CN104126010B - 嵌合的双链核酸 - Google Patents

嵌合的双链核酸 Download PDF

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CN104126010B
CN104126010B CN201280062110.XA CN201280062110A CN104126010B CN 104126010 B CN104126010 B CN 104126010B CN 201280062110 A CN201280062110 A CN 201280062110A CN 104126010 B CN104126010 B CN 104126010B
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nucleic acid
nucleotides
acid strand
strand
double
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CN104126010A (zh
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横田隆德
仁科一隆
小比贺聪
水泽英洋
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Tokyo Medical and Dental University NUC
University of Osaka NUC
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Tokyo Medical and Dental University NUC
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2320/00—Applications; Uses
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    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280062110.XA 2011-12-16 2012-12-17 嵌合的双链核酸 Active CN104126010B (zh)

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JP2011275488 2011-12-16
JP2011-275488 2011-12-16
PCT/JP2012/083180 WO2013089283A1 (en) 2011-12-16 2012-12-17 Chimeric double-stranded nucleic acid

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CN104126010A CN104126010A (zh) 2014-10-29
CN104126010B true CN104126010B (zh) 2021-04-06

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US (6) US9816089B2 (cg-RX-API-DMAC7.html)
EP (1) EP2791335B1 (cg-RX-API-DMAC7.html)
JP (7) JP6112569B2 (cg-RX-API-DMAC7.html)
CN (2) CN104126010B (cg-RX-API-DMAC7.html)
AU (1) AU2012353330B2 (cg-RX-API-DMAC7.html)
CA (2) CA3106312C (cg-RX-API-DMAC7.html)
ES (1) ES2707232T3 (cg-RX-API-DMAC7.html)
IN (1) IN2014CN04590A (cg-RX-API-DMAC7.html)
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