CN104068283B - For preventing and treating the feed of sheep pox, Chinese medicine composition, preparation method and application - Google Patents
For preventing and treating the feed of sheep pox, Chinese medicine composition, preparation method and application Download PDFInfo
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Abstract
The invention provides a kind of feed for preventing and treating sheep pox, this feed comprises: feed vector and the Chinese medicine composition for preventing and treating sheep pox, and Chinese medicine composition comprises schizonepeta, cicada slough, peppermint, windproof, tribulus terrestris, honeysuckle, the capsule of weeping forsythia, Chinese tamarisk, the leaf of bamboo, stiff silkworm, radix bupleuri, rattletop, duckweed, root of Chinese trichosanthes, golden cypress, barberry, radix ampelopsis, radix scrophulariae, akebi, pyrrosia lingua, rush and the shell of areca nut.Beneficial effect of the present invention is: adopt the Feed Energy containing this Chinese medicine composition to overcome the various defects of Chinese medicine of the prior art and Western medicine, to the treatment of the sheep suffering from sheep pox, there is heat-clearing, removing toxic substances, promoting eruption, strengthening vital QI to eliminate pathogenic factors, and the immunity of organisms of sheep can be improved, effectively prevent and treat sheep pox, selected natural Chinese traditional medicines material, drug residue free, good effect, treatment fast, has no side effect.
Description
Technical field
The present invention relates to herbal medicine technical field, be particularly used for the treatment of the feed of sheep pox, Chinese medicine composition, preparation method and application.
Background technology
Sheep pox disease is caused by capripox virus.This is a kind of DNA virus of ether sensitivity.Tissue cultures is carried out in the infringement of animal viral growth.5 ~ 6 days incubation periods, from the beginning of for red or mauve little papule, quality hard, expand later and become the flat blister in top, can develop into hemorrhagic bulla or warts, central authorities can have navel recessed, and size is 3 ~ 5cm.In 24 ~ 48 hours, blister breaks the thick filbert eschar of surface coverage, and scab surrounding has more special canescence or purplish red tinge, and it is outer again around with blush, becomes papilloma sample tubercle later.Finally flatten, dry, incrustation and self-healing.The course of disease is generally 3 weeks, is also 5 ~ 6 weeks, obtains permanent immunity.
Sheep pox: sick sheep body temperature raises and reaches 41 ~ 42 DEG C, and conjunctiva eyelid is red and swollen, breathes and pulse is accelerated, nose flows out mucus, loss of appetite, and the back of a bow is stood, after 1 ~ 2 day, occur acne rash, acne rash is more common in skin without hair or few hair place, first occurs erythema, after become papule and form blister gradually again, finally become warts, after warts ulceration, if dry gradually without scabies secondary infection, form crust, through recovery from illness in 2 ~ 3 weeks.The acne rash occurring in tongue and gums often forms ulcer.Some sheep throats, bronchus, when acne rash occurs for lungs and glandular stomach or abomasum mucous membrane, sick sheep because of secondary bacterial or virus infections, and dies from septicemia.The sick sheep had sees acne rash internal haemorrhage, in black acne: the case acne rash also had occurs to suppurate and gangrene, and form deep layer ulcer, give out a foul smell, be often pernicious process, case fatality rate is up to more than 20% ~ 50%.
Histopathology: have in obvious cell in epidermis and intercellular edema, cavity is formed and ballooning degeneration, and corium has intensive cellular infiltration, and central authorities are primarily of histocyte and macrophage, there are lymphocyte and thick liquid cell, rarely found polymorphonuclear leukocyte infiltration around.Whole infringement has the thin vessels of many endotheli ocytosis and swelling.Eosinophilic inclusion can be seen in the endochylema of dermal vascular endothelial cell.The sheep pox routes of infection are that contact infects, and comprise people, car, herbage, feed, soil, utensil etc., as long as touched any article of sheep pox germ, all may become medium.And sheep only infects, the death rate is quite high, and treatment not in time or must not at that time about about 50% to 80%.
The Chinese medicine sheep pox sick initial stage not only has the antiviral of western modern medicine and waits effect, and there is heat-clearing, removing toxic substances, promoting eruption, strengthening vital QI to eliminate pathogenic factors, and the immunity of organisms of ill sheep can be improved, selected natural Chinese traditional medicines material, drug residue free, prolonged application has no drug resistance, cost price is cheap, and consumer also can play the advantages such as certain health-care effect to body after eating this type of mutton.
Summary of the invention
Technical problem to be solved by this invention is according to theory of traditional Chinese medical science, with heat-clearing, removing toxic substances, promoting eruption for principle of reatment, a kind of Chinese medicine composition for preventing and treating sheep pox and the feed containing described pharmaceutical compositions are provided, adopt this Chinese medicine composition and feed to prevent and treat sheep pox and can overcome the defects such as the drug resistance that Western medicine produces, strengthening vital QI to eliminate pathogenic factors, the feature of aspects such as improving the immunity of sheep, have that preventive effect is good, curative effect fast, good effect, treatment time are short, have no side effect.
In order to realize foregoing invention object, the invention provides a kind of feed for preventing and treating sheep pox, it comprises feed vector and Chinese medicine composition, and described Chinese medicine composition comprises further: schizonepeta, cicada slough, peppermint, windproof, tribulus terrestris, honeysuckle, the capsule of weeping forsythia, Chinese tamarisk, the leaf of bamboo, stiff silkworm, radix bupleuri, rattletop, duckweed, root of Chinese trichosanthes, golden cypress, barberry, radix ampelopsis, radix scrophulariae, akebi, pyrrosia lingua, rush and the shell of areca nut.
Wherein, the ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 10-25 weight portion, cicada slough 12-30 weight portion, peppermint 15-28 weight portion, windproof 10-27 weight portion, tribulus terrestris 15-37 weight portion, honeysuckle 18-36 weight portion, capsule of weeping forsythia 15-35 weight portion, Chinese tamarisk 13-34 weight portion, leaf of bamboo 12-28 weight portion, stiff silkworm 15-35 weight portion, radix bupleuri 12-30 weight portion, rattletop 15-40 weight portion, duckweed 12-25 weight portion, root of Chinese trichosanthes 10-35 weight portion, golden cypress 12-30 weight portion, barberry 10-30 weight portion, radix ampelopsis 14-32 weight portion, radix scrophulariae 10-32 weight portion, akebi 12-30 weight portion, pyrrosia lingua 15-40 weight portion, rush 15-35 weight portion and shell of areca nut 10-30 weight portion.
Wherein, the ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 18-25 weight portion, cicada slough 12-20 weight portion, peppermint 20-28 weight portion, windproof 22-27 weight portion, tribulus terrestris 15-20 weight portion, honeysuckle 30-36 weight portion, capsule of weeping forsythia 15-25 weight portion, Chinese tamarisk 13-24 weight portion, leaf of bamboo 20-28 weight portion, stiff silkworm 15-25 weight portion, radix bupleuri 12-20 weight portion, rattletop 15-20 weight portion, duckweed 18-25 weight portion, root of Chinese trichosanthes 10-15 weight portion, golden cypress 22-30 weight portion, barberry 10-18 weight portion, radix ampelopsis 14-22 weight portion, radix scrophulariae 10-22 weight portion, akebi 12-20 weight portion, pyrrosia lingua 15-22 weight portion, rush 15-25 weight portion and shell of areca nut 10-20 weight portion.
Wherein, relative to the feed vector of 100 weight portions, the addition of described Chinese medicine composition is 1-8 weight portion; Described feed can further include feed adhesive, the ratio of weight and number of described feed vector and described feed adhesive can be 100 weight portions: 20 weight portions, described feed adhesive comprises Strong flour, starch, methionine, lysine, in described feed adhesive, the ratio of weight and number of each composition is: Strong flour is 20 parts, starch is 32 parts, and methionine is 18 parts; Lysine is 30 parts; Described starch is preferably cornstarch, and wherein relative to 100 parts of starch gross weights, farinose ratio of weight and number is 50 parts, and the ratio of weight and number of ripe starch is 50 parts; Described Strong flour is the flour that protein wt degree is greater than 21%.
For solving the problems of the technologies described above, present invention also offers the preparation method of described feed, wherein, described preparation method comprises:
The first step, becomes 205-270 order fine powder by each bulk drug of described Chinese medicine composition in described ratio mixed grinding, is prepared into described Chinese medicine composition;
Second step, adds in proportion by described feed adhesive, and relative to the feed adhesive of 100 weight portions, start modified in the water of 25-40 weight portion, refining temperature is 77-81 DEG C, pours in spraying machine after stirring;
3rd step, pulverizes described feed vector, and grinding particle size is 284-340mm, makes its fine powder amount reach more than 98% of total material;
4th step, the feed vector after described 3rd step being pulverized is poured in spraying machine, and the feed adhesive after modified with second step mixes, and in spraying machine, water temperature is modulated at 79-92 DEG C, opens sprayer, stirs 15 minutes, continues to be warming up to 95 DEG C and completes expanded;
5th step, pulverizes the expanded product that obtains of the 4th step, then adds the Chinese medicine composition that the first step obtains, and after mixing, adds the water of parts by weight 14-17 part of the mixture relative to 100 weight portions, puts into granulator and granulate;
6th step, the pellet the 5th step obtained is dry, and baking temperature is 106-112 DEG C, drying time 20-35 minute; Then cool, pack.
In order to solve the problems of the technologies described above, present invention also offers a kind of Chinese medicine composition for preventing and treating sheep pox, comprising following bulk drug: schizonepeta, cicada slough, peppermint, windproof, tribulus terrestris, honeysuckle, the capsule of weeping forsythia, Chinese tamarisk, the leaf of bamboo, stiff silkworm, radix bupleuri, rattletop, duckweed, root of Chinese trichosanthes, golden cypress, barberry, radix ampelopsis, radix scrophulariae, akebi, pyrrosia lingua, rush and the shell of areca nut.
Wherein, the ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 18-25 weight portion, cicada slough 12-20 weight portion, peppermint 20-28 weight portion, windproof 22-27 weight portion, tribulus terrestris 15-20 weight portion, honeysuckle 30-36 weight portion, capsule of weeping forsythia 15-25 weight portion, Chinese tamarisk 13-24 weight portion, leaf of bamboo 20-28 weight portion, stiff silkworm 15-25 weight portion, radix bupleuri 12-20 weight portion, rattletop 15-20 weight portion, duckweed 18-25 weight portion, root of Chinese trichosanthes 10-15 weight portion, golden cypress 22-30 weight portion, barberry 10-18 weight portion, radix ampelopsis 14-22 weight portion, radix scrophulariae 10-22 weight portion, akebi 12-20 weight portion, pyrrosia lingua 15-22 weight portion, rush 15-25 weight portion and shell of areca nut 10-20 weight portion.
For solving the problems of the technologies described above, present invention also offers the preparation method of described Chinese medicine composition, wherein, the formulation of described Chinese medicine composition is powder, and described preparation method is:
The first step, mixes in proportion by described each bulk drug, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 84 ~ 95%, adds hot reflux 2 ~ 4 hours, extracts, and filters acquisition first extract and the dregs of a decoction;
Second step, the dregs of a decoction filtering first step acquisition add relative to the determining alcohol of described dregs of a decoction quality 2 ~ 3 times to be the ethanol of 84 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction again;
3rd step, merges the first extract and the second extract, reduced pressure concentration removing alcohol solvent, dry, obtains and gets dry extract;
4th step, is placed on the dry cream that the 3rd step obtains in micronizer and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 200 order ~ 300 object fine powders;
5th step, the fine powder the 4th step obtained drops in mixing and blending machine and stirs, and namely obtains described powder.
Present invention also offers the food for preventing and treating sheep pox or medicine, described food or medicine comprise above-mentioned Chinese medicine composition.
Present invention also offers above-mentioned Chinese medicine composition and prepare the application in the food and medicine preventing and treating sheep pox.
The beneficial effect that technical scheme provided by the invention is brought is: adopt the Feed Energy containing this Chinese medicine composition to overcome the various defects of Chinese medicine of the prior art and Western medicine, the treatment of the sheep suffering from sheep pox is had to effect of heat-clearing, removing toxic substances, promoting eruption, strengthening vital QI to eliminate pathogenic factors, and the immunity of organisms of sheep can be improved, effective control, selected natural Chinese traditional medicines material, drug residue free, good effect, treatment fast, has no side effect.
Detailed description of the invention
Chinese veterinarian's theory is thought, " warm pathogen tend to attack the upper orifices, attacking the lung first, inverse telepathy bag.Lung governing qi belongs to be defended; The main blood of the heart belongs to battalion.Though distinguish that ying, wei, qi, xue is same with typhoid fever; If opinion therapy, then different greatly with typhoid fever.Dialect gas after defending, dialect blood after battalion.Can be also what defend sweat; To gas just suitable clear gas; First to join the army point, still all right diathermanous, still turn gas and divide and separate, if the things such as rhinoceros horn, radix scrophulariae, antelope are also; To entering blood, then probably hematozemia moves blood, directly palpus cooling blood to dissipate stasis, if the things such as the dried rhizome of rehmannia, the root bark of tree peony, donkey-hide gelatin, the radix paeoniae rubrathe are also." the sheep pox sick initial stage should promoting eruption, purulence becomes the phase to disappear sore by ulceration, and the later stage should restrain myogenic.
According to above-mentioned theory and principle, the invention provides a kind of Chinese medicine composition for preventing and treating sheep pox, it comprises: schizonepeta, cicada slough, peppermint, windproof, tribulus terrestris, honeysuckle, the capsule of weeping forsythia, Chinese tamarisk, the leaf of bamboo, stiff silkworm, radix bupleuri, rattletop, duckweed, root of Chinese trichosanthes, golden cypress, barberry, radix ampelopsis, radix scrophulariae, akebi, pyrrosia lingua, rush and the shell of areca nut.
Wherein, schizonepeta, cicada slough, peppermint, windproof, tribulus terrestris, honeysuckle, the capsule of weeping forsythia, Chinese tamarisk, the leaf of bamboo, duckweed send out the Chinese and to induce sweat table promoting eruption; Radix bupleuri, rattletop are clearing heat and detoxicating, elevate a turnable ladder yang-energy; Root of Chinese trichosanthes, golden cypress, barberry, radix ampelopsis, clearing heat-fire, detoxification sore treatment; Radix scrophulariae clearing heat and cooling blood, purging intense heat and detonicating, enriching yin; Akebi, pyrrosia lingua, rush, shell of areca nut diuresis, impel heat poison to go from urine.
Now the effect of each taste herbal pharmacology is described below:
Schizonepeta: taste is pungent, micro-hardship, property is micro-wet; Enter lung, Liver Channel." Japan hanako materia medica ": " sharp the five internal organs, promoting digestion to eliminate stagnation, sobers up.Heat-dissipating of cooking is eaten and is simmered tea, and controls a wind and sweating; Fermented soya beans, salted or other wise juice is decocted and is controlled sudden and violent typhoid fever." Compendium of Material Medica: " throat, the sore that disappears swells for loose wind-heat, refresh oneself.Control Xiang Qiang, black flower in order, and raw sore, cloudy ruined, spit blood, bleeding from five sense organs or subcutaneous tissue, lower blood, bloody flux, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, abscess of throat, measles, carbuncle swells, sore scabies, postpartum anemic fainting.For flu, headache, measles, rubella, sore from the beginning of.
Cicada slough: sweet, cold; Return lung, Liver Channel.Amplification on Canon of Materia Medica: " control blurred vision screen.Decocting shell juice again, controlling children's, to go out sore rash unhappy." Compendium of Material Medica: " controls phlegm-accumulating vertigo, skin wind-heat, and acne rash is had an itch, lockjaw and treat pyogenic infections sore, adult's aphonia, and children's hangs in wind sky of keeping silent, the frightened morbid night crying of babies of crying, swelling of vulva." loose wind heat extraction, relieve sore throat, promoting eruption, moves back screen, spasmolysis.For anemopyretic cold, pharyngalgia, hoarsen, measles without adequate eruption, rubella itch, cataract, convulsion, lockjaw.
Peppermint: nature and flavor are pungent is cool.Enter lung channel, Liver Channel.For anemopyretic cold, warm disease from the beginning of.These product are pungent to disperse, cool to heat-clearing, clear light cool loose, are the conventional product of dispelling wind and heat from the body, thus available control anemopyretic cold or warm disease from the beginning of.For hot eyes of having a headache, abscess of throat.These product lightly float and rise floating, awakening consciousness, and merit is kind evacuates part of the body cavity above the diaphragm housing the heart and lungs wind-heat, refresh oneself, throat.Attack with controlling in wind-heat, headache hot eyes.Modern study shows, peppermint has antivirus action; Analgesia, itching-relieving action; Anti-irritant, antitussive action; Bactericidal action; Antibacterial action: peppermint has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, mouth disease, makes breath freshening.Gargle with mint tea juice, can be anti-halitosis in advance.It is said and can be used for the another name that peppermint also has " eyes grass " treating eye illness.Physiological function: peppermint is the best essential oil for the treatment of flu, can suppress fever and mucosa irritation, and promote perspire; Throat-clearing throat-moistening, elimination halitosis have good effect; Effect of relieveing pain and refreshing, can alleviate headache, antimigraine and toothache; In addition for respiratory system, digestive system, internal system, good effect is had.
Windproof: taste is pungent, sweet, slightly warm in nature; Enter urinary bladder channel, lung channel, the spleen channel, Liver Channel." Japan hanako materia medica ": " control wind as 36, all labor of man are bad, the beneficial god of bowl spares, blepharitis marginalis, and only tear and paralysis delay, tonneau the five internal organs Guan pulse, general debility, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." " Changsha medicine solution ": " network of passing through, by wet excessive, gets round by bribery, and relieve the pain pain, relaxing muscles and tendons arteries and veins, stretches anxious twin, podomere of living, and plays paralysis, holds back spontaneous perspiration, night sweat, break, metrorrhagia." function expels pathogenic wind from the body surface, removing dampness to relieve pain, spasmolysis, antipruritic.For catching cold, headache bodily pain, arthralgia due to wind-dampness, joint is ached, and stomachache is had loose bowels, discharging fresh blood stool, lockjaw, rubella itch, sore from the beginning of.
Tribulus terrestris: bitter, pungent, flat, enter Liver Channel.Flat liver solution is strongly fragrant, dispelling pathogenic wind for improving eyesight.For dizziness due to hyperactivity of liver-YANG headache, liver-depressed hypochondrium pain, headache due to pathogenic wind-heat, red eye, swell pain, the diseases such as pruitus.
Honeysuckle: cold in nature, taste is sweet, enters lung, the heart, stomach warp, has effect that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind, cures mainly disease under turgor, warm disease heating, the diseases such as hot malicious large carbuncle and tumour.The illnesss such as it is dizzy for giddy, dry is done yearningly, hidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin infection, ulcer furunculosis, erysipelas, mumps, suppurative tonsillitis all have certain curative effect.
The capsule of weeping forsythia: bitter, cold nature; Enter the heart, lung, small intestinl channel." property of medicine opinion ": " main tonneau five drenches, urinary obstruction, except heart man visitor heat." Tang Materia Medica: " capsule of weeping forsythia has two kinds, sticks up greatly, littlely to stick up.Stick up greatly leaf long and narrow, as wood, brightly yellowish lovely, give birth to wetland, work, like the Chinese toon person of not opening in fact, sticks up outstanding grass as room.On its little Qiao Sheng hilllock is former, Ye Huashi is all carefully little like sticking up greatly, and mountain people from south also uses it.Only with sticking up son greatly under modern capital, without stem flower also." pharmacological action such as have antibacterial, cardiac stimulant, diuresis, town to tell, be clearing heat and detoxicating Chinese medicine, cure mainly pyreticosis from the beginning of, anemopyretic cold, heating, vexed, symptom, its bacteriostasis and the honeysuckle broadly similar such as abscess of throat, acute nephritis, carbuncle sore tumefacting virus.Weakness of the spleen and the stomach, fever due to deficiency of vital energy, ulcer is burst, the light person of the rare look of purulence avoids clothes.Oleanolic acid contained by this product has cardiac stimulant, diuresis and hypotensive activity, and citrin can reduce vasopermeability and fragility, prevents haemolysis.Decoction has the town effect of telling, anti-liver injury effect.
Chinese tamarisk: taste is sweet, pungent, property is put down; Return lung channel, stomach warp, the heart channel of Hang-Shaoyin.Essentials of Matea Medica: " control acute diseases such as cholera and sunstroke rash not go out, breathe heavily vexed unrest of coughing." function dispelling wind, induce sweat, promoting eruption, removing toxic substances.Cure mainly anemopyretic cold, measles goes out saturating from the beginning of, rash, arthralgia due to wind-dampness, pruitus.Control measles thoroughly difficult, rubella body is itched, and flu, coughs and breathe heavily, treating rheumatic ostealgia.
The leaf of bamboo: nature and flavor, sweet, be slightly cold.Compendium of Material Medica: " go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, and children's's acne poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating strangurtia." vegetation is side just ": " dissolving phlegm is quenched the thirst.Control dysphoria with smothery sensation, cough and breathe heavily, spit blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for pyreticosis polydipsia, heart stomach fire is contained.
Stiff silkworm: salty, pungent, flat; Return liver, lung, stomach warp.Shennong's Herbal: " main pediatric epilepsy scared, the morbid night crying of babies, go three worms, goes out black, and it is good to make us complexion, and the cloudy ulcer of man is sick." Compendium of Material Medica: " erysipelas is had an itch for loose wind phlegm tuberculosis, scrofula, head wind, wind worm dentalgia, skin wind sore ... all metal-inflicted wounds, malignant boil swells wind hemorrhoid.”
Radix bupleuri: cold nature, bitter, pungent, return Liver Channel, gallbladder channel, " Bencao Tujing " carries: " between (radix bupleuri) modern passs, Shan, rivers and lakes, shortcut all has it, with silver-colored state person for winning.Life in February seedling, very fragrant, stem is livid purple, and leaf is slightly purple like the leaf of bamboo ... July opens chrysanthemum ... root redness of the skin or complexion is strong like the root of purple-flowered peucedanum.Reed head has red hair as mouse tail, and only nest elder is good.August in February adopts root." tool soothing liver-gallbladder, dredge strongly fragrant, the loose effect of fire of gas solution.Function: table expels the heat-evil thoroughly, soothing liver-qi stagnation, elevate a turnable ladder yang-energy.Cure mainly: the heating that cures cold, fever and chills deficient fever.Children's's acne rash waste heat, lean and haggard belly expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, and uterus comes off, irregular menstruation.Bupleurum Chinense volatile oil has trivial solution heat effect to the caused heating such as typhoid fever, paratyphoid vaccine, Escherichia coli liquid, fermented milk, yeast, and animal normal body temperature can be made to decline.To ankle-joint caused by multiple proinflammatory agent, swollen and desmoplastic inflammation all has inhibitory action.
Rattletop: taste is pungent, sweet, cold nature; Return lung channel, the spleen channel, large intestine channel, stomach warp." property of medicine opinion ": " control children's's wind, frightened epilepsy, time gas hot disease.Can control the swollen pain of ability to speak wind NI, root of the tooth floats rotten stench, hot malicious purulence blood.Except cardiopulmonary wind is scorchingly hot obstructed and constipated, aphtha, unhappy.Treatment carbuncle swells, smallpox; Decocting silk floss is stained with and is wiped in sore." Compendium of Material Medica: " ecchymose removing rash, row hemostasis are controlled sun and are fallen into dizzy fortune, the empty pain of the chest side of body, heavy after letting out diarrhea for a long time, lose turbid, and under band, metrorrhagia, blood drenches, lower blood, and impotence foot is cold." function is clearing heat and detoxicating, promoting eruption.Thoroughly send out smooth, maculopapulae due to toxic heat, diseases caused by external factors illness that has not attacked the vital organs of the human body for measles, weigh under epidemic disease fire poison, aphtha, pharyngalgia, headache fever and chills, carbuncle sore tumefacting virus, the sinking of qi of middle-jiao, splenasthenic diarrhea, protracted dysentery, women is with down, metrorrhagia.
Duckweed: pungent, cold; Enter lung, small intestinl channel.Tang Materia Medica: " duckweed person, has three kinds: large person's name apple; Jiang's dish is had again, also similar and leaf circle in water; The main fiery sore of little duckweed waterborne." " Mingyi Bielu ": " the main person of quenching one's thirst, go with damp and hot heresy, then body fluid is spontaneous, and thirsty from stopping also.It says lower gas, to stop bath setation originator, also with cold energy heat extraction, and testing also of cool blood." sweating, dispel the wind, row water, heat-clearing, removing toxic substances.Row hot carbuncle when controlling, macula is not saturating, wind-heat pain rash, pruitus, oedema, and through closing, sore tinea, erysipelas, scalds.Duckweed has diuresis, and its active ingredient is mainly potassium acetate and potassium chloride.
Root of Chinese trichosanthes: sweet, micro-hardship, is slightly cold; Attach to the lung and stomach meridians.Clearing heat and promoting fluid, detumescence and apocenosis." book on Chinese herbal medicine justice ": " medicine so-called root of Chinese trichosanthes person wantonly, namely cuts into slices with it with the root that withers, have the name of powder, real without powder.It smashes the method for thin clear powder." " book on Chinese herbal medicine is looked for the truth ": " and root of Chinese trichosanthes, than snakegourd, its property is slightly flat, seemingly do not wither impatient compel, and have push away wall fall wall merit also.Have Yan Anzhong absolutely continuous to " warp ", say like anon-normal, but Yun Qire is except the meaning from peace." for pyreticosis polydipsia, lung-heat type cough, interior heat is quenched one's thirst, sore swollen toxin.
Golden cypress: be the dry bark of rutaceae wampee or cork tree.The former practises title " CORTEX PHELLODENDRI CHINENSE ", and the latter practises title " CORTEX PHELLODENDRI AMURENE ".Can be used as medicine, nature and flavor bitter cold, has heat-clearing and damp-drying drug, and purging intense heat removes steams, effect of detoxification sore treatment.Cork tree is distributed in the area such as Northeast China and North China each province, and happiness is grown among mountain area, assorted woods, and strong adaptability, is applicable to the cultivation of sun-drenched place, also can anti-severe cold.Golden cypress is conventional Chinese medicine, its cold in nature, bitter, the effects such as tool heat-clearing and damp-drying drug, purging intense heat and detonicating, is usually used in damp-heat dysentery, jaundice, leukorrhea and the disease such as hot numbness, heat pouring.Modern study shows, golden cypress is containing the main component such as berberine, obakunone, and have the effect of antibacterial, convergence, anti-inflammatory, to symptoms such as various skin wet poison, sores, effect is good." herbal classic is met former " is said: " golden cypress, raw with falling excess fire, wine system is controlled on yin fire scorching, and salt system controls the inferior the fire of Jiao, and ginger system controls middle burnt convulsive seizure due to phlegm-fire, and ginger juice is fried and blackly controlled damp and hot, and the black fire of deficiency type processed fried by salt wine, deficiency of Yin fire Sheng flushing floating yang, monkshood juice system ".
Barberry: bitter, cold.Happiness light, resistance to the moon, happiness is loose, rich soil, barren-resistant, strong adaptability.Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp-heat dysentery, jaundice eczema, pharyngalgia hot eyes, Ting discharging ear, carbuncle sore tumefacting virus.Main containing jamaicin (berberine), palmatine (palmatine palmatine), berbamine (berbamine).
Radix ampelopsis: clearing heat and detoxicating, eliminating stagnation to stop pain, regenerating tissue to heal wond.Treatment of ulcer pyogenic infections, scrofula, scalds, wet sore, a kind of malaria, frightened epilepsy, bloody flux, intestines wind, anal fistula, leukorrhea, traumatic injury, traumatism and bleeding.Radix ampelopsis decoction itself without analgesic activity, but significantly can strengthen RADIX ACONITI LATERALIS PREPARATA and process the analgesic activity of monkshood, antagonism RADIX ACONITI LATERALIS PREPARATA, contraction to isolated frog heart when processing monkshood and Radix Aconiti Kusnezoffii Preparata.
Radix scrophulariae: taste is sweet, bitter, salty, cold nature, returns lung, stomach, kidney channel.Compendium of Material Medica: " kidney water is injured, Kidney-Yin fall, lonely positive unrooted, and send out as fire is sick, method should strengthen water with fire processed, therefore radix scrophulariae and the same merit of glutinous rehmannia.Its scrofula that disappears also is loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." " Records of Tradition Chinese and Western Medicine in Combination ": " many liquid cool in nature was the medicine of kidney tonifying warp clearly originally for radix scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of clearing lung-heat man, removing toxic substances quench, is suitable for tuberculosis tuberculosis most, cough with lung heat." " Japan hanako materia medica ": " control a wind-heat poison urticaria, qi-restoratives strains, and the heart is frightened irritated, and bad weary hectic fever due to yin passes corpse perverse trend, only forgetful, detumescence poison." there is clearing heat and cooling blood, purging intense heat and detonicating, effect of enriching yin, cure mainly warm heat disease heat and ying blood, body heat, polydipsia, tongue are deep red, a spot, hectic fever due to yin labor are coughed, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula subcutaneous nodule, skin sore are not hindered in awake, Tianjin to dysphoria.
Akebi: bitter, cold in nature; Enter the heart channel of Hang-Shaoyin, small intestinl channel, urinary bladder channel.Collective Notes to the Canon of Materia medica: " stem pith of the rice-paper plant, the present goes out shortcut, raw around timbo, and juice is white, and stem has pore, and two is all logical, blows it containing one, then to go out those persons good for gas.Or cloud and Weed rattan." " property of medicine opinion ": " cure mainly five pouring, diuresis, switch lattice.Control people to sleep, main oedema is floating large, except dysphoria with smothery sensation more." function inducing diuresis for treating strangurtia, clear away heart-fire relieving restlessness, lactogenesis of stimulating the menstrual flow.For stranguria, oedema, vexed urine is red, few through closing breast, damp-heat arthralgia pain.This product energy inducing diuresis for removing edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Can the fire of supernatant the heart channel of Hang-Shaoyin, under let out the heat of small intestine.
Pyrrosia lingua: cold nature, taste is sweet, bitter.Gas is micro-, the micro-puckery hardship of taste.Shennong's Herbal: " pyrrosia lingua, bitter is put down, main labor heat evil gas, and five retention of urines are obstructed, and diuresis water leads to, a stone fasten hide or leather on (sound sugarcane), on the stone of raw mountain valley." " new compilation of materia medica ": " and raw stone the moon place, pliable and tough as skin.Person on raw ancient tile, name Wa Wei, controls pouring also good." " book on Chinese herbal medicine is high former ": " pyrrosia lingua cures mainly labor heat evil gas person, and labor heat is at bone, and perverse trend is at skin, and the institute of lung kidney is main also.Five infirmity persons, the five liquid retention of urines, difficult urination also.Pyrrosia lingua helps the vital essence of lung kidney, and upper downcrossings, crystal is moistened, then the outer key of upper orifices is all logical, changes, then capable the and little facility of water channel under lung qi." function promoting diuresis for stranguria, clearing lung-heat expels the heat-evil.Control and drench pain, hematuria, lithangiuria, ephritis, uterine bleeding, dysentery, cough with lung heat, chronic bronchitis, metal-inflicted wound, ulcer.Pyrrosia lingua can strengthen the cytophagous activate the phagocytic capacity of body, and has some antitumaous effect.
Rush: to be slightly cold, sweet, light; The thoughts of returning home, lung, small intestine, urinary bladder channel." Bencao Jingshu ": " rush, its light weight leads to, and it is cold in nature, slightly sweet flavor, therefore can tonneau small intestine hot gas, descendingly goes out from urine, and small intestine is the internal organs of the heart, therefore also except the heart channel of Hang-Shaoyin heat also." function promoting diuresis for stranguria, clearing heart fire.Cure mainly: gonorrhoea, oedema, difficult urination, the puckery pain of oliguria, jaundice with damp-heat pathogen, dysphoria and insomnia, nocturnal fretfulness in infants, larynx numbness, aphthae, wound.
The shell of areca nut: taste is pungent, slightly warm in nature; Return spleen, stomach, large intestine, small intestinl channel." Kaibao Bencao ": " main cold and hot gas is made a psychological attack abdomen, and large intestine stops up poison, phlegm diaphragm, the belching of acid from stomach.And decoct with Jiang Yantong, enter thin gas medicine good." " detailed outline ": " beriberi is stopped up inverse for lowering the adverse flow of qi, aqueous vapor edema in the skin that disappears, and malignant malaria ruffian is full, and it is vexed that nausea vomiting during early pregnancy is swollen." " property of medicine class is bright ": " and the shell of areca nut, Dan Xi conventional to control lung qi syndrome characterized by dyspnea, and in oedema medicine again multiplex it, lid is also got it and is let out lung, to kill the source of water also." under gas wide in, line water detumescence.For retention of damp leading to blockage of QI, chest abdominal distension is vexed, defecates not well, oedema, beriberi, difficult urination.
Wherein, the ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 10-25 weight portion, cicada slough 12-30 weight portion, peppermint 15-28 weight portion, windproof 10-27 weight portion, tribulus terrestris 15-37 weight portion, honeysuckle 18-36 weight portion, capsule of weeping forsythia 15-35 weight portion, Chinese tamarisk 13-34 weight portion, leaf of bamboo 12-28 weight portion, stiff silkworm 15-35 weight portion, radix bupleuri 12-30 weight portion, rattletop 15-40 weight portion, duckweed 12-25 weight portion, root of Chinese trichosanthes 10-35 weight portion, golden cypress 12-30 weight portion, barberry 10-30 weight portion, radix ampelopsis 14-32 weight portion, radix scrophulariae 10-32 weight portion, akebi 12-30 weight portion, pyrrosia lingua 15-40 weight portion, rush 15-35 weight portion and shell of areca nut 10-30 weight portion.
Wherein, the ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 18-25 weight portion, cicada slough 12-20 weight portion, peppermint 20-28 weight portion, windproof 22-27 weight portion, tribulus terrestris 15-20 weight portion, honeysuckle 30-36 weight portion, capsule of weeping forsythia 15-25 weight portion, Chinese tamarisk 13-24 weight portion, leaf of bamboo 20-28 weight portion, stiff silkworm 15-25 weight portion, radix bupleuri 12-20 weight portion, rattletop 15-20 weight portion, duckweed 18-25 weight portion, root of Chinese trichosanthes 10-15 weight portion, golden cypress 22-30 weight portion, barberry 10-18 weight portion, radix ampelopsis 14-22 weight portion, radix scrophulariae 10-22 weight portion, akebi 12-20 weight portion, pyrrosia lingua 15-22 weight portion, rush 15-25 weight portion and shell of areca nut 10-20 weight portion.
The invention provides a kind of preparation method being used for the treatment of the Chinese medicine composition of sheep pox disease, the formulation of described Chinese medicine composition is powder, and described preparation method is:
The first step, mixes in proportion by described each bulk drug, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 84 ~ 95%, adds hot reflux 2 ~ 4 hours, extracts, and filters acquisition first extract and the dregs of a decoction;
Second step, the dregs of a decoction filtering first step acquisition add relative to the determining alcohol of described dregs of a decoction quality 2 ~ 3 times to be the ethanol of 84 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction again;
3rd step, merges the first extract and the second extract, reduced pressure concentration removing alcohol solvent, dry, obtains and gets dry extract;
4th step, is placed on the dry cream that the 3rd step obtains in micronizer and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 200 order ~ 300 object fine powders;
5th step, the fine powder the 4th step obtained drops in mixing and blending machine and stirs, and namely obtains described powder.
Present invention also offers a kind of feed for preventing and treating sheep pox, described feed comprises feed vector and the Chinese medicine composition for preventing and treating sheep pox.
Wherein, relative to the feed vector of 100 weight portions, the addition of described Chinese medicine composition is 1-8 weight portion; Described feed can further include feed adhesive, and the ratio of weight and number of described feed vector and described feed adhesive can be 100 weight portions: 20 weight portions; Described feed adhesive comprises Strong flour, starch, methionine, lysine, and in described feed adhesive, the ratio of weight and number of each composition is: Strong flour is 20 parts, and starch is 32 parts, and methionine is 18 parts; Lysine is 30 parts; Described starch is preferably cornstarch, and wherein relative to 100 parts of starch gross weights, farinose ratio of weight and number is 50 parts, and the ratio of weight and number of ripe starch is 50 parts; Described Strong flour is the flour that protein wt degree is greater than 21%.
Present invention also offers the preparation method of above-mentioned feed, it comprises:
The first step, becomes 205-270 order fine powder by each bulk drug of described Chinese medicine composition in described ratio mixed grinding, is prepared into described Chinese medicine composition;
Second step, adds in proportion by described feed adhesive, and relative to the feed adhesive of 100 weight portions, start modified in the water of 25-40 weight portion, refining temperature is 77-81 DEG C, pours in spraying machine after stirring;
3rd step, pulverizes described feed vector, and grinding particle size is 284-340mm, makes its fine powder amount reach more than 98% of total material;
4th step, the feed vector after described 3rd step being pulverized is poured in spraying machine, and the feed adhesive after modified with second step mixes, and in spraying machine, water temperature is modulated at 79-92 DEG C, opens sprayer, stirs 15 minutes, continues to be warming up to 95 DEG C and completes expanded;
5th step, pulverizes the expanded product that obtains of the 4th step, then adds the Chinese medicine composition that the first step obtains, and after mixing, adds the water of parts by weight 14-17 part of the mixture relative to 100 weight portions, puts into granulator and granulate;
6th step, the pellet the 5th step obtained is dry, and baking temperature is 106-112 DEG C, drying time 20-35 minute; Then cool, pack.
Present invention also offers the food for preventing and treating sheep pox or medicine, described food or medicine comprise above-mentioned Chinese medicine composition.
Present invention also offers above-mentioned Chinese medicine composition and prepare the application in the food and medicine preventing and treating sheep pox.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition of the present invention is to the toxicity test of sheep
1, trial drug
The first step, schizonepeta 18g, cicada slough 15g, peppermint 23g, windproof 25g, tribulus terrestris 17g, honeysuckle 35g, capsule of weeping forsythia 19g, Chinese tamarisk 18g, leaf of bamboo 21g, stiff silkworm 17g, radix bupleuri 15g, rattletop 17g, duckweed 19g, root of Chinese trichosanthes 12g, golden cypress 26g, barberry 12g, radix ampelopsis 16g, radix scrophulariae 18g, akebi 15g, pyrrosia lingua 22g, rush 15g and shell of areca nut 16g are mixed, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 88%, add hot reflux 3 hours, extract, filter acquisition first extract and the dregs of a decoction;
Second step, the dregs of a decoction filtering first step acquisition add relative to the determining alcohol of described dregs of a decoction quality 2 times to be the ethanol of 88%, to add hot reflux 2 hours that acquisition second extract is filtered in extraction again;
3rd step, merges the first extract and the second extract, reduced pressure concentration removing alcohol solvent, dry, obtains and gets dry extract;
4th step, is placed on the dry cream that the 3rd step obtains in micronizer and pulverizes 2 hours, pulverize, sieve, obtain 250 object fine powders;
5th step, the fine powder the 4th step obtained drops in mixing and blending machine and stirs, and namely obtains described powder.
2, test method
Acute toxicity test
Select 20 white mouse, with the powder of the embodiment of the present invention 1 for object, give dispensing in white mouse large intestine, observe 7 for 150 times of clinical consumption per day.20 white mouse are strong as a result deposits, and its activity, diet, hair, excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other bad reaction.Acute toxicity test proves, this medicine does not have acute toxicity.
Cumulative toxicity test
Test method: select 20 healthy mices, female, each 10 of hero, with the powder of the embodiment of the present invention 1 for object, is mixed into powder in diet, dose design is first phase in every 5 days, and each issue dosage is respectively 10 times, 20 times, 50 times and 100 times of clinical application amount.The vital sign observing small white mouse for every 5 days once, adjusts dosage gradually.After 20 days, animal occurs without death condition.Off-test, by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Animal subject general state is good, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Hematological examination, blood biochemical analysis, urine biochemical analysis are all in normal range (NR); Main organs histopathological examination shows no obvious abnormalities.Judge that this powder does not have cumulative toxicity thus.
The preparation of embodiment 2 embodiment 2 Chinese traditional medicine composition composition powders
The first step, schizonepeta 15g, cicada slough 16g, peppermint 20g, windproof 18g, tribulus terrestris 22g, honeysuckle 30g, capsule of weeping forsythia 23g, Chinese tamarisk 20g, leaf of bamboo 18g, stiff silkworm 23g, radix bupleuri 20g, rattletop 25g, duckweed 22g, root of Chinese trichosanthes 25g, golden cypress 20g, barberry 18g, radix ampelopsis 25g, radix scrophulariae 22g, akebi 16g, pyrrosia lingua 25g, rush 24g and shell of areca nut 20g are mixed, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, add hot reflux 3 hours, extract, filter acquisition first extract and the dregs of a decoction;
Second step, the dregs of a decoction filtering first step acquisition add relative to the determining alcohol of described dregs of a decoction quality 3 times to be the ethanol of 90%, to add hot reflux 1.5 hours that acquisition second extract is filtered in extraction again;
3rd step, merges the first extract and the second extract, reduced pressure concentration removing alcohol solvent, dry, obtains and gets dry extract;
4th step, is placed on the dry cream that the 3rd step obtains in micronizer and pulverizes 2 hours, pulverize, sieve, obtain 280 object fine powders;
5th step, the fine powder the 4th step obtained drops in mixing and blending machine and stirs, and namely obtains described powder.
The preparation of embodiment 3 feed
The first step, schizonepeta 20g, cicada slough 30g, peppermint 20g, windproof 25g, tribulus terrestris 30g, honeysuckle 20g, capsule of weeping forsythia 20g, Chinese tamarisk 20g, leaf of bamboo 20g, stiff silkworm 20g, radix bupleuri 25g, rattletop 20g, duckweed 20g, root of Chinese trichosanthes 15g, golden cypress 20g, barberry 30g, radix ampelopsis 20g, radix scrophulariae 25g, akebi 20g, pyrrosia lingua 20g, rush 30g are become 250 order fine powders with shell of areca nut 30g mixed grinding, is prepared into described Chinese medicine composition;
Second step, by feed adhesive: Strong flour is 500g, starch is 800g; Methionine is 450g; Lysine is 750g; Wherein starch is cornstarch, and wherein uncooked amylum is 400g, and ripe starch is that 400g adds and starts modified in the water of 625g, and refining temperature is 80 DEG C, pours in spraying machine after stirring;
3rd step, pulverizes the feed vector of 12.5kg, and grinding particle size is 300mm, makes its fine powder amount reach more than 98% of total material;
4th step, the feed vector after described 3rd step being pulverized is poured in spraying machine, and the feed adhesive after modified with second step mixes, and in spraying machine, water temperature is modulated at 85 DEG C, opens sprayer, stirs 15 minutes, continues to be warming up to 95 DEG C and completes expanded;
5th step, pulverizes the expanded product that obtains of the 4th step, then adds the Chinese medicine composition that the first step obtains, and after mixing, adds the water of 2500g, puts into granulator and granulate;
6th step, the pellet the 5th step obtained is dry, and baking temperature is 108 DEG C, 25 minutes drying times; Then cool, pack.
Clinical testing
For examination material
Select the sheep of a group 500 about body weight 25kg of sheep feed lot, there is no inoculated sheep pox vaccine.Wherein, the sheep suffering from sheep pox is 200, contacted ill sheep the sheep of suspected infection capripox virus is 300, and prerun 7 days, carries out expelling parasite during this period.Group feeding, every day, feeding 3 times, freely drank water.
Diagnostic criteria
(1) clinical symptoms: sick sheep initial stage body temperature rising, poor appetite, lassitude, to be short of breath, mucus is had in nose, eye conjunctiva flush, the both sides opening and closing of the wing of nose bridge of the nose are frequent, then visible eyelid, nostril, lip, bridge of the nose both sides, front and back inboard leg, perineum, breast, oxter, have the circular erythema of about 20cm in various degree without places such as hairs, the flat little papule of circle of skin surface is swelled as seen without hair position, be referred to as to blush greatly, within second day, papular top starts deliquescing, form bubble, within several days, turn to be yellow afterwards and become useless fellow, finally in brown incrustation.Have for developing into bubble, be hard mound shape thing, in umbilical, leave light red scar;
(2) Clinical anatomic: sick sheep oral cavity and pharyngeal mucosa thicken oedema, in kermesinus, there are red stain, papule and bubble, nasal cavity, tunica mucosa tracheae have a small amount of ulcer, inner surface of trachea toughness exudate, and esophagus has several circular erythema, cud and abomasum have rotten to the corn district and the point-like ulcer surface of small pieces, liver has flaxen cheesy tubercle, and lung has the red area of sheet, and swollen lymph node, look red;
According to popularity and above-mentioned clinical symptoms and anatomy, be diagnosed as sheep pox disease.
Test method one:
Test for 200 ill sheep.Be divided into two groups at random, treatment by Chinese herbs group 100 and western medicine group 100.
Treatment by Chinese herbs group: use the Chinese traditional medicine composition composition powders of the embodiment of the present invention 2 to treat, be mixed in daily feed by Chinese traditional medicine composition composition powders and feed, the ratio of Chinese traditional medicine composition composition powders and feed is: 3:100.Twice on the one 1 day is a course for the treatment of, treats three courses for the treatment of.
Western medicine group: first use the liquor potassic permanganate shower pars affecta skin of 0.1%, then smear 5% tincture of iodine at lesions position, twice on the one; Moroxydine parenteral solution 10ml intramuscular injection, twice on the one; Acne gram parenteral solution 0.1ml/kg intramuscular injection, once-a-day; Said method combines and carries out simultaneously.Within 1 day, be a course for the treatment of, treat three courses for the treatment of.
The standard of curative effect evaluation:
Cure: acne is swollen all to disappear, and symptom all disappears, and recovers normal; Effective: acne is swollen obviously to be alleviated, and other symptoms all obtain very large alleviation, and basic recovery is normal; Invalid: symptom is without any improvement, or death.
Treatment results
Table 1 is the efficacy result contrast of four groups
Can be found out by table 1, treatment by Chinese herbs group is compared with western medicine group, and healing number and significant figure are all apparently higher than western medicine group.Can learn, Chinese traditional medicine composition composition powders of the present invention, in treatment sheep pox, than conventional medicament good effect, cure rate is high, efficient height.
The treatment time contrast of the summation of the healing number that table 2 is respectively organized and significant figure
As can be seen from Table 2, the sheep for the treatment of by Chinese herbs group, will faster than western medicine group in treatment speed.That is, Chinese medicine composition of the present invention, has determined curative effect, rapid-action, good effect, cure rate advantages of higher.
Test method two
For 300 contacted ill sheep and the sheep of suspected infection capripox virus test.Be divided into two groups at random, treatment by Chinese herbs group 150 and blank treatment group 150.
Treatment by Chinese herbs group: use the Chinese traditional medicine composition composition powders of the embodiment of the present invention 2 to treat, be mixed in daily feed by Chinese traditional medicine composition composition powders and feed, the ratio of Chinese traditional medicine composition composition powders and feed vector is: 3:100.Twice on the one.Feed and carry out 7 days.Then observe.
Blank group: normally feed, twice on the one, daily feed.Feed and carry out 7 days.Then observe.
Experimental result
Table 3 is the sheep pox outbreak situation contrast for the treatment of by Chinese herbs group and blank group
As can be seen from Table 3, the number of the sheep health for the treatment of by Chinese herbs group is more than the number of the sheep health of blank group.Namely exist, Chinese traditional medicine composition composition powders can be good at prevention sheep and suffers from sheep pox disease.Illustrate, Chinese medicine composition has good prevention effect.
In sum, Chinese medicine composition of the present invention, effectively prevents preventing and treating in sheep pox; Determined curative effect in treatment sheep pox, good effect, cures speed soon, and has no side effect.
Citing 1:2010 Lee in May sheep raising field is supported 80 sheep.Wherein there is acne rash without on hair or few hair portion skin and visual private film in 40 sheep body surfaces, occur being dispersed in or intensive acne rash subsequently, and then it is swollen to form acne, is diagnosed as sheep pox disease according to clinical symptoms at whole body.To the feed of 40 sow feeding embodiments 3,1 day is a course for the treatment of, is used in conjunction 3 courses for the treatment of, and cure 38,2 invalid death, cure rate is 95%, after therapeutic process and treatment, do not occur side effect.Feeding 7 days to the feed that remaining 40 sheep carry out embodiment 3, there is not the disease condition of sheep pox in rear 40 sheep of feeding, all healthy.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
1. for preventing and treating a feed for sheep pox, it is characterized in that, comprising feed vector and the Chinese medicine composition for preventing and treating sheep pox disease, also comprising feed adhesive;
Relative to the described feed vector of 100 weight portions, the addition of described Chinese medicine composition is 1-8 weight portion; The addition of described feed adhesive is 20 weight portions; In described feed adhesive, the ratio of weight and number of each composition is: Strong flour is 9-20 weight portion, and starch is 21-32 weight portion, and methionine is 10-18 weight portion, and lysine is 18-30 weight portion; Described starch is cornstarch, wherein relative to 100 weight starch gross weights: uncooked amylum is 50 weight portions, and ripe starch is 50 weight portions; Described Strong flour is the flour that protein wt degree is greater than 21%;
The ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 10-25 weight portion, cicada slough 12-30 weight portion, peppermint 15-28 weight portion, windproof 10-27 weight portion, tribulus terrestris 15-37 weight portion, honeysuckle 18-36 weight portion, capsule of weeping forsythia 15-35 weight portion, Chinese tamarisk 13-34 weight portion, leaf of bamboo 12-28 weight portion, stiff silkworm 15-35 weight portion, radix bupleuri 12-30 weight portion, rattletop 15-40 weight portion, duckweed 12-25 weight portion, root of Chinese trichosanthes 10-35 weight portion, golden cypress 12-30 weight portion, barberry 10-30 weight portion, radix ampelopsis 14-32 weight portion, radix scrophulariae 10-32 weight portion, akebi 12-30 weight portion, pyrrosia lingua 15-40 weight portion, rush 15-35 weight portion and shell of areca nut 10-30 weight portion.
2. feed according to claim 1, it is characterized in that, the ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 18-25 weight portion, cicada slough 12-20 weight portion, peppermint 20-28 weight portion, windproof 22-27 weight portion, tribulus terrestris 15-20 weight portion, honeysuckle 30-36 weight portion, capsule of weeping forsythia 15-25 weight portion, Chinese tamarisk 13-24 weight portion, leaf of bamboo 20-28 weight portion, stiff silkworm 15-25 weight portion, radix bupleuri 12-20 weight portion, rattletop 15-20 weight portion, duckweed 18-25 weight portion, root of Chinese trichosanthes 10-15 weight portion, golden cypress 22-30 weight portion, barberry 10-18 weight portion, radix ampelopsis 14-22 weight portion, radix scrophulariae 10-22 weight portion, akebi 12-20 weight portion, pyrrosia lingua 15-22 weight portion, rush 15-25 weight portion and shell of areca nut 10-20 weight portion.
3. the preparation method of the feed described in claim 1 or 2, is characterized in that, described preparation method comprises:
The first step, becomes 205-270 order fine powder by each bulk drug of described Chinese medicine composition in described ratio mixed grinding, is prepared into Chinese medicine composition;
Second step, adds in proportion by described feed adhesive, and relative to the feed adhesive of 100 weight portions, start modified in the water of 25-40 weight portion, refining temperature is 77-81 DEG C, pours in spraying machine after stirring;
3rd step, pulverizes described feed vector, and grinding particle size is 284-340mm, makes its fine powder amount reach more than 98% of total material;
4th step, the described feed vector after described 3rd step being pulverized is poured in spraying machine, and the described feed adhesive after modified with second step mixes, in spraying machine, water temperature is modulated at 79-92 DEG C, open sprayer, stir 15 minutes, continue to be warming up to 95 DEG C and complete expanded;
5th step, pulverizes the expanded product that obtains of the 4th step, then adds the described Chinese medicine composition that the first step obtains, and after mixing, adds the water of parts by weight 14-17 part of the mixture relative to 100 weight portions, puts into granulator and granulate;
6th step, the pellet the 5th step obtained is dry, and baking temperature is 106-112 DEG C, drying time 20-35 minute; Then cool, pack.
4. one kind for preventing and treating the Chinese medicine composition of sheep pox, it is characterized in that, the ratio of weight and number of each bulk drug in described Chinese medicine composition is: schizonepeta 10-25 weight portion, cicada slough 12-30 weight portion, peppermint 15-28 weight portion, windproof 10-27 weight portion, tribulus terrestris 15-37 weight portion, honeysuckle 18-36 weight portion, capsule of weeping forsythia 15-35 weight portion, Chinese tamarisk 13-34 weight portion, leaf of bamboo 12-28 weight portion, stiff silkworm 15-35 weight portion, radix bupleuri 12-30 weight portion, rattletop 15-40 weight portion, duckweed 12-25 weight portion, root of Chinese trichosanthes 10-35 weight portion, golden cypress 12-30 weight portion, barberry 10-30 weight portion, radix ampelopsis 14-32 weight portion, radix scrophulariae 10-32 weight portion, akebi 12-30 weight portion, pyrrosia lingua 15-40 weight portion, rush 15-35 weight portion and shell of areca nut 10-30 weight portion.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that, the formulation of described Chinese medicine composition is powder, and preparation method is:
The first step, mixes in proportion by described each bulk drug, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 84 ~ 95%, adds hot reflux 2 ~ 4 hours, extracts, and filters acquisition first extract and the dregs of a decoction;
The dregs of a decoction that the first step obtains are added relative to the determining alcohol of described dregs of a decoction quality 2 ~ 3 times and are the ethanol of 84 ~ 95%, add hot reflux 1 ~ 3 hour by second step again, extract, and filter acquisition second extract;
3rd step, merges described first extract and described second extract, and reduced pressure concentration removing alcohol solvent is dry, obtains and gets dry extract;
4th step, is placed on the dry cream that the 3rd step obtains in micronizer and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 200 order ~ 300 object fine powders;
5th step, the described fine powder the 4th step obtained drops in mixing and blending machine and stirs, and namely obtains described powder.
6., for preventing and treating feed or the medicine of sheep pox, it is characterized in that: described feed or medicine comprise Chinese medicine composition according to claim 4.
7. the application of Chinese medicine composition according to claim 4 in the feed and medicine of preparation treatment sheep pox.
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| CN102846736A (en) * | 2011-07-01 | 2013-01-02 | 施瑞客（天津）生物技术有限公司 | Chinese medicinal preparation for treating ovine smallpox |
| CN102895418A (en) * | 2012-10-31 | 2013-01-30 | 天津集合科技有限公司 | Traditional Chinese medical composition for treatment of sheep pox |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846736A (en) * | 2011-07-01 | 2013-01-02 | 施瑞客（天津）生物技术有限公司 | Chinese medicinal preparation for treating ovine smallpox |
| CN102895418A (en) * | 2012-10-31 | 2013-01-30 | 天津集合科技有限公司 | Traditional Chinese medical composition for treatment of sheep pox |
Non-Patent Citations (2)
| Title |
|---|
| "羊痘的综合防治";刘文钦等;《山东畜牧兽医》;20121231;见第37页右栏第3段 * |
| 中药竹叶柳旁汤治疗羊痘的探讨;陈淮钰;《中兽医学杂志》;19921231(第02期);第20页右栏第3-4段 * |
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