CN1042533C - 取代1-(7-氯喹啉-4-基)吡唑-3-甲酰胺n-氧化物衍生物,其制备方法及药物组合物 - Google Patents

取代1-(7-氯喹啉-4-基)吡唑-3-甲酰胺n-氧化物衍生物,其制备方法及药物组合物 Download PDF

Info

Publication number
CN1042533C
CN1042533C CN95109950A CN95109950A CN1042533C CN 1042533 C CN1042533 C CN 1042533C CN 95109950 A CN95109950 A CN 95109950A CN 95109950 A CN95109950 A CN 95109950A CN 1042533 C CN1042533 C CN 1042533C
Authority
CN
China
Prior art keywords
formula
acid
compound
pharmaceutically acceptable
chloroquinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95109950A
Other languages
English (en)
Chinese (zh)
Other versions
CN1120042A (zh
Inventor
R·博格雷恩
D·古利
F·珍妮琼
A·帕拉迪恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of CN1120042A publication Critical patent/CN1120042A/zh
Application granted granted Critical
Publication of CN1042533C publication Critical patent/CN1042533C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN95109950A 1994-07-08 1995-07-07 取代1-(7-氯喹啉-4-基)吡唑-3-甲酰胺n-氧化物衍生物,其制备方法及药物组合物 Expired - Fee Related CN1042533C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9408459 1994-07-08
FR9408459A FR2722193B1 (fr) 1994-07-08 1994-07-08 Derives n-oxydes de 1-(7-chloro-4-quinoleinyl)pyrazole-3-carboxamides substitues, procede pour leur preparation et les compositions pharmaceitiques les contenant

Publications (2)

Publication Number Publication Date
CN1120042A CN1120042A (zh) 1996-04-10
CN1042533C true CN1042533C (zh) 1999-03-17

Family

ID=9465167

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95109950A Expired - Fee Related CN1042533C (zh) 1994-07-08 1995-07-07 取代1-(7-氯喹啉-4-基)吡唑-3-甲酰胺n-氧化物衍生物,其制备方法及药物组合物

Country Status (17)

Country Link
US (1) US5561234A (enExample)
EP (1) EP0695747A1 (enExample)
JP (1) JPH0841051A (enExample)
KR (1) KR960004341A (enExample)
CN (1) CN1042533C (enExample)
AU (1) AU695588B2 (enExample)
CA (1) CA2153432A1 (enExample)
FI (1) FI953360A7 (enExample)
FR (1) FR2722193B1 (enExample)
HU (1) HUT73175A (enExample)
IL (1) IL114500A (enExample)
NO (1) NO952715L (enExample)
NZ (1) NZ272525A (enExample)
PL (1) PL309546A1 (enExample)
RU (1) RU2145323C1 (enExample)
TW (1) TW318847B (enExample)
ZA (1) ZA955673B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033531A1 (en) * 1997-02-03 1998-08-06 Mallinckrodt Medical, Inc. Method for the detection and localization of malignant human tumours
AR038967A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de 2,3 - diaril - pirazolidinas como inhibidores de enzimas que degradan la neurotensina

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0477049A1 (fr) * 1990-08-20 1992-03-25 Sanofi Dérivés d'amido-3 pyrazole, procédé pour leur préparation et compositions pharmaceutiques les contenant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU541846A1 (ru) * 1975-10-28 1977-01-05 Донецкое Отделение Физико-Органической Химии Института Физической Химии Им. Л.В.Писаржевского Ан Украинской Сср Способ получени 2-гетерилзамещенных бензимидазола
JPS5283852A (en) * 1976-01-01 1977-07-13 Christiaens Sa A Pyridine derivatives
US4746671A (en) * 1985-11-04 1988-05-24 Janssen Pharmaceutica N.V. Pharmaceutical use of [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters
JPH02268162A (ja) * 1989-04-10 1990-11-01 Fujisawa Pharmaceut Co Ltd ジフェニルピリジン誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0477049A1 (fr) * 1990-08-20 1992-03-25 Sanofi Dérivés d'amido-3 pyrazole, procédé pour leur préparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
FI953360L (fi) 1996-01-09
EP0695747A1 (fr) 1996-02-07
ZA955673B (en) 1996-02-20
KR960004341A (ko) 1996-02-23
CA2153432A1 (en) 1996-01-09
NZ272525A (en) 1997-02-24
NO952715D0 (no) 1995-07-07
PL309546A1 (en) 1996-01-22
FI953360A7 (fi) 1996-01-09
HU9502081D0 (en) 1995-09-28
IL114500A0 (en) 1995-11-27
AU695588B2 (en) 1998-08-20
FR2722193A1 (fr) 1996-01-12
FR2722193B1 (fr) 1996-10-04
JPH0841051A (ja) 1996-02-13
NO952715L (no) 1996-01-09
HUT73175A (en) 1996-06-28
AU2486795A (en) 1996-01-18
US5561234A (en) 1996-10-01
TW318847B (enExample) 1997-11-01
IL114500A (en) 1999-11-30
CN1120042A (zh) 1996-04-10
FI953360A0 (fi) 1995-07-07
RU2145323C1 (ru) 2000-02-10

Similar Documents

Publication Publication Date Title
JP4898062B2 (ja) アザ二環式カルバメートおよびアルファ−７ニコチン性アセチルコリンレセプターアゴニストとしてのその使用
JP2021504367A (ja) ｃ−ＭＥＴ／ＡＸＬ阻害剤としてのウラシル系化合物
JP2021523875A (ja) Ｆｇｆｒ阻害剤としてのピラジン−２（１ｈ）−オン系化合物
CN1809556A (zh) 1－[2－(苯并咪唑－1－基)喹啉－8－基]哌啶－4－基胺衍生物的制备方法
RU2513856C2 (ru) Способы получения метилового эфира 4-оксооктагидроиндол-1-карбоновой кислоты и ее производные
KR20240157703A (ko) 디-시클로프로필 기재 il-17a 조정제 및 그의 용도
JP2010132705A (ja) 回転異性体の薬学的に活性な塩の量が増加した組成物の調製のためのプロセス
JP3057068B2 (ja) ピペリドン化合物
FR2751649A1 (fr) Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0691342A1 (fr) Nouveaux dérivés de benzopyrane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
JP3399546B2 (ja) 置換されたインダゾール誘導体製造のための方法及び中間体
CN1042533C (zh) 取代1-(7-氯喹啉-4-基)吡唑-3-甲酰胺n-氧化物衍生物,其制备方法及药物组合物
EP0591027A1 (fr) Dérivés de pipéridine, leur préparation et leur application en thérapeutique
JP3598277B2 (ja) エタンスルホニルピペリジン誘導体の製造方法
JP2849128B2 (ja) 炭化水素置換ピロリジノン類
WO2009150388A1 (fr) NOUVEAUX DERIVES DE (PIPERAZINYL PONTE)-1-ALCANONE ET LEUR UTILISATION COMME INHIBITEURS DE p75
EP4662326A1 (en) Ligand-enabled transannular c-h functionalization of cycloalkane carboxylic acids
CN1455770A (zh) (2－氮杂二环[2.2.1]庚烷－7－基)甲醇衍生物作为烟碱类乙酰胆碱受体激动剂
CN1248971A (zh) 喹喔啉二酮
JPH04230279A (ja) 認識力および記憶力増強活性を有する化合物
JPH0568477B2 (enExample)
EP2639212B1 (en) Enantioselective organic anhydride reactions
US7521452B2 (en) Preparation of pharmaceutical salts of piperazine compounds
TW202421103A (zh) 苯烷胺及其製造與使用方法
CZ176895A3 (cs) Substituované N-oxidované deriváty l-(7-chlorchinolein-4-yl)-pyrazoI-3-karboxamidů, způsob jejich přípravy a farmaceutické přípravky sjejich obsahem

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee