CN1041095C - 用于治疗前列腺肥大的甾族化合物及其药物组合物 - Google Patents

用于治疗前列腺肥大的甾族化合物及其药物组合物 Download PDF

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Publication number
CN1041095C
CN1041095C CN93105911A CN93105911A CN1041095C CN 1041095 C CN1041095 C CN 1041095C CN 93105911 A CN93105911 A CN 93105911A CN 93105911 A CN93105911 A CN 93105911A CN 1041095 C CN1041095 C CN 1041095C
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CN
China
Prior art keywords
compound
amino
diene
methyl
carbon atom
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Expired - Fee Related
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CN93105911A
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English (en)
Chinese (zh)
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CN1083070A (zh
Inventor
小岛孝一
藏田等司
石桥公树
堀越大能
滨田孝和
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Sankyo Co Ltd
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Sankyo Co Ltd
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Publication of CN1083070A publication Critical patent/CN1083070A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN93105911A 1992-04-20 1993-04-20 用于治疗前列腺肥大的甾族化合物及其药物组合物 Expired - Fee Related CN1041095C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP9981692 1992-04-20
JP99816/92 1992-04-20
JP32804392 1992-12-08
JP328043/92 1992-12-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN97117777A Division CN1195666A (zh) 1992-04-20 1997-08-26 甾类化合物中间体及其制法和应用

Publications (2)

Publication Number Publication Date
CN1083070A CN1083070A (zh) 1994-03-02
CN1041095C true CN1041095C (zh) 1998-12-09

Family

ID=26440917

Family Applications (2)

Application Number Title Priority Date Filing Date
CN93105911A Expired - Fee Related CN1041095C (zh) 1992-04-20 1993-04-20 用于治疗前列腺肥大的甾族化合物及其药物组合物
CN97117777A Pending CN1195666A (zh) 1992-04-20 1997-08-26 甾类化合物中间体及其制法和应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN97117777A Pending CN1195666A (zh) 1992-04-20 1997-08-26 甾类化合物中间体及其制法和应用

Country Status (25)

Country Link
US (3) US5536714A (enExample)
EP (2) EP0567271B1 (enExample)
JP (1) JP2514778B2 (enExample)
KR (1) KR0146680B1 (enExample)
CN (2) CN1041095C (enExample)
AT (1) ATE154937T1 (enExample)
AU (1) AU656852B2 (enExample)
CA (1) CA2094300C (enExample)
CZ (2) CZ283791B6 (enExample)
DE (1) DE69311837T2 (enExample)
DK (1) DK0567271T3 (enExample)
ES (1) ES2105108T3 (enExample)
FI (1) FI931765L (enExample)
GR (1) GR3024896T3 (enExample)
HK (1) HK1000303A1 (enExample)
HU (1) HU219579B (enExample)
ID (1) ID18576A (enExample)
IL (1) IL105478A (enExample)
MX (1) MX9302300A (enExample)
NO (1) NO304891B1 (enExample)
NZ (1) NZ247449A (enExample)
PH (1) PH31052A (enExample)
RU (2) RU2114861C1 (enExample)
TW (2) TW238312B (enExample)
ZA (1) ZA932732B (enExample)

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IT1259419B (it) * 1991-05-24 1996-03-18 Erba Carlo Spa Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
KR950701340A (ko) * 1992-04-30 1995-03-23 스튜어트 알. 슈터 17알파 및 17베타-치환된 에스트라-1,3,5,(10)-트리엔-3-카르복실산(17α AND 17β-SUBSTITUTED ESTRA-1,2,3(10)-TRIENE-3-CARBOXYLIC ACID)
GB9224148D0 (en) * 1992-11-18 1993-01-06 Smithkline Beecham Corp Compounds
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
JPH09504271A (ja) * 1993-09-03 1997-04-28 スミスクライン・ビーチャム・コーポレイション 安定した錠剤処方
GB9324371D0 (en) * 1993-11-26 1994-01-12 Erba Carlo Spa Side chain fluoro substituted 3-carboxysteroids
GB9411103D0 (en) * 1994-06-03 1994-07-27 Smithkline Beecham Corp Compounds
GB9415183D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 3-carboxysteroids with a fluorinated side-chain
US6117429A (en) * 1997-08-11 2000-09-12 Weider Nutrition International, Inc Compositions and treatments for reducing potential unwanted side effects associated with long-term administration of androgenic testosterone precursors
US5879711A (en) * 1997-11-07 1999-03-09 Sequeira; Joel A. Stable antiandrogenic gel composition
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US7258850B2 (en) * 1999-05-04 2007-08-21 Aradigm Corporation Methods and compositions for treating erectile dysfunction
US6428769B1 (en) * 1999-05-04 2002-08-06 Aradigm Corporation Acute testosterone administration
WO2003029268A1 (en) * 2001-10-03 2003-04-10 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
US20060148725A1 (en) * 2001-12-21 2006-07-06 The Miriam Hospital Selective 11beta HSD inhibitors and methods of use thereof
AU2002361861A1 (en) * 2001-12-21 2003-07-30 Rhode Island Hospital SELECTIVE 11Beta-HSD INHIBITORS AND METHODS FOR USE THEREOF
WO2004097002A2 (en) * 2003-04-29 2004-11-11 The Miriam Hospital SELECTIVE TESTICULAR 11β-HSD INHIBITORS AND METHODS OF USE THEREOF
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
US7604386B2 (en) * 2005-11-18 2009-10-20 Federal-Mogul World Wide, Inc Lamp assembly having a socket made from high temperature plastic
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US8563728B2 (en) * 2009-07-09 2013-10-22 Aurobindo Pharma Ltd. Process for the preparation of Dutasteride
CN111362999B (zh) * 2020-03-16 2022-03-29 江苏联环药业股份有限公司 一种爱普列特杂质及其制备方法和应用

Citations (2)

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EP0465141A2 (en) * 1990-06-28 1992-01-08 Merck & Co. Inc. N-monosubstituted adamantyl/norbornanyl 17beta-carbamides of3-carboxy-androst-3,5-dienes
EP0484094A2 (en) * 1990-10-29 1992-05-06 Sankyo Company Limited Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
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AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US4946834A (en) * 1988-12-23 1990-08-07 Smithkline Beecham Corporation Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5137882A (en) * 1990-06-11 1992-08-11 Holt Dennis A Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
WO1992018132A1 (en) * 1991-04-17 1992-10-29 Merck & Co., Inc. Pharmaceutical combination for the treatment of benign prostatic hyperplasia comtaining a 5 alpha-reductase inhibitor
US5196411A (en) * 1991-08-16 1993-03-23 Merck & Co., Inc. 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0465141A2 (en) * 1990-06-28 1992-01-08 Merck & Co. Inc. N-monosubstituted adamantyl/norbornanyl 17beta-carbamides of3-carboxy-androst-3,5-dienes
EP0484094A2 (en) * 1990-10-29 1992-05-06 Sankyo Company Limited Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY VOL 33,NO.3 1990.3.1 D.A.Holt等,"Inhibition of steroid-5 alpha Reductase by unsaturated 3-carbo *

Also Published As

Publication number Publication date
JPH06279487A (ja) 1994-10-04
CA2094300A1 (en) 1993-10-21
RU2097387C1 (ru) 1997-11-27
US5536714A (en) 1996-07-16
CZ284206B6 (cs) 1998-09-16
CN1195666A (zh) 1998-10-14
GR3024896T3 (en) 1998-01-30
IL105478A0 (en) 1993-08-18
EP0567271B1 (en) 1997-07-02
AU656852B2 (en) 1995-02-16
HU219579B (hu) 2001-05-28
DE69311837T2 (de) 1998-02-12
DE69311837D1 (de) 1997-08-07
TW401420B (en) 2000-08-11
ZA932732B (en) 1993-10-28
NO304891B1 (no) 1999-03-01
HU9301155D0 (en) 1993-07-28
IL105478A (en) 1998-03-10
KR930021654A (ko) 1993-11-22
CN1083070A (zh) 1994-03-02
KR0146680B1 (ko) 1998-08-01
CA2094300C (en) 2003-01-28
FI931765A7 (fi) 1993-10-21
CZ283791B6 (cs) 1998-06-17
FI931765A0 (fi) 1993-04-19
ATE154937T1 (de) 1997-07-15
PH31052A (en) 1998-02-03
EP0567271A2 (en) 1993-10-27
US5760025A (en) 1998-06-02
HK1000303A1 (en) 1998-02-20
RU2114861C1 (ru) 1998-07-10
ID18576A (id) 1998-04-23
DK0567271T3 (da) 1998-02-16
AU3698493A (en) 1993-10-21
EP0567271A3 (en) 1994-11-23
JP2514778B2 (ja) 1996-07-10
FI931765L (fi) 1993-10-21
EP0725074A2 (en) 1996-08-07
NO931401D0 (no) 1993-04-16
US5717088A (en) 1998-02-10
NO931401L (no) 1993-10-21
TW238312B (enExample) 1995-01-11
NZ247449A (en) 1995-02-24
CZ90097A3 (cs) 1998-07-15
CZ67893A3 (en) 1994-01-19
RU95101838A (ru) 1997-01-10
MX9302300A (es) 1994-03-31
HUT64558A (en) 1994-01-28
ES2105108T3 (es) 1997-10-16
EP0725074A3 (en) 1996-11-20

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C19 Lapse of patent right due to non-payment of the annual fee
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