CN104189718A - Preparation method for medicine composition capable of preventing egg chicken from whitecomb - Google Patents
Preparation method for medicine composition capable of preventing egg chicken from whitecomb Download PDFInfo
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Abstract
The invention provides a preparation method for a medicine composition capable of preventing an egg chicken from whitecomb. The medicine composition comprises the following components: ilex purpurea, dark plum fruits, amomum tsao-ko, phoenix-tail ferns, esliptae herba, Chinese pulsatilla roots, dichroae radix, chinaberry seeds, Chinese honeylocust fruits, radis ampelopsis, red paeony roots, bamboo leaves, coptidis rhizoma, frutus forsythiae, herba houttuyniae, cortex moutan, rhizooma imperatae, crinis carbonisatus, radix glycyrrhizae and radix platycodi. The preparation method comprises the following steps: all the components are mixed and extracted by a water extraction method for three times; extracting liquids obtained every time are mixed and cooked to obtain a slabby mixture, and hydroxymethyl cellulose and a corrigent are added into the mixture; the mass ratio of the hydroxymethyl cellulose and the corrigent is 2:1, the mass sum of the hydroxymethyl cellulose and the corrigent is 2-3% of the mass of the slabby mixture, and after the mixture is dried, powder is obtained; the powder is subjected to ultraviolet radiation for disinfection for 10 s, sulfadiazine is added, the mass of the sulfadiazine is 1% of that of the powder, and the powder and the sulfadiazine are uniformly mixed to obtain a disease-resistant auxiliary material. According to the invention, the preparation method is simple and convenient to use, the effect of preventing and treating the whitecomb is good, and loss brought to farmers due to the whitecomb can be significantly lowered.
Description
technical field:
The present invention relates to chicken fowl cultural technique field, relate in particular to a kind of preparation method of the pharmaceutical composition of avoiding laying hen white comb.
background technology:
In the breeding process of chicken fowl, often cause the death of chicken fowl because suffering from various diseases, this treatment is too late, bring huge economic loss to raiser, with chicken fowl white comb, in rainy summer and autumn, chicken usually occurs a kind ofly to turn white as the disease of principal character taking cockscomb, has brought larger economic loss to poultry husbandry.Chicken whitecomb is that chicken leucocyte protozoon parasitizes a kind of haemosoridiasis causing in the leukocyte of chicken and erythrocyte; Chicken leucocyte protozoon has multiple, wherein the most common with Leucocytozoon caulleryi, and harm is the most serious.Generally to mostly occur summer and autumn, infected chicken is extensively hemorrhage as feature taking muscular tissue and internal organs, cockscomb is lost blood pale and is gained the name, the visible corpse of sick chicken is become thin, blood thins out, rare light, chest muscle, lower limb flesh have obvious Semen Sesami shape size petechia or snow speckle, and muscle is pale, and hepatosplenomegaly fragility is with petechia or white point tuberosity.The primary disease 3-6 week chickling in age and the laying hen M & M of high yield are high.The sick chicken fervescence of chickling morbidity, inappetence, spirit is depressed, sialorrhea, row's yellow-white or yellow green loose stool, growth promoter is obstructed, and feather pine is random, walking, dyspnea, spitting of blood etc.The sick chicken of laying hen morbidity is laid eggs and turns white, laying rate decline 15-50% left and right.The most obvious feature of the ill chicken of institute is anemia, and cockscomb is pale without color.
Traditional treatment, can be with safe day clean, Diverdine mixing, is that the aqueous solvent clean 25-30 gram that Thailand can be gone out is watered 50 kilograms and drinks, 50 kilograms of 100 grams of spices of enemy's Diverdine for spice simultaneously only if Thailand goes out; In addition, if when the state of an illness is heavier, another is 40 kilograms of 50 grams of spices of gram ball powder for meal, are used in conjunction 3-5 day.Or use hundred clothes peaces (containing SD, SMZ, SMM, TMP) to treat.Also can use compound sulfamethoxazole pyrimidine, oral 25 milligrams of chicken per kilogram of body weight, initial dose can double, and serve on 3-4 days.Also available chloroquine, oral 100 milligrams of chicken per kilogram of body weight, takes 1 every day, serve on 3 days.Or can calculate whole day amount by 150～170 kilograms of material/bag with BAIGUAN spirit and throw clothes.And coordinate vitamin K3 and etamsylate in order to this disease rehabilitation.In prior art, the western medicine modes that use more, as Chinese patent application 2009100687728 discloses a kind of control chicken whitecomb oral liquid and preparation method thereof: comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by its parts by weight sulfadiazine 1-40 part, trimethoprim 1-10 part, aluminium stearate 1-10 part, ethanol 15-30 part, sodium carboxymethyl cellulose 0.1-1 part, tween 80 1-5 part.
But, in breeding process, along with medicine or antibiotic use increase, chicken fowl Drug resistance is strong, after use, egg product or meat drug residue are high, are unfavorable for that people's is healthy, along with social development, occur that some Chinese patent medicines or Chinese medicine product prevent this type of chicken fowl diseases, for example, " Chinese animal and veterinary digest " the 4th phase of 27 volumes in 2011 disclosed " comprehensive preventive health measures of chicken whitecomb ", it has used protozoon loose clearly, and component is Radix Scutellariae, Radix Sanguisorbae, the Radix Aucklandiae, the Radix Paeoniae Alba, Herba Ecliptae etc.Also can use pure Chinese medicine spice, if Cortex cinnamomi japonici (Ramulus Cinnamomi), the Radix Polygoni Multiflori, Herba Agrimoniae, the Radix Pulsatillae, Herba Artemisiae Annuae are according to 0.25% spice feeding.For example, " the therapy of combining Chinese and Western medicine test of chicken leucocyte protozoon disease " 2006, disclosed prescription: Herba Artemisiae Annuae 150g, Radix Dichroae 130g, Radix Pulsatillae 100g, Cortex Fraxini 50g, Radix Sophorae Flavescentis 100g, Rhizoma Coptidis 40g, Radix Bupleuri 50g, Herba Agrimoniae 100g, Radix Glycyrrhizae 50g.And for example, Chinese patent application 2013102880181 discloses a kind of Chinese medicine composition for the treatment of chicken whitecomb, and said composition is made up of following weight ratio raw material of Chinese medicine: Folium Persicae 20-40, Herba veronicae arvensis 20-40, Herba Verbenae 20-40, Cacumen Platycladi 10-20, Radix seu Herba Gei aleppici 10-20, Lignum Dalbergiae Odoriferae 5-10, Fructus Terminaliae Billericae 1-5.And for example Chinese patent application 2011103068445 discloses a kind of compound bee-glue composition for the treatment of chicken whitecomb and preparation method thereof, be by following component by weight mixed preparing form: propolis 15-35 part, Radix Pulsatillae 10-35 part, Radix Sophorae Flavescentis 15-30 part, Radix Scutellariae 10-25 part, Flos Sophorae 10-35 part, Herba Agrimoniae 10-35 part.
Purport of the present invention on the basis of existing technology, provides a kind of method simple, easy to use, and prevention and cure chicken whitecomb is effective, can obviously reduce the preparation method of the pharmaceutical composition of avoiding laying hen white comb of the loss that therefore disease is brought to raiser.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of method simple, easy to use, prevention and cure chicken whitecomb is effective, can obviously reduce the preparation method of the pharmaceutical composition of avoiding laying hen white comb of the loss that therefore disease is brought to raiser.
To achieve these goals, the invention provides a kind of preparation method of the pharmaceutical composition of avoiding laying hen white comb, wherein, operation in accordance with the following steps:
A laying hen chicken, in the time of 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%;
B laying hen entered after laying period, carried out feeding: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2% by following mass percent configuration feedstuff;
The component of described disease-resistant adjuvant is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 120-180g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 80-100g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 50-70g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 20-50g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, after dry, obtain powder, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine adding is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
Further, the component of described disease-resistant adjuvant can also be: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 120-160g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 80-90g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 50-60g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 20-40g of Radix Platycodonis.
Further, the component of described disease-resistant adjuvant can also be: the component of described disease-resistant adjuvant is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 140-180g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 90-100g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 60-70g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 40-50g of Radix Platycodonis.
Further, be to increase prevention effect, ensure that laying hen during whole cultivation reduces the prevalence of white comb, during the cultivation of steps A and step B, in feedstuff, can further mix vitamin k 3, the addition of vitamin k 3 is that feedstuff per ton adds no more than 5 grams.
Vitamin k 3, Chinese name, menadione; Menadione sodium bisulfite; 2-MNQ; Vitamin K3 is the essential material of the synthetic protoenzyme (factor B) of liver, and participates in proconvertin, and IX, and the synthesizing of X, maintain the blood coagulation physiological process of animal.The K that is deficient in vitamin can cause above-mentioned thrombin dyssynthesis, affects coagulation process and causes bleeding.Vitamin K is also essential by the vitamin K dependence carboxylation system that (mainly refers to be present in the histoorgans such as liver, skeleton, testis, skin and kidney) in animal body, is the indispensable factor in skeleton element (BGP) building-up process.In addition, in energy-rich compound metabolism and oxidative phosphorylation process, and all play an important role with the aspect of other fatsoluble vitamin metabolism, and there is diuresis, enhancing liver detoxification function, participate in the structure of film, the function reducing blood pressure.
Disease-resistant adjuvant of the present invention, adopt the preparation method of Chinese patent medicine, the present invention is taking Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, Fructus Tsaoko as monarch drug, taking Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, Radix Paeoniae Rubra as ministerial drug, taking Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, Crinis Carbonisatus as adjuvant drug, with Radix Glycyrrhizae, Radix Platycodonis for making medicine.Meanwhile, extraction extracts after Effective Component of Chinese Medicine, adds sulfadiazine stiffening effect after improving taste by hydroxy methocel and correctives.
Treat the sick chicken of the white comb of having fallen ill, disease-resistant adjuvant is added water to modulation quality than 8-12%, every gavages 5-10ml, and 2 times on the one, gavage continuously 3, effect is remarkable.
Advantage of the present invention is: method is simple, easy to use, and prevention and cure chicken whitecomb is effective, can obviously reduce the loss that therefore disease is brought to raiser, be specially, easily ill these two of laying hen chicken and high terms during, add disease-resistant adjuvant to reduce ill probability.For the sick chicken of ill white comb, disease-resistant adjuvant bath can be gavaged and treats.
detailed description of the invention:
Avoid the preparation method of the pharmaceutical composition of laying hen white comb, in accordance with the following steps operation:
A laying hen chicken, in the time of 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%;
B laying hen entered after laying period, carried out feeding: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2% by following mass percent configuration feedstuff;
The component of described disease-resistant adjuvant is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 120-180g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 80-100g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 50-70g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 20-50g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, after dry, obtain powder, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine adding is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
Further, the component of described disease-resistant adjuvant can also be: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 120-160g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 80-90g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 50-60g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 20-40g of Radix Platycodonis.
Further, the component of described disease-resistant adjuvant can also be: the component of described disease-resistant adjuvant is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 140-180g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 90-100g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 60-70g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 40-50g of Radix Platycodonis.
Further, be to increase prevention effect, ensure that laying hen during whole cultivation reduces the prevalence of white comb, during the cultivation of steps A and step B, in feedstuff, can further mix vitamin k 3, the addition of vitamin k 3 is that feedstuff per ton adds no more than 5 grams.
Example 1:
The great Xin town week raiser of man:
Laying hen chicken, in the time of 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%; Feeding 4 times on the one.
Laying hen entered after laying period, carried out feeding: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2% by following mass percent configuration feedstuff; Feeding 3 times on the one.
The component of described disease-resistant adjuvant is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 180g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 100g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 70g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 50g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, after dry, obtain powder, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine adding is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
The sick chicken of chicken stage morbidity, is used disease-resistant adjuvant to add water and is configured to the solution of mass percent 8% after morbidity, every gavages 5ml.
The sick chicken of morbidity of laying period, is used disease-resistant adjuvant to add water and is configured to the solution of mass percent 12% after morbidity, every gavages 10ml.
Example 2
Duan Bolan town cultivation Demonstration Garden:
Laying hen chicken, in the time of 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%; After said components is mixed, the vitamin k 3 that adds per ton is for 2g stirs, feeding 4 times on the one.
Laying hen entered after laying period, carried out feeding: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2% by following mass percent configuration feedstuff; After said components is mixed, the vitamin k 3 that adds per ton is for 5g stirs, feeding 3 times on the one.
The component of described disease-resistant adjuvant is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 160g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 90g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 60g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 30g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, after dry, obtain powder, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine adding is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
The sick chicken of chicken stage morbidity, is used disease-resistant adjuvant to add water and is configured to the solution of mass percent 9% after morbidity, every gavages 5ml.
The sick chicken of morbidity of laying period, is used disease-resistant adjuvant to add water and is configured to the solution of mass percent 11% after morbidity, every gavages 10ml.
Example 3
The raiser of grandson family of Anqiu City:
Laying hen chicken, in the time of 3-6 age in week, carries out feeding by following mass percent configuration feedstuff: Semen Maydis 62%, Testa Tritici 3.2%, bean cake 30%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 1%; Feeding 4 times on the one.
Laying hen entered after laying period, carried out feeding: Semen Maydis 58.4%, Testa Tritici 3%, bean cake 27%, calcium hydrogen phosphate 1.3%, stone powder 7%, Sal 0.3%, laying hen multivitamin 1%, disease-resistant adjuvant 2% by following mass percent configuration feedstuff; Feeding 3 times on the one.
The component of described disease-resistant adjuvant is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, the each 160g of Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, the each 80g of Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Lycii, Rhizoma Imperatae, the each 50g of Crinis Carbonisatus, Radix Glycyrrhizae, the each 30g of Radix Platycodonis;
Time prepared by disease-resistant adjuvant: after said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, after dry, obtain powder, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine adding is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
The sick chicken of chicken stage morbidity, is used disease-resistant adjuvant to add water and is configured to the solution of mass percent 8% after morbidity, every gavages 5ml.
The sick chicken of morbidity of laying period, is used disease-resistant adjuvant to add water and is configured to the solution of mass percent 10% after morbidity, every gavages 10ml.
Above-mentioned 3 example list comparisons, (for the sickness rate after the control of white comb, the effective percentage after treatment).
Meanwhile, gather the data of 7300 of the Luo Man laying hens of Qingdao Chen Shi brother cultivation base, as an example 4, the normal feeding of example 4, does not use any medicine for white comb in feedstuff, and Data Comparison is as follows:
By upper table, can find that the application's cultural method can effectively reduce the probability that in breeding process, white comb is fallen ill.
Contrast experiment's data:
Laboratory animal, chooses Luo Man laying hen 600 plumages of Qingdao Tianrui Animal Husbandry Science and Technology Co., Ltd.'s natural occurrence, through clinical symptoms with cut open inspection and determining that it is white comb.
Grouping: the sick chicken of 600 plumage white combs is divided into six groups at random, and 1-5 group is experimental group, and 6 groups is matched group.
The feedstuff that is mixed with disease-resistant adjuvant in stage laying period of 1 group of feeding embodiment of the present invention 2, next day, feeding 3 times, obtained the solution of mass percent 12% after the disease-resistant medicine water mixing dilution that 2 groups directly gavage example 3 of the present invention, gavaged each 10ml every day 2 times.
The decocting liquid of the disclosed prescription of 3 groups of feedings " the therapy of combining Chinese and Western medicine test of chicken leucocyte protozoon disease ", every day 2 times, every gavages 10ml,
The decocting liquid of the Chinese medicine composition of the treatment chicken whitecomb that 4 groups of feedings 2013102880181 disclose, every day 2 times, every gavages 10ml,
5 groups of feeding sulfadiazines, oral 25 milligrams of chicken per kilogram of body weight, initial dose can double, and serve on 3-4 days.
6 groups of normal feedings, do not do treatment means, as a control group.
Each group adopts the corresponding means of each group, processes after 4 days, and image data is listed as follows
Contrast by upper table, can find, the application's cure rate is high, therapeutic effect for white comb is remarkable, and treatment required time is short, and the time of recovering laying rate is fast, mortality rate, lower than other schemes of the prior art, can significantly reduce the therefore sick loss bringing of raiser.
The toxicity test result of the disease-resistant adjuvant of example 3 of the present invention:
The experiment of toxicity to rat:
Acute oral (LD50) > 500mg/kg,
Acute percutaneous (LD50) > 2000mg/kg,
Belong to low toxicity.
Blood sheet checks, selects sick chicken in example 3,
Concrete: to get 1 of blood up to 2 o'clock inferior mornings night 9 and drip on microscope slide, with the dyeing of lignin staining.The compound method of this dye liquor is as follows: haematoxylin 1g is dissolved in absolute alcohol or 95% ethanol 10ml, add saturated Burnt ammonium alum (8%～10%) 100ml, pour in brown bottle, bottleneck is tightened with two-layer gauze, be oxidized in the sun 2～4 weeks, filter glycerol adding 25ml and methanol 25ml, 10 times of left and right of used time dilution.Laky blood, fixing thick blood film dye 10～15 minutes in De Shi haematoxylin liquid, color separation 1～2 minute in 1% sour ethanol, distilled water wash 1～5 minute, be blue to blood film, with 1% Yihong dyeing 0.5～1 minute, with water washing 2～5 minutes, dry rear microscopy again.At low power Microscopic observation, observe zygoblast and schizont,
Principle:
Storehouse midge, in the time sucking blood, is injected the zygoblast in salivary gland in chicken body, and arrives the vascular endothelial cell endoparasitism of the each internal organs of whole body with blood flow, becomes the first generation and second filial generation schizont through growth.The merozoite discharging after second filial generation schizont maturation has had the differentiation of property, start to enter the gametogonia stage, form female, male gametophyte, in the time that storehouse midge is sucked blood, female, male gametophyte enters in the midge body of storehouse, and develop into rapidly female, androgamete, then female, male gametophyte is in conjunction with forming zygote, started the growth in Sporogony stage, finally formed egg capsule, ripe egg capsule contains a large amount of zygoblasts, and be gathered in the salivary gland of storehouse midge, in the time that storehouse midge is sucked blood again, zygoblast enters in chicken body and makes chicken infected, from then on starts again new biocycle.
By observing zygoblast and the schizont number in medication process, determine the effectiveness of medication.
Find by microscopy, in blood, schizont reduces more than 81%, and zygoblast reduces more than 73%.
The inventive method is simple, easy to use, and prevention and cure chicken whitecomb is effective, can obviously reduce the loss that therefore disease is brought to raiser, be specially, easily ill these two of laying hen chicken and high terms during, add disease-resistant adjuvant to reduce ill probability.For the sick chicken of ill white comb, disease-resistant adjuvant bath can be gavaged and treats.
Claims (1)
1. a preparation method of avoiding the pharmaceutical composition of laying hen white comb, is characterized in that,
Component is: Ilex purpurea Hassk.[I.chinensis Sims, Fructus Mume, Fructus Tsaoko, Herba Pteridis Multifidae, Herba Ecliptae, the Radix Pulsatillae, Radix Dichroae, Fructus Toosendan, Fructus Gleditsia, Radix Ampelopsis, Radix Paeoniae Rubra, Folium Bambusae, Rhizoma Coptidis, Fructus Forsythiae, Herba Houttuyniae, Cortex Moutan, Rhizoma Imperatae, Crinis Carbonisatus, Radix Glycyrrhizae, Radix Platycodonis;
After said components is mixed, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, after dry, obtain powder, powder is after ultra-vioket radiation is sterilized 10 seconds, add sulfadiazine, the quality of the sulfadiazine adding is 1% of powder quality, obtains disease-resistant adjuvant after mix homogeneously.
Priority Applications (1)
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| CN106234836A (en) * | 2016-10-13 | 2016-12-21 | 合肥润雨农业科技有限公司 | A kind of feedstuff with prevention chicken whitecomb being applicable to raise common chicken scattered |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106234836A (en) * | 2016-10-13 | 2016-12-21 | 合肥润雨农业科技有限公司 | A kind of feedstuff with prevention chicken whitecomb being applicable to raise common chicken scattered |
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Application publication date: 20141210 |