EA026926B1 - Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения - Google Patents

Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения Download PDF

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EA026926B1
EA026926B1 EA201491171A EA201491171A EA026926B1 EA 026926 B1 EA026926 B1 EA 026926B1 EA 201491171 A EA201491171 A EA 201491171A EA 201491171 A EA201491171 A EA 201491171A EA 026926 B1 EA026926 B1 EA 026926B1
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nucleic acid
sequence
acid sequence
subunit
homologous
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EA201491171A
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Russian (ru)
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EA201491171A1 (ru
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Дэвид Б. Уэйнер
Мэттью П. Морроу
Цзянь Янь
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Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA201491171A1 publication Critical patent/EA201491171A1/ru
Publication of EA026926B1 publication Critical patent/EA026926B1/ru

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EA201491171A 2011-12-12 2012-12-11 Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения EA026926B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161569600P 2011-12-12 2011-12-12
PCT/US2012/069017 WO2013090296A1 (en) 2011-12-12 2012-12-11 Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same

Publications (2)

Publication Number Publication Date
EA201491171A1 EA201491171A1 (ru) 2014-09-30
EA026926B1 true EA026926B1 (ru) 2017-05-31

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EA201491171A EA026926B1 (ru) 2011-12-12 2012-12-11 Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения

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US (4) US9272024B2 (enExample)
EP (2) EP2791157A4 (enExample)
JP (5) JP6333730B2 (enExample)
KR (5) KR102445129B1 (enExample)
CN (1) CN104245719B (enExample)
AU (1) AU2012352457B2 (enExample)
BR (1) BR112014014078A2 (enExample)
CA (1) CA2858893A1 (enExample)
EA (1) EA026926B1 (enExample)
MX (2) MX354986B (enExample)
WO (1) WO2013090296A1 (enExample)
ZA (1) ZA201404199B (enExample)

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US11421011B2 (en) 2017-05-18 2022-08-23 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof
MX2021003539A (es) 2018-09-26 2021-05-27 Astellas Pharma Inc Terapia contra el cancer en donde el virus vaccinia oncolitico e inhibidor de punto de control inmunitario se usan en combinacion, y composicion farmaceutica y medicamento de combinacion usado en ella.
SG11202103192RA (en) 2018-10-03 2021-04-29 Xencor Inc Il-12 heterodimeric fc-fusion proteins
KR102524247B1 (ko) * 2018-12-21 2023-04-21 가톨릭대학교 산학협력단 p40-EBI3의 복합체 및 이의 용도
GB2606844B (en) 2019-09-18 2025-08-06 Aldevron Llc Synthetic DNA vectors and methods of use
WO2021067863A2 (en) 2019-10-03 2021-04-08 Xencor, Inc. Targeted il-12 heterodimeric fc-fusion proteins
KR20220114531A (ko) * 2019-10-24 2022-08-17 이노비오 파마수티컬즈, 인크. 재발성 호흡기 유두종증을 위한 개선된 백신 및 이를 사용하는 방법
CN110777115B (zh) * 2019-11-21 2020-08-21 北京启辰生生物科技有限公司 用于促进辅助T细胞产生TNF-α细胞因子的工程化DC细胞及方法
EP4181957A4 (en) 2020-07-20 2024-08-07 Deka Biosciences, Inc. TWO-CYTOKINE FUSION PROTEIN COMPRISING IL-10
KR20240156653A (ko) * 2021-12-13 2024-10-30 데카 바이오사이언시즈, 인크. 다중-서브유닛 시토카인을 포함하는 이중 시토카인 융합 단백질
JP2025503454A (ja) * 2021-12-17 2025-02-04 ウィリアム マーシュ ライス ユニバーシティ Il-12を発現するカプセル化細胞及びその使用
CN116535491B (zh) * 2022-05-06 2024-03-22 珠海丽凡达生物技术有限公司 治疗性核酸分子、混合物、药物及在治疗实体瘤中的应用
CN119256082A (zh) * 2022-05-27 2025-01-03 北京天一方生物科技发展有限公司 一种恒定地产生IL-12p70的增殖性髓样细胞的制备方法

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