CN104208497A - Drug for reducing inclusion body hepatitis morbidity - Google Patents

Abstract

The invention provides a drug for reducing inclusion body hepatitis morbidity. The drug is characterized by comprising 90-130g of eclipta alba, 90-130g of commelina communis, 90-130g of serrate rabdosia herb, 50-80g of gentian, 50-80g of akebiaquinata, 50-80g of rhizoma cyperi, 50-80g of fructus aurantii, 50-80g of salvia miltiorrhiza, 50-80g of rehmannia glutinosa, 50-80g of hairyvein agrimony, 50-80g of lalang grass rhizome, 30-60g of rhizoma cibotii, 30-60g of golden cypress, 30-60g of houttuynia cordata, 30-60g of andrographis paniculata, 30-60g of red halloysite, 30-60g of moss, 30-60g of herba lagotis and 25-50g of liquorice. The drug is simple in method and convenient to use, inclusion body hepatitis is effectively prevented, and loss of farmers caused by the inclusion body hepatitis can be obviously reduced.

Description

A kind of medicine reducing inclusion body hepatitis sickness rate

technical field:

The present invention relates to chicken fowl cultural technique field, particularly relate to a kind of medicine reducing inclusion body hepatitis sickness rate.

 

background technology:

In the breeding process of chicken fowl, often cause chicken fowl dead because suffering from various disease, this treatment is too late, then bring huge economic loss to raiser, for chicken inclusion body hepatitis, principal character is that young chicken group mortality rate increases suddenly, sick chicken severe anemia is hepatomegaly, hemorrhage and downright bad.Inclusion body is had in visible liver cell nuclear.This disease is also known as anemia syndrome.It is caused by fowl adenovirus, hemorrhage with liver, severe anemia, jaundice, and hemorrhage of muscle and mortality rate increase suddenly, and in hepatocyte, form the infectious disease that intranuclear inclusion is feature.The cause of disease of pathogenic characteristic chicken inclusion body hepatitis is the I group I fowl adenovirus of Adenoviridae.Virion is without cyst membrane, and diameter is 70-90 nanometers, and nucleic acid is distrand DNA.Virus, in endoreduplication, produces basophil inclusion bodies.Have resistance to ether, chloroform, trypsin, 5% ethanol, susceptible animal only has chicken susceptible, and broiler is multiple.Age of onset mostly occurs at the broiler in 3 ~ 7 week age, and laying hen also occasionally has generation.The sick chicken of the source of infection, be with malicious chicken.Virus is discharged virus by feces, trachea and nose and infects healthy chicken.Route of transmission is mainly infected through respiratory tract, digestive tract and eye conjunctiva, is also transmitted to the next generation by hatching egg.Occur more with spring and summer.Chicken of recovering can obtain lifetime immunity.

Sick chicken cuts open inspection, and liver is pale, matter is crisp, swelling, liver, skeleton, skeletal muscle have point-like or ecchymosis.Inclusion body is had in hepatocyte, rounded.Kidney, splenomegaly, the swelling of kidney height, in canescence.Clinical pathology main manifestations is liver enlargement, and in khaki, matter is crisp, and there is hemorrhage speckle in various degree on surface, the necrosis region sometimes differed in size as seen.Some cases can see bone marrow lesion, and femur bone marrow is hemorrhage in pink, meanwhile, chest muscle and lower limb flesh pale and have hemorrhage speckle, subcutaneous tissue, fatty tissue and intestinal serous coat, mucosa are obviously hemorrhage as seen.Through 1 ~ 2 day incubation period of chicken of natural infection, it is dead that initial stage loses any symptom, after 2 ~ 3 days, the sick chicken spirit of minority is depressed, drowsiness, wattle is faded, skin is yellow, subcutaneous have hemorrhage, have water sample loose stool once in a while, within 3 ~ 5 days, reach peak mortality, mortality rate reaches 15-30%, continue after 3 ~ 5 days, stop gradually.Primary disease incubation period, be generally no more than 4 days, in Young cock group, morbidity rapidly, often occurs dead chicken suddenly.Sick chicken heating, down in spirits, poor appetite, dysentery, drowsiness, feather is fluffy and disorderly, and bent lower limb is squatted vertical.The sick chicken of minority presents jaundice symptom.The young chicken in 4 ~ 10 week age, if in both feet paralysis, what before have on one's deathbed sends calling, and occurs the nervous symptoms such as head back to arch, be then usually that anemia and spirit are depressed, the course of disease is 10 ~ 14 days.When the chicken in discontented 5 week age infects, generally can be completely recovered to during 8 week age.Sickness rate can up to 100%, and mortality rate is not from 2% to 10% etc., sometimes can reach 30% ~ 40%.Infect 1 of primary disease, Japanese instar chickling presents severe anemia symptom.

At present very effective therapy be there is no to chicken inclusion body hepatitis, therefore, mainly with putting prevention first in breeding process, the chicken house of primary disease occurring, in feedstuff, adds compound vitamin and trace element.Conventional Therapeutic Method as, the clear spice of sense poison, 3% glucose+vitamin C drinking-water.Also can endure water with Ganshenkang (composition is: Radix Isatidis, the Radix Astragali, Herba Epimedii, Folium Isatidis, Radix Glycyrrhizae etc.), in the ratio that is watered of liquid medicine ratio 1 ︰ more than 8, slow fire boils, boil latter 15 minutes, leach medicine juice, be blended into proper amount of clear water, be used in conjunction 4 ~ 5 days, use 3% glucose+vitamin C drinking-water simultaneously.Method disclosed in other, such as paper " brief talking the diagnosis and treatment of chicken inclusion body hepatitis ", it discloses several groups of therapeutic schemes, as astragalus polysaccharides+the liver benefiting protects kidney: be used in conjunction 3 days ~ 5 days.Medication every day 6 hours, once-a-day, changes clear water after 6 hours.PHA+ ribavirin+strong+3% glucose of bodyguard spy, is used in conjunction 4 days.Chinese medicine formula: Folium Isatidis 60 g, Herba Artemisiae Scopariae 30 g, Fructus Gardeniae 45 g, Rhizoma Polygoni Cuspidati 30 g, Radix Et Rhizoma Rhei 20 g, Herba Plantaginis 35 g, every 100 kg feedstuffs mix 0.5 ~ 1.0 kg, and control secondary infection, to reduce death.Concrete Therapeutic Method (can often prop up 2 milliliters with vitamin C injection; containing 0.1 milligram); vitamin K3, K4 injection (often propping up 1 milliliter, containing 4 milligrams); gentamycin (often props up 1 milliliter; containing 20 milligrams) each 1, to cold water 250 milliliters, allow disease chicken freely drink; 1 week course for the treatment of, drug withdrawal 3 days; Change cold water 250 milliliters, allow disease chicken freely drink, 1 week course for the treatment of, drug withdrawal 3 days; Change cold water 500 milliliters, drink drug withdrawal after 1 week.After Herba Artemisiae Scopariae 600g, Radix Et Rhizoma Rhei 300g, Fructus Gardeniae 300g decoct 2h, filtering extracting liquid is blended in 200kg water, freely drinks.

By the retrieval of above-mentioned prior art, can find, at present for the treatment Chinese medicine of inclusion body hepatitis, Western medicine has certain effect, but Western medicine majority is conventional disease-resistant medicine, multiple chicken fowl diseases all can be general, cause chicken fowl Drug resistance to increase, and drug residue is higher, is unfavorable for the edible safety of people.Therefore, some Chinese medicine succedaneum have been there are, as Chinese patent application 2009101665868 discloses a kind of Chinese medicine feed additive for prevention and therapy chicken liver lesion, its component is Radix Scutellariae 50 parts, Rhizoma Coptidis 25 parts, Cortex Phellodendri 60 parts, Rhizoma Atractylodis Macrocephalae (parched) 60 parts, Radix Gentianae 70 parts, Semen Plantaginis 80 parts, Radix Bupleuri 40 parts, Radix Angelicae Sinensis 40 parts, Radix Rehmanniae 60 parts, 60 parts, Poria, Herba Houttuyniae 80 parts, Flos Chrysanthemi 40 parts, 50 parts, Radix Glycyrrhizae.And for example Chinese patent application 2010102703573 discloses a kind of Chinese medicine feed additive for prevention and therapy chicken liver lesion: the raw medicinal material chosen and composition by weight thereof respectively: Radix Scutellariae 15 parts, Rhizoma Coptidis 15 parts, Radix Gentianae 10 parts, Herba Houttuyniae 10 parts, Herba Plantaginis 12 parts, Radix Rehmanniae 15 parts, Flos Chrysanthemi 7 parts, Radix Isatidis 8 parts.Its preparation method is, mixes after pulverizing after the mixing of above-mentioned raw materials medical material or pulverizing respectively.And for example Chinese patent application 2013100743847 discloses a kind of Chinese medicine oral liquid for the treatment of chicken inclusion body hepatitis, and its constituent is: Folium Isatidis 13-17g, glue stock blue 13-17g, Rhizoma Et Radix Notopterygii 8-12g, Herba Plantaginis 8-12g, Fructus Gardeniae 8-12g, Radix Peucedani 8-12g, Radix Astragali 3-7g, Rhizoma Polygoni Cuspidati 3-7g, Poria 3-7g, Flos Lonicerae 3-7g, Indigo Naturalis 3-7g, Radix Glycyrrhizae 3-7g.

On the basis of existing technology, provide a kind of method simple, easy to use, prevention and cure chicken inclusion body hepatitis is effective, obviously can reduce the cultural method of the laying hen of the loss that therefore disease is brought to raiser for purport of the present invention.

 

summary of the invention:

The object of the invention is to overcome the shortcoming existed in prior art, provide a kind of method simple, easy to use, prevention and cure chicken inclusion body hepatitis is effective, obviously can reduce the cultural method of the laying hen of the loss that therefore disease is brought to raiser.

To achieve these goals, the invention provides a kind of medicine reducing inclusion body hepatitis sickness rate, wherein, operate in accordance with the following steps:

Broiler, when 3-7 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 57.4%, Testa Tritici 3%, bean cake 20%, fish flour 2%, rapeseed cake 4%, cottonseed meal 3%, calcium hydrogen phosphate 1%, compound vitamin 0.3%, stone powder 8%, Sal 0.3%, disease-resistant adjuvant 1%;

The component of described disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 90-130g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 50-80g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 30-60g of Radix Pecteilis susannae, Radix Glycyrrhizae 25-50g;

Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds modified starch, hydroxy methocel and sweeting agent; Modified starch, hydroxy methocel and sweeting agent mass ratio are 4:1:0.5, the quality of modified starch, hydroxy methocel and sweeting agent and be the 1-1.5% of mixture of viscous form quality, stir, obtain powder after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add glucose powder and gentamycin sulfate powder, the mass ratio of glucose powder and gentamycin sulfate powder is 3:1, the quality of the glucose powder added and gentamycin sulfate powder and be 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.

Or, the component of disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 90-110g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 50-70g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 30-50g of Radix Pecteilis susannae, Radix Glycyrrhizae 25-40g.

Or, the component of disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 110-130g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 70-80g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 50-60g of Radix Pecteilis susannae, Radix Glycyrrhizae 40-50g.

Or, the component of disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 95-125g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 55-75g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 35-55g of Radix Pecteilis susannae, Radix Glycyrrhizae 30-45g.

Further, add vitamin K3 in the feedstuff of configuration, the amount added is that feedstuff per ton is no more than 5g.(optional)

Vitamin k 3, Chinese name, menadione; Menadione sodium bisulfite; 2-MNQ; Vitamin K3 is the required material of liver synthesis protoenzyme (factor B), and participates in proconvertin, IX, and the synthesis of X, maintains the blood coagulation physiological process of animal.The K that is deficient in vitamin can cause above-mentioned thrombin dyssynthesis, affects coagulation process and causes bleeding.Vitamin K is also required by the vitamin K dependence carboxylation system (mainly referring to be present in the histoorgans such as liver, skeleton, testis, skin and kidney) in animal body, is the indispensable factor in skeleton element (BGP) building-up process.In addition, in energy-rich compound metabolism and oxidative phosphorylation process, and all play an important role with the aspect of other fatsoluble vitamin metabolism, and there is diuresis, enhancing liver detoxification function, participate in the structure of film, the function reduced blood pressure.

Disease-resistant adjuvant of the present invention, adopts the preparation method of Chinese patent medicine, and the present invention is with the Herba Ecliptae of removing toxic substances, and antitoxin Tradescantia albiflora, the Herba Rabdosiae Lophanthoidis of jaundice eliminating damp eliminating is monarch drug.With liver heat removing dampness removing to medicine Radix Gentianae, Caulis Akebiae; , the Fructus Aurantii attached to medicated incense of soothing the liver circulation of qi promoting, increase hematopoietic potential, increases medicine Radix Salviae Miltiorrhizae, the Radix Rehmanniae Preparata of erythrocyte and hemoglobin, have the Herba Agrimoniae of hemostatic function, Rhizoma Imperatae is ministerial drug.With the Rhizoma Cibotii of increased platelets counts content, Cortex Phellodendri, increase Herba Houttuyniae, the Herba Andrographis of leukocytes phagocytic ability, the Halloysitum Rubrum of removing toxic substances, BIXUAN, antitoxin Radix Pecteilis susannae is adjuvant drug.Be in harmonious proportion the property of medicine as making medicine using Radix Glycyrrhizae.Meanwhile, use modified starch, hydroxy methocel and sweeting agent seasoning, use glucose powder and gentamycin sulfate powder (for animals) to increase effect.

Treat the sick chicken of the inclusion body hepatitis of having fallen ill, disease-resistant adjuvant is added water modulation quality than 8-12%, often only gavages 5-10ml, 2 times on the one, gavage 3 continuously, Be very effective.

Advantage of the present invention is: method is simple, and easy to use, prevention and cure chicken inclusion body hepatitis is effective, obviously can reduce the loss that therefore disease is brought to raiser.Be specially, in the high period of disease of broiler, disease-resistant adjuvant mixed in feedstuff and carries out feeding, increase resistance against diseases.For the sick chicken of ill inclusion body hepatitis, disease-resistant adjuvant bath is gavaged and treats.

detailed description of the invention:

Reduce the medicine of inclusion body hepatitis sickness rate, wherein, operate in accordance with the following steps:

Broiler, when 3-7 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 57.4%, Testa Tritici 3%, bean cake 20%, fish flour 2%, rapeseed cake 4%, cottonseed meal 3%, calcium hydrogen phosphate 1%, compound vitamin 0.3%, stone powder 8%, Sal 0.3%, disease-resistant adjuvant 1%;

The component of described disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 90-130g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 50-80g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 30-60g of Radix Pecteilis susannae, Radix Glycyrrhizae 25-50g;

Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds modified starch, hydroxy methocel and sweeting agent; Modified starch, hydroxy methocel and sweeting agent mass ratio are 4:1:0.5, the quality of modified starch, hydroxy methocel and sweeting agent and be the 1-1.5% of mixture of viscous form quality, stir, obtain powder after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add glucose powder and gentamycin sulfate powder, the mass ratio of glucose powder and gentamycin sulfate powder is 3:1, the quality of the glucose powder added and gentamycin sulfate powder and be 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.

Or, the component of disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 90-110g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 50-70g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 30-50g of Radix Pecteilis susannae, Radix Glycyrrhizae 25-40g.

Or, the component of disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 110-130g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 70-80g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 50-60g of Radix Pecteilis susannae, Radix Glycyrrhizae 40-50g.

Or, the component of disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 95-125g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 55-75g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 35-55g of Radix Pecteilis susannae, Radix Glycyrrhizae 30-45g.

Further, add vitamin K3 in the feedstuff of configuration, the amount added is that feedstuff per ton is no more than 5g.(optional)

Treat the sick chicken of the inclusion body hepatitis of having fallen ill, disease-resistant adjuvant is added water modulation quality than 8-12%, often only gavages 5-10ml, 2 times on the one, gavage 3 continuously, Be very effective.

 

Example 1:

Zhu Qiao town, Laizhou City Qiu Jia plant:

Broiler, when 3-7 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 57.4%, Testa Tritici 3%, bean cake 20%, fish flour 2%, rapeseed cake 4%, cottonseed meal 3%, calcium hydrogen phosphate 1%, compound vitamin 0.3%, stone powder 8%, Sal 0.3%, disease-resistant adjuvant 1%; After mixing feedstuff feeding on the one 3-4 time.

The component of described disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 130g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 80g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 60g of Radix Pecteilis susannae, Radix Glycyrrhizae 50g;

Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds modified starch, hydroxy methocel and sweeting agent; Modified starch, hydroxy methocel and sweeting agent mass ratio are 4:1:0.5, the quality of modified starch, hydroxy methocel and sweeting agent and be the 1-1.5% of mixture of viscous form quality, stir, obtain powder after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add glucose powder and gentamycin sulfate powder, the mass ratio of glucose powder and gentamycin sulfate powder is 3:1, the quality of the glucose powder added and gentamycin sulfate powder and be 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.

For the sick chicken of the inclusion body hepatitis of morbidity, use disease-resistant adjuvant to add water after morbidity and be configured to the solution of mass percent 12%, often only gavage 10ml.

 

Example 2

Changqing District, Jinan king family raiser:

Broiler, when 3-7 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 57.4%, Testa Tritici 3%, bean cake 20%, fish flour 2%, rapeseed cake 4%, cottonseed meal 3%, calcium hydrogen phosphate 1%, compound vitamin 0.3%, stone powder 8%, Sal 0.3%, disease-resistant adjuvant 1%; Obtain feedstuff after mixing, add vitamin K3, the amount added is no more than 5g per ton.Feeding 3-4 time on the one.

The component of described disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 120g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 70g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 50g of Radix Pecteilis susannae, Radix Glycyrrhizae 40g;

Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds modified starch, hydroxy methocel and sweeting agent; Modified starch, hydroxy methocel and sweeting agent mass ratio are 4:1:0.5, the quality of modified starch, hydroxy methocel and sweeting agent and be the 1-1.5% of mixture of viscous form quality, stir, obtain powder after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add glucose powder and gentamycin sulfate powder, the mass ratio of glucose powder and gentamycin sulfate powder is 3:1, the quality of the glucose powder added and gentamycin sulfate powder and be 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.

For the sick chicken of the inclusion body hepatitis of morbidity, use disease-resistant adjuvant to add water after morbidity and be configured to the solution of mass percent 10%, often only gavage 10ml.

 

Example 3

Qingdao Tianrui Ecological Technology Co., Ltd. (the applicant):

Broiler, when 3-7 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 57.4%, Testa Tritici 3%, bean cake 20%, fish flour 2%, rapeseed cake 4%, cottonseed meal 3%, calcium hydrogen phosphate 1%, compound vitamin 0.3%, stone powder 8%, Sal 0.3%, disease-resistant adjuvant 1%; Obtain feedstuff after mixing, add vitamin K3, the amount added is no more than 5g per ton.Feeding 3-4 time on the one.

The component of described disease-resistant adjuvant is: Herba Ecliptae, Tradescantia albiflora, each 110g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 60g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 40g of Radix Pecteilis susannae, Radix Glycyrrhizae 35g;

Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds modified starch, hydroxy methocel and sweeting agent; Modified starch, hydroxy methocel and sweeting agent mass ratio are 4:1:0.5, the quality of modified starch, hydroxy methocel and sweeting agent and be the 1-1.5% of mixture of viscous form quality, stir, obtain powder after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add glucose powder and gentamycin sulfate powder, the mass ratio of glucose powder and gentamycin sulfate powder is 3:1, the quality of the glucose powder added and gentamycin sulfate powder and be 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.

For the sick chicken of the inclusion body hepatitis of morbidity, use disease-resistant adjuvant to add water after morbidity and be configured to the solution of mass percent 8%, often only gavage 10ml.

 

Above-mentioned 3 list of examples compare, (for the sickness rate after the control of inclusion body hepatitis, the effective percentage after treatment).

Example 1-3 respectively selects each 500 of the broiler in 6 week age, select the broiler 500 in 6 week age only as a control group from Qingdao Lan Yingqin industry Science and Technology Ltd. simultaneously, respectively sick chicken 10 inputs suffering from inclusion body hepatitis are raised together with, carry out infecting experiment, observe after 3 days, then the sick chicken of the inclusion body hepatitis of having fallen ill is treated, matched group uses vitamin C injection (often to prop up 2 milliliters, containing 0.1 milligram), vitamin K3, K4 injection (often props up 1 milliliter, containing 4 milligrams), gentamycin (often props up 1 milliliter, containing 20 milligrams) each 1, to cold water 250 milliliters, disease chicken is allowed freely to drink.

By upper table, can find, the cultural method of the application, effectively can reduce the probability of inclusion body hepatitis morbidity in breeding process.And can find the aqueous solution of 12% mass ratio of the application's disease-resistant drug, therapeutic effect is good.

 

Contrast experiment's data:

Laboratory animal, chooses and invades then through the sick chicken of inclusion body hepatitis, determine the broiler 1000 in 4 week age of catching an illness, be divided into 5 groups at random,

1 group of solution using 8% of the disease-resistant adjuvant bath configuration of the embodiment of the present application 1, every day gavages 5ml, every day twice,

2 groups use prior art Chinese patent application 2013100743847 to disclose a kind of Chinese medicine oral liquid for the treatment of chicken inclusion body hepatitis.

3 groups use in prior art, and Chinese medicine formula: Folium Isatidis 60 g, Herba Artemisiae Scopariae 30 g, Fructus Gardeniae 45 g, Rhizoma Polygoni Cuspidati 30 g, Radix Et Rhizoma Rhei 20 g, Herba Plantaginis 35 g, every 100 kg feedstuffs mix 0.5 ~ 1.0 kg.

4 groups, Chinese patent application 2010102703573 is used to disclose a kind of Chinese medicine feed additive for prevention and therapy chicken liver lesion.

5 groups use in background technology, the clear spice of sense poison, 3% glucose+vitamin C drinking-water.

Comparison therapy effect, the treatment of each group is after 4 days, and record mortality rate and body weight contrast, continue feeding after 10 days, compare the time of recovering normal type.Image data is listed as follows

6 groups of healthy broiler selecting 4 week age, for comparison weight recovery time (respectively organize differ be less than 10g with 6 namely calculate the normal value returning back to 6 groups), 6 groups as Normal group.

By upper table contrast, can find, the application's cure rate is high, therapeutic effect for inclusion body hepatitis is remarkable, and treatment required time is short, and the time of recovering body weight is fast, mortality rate, lower than other schemes of the prior art, significantly can reduce raiser's therefore sick loss brought.

 

The toxicity test result of the disease-resistant adjuvant of example 3 of the present invention:

Toxicity is to the experiment of rat:

Acute oral (LD50) > 500mg/kg,

Acute percutaneous (LD50) > 2000mg/kg,

Belong to low toxicity.

 

Antiviral breeding data:

Get a sick chicken and do not do any treatment, as virus control;

Above-mentioned 1-6 group, often group randomly draws one on the 4th day what treat, fixing after taking body weight, dissects, and gets liver and calculates liver exponential quantity, calculates liver index suppression ratio.

Heavy (g)/body weight (g) × 100 of liver index=liver

Liver index suppression ratio=(virus control group liver Mean value of index-experimental group liver Mean value of index)/virus control group liver Mean value of index × 100%

Liver index is larger, represents that liver pathological changes degree is serious,

Hepatic tissue 10% formaldehyde is fixed, and ethanol series is dewatered, and dimethylbenzene is transparent, paraffin embedding, slice thickness 4-5 micron, and HE dyes, and observes blood lipid change with ordinary optical microscope, with the liver of Normal group as a comparison.

The impact (n=10) of liver's checking (virus is observed)

By above-mentioned contrast, the component of 1 group of the application good suppression ratio can be had to virus.

Advantage of the present invention is: method is simple, and easy to use, prevention and cure chicken inclusion body hepatitis is effective, obviously can reduce the loss that therefore disease is brought to raiser.Be specially, in the high period of disease of broiler, disease-resistant adjuvant mixed in feedstuff and carries out feeding, increase resistance against diseases.For the sick chicken of ill inclusion body hepatitis, disease-resistant adjuvant bath is gavaged and treats.

Claims (4)

1. one kind is reduced the medicine of inclusion body hepatitis sickness rate, it is characterized in that, component is: Herba Ecliptae, Tradescantia albiflora, each 90-130g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 50-80g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 30-60g of Radix Pecteilis susannae, Radix Glycyrrhizae 25-50g.

2. reduce the medicine of inclusion body hepatitis sickness rate according to claim 1, it is characterized in that, component is: Herba Ecliptae, Tradescantia albiflora, each 90-110g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 50-70g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 30-50g of Radix Pecteilis susannae, Radix Glycyrrhizae 25-40g.

3. reduce the medicine of inclusion body hepatitis sickness rate according to claim 1, it is characterized in that, component is: Herba Ecliptae, Tradescantia albiflora, each 110-130g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 70-80g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 50-60g of Radix Pecteilis susannae, Radix Glycyrrhizae 40-50g.

4. reduce the medicine of inclusion body hepatitis sickness rate according to claim 1, it is characterized in that, component is:

Herba Ecliptae, Tradescantia albiflora, each 95-125g of Herba Rabdosiae Lophanthoidis, Radix Gentianae, Caulis Akebiae, Rhizoma Cyperi, Fructus Aurantii, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Herba Agrimoniae, each 55-75g of Rhizoma Imperatae, Rhizoma Cibotii, Cortex Phellodendri, Herba Houttuyniae, Herba Andrographis, Halloysitum Rubrum, BIXUAN, each 35-55g of Radix Pecteilis susannae, Radix Glycyrrhizae 30-45g.