CN104187172A - Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed - Google Patents
Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed Download PDFInfo
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Abstract
The invention relates to functional feed for treating enterogastritis diseases of turtles and a preparation method of the functional feed. The feed comprises the following raw materials: silkworm chrysalis meal, millet, fish meal, shrimp meal, carrot powder, lotus root starch, egg shells, cooked egg yolk, Chinese cabbage powder and traditional Chinese medicine additives. The functional feed has the beneficial effects that the traditional Chinese medicine composition in the feed is based on the traditional Chinese medicine principles of China, emphasizes on heat and toxic material clearing and digestion helping, has the advantages of rapid effect-taking, definite curative effect, high security and no toxic or side effect when being used for treating enterogastritis diseases of turtles, and when the functional feed is used together with other raw materials, synergy is brought into play, and not only is the curative effect achieved, but also the nutrition requirement of turtles suffering from diseases can be met.
Description
Technical field
The present invention relates to herbal medicine, particularly a kind of functional feed that is used for the treatment of tortoise enterogastritis disease and preparation method thereof.
Background technology
Tortoise enteritis disease is commonly called as enterogastritis, is common disease in tortoise disease, suffers from the originally lassitude of sick tortoise of enteritis disease, poor appetite, and ight soil is shapeless, is egg white shape, black or live pig Hepatic when serious.Acid-base value inspection is strong basicity, tells food phenomenon when artificial feed.Later stage enophthalmos, dry skin is lax, nonelastic, tarnish, last exhaustion death.Cut open the sick tortoise of inspection, find stomach and intestine inflammation, hyperemia.Tortoise enteritis disease morbidity is many in first spring and autumn end, immediate cause be this in season variation of ambient temperature larger, tortoise can not be absorbed by normal stool.Feed is rotten, and living environment is severe, the most easily causes the generation of tortoise enteritis disease.
Doctor trained in Western medicine control tortoise enterogastritis: 1, carry out cleaning-sterilizing: for foster tortoise pond, putting 50-75 kilogram of quick lime of front every mu of application in a suitable place to breed cleans up the pond, slurry float is digested with quick lime 125 in every square metre, spawning ground, for foster tortoise pond or foster tortoise container, new and oldly all will repeatedly clean putting in a suitable place to breed before tortoise.2, improve Water quality: the water body of supporting tortoise pond should keep clean clean at ordinary times, requires water body as clear as crystal.The every 15 days every square metre of waters surface in tortoise pond digest full pool spilling head after water with quick lime 40.The excreta of foreign material and tortoise in removing water, is strictly on guard against water quality deterioration in time.3, strengthen feeding and management: the feed request of tortoise is fresh, clean, should, according to the feeding habits of different tortoises, often change feed kind at ordinary times, to keep appetite and the food ration of tortoise.Feeding wants timing, location, determines matter, the quantitative food of throwing something and feeding, and the putrid and deteriorated food of can not throwing something and feeding, removes residual bait in time, in order to avoid polluted water.Note climate change, the maintenance tortoise pond winter does not freeze, the summer can heatstroke prevention.If sick tortoise appetite is useless absolutely, can in feed, add antibiotics, as terramycin, chloramphenicol, gentamicin etc.
But doctor trained in Western medicine control tortoise enteritis disease exists certain drawback, as cause the imbalance of animal gastrointestinal tract normal flora, produce drug resistance and dosage is increased, medicament residue affects health and the tortoise product quality of human body., if not medication will be fallen ill, medication will be considered medicament residue, the alternative medicine that the various permissions of throwing something and feeding are used, and effect is not necessarily desirable again, and cost also can rise, and has caused the immunosupress of tortoise, and resistance declines, and easily falls ill, difficult supporting.
But, traditional Chinese medicine prevention tortoise enteritis disease adopts natural Chinese traditional medicines material, safe, pollution-free, indication is extensive, is difficult for producing drug resistance, and has biologically active, contain the material of bringing into play main pharmacodynamics, and can strengthen or relax the material of active ingredient drug action, even if contain invalid even harmful material itself, often also can affect leaching effect, preparation stability, drug effect etc.According to the theory of pharmacology, nutrition, Chinese herbal medicine has medicine and nutrition double action concurrently, has nutrition, strengthens immunity, vitaminoid action, bidirectional modulation, the multifunctionality such as antimicrobial, compound action.
Summary of the invention
Technical problem to be solved by this invention is, a kind of functional feed that is used for the treatment of tortoise enteritis disease and preparation method thereof is provided, this feed comprise taking clearing heat and detoxicating, help digestion as the Chinese medicine additive of primary treatment principle, that treatment tortoise enteritis disease has is rapid-action, determined curative effect, safe, the advantage that has no side effect.
In order to realize foregoing invention object, the invention provides a kind of functional feed that is used for the treatment of tortoise enteritis disease, described feed comprises following raw material: dried silkworm chrysalis meal, millet, fish meal, shrimp med, carrot meal, lotus root starch, egg shell, the egg yolk boiling, Chinese cabbage powder and Chinese medicine additive.
In described feed, the parts by weight of each raw material are: dried silkworm chrysalis meal 10-20 weight portion, millet 15-28 weight portion, fish meal 15-25 weight portion, shrimp med 10-18 weight portion, carrot meal 5-10 weight portion, lotus root starch 5-14 weight portion, egg shell 3-8 weight portion, the egg yolk 5-8 weight portion boiling, Chinese cabbage powder 5-15 weight portion and Chinese medicine additive 0.1-3 weight portion.
In described feed, the parts by weight of each raw material are preferably: dried silkworm chrysalis meal 15 weight portions, millet 19 weight portions, fish meal 21 weight portions, shrimp med 14 weight portions, carrot meal 7 weight portions, lotus root starch 10 weight portions, egg shell 5 weight portions, egg yolk 7 weight portions that boil, Chinese cabbage powder 9 weight portions and Chinese medicine additive 0.5 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: the wind-weed, the coptis, the bark of ash, the root bark of shaggy-fruited dittany, manyleaf meadowure rhizome and root, Herba Andrographitis, dayflower, sargentodoxa cuneata, field pennycress, tomb later, wintercherry fruit or calyx, Oroxylum indicum, the Chinese bulbul, purslane, potentilla chinensis, Chinese lobelia, oldenlandia diffusa, radix cynanchi atrati, herba aristolochiae, rhizoma nardostachyos, santal, hawthorn, fevervine, Mao Ligen, illiteracy common bluebeard, duckweed, scouring rush, Chinese violet, cordate houttuynia, cymose buckwheat rhizome and Chinese yam.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: wind-weed 11-15 weight portion, coptis 11-18 weight portion, bark of ash 10-15 weight portion, root bark of shaggy-fruited dittany 8-14 weight portion, manyleaf meadowure rhizome and root 7-12 weight portion, Herba Andrographitis 15-21 weight portion, dayflower 11-18 weight portion, sargentodoxa cuneata 10-15 weight portion, field pennycress 10-15 weight portion, tomb is turned one's head 10-15 weight portion, wintercherry fruit or calyx 12-18 weight portion, Oroxylum indicum 10-18 weight portion, Chinese bulbul 11-18 weight portion, purslane 10-15 weight portion, potentilla chinensis 10-15 weight portion, Chinese lobelia 12-18 weight portion, oldenlandia diffusa 5-11 weight portion, radix cynanchi atrati 10-14 weight portion, herba aristolochiae 10-16 weight portion, rhizoma nardostachyos 10-16 weight portion, santal 7-12 weight portion, hawthorn 3-10 weight portion, fevervine 15-23 weight portion, Mao Li root 11-15 weight portion, cover common bluebeard 15-26 weight portion, duckweed 10-17 weight portion, scouring rush 10-14 weight portion, Chinese violet 10-16 weight portion, cordate houttuynia 10-14 weight portion, cymose buckwheat rhizome 7-12 weight portion and Chinese yam 15-25 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: the wind-weed 12 weight portions, the coptis 14 weight portions, the bark of ash 12 weight portions, the root bark of shaggy-fruited dittany 11 weight portions, manyleaf meadowure rhizome and root 8 weight portions, Herba Andrographitis 18 weight portions, dayflower 15 weight portions, sargentodoxa cuneata 12 weight portions, field pennycress 12 weight portions, tomb is 14 weight portions later, wintercherry fruit or calyx 15 weight portions, Oroxylum indicum 14 weight portions, the Chinese bulbul 15 weight portions, purslane 12 weight portions, potentilla chinensis 12 weight portions, Chinese lobelia 16 weight portions, oldenlandia diffusa 7 weight portions, radix cynanchi atrati 12 weight portions, herba aristolochiae 14 weight portions, rhizoma nardostachyos 13 weight portions, santal 8 weight portions, hawthorn 4 weight portions, fevervine 18 weight portions, Mao Li root 12 weight portions, cover common bluebeard's 18 weight portions, duckweed 13 weight portions, scouring rush's 12 weight portions, Chinese violet 13 weight portions, cordate houttuynia 12 weight portions, cymose buckwheat rhizome 9 weight portions and Chinese yam 21 weight portions.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, adds hot reflux 1～3 hour, extracts, and filters and obtains the first extract; The ethanol that it is 85～95% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1～2 times of described dregs of a decoction quality again, adds hot reflux 1～3 hour, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step adds the starch with respect to 2～4 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the feed that is used for the treatment of tortoise enteritis disease, described preparation method comprises the following steps:
The first step, takes all raw materials by weight, drops into pulverizer and pulverizes, and grinding particle size is 60-150 order, drops into mixer, mixes the uniformity≤5% of mixing;
Second step, after mixing, pour into be placed in granulating disc and carry out granulation, the granulation disc angle of inclination of granulating disc is 40-60 °, and the rotating speed of granulating disc is 45 revs/min, preparation time is 20 minutes, is prepared into diameter and is the spherical particle feed of 2 millimeters;
The 3rd step, the spherical particle feed that second step is obtained, spreads in having on the mesh-belt drier of the portable stainless steel guipure of multilayer, heat drying 12 minutes, the import air temperature of heating is 130 DEG C, outlet air temperature is 60 DEG C, obtains dry feed granules.
The invention has the beneficial effects as follows: the pharmaceutical composition that feed of the present invention contains, utilize the traditional theory of traditional Chinese medical science of China, taking clearing heat and detoxicating, help digestion as main, that treatment tortoise enteritis disease has is rapid-action, determined curative effect, safe, the advantage that has no side effect, cooperatively interact with other raw materials, acting in conjunction, not only plays the effect for the treatment of, but also can meet the nutritional need of ill tortoise.
Detailed description of the invention
The invention provides the functional feed that a kind for the treatment of is used for the treatment of tortoise enteritis disease, Chinese medicine additive wherein comprises following raw medicinal material: the wind-weed, the coptis, the bark of ash, the root bark of shaggy-fruited dittany, manyleaf meadowure rhizome and root, Herba Andrographitis, dayflower, sargentodoxa cuneata, field pennycress, tomb later, wintercherry fruit or calyx, Oroxylum indicum, the Chinese bulbul, purslane, potentilla chinensis, Chinese lobelia, oldenlandia diffusa, radix cynanchi atrati, herba aristolochiae, rhizoma nardostachyos, santal, hawthorn, fevervine, Mao Ligen, illiteracy common bluebeard, duckweed, scouring rush, Chinese violet, cordate houttuynia, cymose buckwheat rhizome and Chinese yam; Wherein, duckweed, scouring rush, the wind-weed, the coptis, the bark of ash, the root bark of shaggy-fruited dittany, manyleaf meadowure rhizome and root can heat-clearing and damp-drying drug, purging intense heat; Herba Andrographitis, dayflower, Chinese violet, cordate houttuynia, cymose buckwheat rhizome, sargentodoxa cuneata, field pennycress, tomb are later, wintercherry fruit or calyx, Oroxylum indicum, the Chinese bulbul, purslane, potentilla chinensis, Chinese lobelia, oldenlandia diffusa, radix cynanchi atrati can be clearing heat and detoxicating, the diuresis of holding concurrently when disappearing carbuncle; Herba aristolochiae, Chinese yam, rhizoma nardostachyos, santal, hawthorn, fevervine, Mao Ligen, illiteracy common bluebeard can help digestion, and make a general survey of full side, and compatibility is rigorous, not only can disinfection, and protection tortoise digestive system surface mucous membrane, can also help digestion, and supplements qi and blood, improves the immunity of tortoise etc.
Wherein, the pharmacological property of above-mentioned raw materials medicinal material is as follows:
The wind-weed: bitter, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, removing heat from the lung to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat-clearing, can promote the production of body fluid again, kindly controls warm disease and evil and enters gas and divide, and heat is contained and is hindered Tianjin; Also be used for the treatment of diabetes; Phlegm-heat obstructing lung and breathing heavily, xeropulmonary cough, phlegm is few unfavorable; Fire excess from yin deficiency, the symptoms such as flaring up of deficient fire, 1. for warm disease, heresy is divided at gas, and the gas of high heat, polydipsia divides excessive heat syndrome, has the effect of purging intense heat relieving restlessness, has collaborative effect with gypsum, leaf of bamboo compatibility.2. be used for the treatment of cough with lung heat or deficiency of Yin cough caused by dryness, have and let out clearly lung-fire, nourishing Yin and moistening lung effect.Normal and the bulb of fritillary is same in order to strengthen the merit of clearing away the lungheat and moisturizing, as female loose in " collection of prescriptions with notes " two.3. for fire excess from yin deficiency, osteopyrexia and fever, night sweat person, has nourishing Yin and falling fire effect, and normal and golden cypress mutual reinforcement between are use.4. can let out clearly the fire of lung stomach, the moon that again can nourishing the lung and kidney, quenches one's thirst therefore should be used for the deficiency of Yin, and that disease is seen is thirsty, drink is many, urinate many persons, and same Chinese yam, the fruit of Chinese magnoliavine etc. are used in conjunction with and can heighten the effect of a treatment, as good wine soup.The wind-weed has inhibitory action to various bacteria such as shigella dysenteriae, typhoid bacillus, Escherichia coli, proteus, staphylococcus, streptococcus.
The coptis: hardship, cold, nontoxic.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel." drug property cerse ": " bitter, flat, gas is cold, nontoxic.Sink also, the moon also.It is with having four: purge the sthenic heart-fire, the shape that the epigastric fullness that disappears is full; Main intestines Bleach is red except what mix in intestines; Control order disease and break out suitable use, treat sore head and the tail all same." function heat-clearing and damp-drying drug, purging intense heat and detonicating.Full for damp and hot ruffian, vomiting acid regurgitation, rushes down dysentery, jaundice, and unconsciousness due to high fever, is longer than the fire of removing the heart-fire stomach, has the disappear merit of ruffian of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of internal heat due to prosperous, and blood-head is told nosebleed, hot eyes, toothache, quenches one's thirst, the carbuncle furunculosis that swells; Control eczema outward, wet sore, duct is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of prepared RHIZOMA COPTIDIS with vino is burning hot.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and stomach preventing or arresting vomiting.Tie mutually for fever and chills, damp and hot middle resistance, ruffian is completely vomitted.The easypro liver of the cornel coptis and stomach preventing or arresting vomiting.For liver-stomach disharmony, vomiting acid regurgitation.
The bark of ash: bitter, cold; Return Liver Channel, gallbladder channel, large intestine channel." book on Chinese herbal medicine converges and says ": " bark of ash, bitter is puckery and hard, can restrain the vital essence of wandering away.Therefore Zhong Jing baitouweng decoction, controls the inferior burnt abnormal heat and sharp person with this, get bitter with puckery meaning also." Compendium of Material Medica: “ Ash skin, look clear gas is cold, and bitter is puckery, is faint cloudy liver, few positive gallbladder channel medicine also.Therefore control order disease, frightened epilepsy, get its flat wood also; Control the inferior dysentery, collapse band, get its inducing astrigency also; Can control again the few essence of man, beneficial essence has son, all gets that it is puckery and have benefit also." Shennong's Herbal: " heat extraction, blue or green screen tunica albuginea in order." function heat-clearing and damp-drying drug, clearing liver and improving vision, inducing astrigency stops dysentery, only band.Rush down dysentery for hot poison, the lower pruritus vulvae of band, the hot red eye, swell pain of liver, the raw ocular of order.
The root bark of shaggy-fruited dittany: hardship, salty, cold; Enter the spleen channel, lung channel, small intestinl channel, stomach warp, urinary bladder channel." Mingyi Bielu ": " shaggy-fruited dittany.As if the raw upper valley and dried flank meat.April, May adopt root, dry in the shade." " property of medicine opinion ": " control all hot malicious wind, dislike wind, wind sore, mange are red rotten, and eyebrow is sent out de-crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute febrile, paddy Huang, labor Huang etc." Compendium of Material Medica: " bitter is dry, is all yellow wind numbness key medicines for the root bark of shaggy-fruited dittany, the gas benefaction of trembling with fear, and physicians from a family for generations Zhi Shizhi sore section is shallow." the contained dictaminine of this product has excitation to isolated frog heart in the time of a small amount of, can make cardiac muscular tension increase, minute output quantity and rich output all increase.: dictaminine has powerful contraction to rabbit and cavy uterine smooth muscle, Yihong decoration method result shows that this product non-polar solvent extract thing and volatile oil have Anticancer Activity in vitro, root skin has refrigeration function, gives oral its decoction of rabbit of heating (Wen Cifa), can make temperature decline.
Manyleaf meadowure rhizome and root: nature and flavor bitter cold, heat-clearing and damp-drying drug, purging intense heat and detonicating.Control damp-heat dysentery, jaundice, pyreticosis agitation, cough with lung heat, carbuncle pyogenic infections from tumour or sore, red eye, swell pain.Be applied to now enteritis, catarrhal jaundice, flu, measles, the carbuncle sore furuncle that swells, conjunctivitis.Fetidine has hypotensive effect, and its crude preparation by using can be controlled hypertension.Magnoflorine, jamaicin, jateorrhizine etc. are referring to dutchmanspipe root, coptis bar.Congener Thalictrumpetaloideum Thalictrumpetaloideum or T.simplex T.simplex are containing thalcimine (Thalsimine), animal is had to anti-inflammatory, analgesia, cooling effect. purple meadowrue (Thalictrum dasycarpum) T.Dasycarpum is containing grass of meadow rue card product alkali (Thalicarpine), purple meadowrue (Thalictrum dasycarpum) alkali (Thalidasine), thalfetidine, effective to rat watt g cancer 1 and Mice Bearing Lewis Lung Cancer.Grass of meadow rue card product alkali also has weak hypotensive effect.
Herba Andrographitis: have another name called Chun Lianqiuliu, Banlangen, Lan Helian, andrographis paniculata, golden vanilla, golden tack, India's grass, eel grass etc.There are clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect.Cure mainly bacillary dysentery, urinary tract infections, acute tonsillitis, enteritis, sphagitis, pneumonia and influenza etc., external application can be treated sore furuncle poison, trauma infection contamination etc.Herba Andrographitis has eliminating inflammation and expelling toxin effect, once be applied to clinically multi-infection disease, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, the infection of the upper respiratory tract, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infections, endometritis, pelvic infecton, tympanitis, periodontitis etc., all have curative effect in various degree.
Dayflower: sweet, light, cold.Return lung, stomach, small intestinl channel.Function cures mainly: clearing heat and detoxicating, and inducing diuresis for removing edema.For anemopyretic cold, hyperpyrexia, abscess of throat, oedema oliguria, heat is drenched puckery pain, the carbuncle serious case of furuncle that swells.
Sargentodoxa cuneata: bitter, property is flat, returns liver, large intestine channel, " Hunan medicine will ": " stimulate the menstrual flow and enrich blood, strengthen muscles and bones, expelling parasite.Control traumatic injury, rheumatalgia pain, bruise, blood drenches, arthralgia and myalgia, sore furuncle, filariasis." " simple and easy herbal medicine ": " control arthralgia and myalgia, chase after wind, strong waist knee, establishing-Yang thing." there is the carbuncle that disappears that relieves internal heat, promoting blood circulation and removing obstruction in channels, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, arthralgia due to wind-dampness, dysentery characterized by blood in the stool, blood drenches, irregular menstruation, infantile malnutrition due to digestive disturbances or intestinalparasites, worm pain, the cards such as injury from falling down.The effect of Isolated Toad Heart is pressed to Ba Mushi isolated heart device, with 20ml ringer solution perfusion, 0.1g Sargent gloryvine is added to (0.5%) in perfusate, find isolated heart to be slight inhibition, performance heart contracting power weakens, decreased heart rate (P0.05), and cardiac output reduces (P0.01).To the effect of isolated rabbit aortic article, by the aortic article of isolated rabbit, result blood vessel starts to occur obvious contraction, and this effect can be blocked by phentolamine, points out its contraction may be receptor related with a-.Gradually there is again subsequently lasting relexation.
Field pennycress: taste is pungent, bitter, is slightly cold; Return liver, stomach, large intestine channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cool blood-head, cold stomach are sent out all amassing in tripe abdomen, diuresis.Compendium of Material Medica: " control blood and drench hemorrhoid complicated by anal fistula." Tang Materia Medica: " Patrinia scaniosaefolia, does not go out shortcut, and between Duo Shenggang ridge, leaf, like water Liang and common vetch rank, is grown thickly, and brightly yellowish, root purple is made old dark reddish brown; The different Bu Si of its leaf pig Xian also." function is clearing heat and detoxicating, cool blood, the carbuncle that disappears apocenosis, stasis-dispelling and pain-killing, for acute appendicitis, the high heat of lung carbuncle, coughs vomiting of pus and blood, hot carbuncle malignant boil, sore furuncle pain is swollen, chest abdomen pain, appendicitis, enteritis, dysentery, postpartum abdominal pain, dysmenorrhoea.
Tomb is turned one's head: taste is pungent, bitter, and cold nature has hemostasia effect.
Wintercherry fruit or calyx: bitter, sour, cold; Return lung, the spleen channel.Diuresis, heat-clearing, removing toxic substances, relieve sore throat.For abscess of throat, cough with lung heat, hectic fever due to yin labor heat, difficult urination, jaundice, oedema, pemphigus, hoarsen.Wintercherry fruit or calyx fruit water extract has antitumaous effect, and the growth of mouse Ehrlich ascites carcinoma is had to inhibitory action; The fresh juice of its fruit has inhibitory action to staphylococcus aureus, Pseudomonas aeruginosa etc.; Hepatitis b virus s antigen is also had to inhibitory action.In addition, this product ether dissolubility, water soluble ingredient all have the effect of strengthening its contraction to the frog heart, and can cause that faint vessel retraction and blood pressure raise.
Oroxylum indicum: mildly bitter flavor, sweet, cold nature; Return lung, liver, stomach warp." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " broken legendary venomous insect is long-pending, the poison of dehematize legendary venomous insect, gas legendary venomous insect for Dingchuan, dissolving phlegm.Again can qi-restoratives, wide in, feed." " detailed outline is picked up any lost article from the road ": " and control motive pain, irritability pain, bottom is damp and hot.Xiang Qiuzi cloud again, all carbuncle poison do not close up, and paste it with this." relieve sore throat moistening lung, soothing liver and harmonizing stomach, expelling pus and promoting granulation.Cure mainly pharyngalgia larynx numbness, hoarseness, cough, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, sore is burst and is not held back for a long time, acute eczema.Seed, stem skin, containing baicalein, have anti-inflammatory, antiallergic action, diuresis, cholagogic, the effect of norcholesterol.In seed and stem skin, containing Chrysin, human body nasopharyngeal carcinoma (KB) cell is had to cytotoxic activity, its effective dose 50 is 13mg/ml.
The Chinese bulbul: bitter, cold in nature; Return stomach warp, large intestine channel." herbal classic is met former ": " Chinese bulbul, " herbal classic " says bitter temperature person, the mistake of making private copy of is also.It controls the diseases such as the mad easy fever and chills of a kind of malaria, all few sun, the fixed disease of positive bright heat evil, and the loose hematocele of knot goes and only suffers from abdominal pain." not Lu " be nosebleed epistaxis only, and great scape stops fulminant dysentery, is also that hot poison enters the time that blood trouble is divided." " property of medicine opinion ": " only stomachache and also fulminant dysentery, control dentalgia, knurl scrofula under major event.Main hundred pain all over the joints." can be clearing heat and detoxicating, remove heat from the blood and relieve diarrhea, removing dampness and destroying parasites, for pyrotoxic dysentery disease, nosebleed epistaxis, bleeding, under band, pruritus vulvae, carbuncle sore, scrofula.Chinese bulbul infusion can extend the survival date of suffering from influenza virus PR8 small white mouse, and its pulmonary lesion is also had slightly and alleviated.
Purslane: cold in nature, the sweet acid of taste; Enter the heart, liver, spleen, large intestine channel.Compendium of Material Medica: " loose blood detumescence, sharp intestines habitual abortion, detoxifies treating stranguria, abnormal sweating after managing property." " Kaibao Bencao ": not " clothes not white all the year round.Control carbuncle sore, kill parasites.The raw juice clothes of smashing, when disliking thing under profit, go white worm." function is clearing heat and detoxicating, Li Shui dries, loose blood detumescence, and dust-collection sterilization, anti-inflammatory analgetic, cool blood stops blooding.Cure mainly dysentery, enteritis, ephritis, postpartum, uterine hemorrhage, had blood in stool, the illnesss such as mastitis.Loose blood detumescence, sharp intestines habitual abortion, detoxifies treating stranguria, abnormal sweating after managing property.
Potentilla chinensis: bitter, cold in nature, return liver, large intestine channel, has heat-clearing and damp-drying drug, the effect of removing heat from the blood and relieve diarrhea, for damp-heat dysentery, have loose bowels, the card such as dysentery, stomachache, acute bacterial are understood, blood-head is hemorrhage, spit blood, have blood in stool, hematuria, uterine bleeding.The flat board method that burrows for agent, has inhibitory action to shigella and shigella flexneri before herb.Committee's mound Lay all has certain inhibitory action to shigella dysenteriae, staphylococcus aureus, Pseudomonas aeruginosa, hay bacillus with Amoeba.Study its Antibacterial Constituents and be mainly gallic acid, Quercetin.Somebody finds that it has certain kill activity to Trichomonas vaginalis.The isolated heart of this product to the frog, rabbit, rabbit in vitro and be all inhibitory action at body intestinal tube, is expansion to guinea pig in vitro bronchus, and its isolated uterine is played to excitation.
Chinese lobelia: taste is sweet; Property is put down.Thoughts of returning home warp, lung channel, small intestinl channel." Luchuan book on Chinese herbal medicine ": " detoxicating, relieving inflammation, diuresis, hemostasia and promoting granulation.Control ascites, child convulsion, two unilateral tonsillitis, dermatitis rhus, traumatism and bleeding, skin mange, snake honeybee scorpion wound." function is clearing heat and detoxicating, inducing diuresis for removing edema.Cure mainly in venomous snake bite the carbuncle furunculosis that swells, tonsillitis, warm rash, tinea pedis, traumatic injury, jaundice with damp-heat pathogen, appendicitis, enteritis, ephritis, cirrhotic ascites and kinds cancer.
Oldenlandia diffusa: bitter, sweet, cold in nature, enter the heart, liver, spleen, large intestine channel, has clearing heat and detoxicating, the effect of clearing damp and promoting diuresis, for dyspnea and cough due to lung-heat, abscess of throat, acute appendicitis, furuncle sore, venomous snake bite, heat is drenched puckery pain, oedema, dysentery, enteritis, jaundice with damp-heat pathogen, the cards such as cancerous swelling.
Radix cynanchi atrati: " modern Practical Chinese medicinal ": " control the four limbs edema of apoplexy patient, again for the chargeable heat of the scorching hot and weak disease in acute fever latter stage, the osteopyrexia and fever of pulmonary tuberculosis etc., have the effect of refrigerant property nourishing; Also puckery for urine again, the cards such as cough with lung heat." clearing heat and cooling blood, inducing diuresis for treating strangurtia, detoxification sore treatment.For the heating of the evil wound of temperature battalion, fever due to yin deficiency, hectic fever due to yin labor heat, postpartum fever caused by blood deficiency, heat is drenched, blood drenches, swollen ulcer drug.
Herba aristolochiae: hardship, temperature; Enter liver,spleen,kidney warp." Bencao Tujing ": " Xie Fenglao.The Chinese ephedra cold sweating that cures the wound, with rheum officinale with clothes induced abortion gas." " book on Chinese herbal medicine is new again ": " cooling and activating blood, removes wind dampness removing, walks channels and collaterals, the double swollen pain of waist leg of controlling." promoting the circulation of qi dampness elimination, promoting blood circulation and stopping pain.Treat for stomachache, hernia pain, cyesedema, postpartum, vim and vigour were suffered from abdominal pain, rheumatalgia pain.The promoting flow of qi and blood circulation, pain relieving, diuresis.Cyesedema, chest stomachache, colic, rheumatalgia.Herba aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable peaceful, contrary pain vexed work.Control the brachialgia of phlegm note as Young " side of directing at " herba aristolochiae, gas stays colic, and lump in the abdomen is poly-, the globefish stomachache of running quickly, and postpartum, vim and vigour were suffered from abdominal pain, and he is as cyesedema, and face floats shortness of breath, and man's wind labor, coughs and does not heal for a long time, knows with this medicine and controls it, the peace of invariably getting into bed.Therefore Gai Weiqi is good at popular vim and vigour also.See book and discuss and cure mainly, only belong to the diseases such as pregnant edema during pregnancy, stomachache, wind consumptive disease, in his disease not and here.Be its reason of controlling, also only because bitter master is in catharsis, warm in nature being led to lives, thus the passage of invigorating blood circulation, and make water without unfavorable, and wind removes invariably, and blood is lived invariably, therefore pain is all controlled also invariably with swollen.
Rhizoma nardostachyos: taste is pungent, sweet, warm in nature; Return spleen, stomach warp.Compendium of Material Medica: " rhizoma nardostachyos, it is strongly fragrant that fragrance can be opened spleen, adds less in taste medicine the gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, lower gas." to have fragrance row loose for rhizoma nardostachyos, warming spleen and stomach for dispelling cold, regulating qi-flowing for relieving pain, effect of the appetizing of being amusing.Cure mainly coldness and pain in the epigastrium turgor, do not feel like eating, pectoralgia, toothache, falls the pain of injury of falling forward, beriberi edema, choleraic myospasm.Jatamansi volatile oil has faint antibacterial, wind dispelling and spasmolysis, to skin, mucous membrane without local irritation.Jatamansi is to rabbit hemostasis, and rabbit performance is to slow in reacting, sleepy, the anorexia that stimulate.Rhizoma nardostachyos alcohol extract has step-down and antiulcer action.
Santal: pungent, temperature.Return spleen, stomach, the heart, lung channel.Function cures mainly: in promoting the circulation of qi temperature, and appetizing pain relieving.For cold obstruction causing qi stagnation, pectoralgia, stomachache, stomachache food is few; Coronary heart disease, angina pectoris.
Hawthorn: taste acid, sweet, slightly warm in nature, return spleen, stomach, Liver Channel, for food digesting stomach fortifying, the promoting the circulation of qi stasis of blood of faling apart, modern study hawthorn, containing materials such as carbohydrate, protein, fat, vitamin C, carrotene, starch, malic acid, citric acid, calcium and iron, has the effects such as reducing blood lipid, blood pressure, cardiac stimulant and arrhythmia.Flavone compound Vitexin in hawthorn, is the medicine that a kind of antitumaous effect is stronger, and haw thorn extract all has certain inhibitory action to cancer cell tumor growth, propagation and infiltration metastasis.Hawthorn can enter taste and disappear stagnantly, and loose place blood, therefore in harness the river dysentery and puerpera's abdomen piece pain is also.On the whole its being longer than of merit diet, strengthening the spleen and stomach, row knot gas, the hemostasis that disappears, therefore the suitable many foods of children's puerpera.Can prevention and cure of cardiovascular disease, there is hemangiectasis, increase CF, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, softening blood vessel and diuresis and sedation; There is cardiotonic, helpful to senile heart disease; Energy appetite-stimulating indigestion-relieving, offsets carnivorous stagnant effect better; There is the effect activating blood circulation and dispersing blood clots, contribute to remove local extravasated blood state, traumatic injury is had to auxiliary curative effect; There is to contraction in uterus, has the effect expediting the emergence of pregnant woman just before giving birth time, and can promote uterine involution in postpartum; The substance blocking-up such as contained flavonoids and vitamin C, carrotene, reduce the generation of free radical, strengthen the immunity of body, have anti-aging, anticancer effect; In hawthorn, having relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
Fevervine: property is flat, sweet, the micro-hardship of taste." the sward property of medicine is standby to be wanted ": " its head is controlled new internal injury, and pot is carnivorous, and qi-restoratives kidney-nourishing, except fire is enriched blood; Wash sore pain relieving, the loose poison of the heat that disappears.Its leaf is beaten rice with confectionery, only dysentery." " Illustrated Book on Plants ": " be wash, removing toxic substances, removes wind, and heat-clearing is loose cold.Apply nameless sores or boils, and mend muscles and bones." expelling wind and activating blood flow, analgesic antidotal, promoting digestion, dehumidifying detumescence.Treatment of rheumatalgia pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy food is few, hepatosplenomegaly, scrofula, acute appendicitis, nameless sores or boils, traumatic injury.Fevervine TA lumbar injection can suppress mouse spontaneous activity, extends yellow Jackets lengths of one's sleep, has certain sedation.Fevervine TA can suppress myenteron and shrink, and can antagonism myenteron contracture due to acetylcholine.Fevervine decoction has inhibitory action to external staphylococcus aureus and Fu Shigella flexneri, and medicinal extract also has bacteriostasis to staphylococcus aureus and streptococcus pneumonia.
Mao Ligen: hardship; Cold in nature.Function cures mainly: clearing heat and detoxicating; Help digestion.Main pneumonia; Pulmonary tuberculosis; Indigestion.
Cover common bluebeard: sweet, temperature.Function cures mainly: help digestion and regulate the flow of vital energy, wines used as antirheumatic, promoting blood circulation and stopping pain.Cure mainly indigestion, abdominal distension; External application treating rheumatic arthritis.
Duckweed: pungent, cold; Enter lung, small intestinl channel.Tang Materia Medica: " duckweed person, has three kinds: large person's name apple; In water, there is again Jiang's dish, also similar and leaf circle; The main fiery sore of little duckweed waterborne." " Mingyi Bielu ": " the main person of quenching one's thirst, goes with damp and hot heresy, and body fluid is spontaneous, and thirsty from stopping also.It says lower gas, with the person that not bathes piliation, also can heat extraction to tremble with fear, and the testing also of cool blood." sweating, dispel the wind, row water, heat-clearing, removing toxic substances.The hot carbuncle of row while controlling, macula is not saturating, wind-heat pain rash, pruitus, oedema, through closing, sore tinea, erysipelas, scalds.Duckweed has diuresis, and its active ingredient is mainly potassium acetate and potassium chloride.Thoroughly send out and freely do not wait disease for affection of exogenous wind-heat and measles, the compatibilities such as clinical normal and Chinese tamarisk tops, great burdock achene, peppermint are applied.To also oral administration, the external application of wind-heat urticaria.The duckweed Li Shui that can expel the heat-evil, therefore have exterior heat person to use it for oedema.Duckweed aqueous extract causes that to quinine the frog heart of exhaustion has cardiotonic, and calcium can strengthen it, and heavy dose makes heart stop at diastole; And can make increased blood pressure by vasoconstriction.
Scouring rush: taste is sweet, bitter, property is flat; Return lung, Liver Channel.Compendium of Material Medica: " scouring rush, with the Chinese ephedra similar shape same sex, thus also can sweating expelling pathogenic factors from muscles and skin, rise loose fiery strongly fragrant rheumatism, control all blood diseases of eyes also." " book on Chinese herbal medicine justice ": " sweating, expelling pathogenic factors from muscles and skin.Cold, malaria cures the wound.Curing rheumatism, loose fire-evil." scouring rush's alcohol extract 10-15g/kg lumbar injection or 20g/kg duodenal administration, anesthetized cat is had to lasting hypotensive effect.Step-down intensity has certain correlation with holding time with dosage.And can be to the effect of antihistamine vasoconstriction, still have hypotensive effect to the cat of cutting off spinal cord, therefore think the periphery at its step-down position.Rabbit myocardium vessel is had to obvious dilating effect.When scouring rush's alcohol extract low concentration, rabbit intestinal and GPI are had to excitation, can make myenteron contraction frequency and flesh tension force increase, contractive amplitude strengthens, and is inhibitory action when high concentration.Rabbit is breathed scouring rush's parenteral solution and heart in place has no significant effect; The convergent force of rabbit isolated heart is had to certain inhibitory action.
Chinese violet: bitter, pungent, cold in nature, enter the heart, Liver Channel, there is the effect of clearing heat and detoxicating, cool blood detumescence, main influenza; The infection of the upper respiratory tract; Tonsillitis; Catarrhal jaundice; Enteritis; Dysentery; Ephritis; Mumps; Conjunctivitis; Acute appendicitis; Furunculosis carbuncle is swollen; Scrofula.Clearing heat and detoxicating.Control furunculosis carbuncle swollen, heat in jaundice, children's's nosebleed, appendicitis, venomous snake bite.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": broken blood, separate ulcer scabies leprosy, nine kinds of hemorrhoid, all sore diseases.2. " detailed outline ": cure mainly all ulcer carbuncle on the back, the malignant boil scrofula that swells, nameless sores or boils, dislikes sore.3. " it is former that book on Chinese herbal medicine is asked ": cool blood, detumescence poison.Control blood-head muscle impotence, deposited sore is wonderful.4. " south of the Five Ridges gather medicinal herbs record ": make cathartic and tell medicine.5. " Chinese herbal medicine is commonly used in Shanghai ": clearing heat and detoxicating, externally applied toxicity removing detumescence.Control red eye, swell pain, sty, treats pyogenic infections from tumour or sore, acute mastitis, enteritis, diarrhea, venomous snake bite.6. the doctor of Soviet Union " Chinese herbal medicine handbook ": control all pyogenic infections, venomous snake bite, scrofula, jaundice, ephritis, cystitis, painful swelling of joints, has blood in stool, nosebleed, eye conjunctivitis, prostatitis.Chinese violet has inhibitory action in various degree to yellow gold-coloured staphylococci, pneumobacillus, Escherichia coli, alpha streptococcus, beta streptococcus, Bacillus influenzae, corynebacterium diphtheriae, Pseudomonas aeruginosa, white grapes sugar coccus, Candida albicans.
Cordate houttuynia: cold nature, bitter.Return lung channel, bladder, large intestine channel.Have clearing heat and detoxicating; Removing pus and relieving carbuncle; The function of inducing diuresis for treating strangurtia.Cure mainly heat and drench main lung carbuncle pyemesis; Phlegm heat panting is coughed; Larynx; Hot dysentery; Carbuncle sore tumefacting virus; Heat is drenched.Effect: clearing heat and detoxicating, inducing diuresis to reduce edema.Control pneumonia, lung abscess, hot dysentery, malaria, oedema, gonorrhoea, leukorrhea, carbuncle is swollen, hemorrhoid, prolapse of the anus, eczema, the favus of the scalp, mange.The modern multiplex lung abscess of controlling, pneumonia, acute and chronic tracheitis, urinary tract infections etc.Modern pharmacology experiment shows, that these product have is antibacterial, antiviral, improve the effects such as immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, the infection of the upper respiratory tract, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, lung cancer, cervical erosion, pyogenic arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitis, nephrotic syndrome, herpes simplex keratitis, rhinitis, otitis media suppurative, mumps, papule shape nettle rash, chronic pharyngitis, anus enteropathy, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.
Cymose buckwheat rhizome: cool in nature, taste is pungent, bitter.Can be clearing heat and detoxicating, the carbuncle that disappears of invigorating blood circulation, the sore of dispelling rheumatism, snake bite and insect sting.Main lung carbuncle, lung heat is coughed and is breathed heavily, abscess of throat, dysentery, rheumatism bi Zheng, traumatic injury, carbuncle cancer.Though experiment in vitro is without obvious antibacterial action, coagulase, hemolysin and Pseudomonas aeruginosa endogenous toxic material to staphylococcus aureus have antagonism.
Chinese yam: sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.Few for insufficiency of the spleen food, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) tonifying spleen stomach invigorating.Few for insufficiency of the spleen food, the loose stool of having loose bowels, leukorrhea.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive powder
The embodiment of the present invention provides a kind of pharmaceutical composition that is used for the treatment of tortoise enteritis disease, its formulation is powder, wherein the parts by weight of each raw medicinal material are: the wind-weed 12 weight portions, the coptis 14 weight portions, the bark of ash 12 weight portions, the root bark of shaggy-fruited dittany 11 weight portions, manyleaf meadowure rhizome and root 8 weight portions, Herba Andrographitis 18 weight portions, dayflower 15 weight portions, sargentodoxa cuneata 12 weight portions, field pennycress 12 weight portions, tomb is 14 weight portions later, wintercherry fruit or calyx 15 weight portions, Oroxylum indicum 14 weight portions, the Chinese bulbul 15 weight portions, purslane 12 weight portions, potentilla chinensis 12 weight portions, Chinese lobelia 16 weight portions, oldenlandia diffusa 7 weight portions, radix cynanchi atrati 12 weight portions, herba aristolochiae 14 weight portions, rhizoma nardostachyos 13 weight portions, santal 8 weight portions, hawthorn 4 weight portions, fevervine 18 weight portions, Mao Li root 12 weight portions, cover common bluebeard's 18 weight portions, duckweed 13 weight portions, scouring rush's 12 weight portions, Chinese violet 13 weight portions, cordate houttuynia 12 weight portions, cymose buckwheat rhizome 9 weight portions and Chinese yam 21 weight portions.
Its preparation method comprises the following steps:
The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 90%, adds hot reflux 2 hours, extracts, and filters and obtains the first extract; The ethanol that it is 90% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1.5 times of described dregs of a decoction quality again, adds hot reflux 2 hours, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 1 hour, pulverizes, and sieves, and obtains 300 object micropowders;
The 3rd step adds the starch with respect to 3 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
Embodiment 2 feeds
The embodiment of the present invention provides a kind of functional feed that is used for the treatment of tortoise enteritis disease, has the raw material of following parts by weight to make: dried silkworm chrysalis meal 15 weight portions, millet 19 weight portions, fish meal 21 weight portions, shrimp med 14 weight portions, carrot meal 7 weight portions, lotus root starch 10 weight portions, egg shell 5 weight portions, egg yolk 7 weight portions that boil, Chinese cabbage powder 9 weight portions and Chinese medicine additive 0.5 weight portion.
Wherein, Chinese medicine additive has the raw medicinal material of following parts by weight to make: the wind-weed 15 weight portions, the coptis 18 weight portions, the bark of ash 10 weight portions, the root bark of shaggy-fruited dittany 8 weight portions, manyleaf meadowure rhizome and root 7 weight portions, Herba Andrographitis 21 weight portions, dayflower 11 weight portions, sargentodoxa cuneata 10 weight portions, field pennycress 10 weight portions, tomb is 10 weight portions later, wintercherry fruit or calyx 12 weight portions, Oroxylum indicum 18 weight portions, the Chinese bulbul 18 weight portions, purslane 15 weight portions, potentilla chinensis 15 weight portions, Chinese lobelia 12 weight portions, oldenlandia diffusa 5 weight portions, radix cynanchi atrati 10 weight portions, herba aristolochiae 10 weight portions, rhizoma nardostachyos 10 weight portions, santal 7 weight portions, hawthorn 3 weight portions, fevervine 15 weight portions, Mao Li root 15 weight portions, cover common bluebeard's 26 weight portions, duckweed 10 weight portions, scouring rush's 10 weight portions, Chinese violet 10 weight portions, cordate houttuynia 14 weight portions, cymose buckwheat rhizome 7 weight portions and Chinese yam 25 weight portions,
The preparation method of Chinese medicine additive comprises the following steps:
The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 90%, adds hot reflux 2 hours, extracts, and filters and obtains the first extract; The ethanol that it is 90% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1.5 times of described dregs of a decoction quality again, adds hot reflux 2 hours, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 1.5 hours, pulverizes, and sieves, and obtains 350 object micropowders;
The 3rd step adds the starch with respect to 3 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
Feed link is crossed following preparation method and is made:
The first step, takes all raw materials by weight, drops into pulverizer and pulverizes, and grinding particle size is 60-150 order, drops into mixer, mixes the uniformity≤5% of mixing;
Second step, pours into after mixing to be placed in granulating disc and carries out granulation, and the granulation disc angle of inclination of granulating disc is 50 °, and the rotating speed of granulating disc is 45 revs/min, and preparation time is 20 minutes, is prepared into diameter and is the spherical particle feed of 2 millimeters;
The 3rd step, the spherical particle feed that second step is obtained, spreads in having on the mesh-belt drier of the portable stainless steel guipure of multilayer, heat drying 12 minutes, the import air temperature of heating is 130 DEG C, outlet air temperature is 60 DEG C, obtains dry feed granules.
Toxicity test
Acute toxicity test: 60 of application NIH mouse, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mouse is divided into two groups at random, and 20 every group, i.e. control group and administration group, fasting 12 hours before experiment; Powder prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mouse toxic reaction and death toll.Experimental result shows: with control group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, and mouse overall health of patients, diet, drinking-water, body weight gain are all normal.Therefore tablet acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the powder of the embodiment of the present invention 1 to mouse by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mouse, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mouse long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Contrast test
Shandong tortoise cultivation factory, mainly cultivates grass tortoise, and in February, 2012, lassitude appearred in tortoise in enormous quantities, poor appetite, the symptoms such as ight soil is shapeless, there is enophthalmos in ill serious tortoise, dry skin is lax, nonelastic, tarnish, finally dead, find stomach inflammation, hyperemia through cuing open inspection, be because feed is rotten through inquiry reason, cause grass tortoise to suffer from enteritis disease.At random ill tortoise is quarantined, wherein, ill grass tortoise has 267, selects 120 of the obvious ill grass tortoises of illness, is divided at random 3 groups, 40 every group, is respectively embodiment group 1, embodiment group 2 and control group.
Methods for the treatment of:
Embodiment group 1: use the powder of the embodiment of the present invention 1, powder is sneaked in feed according to 0.3:100 ratio of weight and number, feed according to normal feeding time, treatment 4-8 days;
Embodiment group 2: use the feed of the embodiment of the present invention 2, feed according to normal feeding time, treatment 4-8 days;
Control group: use Chinese traditional herbs to treat, prescription is: coptis 5g, sealwort 5g, Asiatic plantain 5g, purslane 6g, dandelion 3g, said herbal medicine dry product is put into the marmite appropriate slow fire boiling 2h that adds water, getting liquid removes slag, after cooling, add feed, allow liquid suck in feed, feed, feed treatment 4-8 days according to normal feeding time.
The standard of curative effect evaluation: recovery from illness: all transference cures, it is normal that appetite is recovered; Effective: symptom disappears substantially, it is normal that appetite is recovered substantially; Invalid: symptom is even dead without any changing.
Treatment results:
Referring to table 1 and table 2, as can be seen from Table 1, adopt medicine composite for curing tortoise enteritis disease of the present invention, in result for the treatment of, there is significant improvement with respect to traditional Chinese medicine; As can be seen from Table 2, adopt medicine composite for curing tortoise enteritis disease of the present invention, with respect to traditional Chinese medicine, treating significantly shortening on the course for the treatment of.
Each group of table 1 is relatively only treated respectively after 8 days curative effect
Each group of table 2 is treated respectively after 8 days, fully recover number of elements and relatively only (%) of time
Known according to the clinical statistics in above table, pharmaceutical composition provided by the invention has rapid-action, efficient height, determined curative effect, safe, the advantage that has no side effect, especially use the ill tortoise of the feed treatment of embodiment 2, fully recover fastest, quick-recovery is normal soon to observe tortoise feed intake, the state of mind etc. of visible embodiment group 2; And treatment finishes the rear grass tortoise of picking out respectively each group of recovery from illness and continues grouping and raise, later annual by the end of February and by the end of November the grass tortoise of embodiment group 1-2 is respectively according to the above-mentioned methods for the treatment of 3-5 days that feeds, and forms into find no enteritis disease before tortoise and occur.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. the functional feed that is used for the treatment of tortoise enteritis disease, is characterized in that, described feed comprises following raw material: dried silkworm chrysalis meal, millet, fish meal, shrimp med, carrot meal, lotus root starch, egg shell, the egg yolk boiling, Chinese cabbage powder and Chinese medicine additive.
2. the functional feed that is used for the treatment of tortoise enteritis disease according to claim 1, it is characterized in that, in described feed, the parts by weight of each raw material are: dried silkworm chrysalis meal 10-20 weight portion, millet 15-28 weight portion, fish meal 15-25 weight portion, shrimp med 10-18 weight portion, carrot meal 5-10 weight portion, lotus root starch 5-14 weight portion, egg shell 3-8 weight portion, the egg yolk 5-8 weight portion boiling, Chinese cabbage powder 5-15 weight portion and Chinese medicine additive 0.1-3 weight portion.
3. the functional feed that is used for the treatment of tortoise enteritis disease according to claim 1 and 2, it is characterized in that, in described feed, the parts by weight of each raw material are: dried silkworm chrysalis meal 15 weight portions, millet 19 weight portions, fish meal 21 weight portions, shrimp med 14 weight portions, carrot meal 7 weight portions, lotus root starch 10 weight portions, egg shell 5 weight portions, egg yolk 7 weight portions that boil, Chinese cabbage powder 9 weight portions and Chinese medicine additive 0.5 weight portion.
4. according to the feed that is used for the treatment of tortoise enteritis disease described in claim 1-3 any one, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: the wind-weed, the coptis, the bark of ash, the root bark of shaggy-fruited dittany, manyleaf meadowure rhizome and root, Herba Andrographitis, dayflower, sargentodoxa cuneata, field pennycress, tomb later, wintercherry fruit or calyx, Oroxylum indicum, the Chinese bulbul, purslane, potentilla chinensis, Chinese lobelia, oldenlandia diffusa, radix cynanchi atrati, herba aristolochiae, rhizoma nardostachyos, santal, hawthorn, fevervine, Mao Ligen, illiteracy common bluebeard, duckweed, scouring rush, Chinese violet, cordate houttuynia, cymose buckwheat rhizome and Chinese yam.
5. according to the functional feed that is used for the treatment of tortoise enteritis disease described in claim 1-4 any one, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: wind-weed 11-15 weight portion, coptis 11-18 weight portion, bark of ash 10-15 weight portion, root bark of shaggy-fruited dittany 8-14 weight portion, manyleaf meadowure rhizome and root 7-12 weight portion, Herba Andrographitis 15-21 weight portion, dayflower 11-18 weight portion, sargentodoxa cuneata 10-15 weight portion, field pennycress 10-15 weight portion, tomb is turned one's head 10-15 weight portion, wintercherry fruit or calyx 12-18 weight portion, Oroxylum indicum 10-18 weight portion, Chinese bulbul 11-18 weight portion, purslane 10-15 weight portion, potentilla chinensis 10-15 weight portion, Chinese lobelia 12-18 weight portion, oldenlandia diffusa 5-11 weight portion, radix cynanchi atrati 10-14 weight portion, herba aristolochiae 10-16 weight portion, rhizoma nardostachyos 10-16 weight portion, santal 7-12 weight portion, hawthorn 3-10 weight portion, fevervine 15-23 weight portion, Mao Li root 11-15 weight portion, cover common bluebeard 15-26 weight portion, duckweed 10-17 weight portion, scouring rush 10-14 weight portion, Chinese violet 10-16 weight portion, cordate houttuynia 10-14 weight portion, cymose buckwheat rhizome 7-12 weight portion and Chinese yam 15-25 weight portion.
6. according to the functional feed that is used for the treatment of tortoise enteritis disease described in claim 1-5 any one, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: the wind-weed 12 weight portions, the coptis 14 weight portions, the bark of ash 12 weight portions, the root bark of shaggy-fruited dittany 11 weight portions, manyleaf meadowure rhizome and root 8 weight portions, Herba Andrographitis 18 weight portions, dayflower 15 weight portions, sargentodoxa cuneata 12 weight portions, field pennycress 12 weight portions, tomb is 14 weight portions later, wintercherry fruit or calyx 15 weight portions, Oroxylum indicum 14 weight portions, the Chinese bulbul 15 weight portions, purslane 12 weight portions, potentilla chinensis 12 weight portions, Chinese lobelia 16 weight portions, oldenlandia diffusa 7 weight portions, radix cynanchi atrati 12 weight portions, herba aristolochiae 14 weight portions, rhizoma nardostachyos 13 weight portions, santal 8 weight portions, hawthorn 4 weight portions, fevervine 18 weight portions, Mao Li root 12 weight portions, cover common bluebeard's 18 weight portions, duckweed 13 weight portions, scouring rush's 12 weight portions, Chinese violet 13 weight portions, cordate houttuynia 12 weight portions, cymose buckwheat rhizome 9 weight portions and Chinese yam 21 weight portions.
7. according to the functional feed that is used for the treatment of tortoise enteritis disease described in claim 1-6 any one, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, adds hot reflux 1～3 hour, extracts, and filters and obtains the first extract; The ethanol that it is 85～95% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1～2 times of described dregs of a decoction quality again, adds hot reflux 1～3 hour, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step adds the starch with respect to 2～4 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
8. according to the preparation method of the functional feed that is used for the treatment of tortoise enteritis disease described in claim 1-7 any one, it is characterized in that, described preparation method comprises the following steps:
The first step, takes all raw materials by weight, drops into pulverizer and pulverizes, and grinding particle size is 60-150 order, drops into mixer, mixes the uniformity≤5% of mixing;
Second step, after mixing, pour into be placed in granulating disc and carry out granulation, the granulation disc angle of inclination of granulating disc is 40-60 °, and the rotating speed of granulating disc is 45 revs/min, preparation time is 20 minutes, is prepared into diameter and is the spherical particle feed of 2 millimeters;
The 3rd step, the spherical particle feed that second step is obtained, spreads in having on the mesh-belt drier of the portable stainless steel guipure of multilayer, heat drying 12 minutes, the import air temperature of heating is 130 DEG C, outlet air temperature is 60 DEG C, obtains dry feed granules.
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| CN105832831A (en) * | 2016-05-23 | 2016-08-10 | 安徽省旌德县国友龟鳖良种繁育场 | Traditional Chinese medicine composition for treating enteritis of turtles and preparation method of traditional Chinese medicine composition |
| CN105994944A (en) * | 2016-06-01 | 2016-10-12 | 蚌埠市宝煦家庭农场 | Feed capable of preventing and curing enteritis of megalobrama amblycephala |
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| CN109170160A (en) * | 2018-08-28 | 2019-01-11 | 安徽蓝田特种龟鳖有限公司 | A kind of mixed feed improving soft-shelled turtle quality |
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