CN104138342A - Skin-care product for preventing external stimulation by using radix pseudostellariae as main component and preparation method of skin-care product - Google Patents
Skin-care product for preventing external stimulation by using radix pseudostellariae as main component and preparation method of skin-care product Download PDFInfo
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Abstract
The invention discloses a skin-care product for preventing external stimulation by using radix pseudostellariae as a main component and a preparation method of the skin-care product. The skin-care product includes sun-screen, sunscreen day cream, moisturizing facial cleansing milk, whitening facial cleansing soap and perfume. The invention further provides a formula and preparation method of the skin-care product. Tests by the inventor discover and prove that the radix pseudostellariae extract has functions of moistening skin, protecting DNA and/or resisting inflammation, does not have cytotoxicity and is safe to use. Therefore, the radix pseudostellariae extract can be used for preparing skin-care products for preventing external stimulation by serving as the main component. The skin-care product for preventing external stimulation has an effect of improving the skin quality, and is capable of keeping skin moistened, improving skin elasticity, maintaining skin normal functions and preventing external stimulation.
Description
Technical field
The present invention relates to cosmetic field, relate to particularly a kind of prevention environmental stimuli skin care item skin care item that Radix Pseudostellariae is main component of take.
Background technology
Radix Pseudostellariae is the dried root of pinkwort Radix Ginseng Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm.Excavate when stem and leaf is most of withered summer, cleans, and removes fibrous root, and put after slightly scalding in boiling water and dry or directly dry, be the Chinese crude drug that possesses good value.Its chemical composition includes trace element, aminoacid, saccharide, glycoside, phospholipid, cyclic peptide, fatty acid, oils, volatile oil, sterols etc.< < Chinese Pharmacopoeia > > records its function for 2010 and has cured mainly replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung under version Radix Pseudostellariae item.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Summary of the invention
The object of the present invention is to provide Radix Pseudostellariae is the prevention environmental stimuli skin care item of main component.
Prevention environmental stimuli skin care item skin care item of the present invention comprise sun screen, intensified day moisture, moisturizing cleansing milk, the clean facial soap of whitening, perfume.
The inventor finds and has verified that Radix Pseudostellariae extract has the function of skin moisture-keeping, DNA protection and/or antiinflammatory through test, and the Radix Pseudostellariae extract no cytotoxicity obtaining, and uses safety.The wettability power of Radix Pseudostellariae crude polysaccharides body is all slightly excellent than hyaluronic acid under 65% and 85% ambient humidity.Radix Pseudostellariae 95% ethanolic extract has the ability of DNA protection, and is just to show protection effect at 50 μ g/mL.Separately also there is antiinflammatory action.Therefore,, using it as main component, making Radix Pseudostellariae is the prevention environmental stimuli skin care item of main component.These prevention environmental stimuli skin care item have the effect that improves skin skin quality, make skin keep moisture, increase elasticity, maintain the normal function of skin, and prevent environmental stimuli.
Accompanying drawing explanation
Fig. 1 is Radix Pseudostellariae crude polysaccharides body in normal skin skin moisture loss rate assessment under 27 ℃, 50-55%RH;
Fig. 2 is Radix Pseudostellariae water extract DNA protection assessment result;
Fig. 3 is Radix Pseudostellariae 95% ethanolic extract DNA protection assessment result.
The specific embodiment
The preparation of embodiment 1 Radix Pseudostellariae concentrated solution
Radix Pseudostellariae extract extraction process: get by the ratio of Radix Pseudostellariae comminuted powder: water=1:3-5 centrifugalize ginseng body and water body after adding extraction heat.
Radix Pseudostellariae extract centrifugal separation process: (rotating speed of centrifuge is 4000～10000r/min to filtrate by Radix Pseudostellariae extract in high speed centrifugation mode, get upper strata liquid), Radix Pseudostellariae extract is through concentrating under reduced pressure water body, make it to be configured to containing Radix Pseudostellariae nonvolatile component between 10%～30% aqueous solution (percentage by weight), this is Radix Pseudostellariae extract.
The characterization processes of the contained nonvolatile component ratio of Radix Pseudostellariae extract: get 10.0g Radix Pseudostellariae concentrated solution after the concentrated water body of decompression rotation (three repeat), lyophilization is 8 hours at-30 ℃, the content of the non-volatile solid content of weighing.The cubage of the non-volatile solid content of Radix Pseudostellariae is that the non-volatile solid species of Radix Pseudostellariae that weighing goes out weigh X100% divided by 10.0g Radix Pseudostellariae concentrated solution.
The ratio of the contained nonvolatile component of Radix Pseudostellariae extract: the content of the bright fixed non-volatile solid content of the present invention need be between 10-30% (percentage by weight) in Radix Pseudostellariae extract percentage ratio.
The adjustment of the contained nonvolatile component of Radix Pseudostellariae extract: if the content of the non-volatile solid content of Radix Pseudostellariae is lower than 10%, Radix Pseudostellariae extract is detached to part water body in concentrating under reduced pressure mode, till extremely the content of non-volatile solid content reaches 10-30%; If the content of non-volatile solid content need be between 30% (percentage by weight) higher than Radix Pseudostellariae extract percentage ratio, according to certain proportion, add pure water and (can calculate and obtain the water yield of need adding) in Radix Pseudostellariae clear liquor, make the non-volatile solid content of Radix Pseudostellariae concentrated solution can be between 10-30%.
Radix Pseudostellariae supercritical extract: preparation method is that Radix Pseudostellariae dry product is first done broken pre-treatment, be Powdered, be placed in supercritical extraction head tank, with pure CO2 extraction, extraction tank pressure 300-400bar, 30-70 ℃ of extraction tank Warm degree, gas flow rate 2-4ml/L, nozzle temperature: 40-60 ℃, continuous extraction 30-60 minute.
Radix Pseudostellariae 95% ethanolic extract: preparation method is: after Radix Pseudostellariae dry product is pulverized, with weight ratio 1, than the Radix Pseudostellariae of 5-8, mix immersion with 95% amount of alcohol, soak two days, all take ultrasonic disruption machine vibration 20-40 minute (power is 300W) every day, after filtration, residue adds recovery 95% soak with ethanol three days again, soak and mix with 95% amount of alcohol than the Radix Pseudostellariae residue of 5-8 for weight ratio 1, all take ultrasonic disruption machine vibration 20-40 minute (power is 200-600W) every day, twice filtrate before and after merging after filtering, after concentrated and lyophilization, the dry thing of filtrate is described Radix Pseudostellariae 95% ethanolic extract.
Embodiment 2
Radix Pseudostellariae be take water by embodiment 1 water extract that solvent is obtained, and adds after 95% ethanol (3-5 times of water extract volume) precipitation, and the precipitate obtaining is Radix Pseudostellariae crude polysaccharides body, and it has the effect of moisturizing.With the moisture-retaining capacity of three kinds of different experiments assessment Radix Pseudostellariae crude polysaccharides bodies, be respectively that the assessment of hydroscopicity, the assessment of moisturizing rate and transepidermal water loss rate (Trasepidermal Water Loss, TEWL) are measured.
Different wetting agents are different to the active force of hydrone, absorb moisture and keep the ability of moisture also different, and large strong to water molecules power of active force, absorbs and keep the amount of moisture also larger.Therefore,, according to the difference of wetting agent moisture absorption, performance of keeping humidity, under the prerequisite of Control experiment condition, can evaluate by the method for weighing the moisture-keeping efficacy of wetting agent.
The moisturizing usefulness of mensurationization wetting agent need to be selected under the environment of constant temperature and humidity and carry out, and generally adopts airtight small container, places the saturated aqueous solution of a certain chemical reagent, makes it the relative humidity that keeps certain at the temperature of regulation.
(1) assessment of hydroscopicity
The mensuration of hydroscopicity will be dried to the samples weighing of constant weight, and respectively under identical room temperature, humidity is in 80%, 65%, 44% constant exsiccator, places and claims its quality after 4,8,24,48 hours.Measure under the same conditions three times, average.
Computing formula is as follows: hydroscopicity %=(M0-M)/M0x100%
(M0: sample quality before placing; M: sample quality after placing)
(2) assessment of moisturizing rate
Take the sample of a certain amount of moisture content, be placed in exsiccator and be dried, after 2,4,8,24,48,72 hours, weigh the minimizing of sample quality, calculate the moisturizing rate of sample, through relative analysis, compare the size of different sample moisture retentions.
Computing formula is as follows: moisturizing rate %=Mt/M0x100%
(M0: sample quality before placing; Mt: place sample quality after t hour)
(3) transepidermal water loss rate (Trasepidermal Water Loss, TEWL) is measured
Many research institutions pass through to measure transepidermal water loss rate (Trasepidermal Water Loss in the world at present, TEWL) carry out evaluating skin barrier function, so the skin care product research method of this plan will adopt transepidermal water loss rate (TEWL) to measure.
TEWL reacts horny layer for the barrier function of water, is the important factor of evaluating horny layer state.TEWL by evaluate stratum corneum barrier function reach prediction skin care item by moisture-keeping function to the maintenance of epidermal barrier function, reparation and booster action; Also can be applied to the evaluation to skin barrier function under different skin morbid state.
Summary experiment flow:
(a) hand, first to use soap clean, is evenly applied in polysaccharide series product the anteflexion side epidermis of left hand arm after natural drying;
(b) in cold air room, control under approximately 25 ℃ of temperature, humidity approximately 60 ﹪ and measure, remember the temperature and humidity arround Recording at that time simultaneously;
(c) percutaneous moisture loss can relevantly react cuticular water flow speed, with percutaneous moisture content scatter and disappear analyzer (
tM300) probe measurement is recognized and is got 4 points, according to the time point of difference, detects six times;
(d) six detecting time points be respectively (1) smear before, (2) smear latter 10 minutes, (3) and smear latter 30 minutes, (4) and smear latter 60 minutes, (5) and smear latter 90 minutes, (6) and smear latter 120 minutes; (detect three and repeat, average)
(e) record arm skin capacitance value, deducts the blank numerical value of each test point by each test point mean values of per period,
Be the measured value (g/m2h) of this this test point of period, also can calculate the ratio of the blank numerical value of each test point mean values of per period and each test point;
(f) measured value and ratio are lower, represent that moisturizer is better to the influence of skin skin barrier function by its moisture-keeping functions.
The hydroscopicity assessment of table 2, Radix Pseudostellariae crude polysaccharides body
Experimental result by upper table 2 is presented at ambient humidity 44%, 65%, 85% time, pure water is evaporation drying gradually all, and Radix Pseudostellariae crude polysaccharides body and hyaluronic acid show along with the time increases the also increase gradually of its ability that absorbs moisture, and reduce its wettability power along with the reduction of relative humidity in environment.But applicant finds that the wettability power of Radix Pseudostellariae crude polysaccharides body is except slightly poor than hyaluronic acid under low-humidity environment (44%), all slightly excellent than hyaluronic acid under 65% and 85% ambient humidity, shows that Radix Pseudostellariae crude polysaccharides body possesses moisture absorption usefulness.
The moisturizing rate assessment of table 3, Radix Pseudostellariae crude polysaccharides body
The moisture-retaining capacity of being learnt Radix Pseudostellariae crude polysaccharides body by the result of upper table 3 is close with standard substance hyaluronic acid.
Table 4, Radix Pseudostellariae crude polysaccharides body are in normal skin skin moisture loss rate assessment under 27 ℃, 50-55%RH
Unit: g/hm
2
Comparison sheet 4 is known with Fig. 1,5% and 10% Radix Pseudostellariae crude polysaccharides body aqueous solution all can make the lost ability of skin table water decline, show and have the evapotranspiration that prevents severe edema due to hypofunction of the spleen table water, 10% the thick polysaccharide aqueous solution of Radix Pseudostellariae manifests the lost effect of lower skin table water after smearing 90 minutes.
Comprehensive above-mentioned three moisturizings experiment all confirms that Radix Pseudostellariae crude polysaccharides body possesses moisture-retaining capacity.
Embodiment 3 Radix Pseudostellariaes be take ethanol and are found to have the effect of DNA protection as extract that solvent was obtained
With DNA protection test, verify
PUC119DNA plastid is former is a supercoiled structure (S-form); after UV or oxidative damage; the superhelix stroke (L-form) that can be opened, therefore take ethanol, water by this test assessment Radix Pseudostellariae and whether has the ability of protecting plasmid DNA as the extract that solvent was obtained.Utilize Fenton's reaction to produce free radical and attack DNA, if Radix Pseudostellariae has protection DNA with ethanol, water extract, can not rupture, through electrophoretic analysis, can verify its protection effect.
Test method is as follows:
(1) quantitative pUC119DNA is got to 2 μ l in 1.5ml centrifuge tube, secondly every pipe adds the 1X PBS of 3 μ l and the testing sample that has been mixed with variable concentrations, finally respectively adds respectively the 0.3%H2O2 of 5 μ l to be measured.
(2) from each centrifuge tube, the sample concentration preparing is taken out respectively and is placed in quartzy slide.
(3) quartzy slide is placed on ultraviolet case, irradiates UV30mJ/cm2.
(4) irradiated, respectively added respectively the 6X sample-loading buffer of 3 μ l, mix homogeneously, then take out the electrophoresis film having made, respectively different sample concentrations are injected into electrophoresis film to carry out electrophoresis.
(5) after electrophoresis is run through, the taking-up film dislocation that puts on one's gloves has added in the de-ionized water tank of appropriate ethidium bromide, and about 30min dyes.
(6) wait to have dyeed, the taking-up film that puts on one's gloves, with the deposit of taking pictures of electrophoresis film image capture analytical system.
According to the result of Fig. 2 and Fig. 3, can judge that Radix Pseudostellariae 95% ethanolic extract has the ability of DNA protection, and be just to show protection effect at 50 μ g/mL.
Embodiment 4 Radix Pseudostellariaes be take ethanol, water and are found to have the effect of anti-inflammatory as the extract that solvent was obtained
The specific embodiment is verified anti-inflammatory effect to suppress LOX-1 and nitric oxide production generation
(1) assessment of lipoxygenase inhibitor (LOX-1)
LOX-1 is a ferment important in inflammatory response, therefore by this, test to assess the inflammation ability that suppresses, extract is got the LOX-1 (135 unit) that 1 μ L adds 2 μ L, then using the linoleic acid (linoleic acid) of 1.5 μ L10mM as the substrate inducing reaction, and add the Tris-HCl buffer (pH9.0) of 95.5 μ L.Control group take that to wait the DMSO of dose be benchmark, after completely evenly mixing, measures its light absorption value under 234nm.
The assessment of table 5, lipoxygenase inhibitor (LOX-1)
Except Radix Pseudostellariae supercritical extract does not suppress the ability of LOX-1, Radix Pseudostellariae water extract and 95% ethanolic extract all have the usefulness of good inhibition LOX-1.
(1) remove the assessment of content of nitric oxide
Nitric oxide in human body very easily metabolism form the stable metabolite of nitrite/nitrate, therefore with the concentration of cell culture fluid nitrite/nitrate, assess the burst size of NO and the activity of NOS.The Griess reagent of this experiment use can react with nitrite and produce color reaction, first utilizing sodium nitroprusside (SNP) itself is a kind of nitric oxide donors, under normal physiological conditions, can produce NO, this experimental evaluation utilizes Griess reaction Come to inquire into nitric oxide and removes ability.
Getting 98 μ L sodium nitroprussides (5mM) adds 2 μ L samples to cultivate for 150 minutes at 25 ℃, add 100 μ L Griess reagent (0.1%naphthylenediamine dihydrochloride, 5% phosphoric acid and 1%sulfanilamine), under 560nm, survey light absorption value.
Table 6, the assessment of removing content of nitric oxide
Three kinds of Radix Pseudostellariae extracts all demonstrate the ability of removing content of nitric oxide, especially the most excellent with the effect of Radix Pseudostellariae water extract.
Embodiment 5 sun screens
Sun screen of the present invention, except protecting skin, quality is relaxed and comfortable, and adornment of the light end just allows the glossy sense of skin, the most important thing is to breathe freely, comfortable.
Manufacture method: first get each component in formula C and mix, dissolve, be heated to 40 ℃ standby, then get superfine titanic oxide, the NB-950 of formula in A and mix, then add other components in formula A, be heated to 80 ℃ of sterilizings, separately get each component in formula B and be heated to 80 ℃ of sterilizings, under equality of temperature, formula A is added in formula B to emulsifying 3min, stirring is cooled to after 45 ℃, add respectively formula C, formula D, continue to be stirred to 36 ℃, obtain.
Embodiment 6 acid in sun-proof day
Sunscreen refers to can absorption, reflection or scatters ultraviolet, reduces the preparation of sunlight to skin damage, and its main function is exactly can block ultraviolet (UV) A and UVB to the injury of skin and impact.
Generally speaking, can sunscreen is different according to its sun-proof mechanism, be divided into chemical and physical property two classes
1, chemical sunscreen: be mainly absorption action of ultraviolet radiation, effect is good compared with physical property sunscreen, but easily cause stimulation and the allergic phenomena of skin.
1., UVA absorbent: benzophenone derivates, methane Derivatives class
2., UVB absorbent: cinnamic acid salt, salicylic acid salt, para-aminobenzoate, phosphorus amino benzoic Acid salt
2, physical property sunscreen: be mainly uv reflectance effect, generally use the powder body sunscreen of carbon-free inorganic salts, its character is stable and to skin nonirritant and anaphylaxis, but effect is poor compared with chemical sunscreen.
1. UVA reflective agent: zinc oxide is UVB reflective agent 2.: titanium dioxide
1, formula A is weighed in beaker, with 75 ℃ of heating in water bath, extremely dissolves completely.
2, formula B is weighed in beaker, with 75 ℃ of heating in water bath, extremely dissolves completely
3, formula A is slowly poured in formula B, be stirred to (emulsifying completely) after mix homogeneously, be cooled to room temperature.
4, formula C is added in formula A, B, be stirred to mix homogeneously.
Embodiment 7 moisturizing cleansing milk
Cleansing milk claims again clean emulsion, and in formula, oiliness composition generally accounts for 10%～35%, is generally O/W type emulsion, and the aftersensation of washing one's face is smooth, moist, without tight sense.Its formula forms and mainly comprises oil phase, emulsifying agent, wetting agent, water and various additive.
Lauryl alcohol succinate disodium sulfonate salt in formula and lauryl acetate sulfonate sodium are the composite products of a class, do not need emulsifying, there is good foaminess, performance is gentle, only need be by itself and cocamido propyl betaine, benzoic acid C12-15 ester, 1 during preparation, 3-butanediol and water mix, even through being stirred to emulsifying.Formula B is weighed in beaker, with heating in water bath to 75 ℃, extremely dissolves completely.Slowly formula A is poured in formula B, be stirred to after mix homogeneously, with citric acid, regulate
PH value is 6.0～6.5, adds essence and antiseptic, and viscosity regulates with sodium chloride, and all the components adds rear mix homogeneously.
The clean facial soap of embodiment 8 whitening
Clean glycerin soap formula of transparent whitening
Neutral synthetic soap
Transparent glycerin soap modulation step
1, formula A is weighed in beaker, with heating in water bath to 75 ℃, continues to be stirred to completely and dissolve.
2, formula B is weighed in beaker, is stirred to completely and dissolves.
3, formula B is slowly poured in formula A, reaction is to fully saponified.
4, formula A, B is cooled to after 45～50 ℃, adds formula C.
5, before being cooled to room temperature, deployed formula inserts in mould.
Neutral synthetic soap modulation step
1, formula A is weighed in beaker, with heating in water bath to 75 ℃, continues stirring until completely and dissolve.
2, formula B is weighed in beaker, is stirred to completely and dissolves.
3, formula B is slowly poured in formula A, be stirred to mix homogeneously.
4, finally all the components is rolled, mediated to complete and homogeneous, the molding of milling.
Embodiment 9 perfume
Claims (10)
1. take the prevention environmental stimuli skin care item that Radix Pseudostellariae is main component for one kind, described prevention environmental stimuli skin care item skin care item comprise sun screen, intensified day moisture, moisturizing cleansing milk, the clean facial soap of whitening or perfume, it is characterized in that, in mass ratio, in these prevention environmental stimuli skin care item, comprise 3-6% Radix Pseudostellariae extract.
2. a kind of prevention environmental stimuli skin care item that Radix Pseudostellariae is main component of take as claimed in claim 1, is characterized in that, these prevention environmental stimuli skin care item are sun screen, comprise by weight:
3. as claimed in claim 2ly take the prevention environmental stimuli skin care item that Radix Pseudostellariae is main component, its preparation method comprises the steps: first to get each component in formula C and mixes, dissolves, be heated to 40 ℃ standby, the superfine titanic oxide, the NB-950 that get in formula A mix again, add again other components in formula A, be heated to 80 ℃ of sterilizings, separately get each component in formula B and be heated to 80 ℃ of sterilizings, under equality of temperature, formula A is added in formula B, emulsifying 3min, stirs and is cooled to after 45 ℃, adds respectively formula C, formula D, continue to be stirred to 36 ℃, obtain.
4. a kind of prevention environmental stimuli skin care item that Radix Pseudostellariae is main component of take as claimed in claim 1, is characterized in that, these prevention environmental stimuli skin care item are acid in sun-proof day, comprise by weight:
5. as claimed in claim 4ly take the prevention environmental stimuli skin care item that Radix Pseudostellariae is main component, its preparation method comprises the steps:
1), formula A is weighed in beaker, with the dissolving extremely completely of 75 ℃ of heating in water bath;
2), formula B is weighed in beaker, with the dissolving extremely completely of 75 ℃ of heating in water bath;
3), by formula A slowly pour into formula B in, be stirred to after mix homogeneously, be cooled to room temperature;
4), by formula C add formula A, B in, be stirred to mix homogeneously.
6. a kind of prevention environmental stimuli skin care item that Radix Pseudostellariae is main component of take as claimed in claim 1, is characterized in that, these prevention environmental stimuli skin care item are moisturizing cleansing milk, comprise by weight:
7. as claimed in claim 6ly take the prevention environmental stimuli skin care item that Radix Pseudostellariae is main component, its preparation method comprises the steps:
Lauryl alcohol succinate disodium sulfonate salt in formula and lauryl acetate sulfonate sodium mix with cocamido propyl betaine, benzoic acid C12-15 ester, 1,3 butylene glycol and water, even through being stirred to emulsifying; Formula B is weighed in beaker, with heating in water bath to 75 ℃, extremely dissolves completely; Slowly formula A is poured in formula B, be stirred to after mix homogeneously, with citric acid, regulating pH value is 6.0～6.5, adds essence and antiseptic, and viscosity regulates with sodium chloride, and all the components adds rear mix homogeneously.
8. a kind of prevention environmental stimuli skin care item that Radix Pseudostellariae is main component of take as claimed in claim 1, is characterized in that, these prevention environmental stimuli skin care item are the clean facial soap of whitening, comprise by weight:
Or neutral synthetic soap
9. as claimed in claim 8ly take the prevention environmental stimuli skin care item that Radix Pseudostellariae is main component, its collocation method comprises the steps:
Transparent glycerin soap modulation step
Formula A is weighed in beaker, with heating in water bath to 75 ℃, continues to be stirred to completely and dissolve;
Formula B is weighed in beaker, is stirred to completely and dissolves;
Formula B is slowly poured in formula A, and reaction is to fully saponified;
Formula A, B are cooled to after 45～50 ℃, add formula C;
Before being cooled to room temperature, deployed formula inserts in mould;
Neutral synthetic soap modulation step is:
Formula A is weighed in beaker, with heating in water bath to 75 ℃, continues stirring until completely and dissolve;
Formula B is weighed in beaker, is stirred to completely and dissolves;
Formula B is slowly poured in formula A, be stirred to mix homogeneously;
Finally all the components is rolled, mediated to complete and homogeneous, the molding of milling.
10. a kind of prevention environmental stimuli skin care item that Radix Pseudostellariae is main component of take as claimed in claim 1, is characterized in that, these prevention environmental stimuli skin care item are perfume, comprise by weight:
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| CN110141542A (en) * | 2019-06-27 | 2019-08-20 | 福建师范大学 | A kind of Shu Min agent and preparation method thereof containing radix pseudostellariae |
| CN110141542B (en) * | 2019-06-27 | 2022-05-17 | 福建师范大学 | Allergy-relieving agent containing radix pseudostellariae and preparation method thereof |
| CN114146036A (en) * | 2021-12-20 | 2022-03-08 | 宁德师范学院 | Radix pseudostellariae skin lotion for whitening and moisturizing and preparation method thereof |
| CN114146036B (en) * | 2021-12-20 | 2023-11-21 | 宁德师范学院 | Radix pseudostellariae skin-moistening lotion for whitening and moisturizing and preparation method thereof |
| CN115353938A (en) * | 2022-08-20 | 2022-11-18 | 福安市南岩本草文化发展有限公司 | Radix pseudostellariae and pumpkin flower handmade soap and preparation method thereof |
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Application publication date: 20141112 |