CN104245719B - 包含改进的il-12基因构建体的组合物和疫苗、免疫治疗剂及其使用方法 - Google Patents

包含改进的il-12基因构建体的组合物和疫苗、免疫治疗剂及其使用方法 Download PDF

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CN104245719B
CN104245719B CN201280069473.6A CN201280069473A CN104245719B CN 104245719 B CN104245719 B CN 104245719B CN 201280069473 A CN201280069473 A CN 201280069473A CN 104245719 B CN104245719 B CN 104245719B
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nucleic acid
acid sequence
subunit
sequence encoding
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CN104245719A (zh
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D·B·韦纳
M·P·莫罗
严健
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University of Pennsylvania Penn
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CN201280069473.6A 2011-12-12 2012-12-11 包含改进的il-12基因构建体的组合物和疫苗、免疫治疗剂及其使用方法 Active CN104245719B (zh)

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US201161569600P 2011-12-12 2011-12-12
US61/569,600 2011-12-12
PCT/US2012/069017 WO2013090296A1 (en) 2011-12-12 2012-12-11 Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same

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CN104245719A CN104245719A (zh) 2014-12-24
CN104245719B true CN104245719B (zh) 2016-09-14

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US (4) US9272024B2 (enExample)
EP (2) EP2791157A4 (enExample)
JP (5) JP6333730B2 (enExample)
KR (5) KR102101819B1 (enExample)
CN (1) CN104245719B (enExample)
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CN106520779A (zh) * 2016-11-09 2017-03-22 华南农业大学 一种通过密码子优化鸡il‑2基因提高鸡的il‑2蛋白表达效率的方法
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JP7484717B2 (ja) 2018-09-26 2024-05-16 アステラス製薬株式会社 腫瘍溶解性ワクシニアウイルスと免疫チェックポイント阻害剤との併用によるがん療法並びにこれに用いるための医薬組成物及び組合せ医薬
MX2021003765A (es) 2018-10-03 2021-07-15 Xencor Inc Proteínas il-12 de fusión a fc heterodimérico.
KR102524247B1 (ko) 2018-12-21 2023-04-21 가톨릭대학교 산학협력단 p40-EBI3의 복합체 및 이의 용도
GB2700048B (en) 2019-09-18 2026-03-04 Aldevron Llc synthetic dna vectors and method of use
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