EA026926B1 - Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения - Google Patents

Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения Download PDF

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EA026926B1
EA026926B1 EA201491171A EA201491171A EA026926B1 EA 026926 B1 EA026926 B1 EA 026926B1 EA 201491171 A EA201491171 A EA 201491171A EA 201491171 A EA201491171 A EA 201491171A EA 026926 B1 EA026926 B1 EA 026926B1
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nucleic acid
sequence
acid sequence
subunit
homologous
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EA201491171A
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Russian (ru)
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EA201491171A1 (ru
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Дэвид Б. Уэйнер
Мэттью П. Морроу
Цзянь Янь
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Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA201491171A1 publication Critical patent/EA201491171A1/ru
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EA201491171A 2011-12-12 2012-12-11 Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения EA026926B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161569600P 2011-12-12 2011-12-12
PCT/US2012/069017 WO2013090296A1 (en) 2011-12-12 2012-12-11 Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same

Publications (2)

Publication Number Publication Date
EA201491171A1 EA201491171A1 (ru) 2014-09-30
EA026926B1 true EA026926B1 (ru) 2017-05-31

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EA201491171A EA026926B1 (ru) 2011-12-12 2012-12-11 Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения

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US (4) US9272024B2 (enExample)
EP (2) EP3336096A1 (enExample)
JP (5) JP6333730B2 (enExample)
KR (5) KR20240096837A (enExample)
CN (1) CN104245719B (enExample)
AU (1) AU2012352457B2 (enExample)
BR (1) BR112014014078A2 (enExample)
CA (1) CA2858893A1 (enExample)
EA (1) EA026926B1 (enExample)
MX (2) MX354986B (enExample)
WO (1) WO2013090296A1 (enExample)
ZA (1) ZA201404199B (enExample)

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AU2014235120B2 (en) * 2013-03-15 2017-01-05 The Trustees Of The University Of Pennsylvania Vaccines having an antigen and interleukin-23 as an adjuvant
US20180000895A1 (en) * 2015-01-09 2018-01-04 Oncosec Medical Incorporated Method for the treatment of malignancies
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PL3458083T3 (pl) 2016-05-18 2023-03-13 Modernatx, Inc. Polinukleotydy kodujące interleukinę-12 (il12) i ich zastosowania
US20190336552A1 (en) 2016-05-30 2019-11-07 Astellas Pharma Inc. Genetically engineered vaccinia viruses
AU2017272721B2 (en) 2016-05-30 2023-03-30 Astellas Pharma Inc. Novel genetically engineered vaccinia viruses
CN106520779A (zh) * 2016-11-09 2017-03-22 华南农业大学 一种通过密码子优化鸡il‑2基因提高鸡的il‑2蛋白表达效率的方法
AU2018270111B2 (en) 2017-05-18 2022-07-14 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof
CN111479583A (zh) 2017-12-13 2020-07-31 艾诺奥医药品有限公司 靶向存活素的癌症疫苗和其用途
PH12021550661A1 (en) 2018-09-26 2022-03-21 Astellas Pharma Inc Cancer therapy by combination use of oncolytic vaccinia virus and immune checkpoint inhibitor, and pharmaceutical composition and combination medicine for use in the cancer therapy
KR102884523B1 (ko) 2018-10-03 2025-11-10 젠코어 인코포레이티드 IL-12 이종이량체 Fc-융합 단백질
KR102524247B1 (ko) * 2018-12-21 2023-04-21 가톨릭대학교 산학협력단 p40-EBI3의 복합체 및 이의 용도
WO2021055760A1 (en) 2019-09-18 2021-03-25 Intergalactic Therapeutics, Inc. Synthetic dna vectors and methods of use
EP4037700A2 (en) 2019-10-03 2022-08-10 Xencor, Inc. Targeted il-12 heterodimeric fc-fusion proteins
CN115443287A (zh) * 2019-10-24 2022-12-06 艾诺奥医药品有限公司 复发性呼吸道乳头瘤病的改进疫苗及其使用方法
CN110777115B (zh) * 2019-11-21 2020-08-21 北京启辰生生物科技有限公司 用于促进辅助T细胞产生TNF-α细胞因子的工程化DC细胞及方法
CN116322785A (zh) 2020-07-20 2023-06-23 德卡生物科学公司 包含il-10的双细胞因子融合蛋白
KR20240156653A (ko) * 2021-12-13 2024-10-30 데카 바이오사이언시즈, 인크. 다중-서브유닛 시토카인을 포함하는 이중 시토카인 융합 단백질
JP2025503454A (ja) * 2021-12-17 2025-02-04 ウィリアム マーシュ ライス ユニバーシティ Il-12を発現するカプセル化細胞及びその使用
CN116535491B (zh) * 2022-05-06 2024-03-22 珠海丽凡达生物技术有限公司 治疗性核酸分子、混合物、药物及在治疗实体瘤中的应用
US20260185047A1 (en) * 2022-05-27 2026-07-02 National Cancer Center Production method for proliferative myeloid cells constitutively producing il-12p70

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