CN104244985A - 生物材料的稳定化组合物 - Google Patents

生物材料的稳定化组合物 Download PDF

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Publication number
CN104244985A
CN104244985A CN201380015928.0A CN201380015928A CN104244985A CN 104244985 A CN104244985 A CN 104244985A CN 201380015928 A CN201380015928 A CN 201380015928A CN 104244985 A CN104244985 A CN 104244985A
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China
Prior art keywords
composition
dry
drying
protein
tablet
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Pending
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CN201380015928.0A
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English (en)
Chinese (zh)
Inventor
莫迪·哈莱尔
琼·唐
特丽莎·赖斯
金伯利·詹宁斯
布莱恩·卡朋特
罗杰·德鲁斯
伊丽莎白·拉迪斯
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Advanced Bionutrtion Corp
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Advanced Bionutrtion Corp
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Application filed by Advanced Bionutrtion Corp filed Critical Advanced Bionutrtion Corp
Priority to CN202210319279.4A priority Critical patent/CN114601849A/zh
Publication of CN104244985A publication Critical patent/CN104244985A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P30/00—Shaping or working of foodstuffs characterised by the process or apparatus
    • A23P30/30—Puffing or expanding
    • A23P30/32—Puffing or expanding by pressure release, e.g. explosion puffing; by vacuum treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Animal Husbandry (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fodder In General (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380015928.0A 2012-03-23 2013-03-22 生物材料的稳定化组合物 Pending CN104244985A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210319279.4A CN114601849A (zh) 2012-03-23 2013-03-22 生物材料的稳定化组合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261614994P 2012-03-23 2012-03-23
US61/614,994 2012-03-23
US201261642094P 2012-05-03 2012-05-03
US61/642,094 2012-05-03
US201261646337P 2012-05-13 2012-05-13
US61/646,337 2012-05-13
PCT/US2013/033505 WO2013142792A1 (en) 2012-03-23 2013-03-22 Stabilizing composition for biological materials

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210319279.4A Division CN114601849A (zh) 2012-03-23 2013-03-22 生物材料的稳定化组合物

Publications (1)

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CN104244985A true CN104244985A (zh) 2014-12-24

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CN201380015928.0A Pending CN104244985A (zh) 2012-03-23 2013-03-22 生物材料的稳定化组合物
CN202210319279.4A Pending CN114601849A (zh) 2012-03-23 2013-03-22 生物材料的稳定化组合物

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Country Status (18)

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EP (1) EP2827905B1 (https=)
JP (1) JP6229188B2 (https=)
KR (1) KR102062645B1 (https=)
CN (2) CN104244985A (https=)
AR (1) AR093204A1 (https=)
AU (1) AU2013234931B2 (https=)
BR (1) BR112014023234B1 (https=)
CA (1) CA2866889C (https=)
CL (1) CL2014002506A1 (https=)
ES (1) ES3016483T3 (https=)
IN (1) IN2014DN08599A (https=)
MX (1) MX356072B (https=)
MY (1) MY178686A (https=)
NZ (1) NZ628912A (https=)
PH (1) PH12014502092B1 (https=)
RU (1) RU2666601C2 (https=)
SG (1) SG11201405478VA (https=)
WO (1) WO2013142792A1 (https=)

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CN105504050A (zh) * 2016-03-03 2016-04-20 河南欧普生物科技有限公司 一种抗安卡拉病毒鸡卵黄抗体的制备方法
CN106819418A (zh) * 2017-03-27 2017-06-13 张军军 一种超高脂饲料及其制备方法
CN107250354A (zh) * 2015-02-11 2017-10-13 普瑞特克微生物有限责任公司 用于包埋活大肠杆菌的经改进干基质、其制备方法及其用途
CN108289476A (zh) * 2015-12-18 2018-07-17 雀巢产品技术援助有限公司 动物的水合
CN108347982A (zh) * 2015-07-29 2018-07-31 高级生物营养公司 用于特殊饮食用途的稳定的干燥益生菌组合物
CN108368474A (zh) * 2015-12-04 2018-08-03 高级生物营养公司 没有或几乎没有糖的稳定的干组合物
CN108472321A (zh) * 2015-12-18 2018-08-31 国家农艺研究院 用于保存在生态系统中的微生物群的冻干组合物
CN109561710A (zh) * 2016-06-14 2019-04-02 普瑞特克微生物有限责任公司 包含饲料添加剂的动物饲料颗粒、其制备和使用方法
CN109922670A (zh) * 2016-10-28 2019-06-21 株式会社三养社 具有改进稳定性的低聚糖糖浆
CN110769838A (zh) * 2017-06-05 2020-02-07 普罗比公司 微生物组合物
CN110923145A (zh) * 2019-12-16 2020-03-27 天康生物股份有限公司 支原体的冻干保护剂与冻干支原体及其制备方法
CN114196579A (zh) * 2021-12-13 2022-03-18 张峰 一种建筑通风工程用的甲醛微生物净化器
CN114845549A (zh) * 2019-10-22 2022-08-02 麻省理工学院 递送促进植物生长的微生物的基于生物材料的组合物
CN116491503A (zh) * 2018-10-26 2023-07-28 丹尼斯科美国公司 稳定的微生物组合物和干燥工艺
CN116694581A (zh) * 2023-05-24 2023-09-05 华南农业大学 哈维氏弧菌噬菌体v-ydf132的冻干保护剂及其保藏方法
CN113614055B (zh) * 2018-12-07 2023-12-26 皮沃特生物股份有限公司 用于固氮微生物产品的具有提高的稳定性的聚合物组合物
CN117820507A (zh) * 2023-08-18 2024-04-05 苏州市立医院 一种纳米膳食纤维及其制备、纳米膳食纤维载药系统及其制备与应用
WO2025055959A1 (en) * 2023-09-12 2025-03-20 Bing Biotech Limited Encapsulation of dual-enzyme composition for preventing, treating and/or alleviating veisalgia and symptoms associated therewith
US12478068B2 (en) 2020-05-01 2025-11-25 Pivot Bio, Inc. Stable liquid formulations for nitrogen-fixing microorganisms

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MX376352B (es) 2013-10-25 2025-03-07 Nch Corp Sistema de suministro y composicion probiotica para animales y plantas.
US10610552B2 (en) 2016-04-05 2020-04-07 Nch Corporation Nutrient rich germinant composition and spore incubation method
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US12558395B2 (en) 2015-07-29 2026-02-24 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
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US10323226B2 (en) * 2017-03-30 2019-06-18 Nch Corporation Feed material for biomass generator
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US11401500B2 (en) 2018-08-29 2022-08-02 Nch Corporation System, method, and composition for incubating spores for use in aquaculture, agriculture, wastewater, and environmental remediation applications
WO2020130770A1 (es) * 2018-12-19 2020-06-25 Ajtzakbio S.A.P.I. De C.V. Composición probiótica de alto valor sin necesidad de cadena de frio, desarrollada para reducir el impacto ambiental, aumentar la producción y mejorar la supervivencia de larvas de camarón
WO2021055352A1 (en) * 2019-09-16 2021-03-25 Vedanta Biosciences, Inc. Methods and compositions for preserving bacteria
US11576937B2 (en) 2020-02-06 2023-02-14 Nch Corporation Method of reducing gut inflammation reduction in humans by consuming a heated probiotic composition
US20230080017A1 (en) * 2020-02-19 2023-03-16 Zantebio Limited Coated microcapsules and methods for the production thereof
RU2736064C1 (ru) * 2020-04-03 2020-11-11 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Защитная среда для стабилизации клеток возбудителя туляремии в процессе приготовления и хранения сухих препаратов
RU2746022C1 (ru) * 2020-04-03 2021-04-06 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ стабилизации бактериальных клеток чумного микроба перед сублимационным высушиванием
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WO2022171617A1 (en) * 2021-02-10 2022-08-18 Dsm Ip Assets B.V. Powderous composition (i)
JP2024506466A (ja) * 2021-02-10 2024-02-14 ディーエスエム アイピー アセッツ ビー．ブイ． 粉末状組成物（ｉｉ）
CN112843328B (zh) * 2021-02-25 2022-05-13 山东大学 一种具有抑菌作用的鲍鱼壳粉/ZnO复合材料掺杂的智能水凝胶伤口敷料的制备方法
CN113621519B (zh) * 2021-08-11 2023-07-18 河南农业大学 一种复合酵母冻干保护剂
CN119255821A (zh) * 2021-08-25 2025-01-03 奥古斯汀·T·兹维纳瓦什 微生物组递送平台
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CN102186360A (zh) * 2008-10-20 2011-09-14 雀巢产品技术援助有限公司 具有抗反流性质的营养组合物
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