CN104208496A - White comb disease resistant drug - Google Patents
White comb disease resistant drug Download PDFInfo
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- CN104208496A CN104208496A CN201410510166.8A CN201410510166A CN104208496A CN 104208496 A CN104208496 A CN 104208496A CN 201410510166 A CN201410510166 A CN 201410510166A CN 104208496 A CN104208496 A CN 104208496A
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Abstract
The invention provides a white comb disease resistant drug. The white comb disease resistant drug comprises the following components of 120-180g of brucea javanica, 120-180g of gentian, 120-180g of purslane, 80-100g of usnea, 80-100g of cohosh, 80-100g of eucalyptus robusta, 80-100g of saponin, 80-100g of radix sophorae flavescentis, 80-100g of fructus cnidii, 80-100g of rhizoma atractylodis, 80-100g of cockscomb, 50-70g of reed rhizome, 50-70g of cape jasmine, 50-70g of herba andrographitis, 50-70g of scrophularia ningpoensis, 50-70g of toosendan, 50-70g of burnet, 50-70g of ocher, 20-50g of licorice and 20-50g of platycodon grandiflorum. The white comb disease resistant drug is simple in method, easy to use, good in prevention and control effects of white comb disease of chickens and capable of significantly reducing the losses caused by the disease to farmers.
Description
technical field:
The present invention relates to chicken fowl cultural technique field, particularly relate to a kind of disease-resistant drug of white comb.
background technology:
In the breeding process of chicken fowl, often cause chicken fowl dead because suffering from various disease, this treatment is too late, then bring huge economic loss to raiser, with chicken fowl white comb, in rainy summer and autumn, chicken usually occurs a kind ofly to turn white as the disease of principal character with cockscomb, has carried out larger economic loss to poultry industrial belt.Chicken whitecomb is that chicken leucocyte protozoon parasitizes a kind of haemosoridiasis caused in the leukocyte of chicken and erythrocyte; Chicken leucocyte protozoon has multiple, wherein the most common with Leucocytozoon caulleryi, and harm is the most serious.General to mostly occur summer and autumn, infected chicken with muscular tissue and internal organs extensively hemorrhage for feature, cockscomb is lost blood pale and gains the name, the visible corpse of sick chicken is become thin, blood thins out, rare light, chest muscle, lower limb flesh have obvious Semen Sesami shape size petechia or snow speckle, and muscle is pale, and hepatosplenomegaly is fragile with petechia or white point tuberosity.The laying hen M & M of the primary disease 3-6 week chickling in age and high yield is high.The sick chicken body temperature of chickling morbidity raises, inappetence, and spirit is depressed, sialorrhea, row's yellow-white or yellow green loose stool, and growth promoter is obstructed, and feather is disorderly loose, walking, dyspnea, spitting of blood etc.The sick chicken of laying hen morbidity is laid eggs and turns white, laying rate decline about 15-50%.The most obvious feature of the ill chicken of institute is anemia, and cockscomb is pale without color.
Traditional treatment, can, Diverdine mixing clean with safe sky, if it is that the aqueous solvent clean 25-30 gram that Thailand can be gone out is watered 50 kilograms and drinks, spice enemy's Diverdine 100 grams of spices 50 kilograms simultaneously only that Thailand goes out; In addition, if when the state of an illness is heavier, another meal gram ball powder 50 grams of spices 40 kilograms, are used in conjunction 3-5 day.Or use hundred clothes peace (containing SD, SMZ, SMM, TMP) to treat.Also can use compound sulfamethoxazole pyrimidine, oral 25 milligrams of chicken per kilogram of body weight, initial dose can double, and serve on 3-4 days.Also available chloroquine, oral 100 milligrams of chicken per kilogram of body weight, takes 1 every day, serve on 3 days.Or whole day amount throwing clothes can be calculated by 150 ~ 170 kilograms of material/bags with BAIGUAN spirit.And coordinate vitamin K3 and etamsylate in order to this sick rehabilitation.In prior art, many uses western medicine mode, as Chinese patent application 2009100687728 discloses a kind of control chicken whitecomb oral liquid and preparation method thereof: comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by its weight parts sulfadiazine 1-40 part, trimethoprim 1-10 part, aluminium stearate 1-10 part, ethanol 15-30 part, sodium carboxymethyl cellulose 0.1-1 part, tween 80 1-5 part.
But, in breeding process, along with medicine or antibiotic use increase, chicken fowl Drug resistance is strong, after using, egg product or meat drug residue high, be unfavorable for that people's is healthy, along with social development, occur that some Chinese patent medicines or Chinese medicine product are to prevent this type of chicken fowl diseases, such as, " Chinese animal and veterinary digest " 27 volumes the 4th phase in 2011 disclosed " comprehensive preventive health measures of chicken whitecomb ", it use protozoon loose clearly, component is Radix Scutellariae, Radix Sanguisorbae, the Radix Aucklandiae, the Radix Paeoniae Alba, Herba Ecliptae etc.Also pure Chinese medicine spice can be used, if Cortex cinnamomi japonici (Ramulus Cinnamomi), the Radix Polygoni Multiflori, Herba Agrimoniae, the Radix Pulsatillae, Herba Artemisiae Annuae are according to 0.25% spice feeding.Such as, " the therapy of combining Chinese and Western medicine test of chicken leucocyte protozoon disease " 2006, disclosed prescription: Herba Artemisiae Annuae 150g, Radix Dichroae 130g, Radix Pulsatillae 100g, Cortex Fraxini 50g, Radix Sophorae Flavescentis 100g, Rhizoma Coptidis 40g, Radix Bupleuri 50g, Herba Agrimoniae 100g, Radix Glycyrrhizae 50g.And for example, Chinese patent application 2013102880181 discloses a kind of Chinese medicine composition for the treatment of chicken whitecomb, and said composition is made up of following weight ratio raw material of Chinese medicine: Folium Persicae 20-40, Herba veronicae arvensis 20-40, Herba Verbenae 20-40, Cacumen Platycladi 10-20, Radix seu Herba Gei aleppici 10-20, Lignum Dalbergiae Odoriferae 5-10, Fructus Terminaliae Billericae 1-5.And for example Chinese patent application 2011103068445 discloses a kind of compound bee-glue composition for the treatment of chicken whitecomb and preparation method thereof, be by following component by weight mixed preparing form: propolis 15-35 part, Radix Pulsatillae 10-35 part, Radix Sophorae Flavescentis 15-30 part, Radix Scutellariae 10-25 part, Flos Sophorae 10-35 part, Herba Agrimoniae 10-35 part.
On the basis of existing technology, provide a kind of method simple, easy to use, prevention and cure chicken whitecomb is effective, obviously can reduce the disease-resistant drug of the white comb of the loss that therefore disease is brought to raiser for purport of the present invention.
summary of the invention:
The object of the invention is to overcome the shortcoming existed in prior art, provide a kind of method simple, easy to use, prevention and cure chicken whitecomb is effective, obviously can reduce the disease-resistant drug of the white comb of the loss that therefore disease is brought to raiser.
To achieve these goals, the invention provides a kind of disease-resistant drug of white comb, wherein, operate in accordance with the following steps:
A laying hen chicken, when 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%;
After B laying hen enters laying period, carry out feeding by following mass percent configuration feedstuff: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2%;
The component of described disease-resistant adjuvant is: Fructus Bruceae, Radix Gentianae, each 120-180g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 80-100g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 50-70g of Haematitum, Radix Glycyrrhizae, each 20-50g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine added is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
Further, the component of described disease-resistant adjuvant can also be: Fructus Bruceae, Radix Gentianae, each 120-160g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 80-90g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 50-60g of Haematitum, Radix Glycyrrhizae, each 20-40g of Radix Platycodonis.
Further, the component of described disease-resistant adjuvant can also be: the component of described disease-resistant adjuvant is: Fructus Bruceae, Radix Gentianae, each 140-180g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 90-100g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 60-70g of Haematitum, Radix Glycyrrhizae, each 40-50g of Radix Platycodonis.
Further, for increasing prevention effect, during ensureing whole cultivation, laying hen reduces the prevalence of white comb, during the cultivation of steps A and step B, can mix vitamin k 3 further in feedstuff, and the addition of vitamin k 3 is that feedstuff per ton adds no more than 5 grams.
Vitamin k 3, Chinese name, menadione; Menadione sodium bisulfite; 2-MNQ; Vitamin K3 is the required material of liver synthesis protoenzyme (factor B), and participates in proconvertin, IX, and the synthesis of X, maintains the blood coagulation physiological process of animal.The K that is deficient in vitamin can cause above-mentioned thrombin dyssynthesis, affects coagulation process and causes bleeding.Vitamin K is also required by the vitamin K dependence carboxylation system (mainly referring to be present in the histoorgans such as liver, skeleton, testis, skin and kidney) in animal body, is the indispensable factor in skeleton element (BGP) building-up process.In addition, in energy-rich compound metabolism and oxidative phosphorylation process, and all play an important role with the aspect of other fatsoluble vitamin metabolism, and there is diuresis, enhancing liver detoxification function, participate in the structure of film, the function reduced blood pressure.
Disease-resistant adjuvant of the present invention, adopt the preparation method of Chinese patent medicine, the present invention with Fructus Bruceae, Radix Gentianae, Herba Portulacae for monarch drug, with Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, Flos Celosiae Cristatae for ministerial drug, with Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, Haematitum for adjuvant drug, with Radix Glycyrrhizae, Radix Platycodonis for making medicine.Meanwhile, after restricted-access media Effective Component of Chinese Medicine, after improving taste by hydroxy methocel and correctives, add sulfadiazine stiffening effect.
Treat the sick chicken of the white comb of having fallen ill, disease-resistant adjuvant is added water modulation quality than 8-12%, often only gavages 5-10ml, 2 times on the one, gavage 3 continuously, Be very effective.
Advantage of the present invention is: method is simple, and easy to use, prevention and cure chicken whitecomb is effective, obviously can reduce the loss that therefore disease is brought to raiser, be specially, during laying hen chicken and high term these two are easily ill, add disease-resistant adjuvant to reduce ill probability.For the sick chicken of ill white comb, disease-resistant adjuvant bath can be gavaged and treat.
detailed description of the invention:
The disease-resistant drug of white comb, operates in accordance with the following steps:
A laying hen chicken, when 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%;
After B laying hen enters laying period, carry out feeding by following mass percent configuration feedstuff: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2%;
The component of described disease-resistant adjuvant is: Fructus Bruceae, Radix Gentianae, each 120-180g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 80-100g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 50-70g of Haematitum, Radix Glycyrrhizae, each 20-50g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine added is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
Further, the component of described disease-resistant adjuvant can also be: Fructus Bruceae, Radix Gentianae, each 120-160g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 80-90g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 50-60g of Haematitum, Radix Glycyrrhizae, each 20-40g of Radix Platycodonis.
Further, the component of described disease-resistant adjuvant can also be: the component of described disease-resistant adjuvant is: Fructus Bruceae, Radix Gentianae, each 140-180g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 90-100g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 60-70g of Haematitum, Radix Glycyrrhizae, each 40-50g of Radix Platycodonis.
Further, for increasing prevention effect, during ensureing whole cultivation, laying hen reduces the prevalence of white comb, during the cultivation of steps A and step B, can mix vitamin k 3 further in feedstuff, and the addition of vitamin k 3 is that feedstuff per ton adds no more than 5 grams.
Example 1:
Plant of Jimo Mao San village:
Laying hen chicken, when 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%; Feeding 4 times on the one.
After laying hen enters laying period, carry out feeding by following mass percent configuration feedstuff: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2%; Feeding 3 times on the one.
The component of described disease-resistant adjuvant is: Fructus Bruceae, Radix Gentianae, each 180g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 100g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 70g of Haematitum, Radix Glycyrrhizae, each 50g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine added is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
The sick chicken of young chicken period morbidity, uses disease-resistant adjuvant to add water and is configured to the solution of mass percent 8%, often only gavage 5ml after morbidity.
The sick chicken of morbidity of laying period, uses disease-resistant adjuvant to add water and is configured to the solution of mass percent 12%, often only gavage 10ml after morbidity.
Example 2
Kowloon town one, Jiangzhou plant:
Laying hen chicken, when 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%; After said components mixing, per tonly add vitamin k 3 for 2g and stir, feeding 4 times on the one.
After laying hen enters laying period, carry out feeding by following mass percent configuration feedstuff: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2%; After said components mixing, per tonly add vitamin k 3 for 5g and stir, feeding 3 times on the one.
The component of described disease-resistant adjuvant is: Fructus Bruceae, Radix Gentianae, each 160g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 90g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 60g of Haematitum, Radix Glycyrrhizae, each 30g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine added is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
The sick chicken of young chicken period morbidity, uses disease-resistant adjuvant to add water and is configured to the solution of mass percent 9%, often only gavage 5ml after morbidity.
The sick chicken of morbidity of laying period, uses disease-resistant adjuvant to add water and is configured to the solution of mass percent 11%, often only gavage 10ml after morbidity.
Example 3
The Sun Jia plant in Anqiu, Weifang:
Laying hen chicken, when 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%; Feeding 4 times on the one.
After laying hen enters laying period, carry out feeding by following mass percent configuration feedstuff: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2%; Feeding 3 times on the one.
The component of described disease-resistant adjuvant is: Fructus Bruceae, Radix Gentianae, each 160g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 80g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 50g of Haematitum, Radix Glycyrrhizae, each 30g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine added is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
The sick chicken of young chicken period morbidity, uses disease-resistant adjuvant to add water and is configured to the solution of mass percent 8%, often only gavage 5ml after morbidity.
The sick chicken of morbidity of laying period, uses disease-resistant adjuvant to add water and is configured to the solution of mass percent 10%, often only gavage 10ml after morbidity.
Above-mentioned 3 list of examples compare, (for the sickness rate after the control of white comb, the effective percentage after treatment).
Meanwhile, gather the data of Roman egghen 5000 of Qingdao Zhong Taiqin industry Specialty Co-operative Organization cultivation, as an example 4, example 4 diet, do not use any medicine for white comb in feedstuff, Data Comparison is as follows:
By upper table, can find, the cultural method of the application, effectively can reduce the probability of white comb morbidity in breeding process.
Contrast experiment's data:
Laboratory animal, chooses Roman egghen 600 plumage of Qingdao Tianrui Animal Husbandry Science and Technology Co., Ltd.'s natural occurrence, through clinical symptoms with cut open inspection and determine that it is white comb.
Grouping: the sick chicken of 600 plumage white combs is divided into six groups at random, and 1-5 group is experimental group, and 6 groups is matched group.
The feedstuff being mixed with disease-resistant adjuvant in stage laying period of 1 group of feeding embodiment of the present invention 2, feeding 3 times, obtained the solution of mass percent 12%, gavaged 2 every day, each 10ml after 2 groups of disease-resistant drug water mixing dilutions directly gavaging example 3 of the present invention next day.
The decocting liquid of 3 groups of disclosed prescriptions of feeding " the therapy of combining Chinese and Western medicine test of chicken leucocyte protozoon disease ", every day 2 times, often only gavages 10ml,
The decocting liquid of the Chinese medicine composition of the treatment chicken whitecomb that 4 groups of feedings 2013102880181 disclose, every day 2 times, often only gavages 10ml,
5 groups of feeding sulfadiazines, oral 25 milligrams of chicken per kilogram of body weight, initial dose can double, and serve on 3-4 days.
6 groups of diet, do not do treatment means, as a control group.
Each group adopts the corresponding means of each group, and process after 4 days, image data is listed as follows
By upper table contrast, can find, the application's cure rate is high, therapeutic effect for white comb is remarkable, and treatment required time is short, and the time of recovering laying rate is fast, mortality rate, lower than other schemes of the prior art, significantly can reduce raiser's therefore sick loss brought.
The toxicity test result of the disease-resistant adjuvant of example 3 of the present invention:
Toxicity is to the experiment of rat:
Acute oral (LD50) > 500mg/kg,
Acute percutaneous (LD50) > 2000mg/kg,
Belong to low toxicity.
Blood sheet checks, selects sick chicken in example 3,
Concrete: up to secondary morning 2 time, to get blood 1 night 9 drip on microscope slide, dye with lignin staining.The compound method of this dye liquor is as follows: haematoxylin 1g is dissolved in absolute alcohol or 95% ethanol 10ml, add saturated Burnt ammonium alum (8% ~ 10%) 100ml, pour in brown bottle, the two-layer gauze of bottleneck is tightened, be oxidized 2 ~ 4 weeks in the sun, filter, glycerol adding 25ml and methanol 25ml, the used time dilutes about 10 times.Laky blood, fixing thick blood film contaminate 10 ~ 15 minutes in De Shi haematoxylin liquid, color separation 1 ~ 2 minute in 1% sour ethanol, distilled water wash 1 ~ 5 minute, to blood film in blue, use 1% eosin stains 0.5 ~ 1 minute again, with water washing 2 ~ 5 minutes, dry rear microscopy.At low power Microscopic observation, observe zygoblast and schizont,
Principle:
Zygoblast in salivary gland, when sucking blood, injects in chicken body, and with the vascular endothelial cell endoparasitism of blood flow to each internal organs of whole body, becomes the first generation and second filial generation schizont through growth by storehouse midge.The merozoite discharged after second filial generation schizont maturation has had the differentiation of property, start to enter the gametogonia stage, form female, male gametophyte, when storehouse midge is sucked blood, male and female gametophytes enters in the midge body of storehouse, and develop into rapidly female, androgamete, then male and female gametophytes combines and forms zygote, start the growth in Sporogony stage, finally form egg capsule, containing a large amount of zygoblasts in ripe egg capsule, and be gathered in the salivary gland of storehouse midge, when storehouse midge is sucked blood again, zygoblast enters in chicken body and makes chicken infected, from then on starts again new biocycle.
By the zygoblast in observation medication process and schizont number, determine the effectiveness of medication.
Found by microscopy, in blood, schizont reduces more than 82%, and zygoblast reduces more than 76%.
The inventive method is simple, and easy to use, prevention and cure chicken whitecomb is effective, obviously can reduce the loss that therefore disease is brought to raiser, be specially, during laying hen chicken and high term these two are easily ill, add disease-resistant adjuvant to reduce ill probability.For the sick chicken of ill white comb, disease-resistant adjuvant bath can be gavaged and treat.
Claims (3)
1. the disease-resistant drug of a white comb, it is characterized in that, component is: Fructus Bruceae, Radix Gentianae, each 120-180g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 80-100g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 50-70g of Haematitum, Radix Glycyrrhizae, each 20-50g of Radix Platycodonis.
2. the disease-resistant drug of white comb according to claim 1, it is characterized in that, component is: Fructus Bruceae, Radix Gentianae, each 120-160g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 80-90g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 50-60g of Haematitum, Radix Glycyrrhizae, each 20-40g of Radix Platycodonis.
3. the disease-resistant drug of white comb according to claim 1, it is characterized in that, component is: Fructus Bruceae, Radix Gentianae, each 140-180g of Herba Portulacae, Usnea, Rhizoma Cimicifugae, Folium Eucalypti Robustae, Fructus Gleditsia, Radix Sophorae Flavescentis, Fructus Cnidii, Rhizoma Atractylodis, each 90-100g of Flos Celosiae Cristatae, Rhizoma Phragmitis, Fructus Gardeniae, Herba Andrographis, Radix Scrophulariae, Fructus Toosendan, Radix Sanguisorbae, each 60-70g of Haematitum, Radix Glycyrrhizae, each 40-50g of Radix Platycodonis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410510166.8A CN104208496A (en) | 2014-09-29 | 2014-09-29 | White comb disease resistant drug |
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| CN201410510166.8A CN104208496A (en) | 2014-09-29 | 2014-09-29 | White comb disease resistant drug |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107751101A (en) * | 2017-11-17 | 2018-03-06 | 遵义康翠莲养殖有限公司 | A kind of cultural method of laying hen |
| CN109350729A (en) * | 2018-12-18 | 2019-02-19 | 丹东瑞丰动物药业有限责任公司 | A kind of Chinese medicine and preparation method thereof for treating curing gallinaceous leucocyto zoonosis |
| CN111317000A (en) * | 2020-04-03 | 2020-06-23 | 河南城建学院 | Chinese herbal medicine disinfectant and preparation method and application thereof |
-
2014
- 2014-09-29 CN CN201410510166.8A patent/CN104208496A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107751101A (en) * | 2017-11-17 | 2018-03-06 | 遵义康翠莲养殖有限公司 | A kind of cultural method of laying hen |
| CN109350729A (en) * | 2018-12-18 | 2019-02-19 | 丹东瑞丰动物药业有限责任公司 | A kind of Chinese medicine and preparation method thereof for treating curing gallinaceous leucocyto zoonosis |
| CN111317000A (en) * | 2020-04-03 | 2020-06-23 | 河南城建学院 | Chinese herbal medicine disinfectant and preparation method and application thereof |
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