CN104245676B - 用于制备3,5-双(氟烷基)吡唑-4-甲酸衍生物和3,5-双(氟烷基)吡唑类化合物的方法 - Google Patents

用于制备3,5-双(氟烷基)吡唑-4-甲酸衍生物和3,5-双(氟烷基)吡唑类化合物的方法 Download PDF

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CN104245676B
CN104245676B CN201380007228.7A CN201380007228A CN104245676B CN 104245676 B CN104245676 B CN 104245676B CN 201380007228 A CN201380007228 A CN 201380007228A CN 104245676 B CN104245676 B CN 104245676B
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mmol
mixture
room temperature
difluoromethyl
stirred
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CN104245676A (zh
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S.帕泽诺克
N.卢伊
J-P.沃尔
F.R.勒鲁
F.焦尔纳尔
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Bayer CropScience AG
Centre National de la Recherche Scientifique CNRS
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Bayer CropScience AG
Centre National de la Recherche Scientifique CNRS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201380007228.7A 2012-02-01 2013-01-31 用于制备3,5-双(氟烷基)吡唑-4-甲酸衍生物和3,5-双(氟烷基)吡唑类化合物的方法 Active CN104245676B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12356001.3A EP2623496A1 (de) 2012-02-01 2012-02-01 Verfahren zur Herstellung von 3,5-bis (fluoralkyl)-pyrazol-4-carbonsäure-Derivaten und 3,5-bis(fluoralkyl)-pyrazolen
EP12356001.3 2012-02-01
PCT/EP2013/051930 WO2013113829A1 (de) 2012-02-01 2013-01-31 Verfahren zur herstellung von 3,5-bis(fluoralkyl)-pyrazol-4-carbonsäure-derivaten und 3,5-bis(fluoralkyl)-pyrazolen

Publications (2)

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CN104245676A CN104245676A (zh) 2014-12-24
CN104245676B true CN104245676B (zh) 2016-09-21

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US (2) US9309202B2 (enExample)
EP (2) EP2623496A1 (enExample)
JP (1) JP6155283B2 (enExample)
KR (1) KR101861116B1 (enExample)
CN (1) CN104245676B (enExample)
BR (1) BR112014019036B1 (enExample)
DK (1) DK2809653T3 (enExample)
ES (1) ES2647348T3 (enExample)
IL (1) IL233926B (enExample)
IN (1) IN2014DN07129A (enExample)
MX (1) MX362689B (enExample)
TW (1) TWI609006B (enExample)
WO (1) WO2013113829A1 (enExample)

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WO2014187774A1 (de) * 2013-05-22 2014-11-27 Bayer Cropscience Ag Verfahren zur herstellung von 3,5-bis(fluoralkyl)-pyrazol-derivaten
TWI647215B (zh) * 2013-11-11 2019-01-11 德商拜耳作物科學股份有限公司 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法
EP3015458A1 (en) * 2014-11-03 2016-05-04 Bayer CropScience AG Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines
JP6431088B2 (ja) * 2014-03-24 2018-11-28 バイエル・クロップサイエンス・アクチェンゲゼルシャフト α，α−ジハロアミン類およびケチミン類からの３，５−ビス（ハロアルキル）ピラゾール誘導体の製造方法
BR112016028700B1 (pt) * 2014-06-11 2021-03-23 Bayer Cropscience Aktiengesellschaft Processo para preparação de 3,5-bis(haloalquil)pirazóis via acilação de cetiminas
ES2672577T3 (es) 2014-06-11 2018-06-15 Bayer Cropscience Aktiengesellschaft Proceso para preparar derivados de 3,5-bis(haloalquil)pirazol por medio de la acilación de Hidrazonas
CR20170413A (es) 2015-02-11 2018-02-06 Basf Se Mezcla plaguicida que comprende un compuesto pirazol, un insecticida y un fungicida
EP3313820A1 (en) * 2015-06-26 2018-05-02 Bayer CropScience Aktiengesellschaft Process for preparing substituted pyrazoles containing haloalkoxy- and haloalkylthio groups from , -dihaloalkylamines and ketimines
TW202014410A (zh) 2018-06-18 2020-04-16 德商拜耳廠股份有限公司 二取代的５（３）－吡唑羧酸酯及由烯醇鹽與氟烷基胺基試劑（ｆａｒ）製備其之方法
US11014945B2 (en) * 2019-04-06 2021-05-25 Trinapco, Inc. Sulfonyldiazoles and N-(fluorosulfonyl)azoles, and methods of making the same

Citations (2)

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CN1871204A (zh) * 2003-10-23 2006-11-29 拜尔农作物科学股份公司 制备2－二卤代酰基－3－氨基丙烯酸酯以及3－二卤代甲基吡唑－4－羧酸酯的方法
CN101228156A (zh) * 2005-07-26 2008-07-23 杜邦公司 杀真菌甲酰胺

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ES2004460A6 (es) * 1987-07-29 1989-01-01 Consejo Superior Investigacion Procedimiento para la preparacion de derivados de 3-5-bis-(halometil) pirazol
JP3533134B2 (ja) * 1999-02-15 2004-05-31 三井化学株式会社 フッ素化剤及びその製法と使用
JP2001192369A (ja) * 2000-01-12 2001-07-17 Mitsui Chemicals Inc フッ素含有複素環式芳香族化合物の製造方法および新規ピラゾール環化合物
DE10215292A1 (de) 2002-02-19 2003-08-28 Bayer Cropscience Ag Disubstitutierte Pyrazolylcarbocanilide
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
GB0526044D0 (en) * 2005-12-21 2006-02-01 Syngenta Ltd Novel herbicides
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
DE102006039909A1 (de) 2006-08-25 2008-03-13 Bayer Cropscience Ag Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten
WO2008091594A2 (en) * 2007-01-24 2008-07-31 E. I. Du Pont De Nemours And Company Fungicidal mixtures
EP2133341A1 (de) 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
EP2100883A1 (de) 2008-03-10 2009-09-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten
JP2010083763A (ja) * 2008-09-29 2010-04-15 Mitsui Chemicals Inc ピラゾール誘導体およびその製造方法、ならびに殺菌剤

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CN1871204A (zh) * 2003-10-23 2006-11-29 拜尔农作物科学股份公司 制备2－二卤代酰基－3－氨基丙烯酸酯以及3－二卤代甲基吡唑－4－羧酸酯的方法
CN101228156A (zh) * 2005-07-26 2008-07-23 杜邦公司 杀真菌甲酰胺

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Reaction of 1,1,2-trifluoro-2-chloroethyl-N,N-diethylamine with N,N-dichloroarene-sulfamides and some compounds with mobile hydrogen-atoms;Yagupolskii等;《Zh. Organicheskoi Khim.》;19781231;第14卷(第12期);第2493-2496页 *

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DK2809653T3 (da) 2017-11-27
US9309202B2 (en) 2016-04-12
JP6155283B2 (ja) 2017-06-28
TWI609006B (zh) 2017-12-21
KR20140128344A (ko) 2014-11-05
CN104245676A (zh) 2014-12-24
EP2809653B1 (de) 2017-08-16
MX362689B (es) 2019-02-01
TW201336826A (zh) 2013-09-16
US10035773B2 (en) 2018-07-31
JP2015511227A (ja) 2015-04-16
BR112014019036A2 (pt) 2017-08-22
ES2647348T3 (es) 2017-12-21
KR101861116B1 (ko) 2018-05-25
EP2809653A1 (de) 2014-12-10
IL233926A0 (en) 2014-09-30
IL233926B (en) 2018-08-30
IN2014DN07129A (enExample) 2015-04-24
US20150011779A1 (en) 2015-01-08
MX2014009203A (es) 2014-11-12
US20160185731A1 (en) 2016-06-30
EP2623496A1 (de) 2013-08-07
BR112014019036B1 (pt) 2019-10-08
WO2013113829A1 (de) 2013-08-08

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