地黄14重量份、龙眼肉22重量份、楮实子14重量份、夜交藤24重量份、珍珠母14重量份、刺蒺藜13重量份、钩藤25重量份、地龙12重量份、蜈蚣5重量份、夏天无14重量份、鸡血藤14重量份、凌霄花25重量份、禹白附5重量份、稻芽28重量份、鸡矢藤25重量份、威灵仙4重量份、乌梢蛇13重量份、伸筋草27重量份、丁公藤1重量份、路路通14重量份、土牛膝27重量份、叶上珠根29重量份、八角莲2重量份、秋海棠根12重量份、蝤蛑27重量份、三棱15重量份、泽兰27重量份、牛马藤13重量份、红曲12重量份、多刺绿绒蒿26重量份、红娘子3重量份、牡丹皮30重量份、花榈木24重量份、波缘楤木14重量份、琼越线蕨26重量份、麦饭石13重量份、萱藻25重量份、叶上花12重量份、金丝木通29重量份、马蔺子13重量份、漏芦3重量份、蝇虎14重量份和铜罗伞15重量份。
5.如权利要求1至4任一项所述的中药组合物,其特征在于,所述中药组合物中各原料药材的重量份数比为:熟地黄20重量份、龙眼肉20重量份、楮实子20重量份、夜交藤18重量份、珍珠母20重量份、刺蒺藜17重量份、钩藤18重量份、地龙18重量份、蜈蚣3重量份、夏天无20重量份、鸡血藤20重量份、凌霄花18重量份、禹白附3重量份、稻芽18重量份、鸡矢藤16重量份、威灵仙2重量份、乌梢蛇16重量份、伸筋草18重量份、丁公藤3重量份、路路通20重量份、土牛膝18重量份、叶上珠根16重量份、八角莲3重量份、秋海棠根16重量份、蝤蛑15重量份、三棱18重量份、泽兰15重量份、牛马藤28重量份、红曲15重量份、多刺绿绒蒿16重量份、红娘子4重量份、牡丹皮18重量份、花榈木17重量份、波缘楤木18重量份、琼越线蕨18重量份、麦饭石20重量份、萱藻20重量份、叶上花18重量份、金丝木通20重量份、马蔺子20重量份、漏芦5重量份、蝇虎20重量份和铜罗伞24重量份。
6.如权利要求1至5任一项所述的中药组合物,其特征在于,所述中药组合物的剂型为蜜炼丸剂时,其制备方法为:
第一步,将所述原料药材加1-3倍量的水浸泡30分钟-1小时,加热煮沸30-50分钟,过滤,滤液备用;
第二步,将所述第一步得到的所述滤渣加入1-3倍量的水,第二次加热,煮沸30-50分钟,再过滤,滤液备用;
第三步,将所述第二步得到的滤渣再加1-3倍量的水,第三次加热煮沸30-40分钟,过滤;
第四步,将三次滤液合在一起,加热浓缩至糊状,放入烘箱,控制在75℃-80℃,烘干后冷却成粉末状与蜂蜜适量混和在一起搓成细条;以每5g为一丸腊封包装。
7.如权利要求1至5任一项所述的中药组合物,其特征在于,所述中药组合物的剂型为片剂时,其制备方法为:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉;
第三步,将第二步获得的超微细粉,加入相对于其质量0.1~0.3倍的微晶纤维素、0.05~0.15倍乳糖、0.1~0.3倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.005~0.05倍硬脂酸镁,整粒,压片,制成。
8.一种权利要求1至5任一项所述的中药组合物的制备方法,其特征在于,所述中药组合物的剂型为蜜炼丸剂,其制备方法为:
第一步,将所述原料药材加1-3倍量的水浸泡30分钟-1小时,加热煮沸30-50分钟,过滤,滤液备用;
第二步,将所述第一步得到的所述滤渣加入1-3倍量的水,第二次加热,煮沸30-50分钟,再过滤,滤液备用;
第三步,将所述第二步得到的滤渣再加1-3倍量的水,第三次加热煮沸30-40分钟,过滤;
第四步,将三次滤液合在一起,加热浓缩至糊状,放入烘箱,控制在75℃-80℃,烘干后冷却成粉末状与蜂蜜适量混和在一起搓成细条;以每5g为一丸腊封包装。
9.一种权利要求1至5任一项所述的中药组合物的制备方法,其特征在于,所述中药组合物的剂型为片剂,其制备方法为:
第一步,将所述中药各原料药材按比例混合,加入相对于混合物质量2~4倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第一提取液;过滤获得的药渣再加入相对于所述药渣质量1~2倍的醇浓度为85~95%的乙醇,加热回流1~3小时,提取,过滤获得第二提取液;将第一提取液和第二提取液合并,减压浓缩除去乙醇溶剂,干燥,获得干膏;
第二步,将第一步获得的干膏放置在超微粉碎机中粉碎1~2小时,粉碎,过筛,获得300目~400目的超微细粉;
第三步,将第二步获得的超微细粉,加入相对于其质量0.1~0.3倍的微晶纤维素、0.05~0.15倍乳糖、0.1~0.3倍的淀粉,过筛,混合均匀,制粒,干燥,加入相对于超微细粉质量0.005~0.05倍硬脂酸镁,整粒,压片,制成。
10.如权利要求1至5任一项所述的中药组合物,其特征在于,所述中药组合物的剂型为:片剂、胶囊剂、蜜炼丸剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂、糖浆剂、散剂、擦剂、灌肠剂和贴剂。
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