CN104096108A - 一种治疗疼痛性亚甲炎的蒙药及其制备方法 - Google Patents
一种治疗疼痛性亚甲炎的蒙药及其制备方法 Download PDFInfo
- Publication number
- CN104096108A CN104096108A CN201410341039.XA CN201410341039A CN104096108A CN 104096108 A CN104096108 A CN 104096108A CN 201410341039 A CN201410341039 A CN 201410341039A CN 104096108 A CN104096108 A CN 104096108A
- Authority
- CN
- China
- Prior art keywords
- parts
- mongolian medicine
- preparation
- painful
- subacute thyroiditis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 201000007497 subacute thyroiditis Diseases 0.000 title claims abstract description 23
- 206010043784 Thyroiditis subacute Diseases 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 241000689249 Saussurea obvallata Species 0.000 claims description 11
- 235000012239 silicon dioxide Nutrition 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 241001057584 Myrrha Species 0.000 claims description 7
- 229930006000 Sucrose Natural products 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
- 239000007888 film coating Substances 0.000 claims description 7
- 238000009501 film coating Methods 0.000 claims description 7
- 241000147945 Oxytropis kansuensis Species 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 5
- 241000209128 Bambusa Species 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 238000005550 wet granulation Methods 0.000 claims description 3
- 230000006870 function Effects 0.000 abstract description 7
- 230000003285 pharmacodynamic effect Effects 0.000 abstract description 5
- 238000011160 research Methods 0.000 abstract description 5
- 241000173529 Aconitum napellus Species 0.000 abstract description 3
- 240000007311 Commiphora myrrha Species 0.000 abstract description 3
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract description 3
- 244000020518 Carthamus tinctorius Species 0.000 abstract description 2
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract description 2
- 241001537183 Hypecoum Species 0.000 abstract description 2
- 240000000513 Santalum album Species 0.000 abstract description 2
- 235000008632 Santalum album Nutrition 0.000 abstract description 2
- 229940023019 aconite Drugs 0.000 abstract description 2
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 208000035473 Communicable disease Diseases 0.000 abstract 2
- 240000002853 Nelumbo nucifera Species 0.000 abstract 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 abstract 2
- 230000001154 acute effect Effects 0.000 abstract 2
- 206010004542 Bezoar Diseases 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 240000003864 Ulex europaeus Species 0.000 abstract 1
- 235000010730 Ulex europaeus Nutrition 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 27
- 235000019640 taste Nutrition 0.000 description 25
- 238000000034 method Methods 0.000 description 24
- 238000012360 testing method Methods 0.000 description 23
- 241000699670 Mus sp. Species 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 238000000576 coating method Methods 0.000 description 15
- 238000002474 experimental method Methods 0.000 description 15
- 230000008569 process Effects 0.000 description 15
- 239000011248 coating agent Substances 0.000 description 14
- 229940079593 drug Drugs 0.000 description 14
- 239000000047 product Substances 0.000 description 14
- 239000012567 medical material Substances 0.000 description 12
- 230000033228 biological regulation Effects 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 9
- 210000003743 erythrocyte Anatomy 0.000 description 8
- 229960004756 ethanol Drugs 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 229960004793 sucrose Drugs 0.000 description 6
- 210000001685 thyroid gland Anatomy 0.000 description 6
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 5
- 239000013558 reference substance Substances 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 5
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 5
- 235000005493 rutin Nutrition 0.000 description 5
- 229960004555 rutoside Drugs 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 241000287828 Gallus gallus Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 206010035737 Pneumonia viral Diseases 0.000 description 4
- 229960000583 acetic acid Drugs 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 239000012362 glacial acetic acid Substances 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 210000003024 peritoneal macrophage Anatomy 0.000 description 4
- 208000037920 primary disease Diseases 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 230000005180 public health Effects 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 238000004809 thin layer chromatography Methods 0.000 description 4
- 208000009421 viral pneumonia Diseases 0.000 description 4
- 206010057190 Respiratory tract infections Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 208000003532 hypothyroidism Diseases 0.000 description 3
- 230000002989 hypothyroidism Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 230000007306 turnover Effects 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000004380 Cholic acid Substances 0.000 description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010020850 Hyperthyroidism Diseases 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 241001053158 Oxytropis Species 0.000 description 2
- 229920003081 Povidone K 30 Polymers 0.000 description 2
- 241000403513 Schizostachyum chinense Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 2
- 235000019416 cholic acid Nutrition 0.000 description 2
- 229960002471 cholic acid Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229960000935 dehydrated alcohol Drugs 0.000 description 2
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 2
- 229960000991 ketoprofen Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000227129 Aconitum Species 0.000 description 1
- 241000701413 Aconitum kusnezoffii Species 0.000 description 1
- 241000234599 Aconitum naviculare Species 0.000 description 1
- 241001586435 Aconitum tanguticum Species 0.000 description 1
- 208000010370 Adenoviridae Infections Diseases 0.000 description 1
- 206010060931 Adenovirus infection Diseases 0.000 description 1
- 241001317465 Bambusa textilis Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 102000003712 Complement factor B Human genes 0.000 description 1
- 108090000056 Complement factor B Proteins 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 101100285402 Danio rerio eng1a gene Proteins 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 241000195955 Equisetum hyemale Species 0.000 description 1
- 241000167880 Hirundinidae Species 0.000 description 1
- DGABKXLVXPYZII-UHFFFAOYSA-N Hyodeoxycholic acid Natural products C1C(O)C2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 DGABKXLVXPYZII-UHFFFAOYSA-N 0.000 description 1
- 241001623623 Hypecoum erectum Species 0.000 description 1
- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000711386 Mumps virus Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- JMUFJNCIWRHXIR-UHFFFAOYSA-N O.OC.OC=O.CCOC(C)=O Chemical compound O.OC.OC=O.CCOC(C)=O JMUFJNCIWRHXIR-UHFFFAOYSA-N 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 241001347883 Oxytropis falcata Species 0.000 description 1
- 241000904014 Pappus Species 0.000 description 1
- 240000007711 Peperomia pellucida Species 0.000 description 1
- 240000000103 Potentilla erecta Species 0.000 description 1
- 235000016551 Potentilla erecta Nutrition 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241000612118 Samolus valerandi Species 0.000 description 1
- 241000221035 Santalaceae Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 206010043757 Thyroid pain Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 208000011589 adenoviridae infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- ONBIUAZBGHXJDM-UHFFFAOYSA-J bismuth;potassium;tetraiodide Chemical compound [K+].[I-].[I-].[I-].[I-].[Bi+3] ONBIUAZBGHXJDM-UHFFFAOYSA-J 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- DGABKXLVXPYZII-SIBKNCMHSA-N hyodeoxycholic acid Chemical compound C([C@H]1[C@@H](O)C2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 DGABKXLVXPYZII-SIBKNCMHSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000849 parathyroid Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 238000011020 pilot scale process Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002955 secretory cell Anatomy 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000008718 systemic inflammatory response Effects 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- -1 test high Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229960003107 tramadol hydrochloride Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410341039.XA CN104096108B (zh) | 2014-07-18 | 2014-07-18 | 一种治疗疼痛性亚甲炎的蒙药及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410341039.XA CN104096108B (zh) | 2014-07-18 | 2014-07-18 | 一种治疗疼痛性亚甲炎的蒙药及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104096108A true CN104096108A (zh) | 2014-10-15 |
CN104096108B CN104096108B (zh) | 2017-12-22 |
Family
ID=51664899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410341039.XA Expired - Fee Related CN104096108B (zh) | 2014-07-18 | 2014-07-18 | 一种治疗疼痛性亚甲炎的蒙药及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104096108B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1883665A (zh) * | 2006-05-18 | 2006-12-27 | 向云平 | 八味主药口服片剂、胶囊剂、丸剂及其制备方法 |
CN102058817A (zh) * | 2010-11-01 | 2011-05-18 | 西藏金哈达药业有限公司 | 一种治疗肝病的藏药制剂 |
CN102590212A (zh) * | 2012-01-16 | 2012-07-18 | 西藏奇正藏药股份有限公司 | 九味竺黄制剂的检测方法 |
-
2014
- 2014-07-18 CN CN201410341039.XA patent/CN104096108B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1883665A (zh) * | 2006-05-18 | 2006-12-27 | 向云平 | 八味主药口服片剂、胶囊剂、丸剂及其制备方法 |
CN102058817A (zh) * | 2010-11-01 | 2011-05-18 | 西藏金哈达药业有限公司 | 一种治疗肝病的藏药制剂 |
CN102590212A (zh) * | 2012-01-16 | 2012-07-18 | 西藏奇正藏药股份有限公司 | 九味竺黄制剂的检测方法 |
Non-Patent Citations (1)
Title |
---|
任志雄等: "林兰教授谈亚急性甲状腺炎的中医诊治", 《天津中医药》 * |
Also Published As
Publication number | Publication date |
---|---|
CN104096108B (zh) | 2017-12-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Wang et al. | Toxic effects caused by rhubarb (Rheum palmatum L.) are reversed on immature and aged rats | |
CN102228479B (zh) | 一种治疗口腔疾病的药物及其制备方法 | |
CN107714805B (zh) | 衢枳壳提取物在制备中药制剂或功能性食品中的应用 | |
CN102961469B (zh) | 一种治疗上呼吸道感染的中药分散片及其制备和检测方法 | |
CN104083744B (zh) | 一种治疗疼痛性亚甲炎的蒙药制剂 | |
CN101023976B (zh) | 一种具有抗流感病毒作用的组合物 | |
CN109674866A (zh) | 一种抗胃肠癌药物组合物、制备方法及其应用 | |
CN103356812B (zh) | 一种了哥王颗粒 | |
CN102198192B (zh) | 一种防治甲流的中药组合物及其应用 | |
CN104096108B (zh) | 一种治疗疼痛性亚甲炎的蒙药及其制备方法 | |
CN106309758A (zh) | 一种抗胃肠癌的药物组合物 | |
CN102240328B (zh) | 一种治疗感冒的中药及其制备方法 | |
CN102293948A (zh) | 一种治疗小儿食滞内热的制剂及其制备方法和检测方法 | |
CN101371861A (zh) | 繁缕中一种高效抗病毒药物组合物及其制备方法和应用 | |
CN105434895A (zh) | 一种天麻景天膏及其制备方法 | |
CN103356813B (zh) | 一种了哥王胶囊 | |
CN110279673A (zh) | AuNP@PP/poly(I:C)及其制备方法与其在制备治疗胶质瘤药物中的应用 | |
CN100450545C (zh) | 肌肉生长抑制素在制备抗肿瘤药物中的应用 | |
CN101618157B (zh) | 一种用于治疗秋燥感冒的药物组合物及其制备方法 | |
CN106924448A (zh) | 治疗风热感冒的药物组合物及其制备方法 | |
CN102258615B (zh) | 炎宁胶囊及其制备方法 | |
CN104721798B (zh) | 一种治疗咳嗽的中药组合物及其制备方法 | |
CN101390921A (zh) | 繁缕总糖肽与总黄酮成份的组合物及其制备方法和应用 | |
CN107050340B (zh) | 一种治疗坏死性淋巴结炎的中药组合物及其应用 | |
Yang et al. | Differential absorption and metabolic characteristics of organic acid components in Pudilan Xiaoyan Oral Liquid between young rats and adult rats |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: NA SHENGSANG Effective date: 20150826 Owner name: WUSURILETE Free format text: FORMER OWNER: NA SHENGSANG Effective date: 20150826 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Wu Surilete Inventor after: Na Shengsang Inventor before: Na Shengsang |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: NA SHENGSANG TO: WUSURILETE NA SHENGSANG |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20150826 Address after: 750306 the Inner Mongolia Autonomous Region Alashanzuoqi of Alashan Bayehot Turehot Road East 4 Lane No. 6 Applicant after: Wu Surilete Applicant after: Na Shengsang Address before: 010000 the Inner Mongolia Autonomous Region Saihan District of Hohhot City Road Xilinguole TCM Hospital No. 41 Department of No. 5 unit 5 Building No. 4 Applicant before: Na Shengsang |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
DD01 | Delivery of document by public notice |
Addressee: Na Shengsang Document name: Notice of supplement and correction for handling the formalities of restoration of rights |
|
DD01 | Delivery of document by public notice | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171222 Termination date: 20210718 |