CN104857360A - Pharmaceutical composition for treating cow urinary stone and preparation method of pharmaceutical composition - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating a cow urinary stone and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises the following medicinal materials: adiantum capillus-veneris, herb of lygodium japonicum, senna, muskroot-like semiaquilegia root, lupuline bugle, spreading violet, lysimachia christinae hance, radix cudramiae, scrophularia ningpoensis, rhizoma corydalis, hypericum japonicum, sapium sebiferum, folium isatidis, roasted rhizoma atractylodis macrocephalae, Chinese yam, gorgon euryale seeds, rhizoma cyperi, fructus forsythia, lophatherum gracile, white paeony root and radix clematidis. The pharmaceutical composition has the beneficial effects that the pharmaceutical composition is capable of relieving pain, removing urinary calculus, clearing away heat and toxic materials and inducing diuresis for treating stranguria as main functions, and regulating lung qi, benefiting qi and removing urinary calculus as auxiliary functions, is capable of timely shortening the disease course and improving the recovery rate, simultaneously is low in medicine residue, low in cost, suitable for large-area application, relatively short in treatment course, relatively good in curative effect, free of a medicine residue and low in cost price, and can be marketed; and the disease condition can be effectively controlled.

Description

Be used for the treatment of pharmaceutical composition of cattle urinary stone and preparation method thereof

Technical field

The present invention relates to field of veterinary, particularly relate to and be a kind ofly used for the treatment of pharmaceutical composition of cattle urinary stone and preparation method thereof.

Background technology

Urinary stone refers to the salts substances crystallization dissolved in urine, the mineral concretion of formation, stimulates urinary tract and causes ureteral obstruction, being called urinary stone disease.

The shape of urinary stone has spherical, square, cylindrical and irregular shape.The color adularescent of calculus, brown.The quality of calculus has hard, also has softness or loose.

Urinary stone forms general and inflammation-related, and the exudate of inflammation is the lithogenous core of shape, promotes the precipitation of inorganic salt.Relevant with the forage grass and feed that people are supplied to domestic animal, if Long-term Feeding is rich in the feedstuff of calcium, phosphorus and silicate, cause the disorder of salt metabolism in body, urate concentration increases, and forms calculus gradually.Relevant with the sex of domestic animal, bull, ram, boar are easy to get.

If calculus of urethra finds evening, easily cause domestic animal urine poisoning, renal failure, rupture of bladder, cause death.

Cattle urinary stone according to circumstances operative treatment has abdominal paracentesis urethral catheterization, and urethrotomy gets stone method, the penis process of chopping, bladder cannula method, bladder patching.Therapeutic scheme, medicine are all limited, do not reach desirable therapeutic effect, and treatment cost are higher.But Chinese medicine cattle urinary stone, improves the immunity of organisms of ill cattle, selected natural Chinese medicines material, make drug effect directly arrive focus, the course for the treatment of is shorter, and curative effect is better, drug residue free, and cost price is cheap, can effective symptom management.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition being used for the treatment of cattle urinary stone, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, have with pain relieving calculus, heat-clearing and toxic substances removing, the effect of inducing diuresis for treating stranguria syndrome, treatment cattle urinary stone is evident in efficacy, the course of disease can be reduced in time, improve cure rate, reduce mortality rate, low drug residue simultaneously, cost is low, be applicable to large-area applications, marketing can be carried out, the course for the treatment of is shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.

In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of cattle urinary stone, described pharmaceutical composition comprises following raw medicinal material: Herba Adianti, Herba lygodii, Herba Cassiae Mimosoidis, Radix Semiaquilegiae, Herba Ajugae Lupulinae, Herba Violae diffusae, Herba Lysimachiae, Radix Cudraniae, Radix Scrophulariae, Rhizoma Corydalis, Herba Hyperici Japonici, Cortex Sapii Radicis, Folium Isatidis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, Semen Euryales, Rhizoma Cyperi, Fructus Forsythiae, Herba Lophatheri, the Radix Paeoniae Alba and Radix Clematidis.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 25-35 weight portion, Herba lygodii 10-15 weight portion, Herba Cassiae Mimosoidis 25-35 weight portion, Radix Semiaquilegiae 20-32 weight portion, Herba Ajugae Lupulinae 12-18 weight portion, Herba Violae diffusae 9-18 weight portion, Herba Lysimachiae 25-35 weight portion, Radix Cudraniae 20-32 weight portion, Radix Scrophulariae 32-42 weight portion, Rhizoma Corydalis 10-17 weight portion, Herba Hyperici Japonici 10-19 weight portion, Cortex Sapii Radicis 12-19 weight portion, Folium Isatidis 10-18 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 30-40 weight portion, Rhizoma Dioscoreae 18-26 weight portion, Semen Euryales 19-27 weight portion, Rhizoma Cyperi 9-15 weight portion, Fructus Forsythiae 10-18 weight portion, Herba Lophatheri 10-14 weight portion, Radix Paeoniae Alba 30-42 weight portion and Radix Clematidis 6-12 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 32 weight portion, Herba lygodii 13 weight portion, Herba Cassiae Mimosoidis 29 weight portion, Radix Semiaquilegiae 30 weight portion, Herba Ajugae Lupulinae 16 weight portion, Herba Violae diffusae 15 weight portion, Herba Lysimachiae 28 weight portion, Radix Cudraniae 27 weight portion, Radix Scrophulariae 39 weight portion, Rhizoma Corydalis 16 weight portion, Herba Hyperici Japonici 17 weight portion, Cortex Sapii Radicis 18 weight portion, Folium Isatidis 14 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 37 weight portion, Rhizoma Dioscoreae 25 weight portion, Semen Euryales 26 weight portion, Rhizoma Cyperi 13 weight portion, Fructus Forsythiae 12 weight portion, Herba Lophatheri 11 weight portion, the Radix Paeoniae Alba 41 weight portion and Radix Clematidis 8 weight portion.

Described pharmaceutical composition also comprises Semen Arecae, Cortex Magnoliae Officinalis, Semen Raphani, Cortex Mori, Periostracum Cicadae and Folium Mori.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 25-35 weight portion, Herba lygodii 10-15 weight portion, Herba Cassiae Mimosoidis 25-35 weight portion, Radix Semiaquilegiae 20-32 weight portion, Herba Ajugae Lupulinae 12-18 weight portion, Herba Violae diffusae 9-18 weight portion, Herba Lysimachiae 25-35 weight portion, Radix Cudraniae 20-32 weight portion, Radix Scrophulariae 32-42 weight portion, Rhizoma Corydalis 10-17 weight portion, Herba Hyperici Japonici 10-19 weight portion, Cortex Sapii Radicis 12-19 weight portion, Folium Isatidis 10-18 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 30-40 weight portion, Rhizoma Dioscoreae 18-26 weight portion, Semen Euryales 19-27 weight portion, Rhizoma Cyperi 9-15 weight portion, Fructus Forsythiae 10-18 weight portion, Herba Lophatheri 10-14 weight portion, Radix Paeoniae Alba 30-42 weight portion, Radix Clematidis 6-12 weight portion, Semen Arecae 12-19 weight portion, Cortex Magnoliae Officinalis 15-28 weight portion, Semen Raphani 15-25 weight portion, Cortex Mori 10-15 weight portion, Periostracum Cicadae 10-18 weight portion and Folium Mori 12-19 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 32 weight portion, Herba lygodii 13 weight portion, Herba Cassiae Mimosoidis 29 weight portion, Radix Semiaquilegiae 30 weight portion, Herba Ajugae Lupulinae 16 weight portion, Herba Violae diffusae 15 weight portion, Herba Lysimachiae 28 weight portion, Radix Cudraniae 27 weight portion, Radix Scrophulariae 39 weight portion, Rhizoma Corydalis 16 weight portion, Herba Hyperici Japonici 17 weight portion, Cortex Sapii Radicis 18 weight portion, Folium Isatidis 14 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 37 weight portion, Rhizoma Dioscoreae 25 weight portion, Semen Euryales 26 weight portion, Rhizoma Cyperi 13 weight portion, Fructus Forsythiae 12 weight portion, Herba Lophatheri 11 weight portion, the Radix Paeoniae Alba 41 weight portion, Radix Clematidis 8 weight portion, Semen Arecae 16 weight portion, Cortex Magnoliae Officinalis 23 weight portion, Semen Raphani 19 weight portion, Cortex Mori 13 weight portion, Periostracum Cicadae 11 weight portion, Folium Mori 17 weight portion.

Also provide a kind of preparation method being used for the treatment of the pharmaceutical composition of cattle urinary stone to realize goal of the invention the present invention better, when the dosage form of described pharmaceutical composition is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Also provide a kind of preparation method being used for the treatment of the pharmaceutical composition of cattle urinary stone to realize goal of the invention the present invention better, when the dosage form of described pharmaceutical composition is powder, its preparation method comprises the following steps:

The first step, Herba Adianti, Herba lygodii, Herba Cassiae Mimosoidis, Radix Semiaquilegiae, Herba Ajugae Lupulinae and Herba Violae diffusae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Cudraniae, Radix Scrophulariae, Rhizoma Corydalis, Herba Hyperici Japonici and Cortex Sapii Radicis are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The invention has the beneficial effects as follows: pharmaceutical composition pain relieving calculus of the present invention, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome are main, to regulate lung qi, help gas calculus to be auxiliary, the course of disease can be reduced in time, improve cure rate, simultaneously low drug residue, cost is low, is applicable to large-area applications, can carries out marketing, the course for the treatment of is shorter, curative effect is better, and prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.

Detailed description of the invention

Pharmaceutical composition of the present invention follows the principle of pain relieving calculus, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, provide one and be used for the treatment of cattle urinary stone pharmaceutical composition, comprise following raw medicinal material: Herba Adianti, Herba lygodii, Herba Cassiae Mimosoidis, Radix Semiaquilegiae, Herba Ajugae Lupulinae, Herba Violae diffusae, Herba Lysimachiae, Radix Cudraniae, Radix Scrophulariae, Rhizoma Corydalis, Herba Hyperici Japonici, Cortex Sapii Radicis, Folium Isatidis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, Semen Euryales, Rhizoma Cyperi, Fructus Forsythiae, Herba Lophatheri, the Radix Paeoniae Alba and Radix Clematidis; Preferably, Semen Arecae, Cortex Magnoliae Officinalis, Semen Raphani, Cortex Mori, Periostracum Cicadae and Folium Mori can also be comprised.Wherein, Herba Adianti, Herba lygodii, Herba Cassiae Mimosoidis, Radix Semiaquilegiae, Herba Ajugae Lupulinae, Herba Violae diffusae inducing diuresis for treating stranguria syndrome, Herba Lysimachiae, Radix Cudraniae blood stasis dispelling amass settles accounts stone, and Herba Hyperici Japonici, Cortex Sapii Radicis, Folium Isatidis, Fructus Malvae, Rhizoma Saururi (Herba Saururi) pathogenic fire purging prevent Tianjin wound, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, the righting of Semen Euryales invigorating the spleen and replenishing QI; Semen Arecae, Cortex Magnoliae Officinalis, Semen Raphani, Rhizoma Cyperi, Cortex Mori, Periostracum Cicadae, Folium Mori regulate lung qi, help gas calculus; Fructus Forsythiae, Herba Lophatheri, Radix Scrophulariae, Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Clematidis removing toxic substances, yin nourishing, pain relieving, help calculus.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Herba Adianti: light is cool.Enter liver, kidney two warp.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cold, fever, cough spitting of blood, hepatitis, enteritis, dysentery, urinary tract infection, acute nephritis, mastitis; Furuncle is controlled in external, burn and scald.

Herba lygodii: sweet; Cold; Nontoxic.Return small intestinal; Bladder; Liver Channel.Heat-clearing and toxic substances removing; Relieving stranguria by diuresis; Promoting blood circulation to remove obstruction in the collateral.Main pyretic stranguria; Stranguria caused by urinary stone; Stranguria with blood; Dysuria; Edema; Nebulousurine; Leukorrhagia; Hepatitis; Have loose bowels; Dysentery; Cold, fever; Cough with asthma; Laryngopharynx swelling and pain; Aphtha; Conjunctival congestion and swelling pain; Mumps; Acute mastitis; Erysipelas; Herpes zoster; Burn due to hot liquid or fire; Skin pruritus; Traumatic injury wound is swollen; Rheumatic arthralgia; Traumatic hemorrhage.

Herba Cassiae Mimosoidis: sweet, micro-hardship is flat.Heat-clearing and toxic substances removing, diuresis, relieving constipation.For oedema due to nephritis, thirsty, cough with copious phlegm, habitual constipation, venom.

Radix Semiaquilegiae: sweet, bitter, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Control urate calculus, dribbling urination is unclear.For carbuncle furuncle, acute mastitis, scrofula, venom.

Herba Ajugae Lupulinae: bitter in the mouth; Pungent; Cold in nature.Return lung; Stomach; Liver Channel.Heat-clearing and toxic substances removing; Removing heat from blood is subsided a swelling.Main affection due to external wind and heat; Unconsciousness due to high fever; Tell nosebleed; Face is completed mouth and is drunk; Hypertension; Lung-heat cough with asthma; Lung abscess; Dysentery is suffered from abdominal pain; Hepatitis; Lithangiuria; Intestinal carbuncle; Conjunctival congestion and swelling pain; Laryngopharynx swelling and pain; Prunus mume (sieb.) sieb.et zucc. poison; Furuncle toxic swelling; Traumatic injury congestive edema; Traumatic hemorrhage; Venom.

Herba Violae diffusae: bitter, cold.Dispel the wind, heat clearing away, diuresis, removing toxic substances.Control cough due to pathogenic wind-heat, dysentery, stranguria with turbid discharge, carbuncle sore tumefacting virus, blepharitis, scald.

Herba Lysimachiae: sweet, salty, is slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.Eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom; Liver and bile stone, lithangiuria.

Radix Cudraniae: lightly seasoned; Micro-hardship; Cool in nature.Dispelling wind and removing obstruction in the collateral; Removing damp-heat; Removing toxic substances and promoting subsidence of swelling.Blood stimulates the menstrual flow, and controls stranguria with turbid discharge, goes long-pending, the calculus of the many years ago stasis of blood.Main air pain of dampness syndrome; Traumatic injury; Yellow cellulitis; Parotitis; Pulmonary tuberculosis; Gastric duodenal ulcer; Stranguria with turbid discharge; Distention of the abdomen caused by various parasites; Amenorrhea; Impairment caused by overstrain hemoptysis; Treatment carbuncle sore swells.

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel.Clearing away heat-fire, YIN nourishing and the production of body fluid promoting." detailed outline ": " kidney water is injured, Kidney-Yin fall, lonely positive unrooted, and send out as fire is sick, method should strengthen water with fire processed, therefore Radix Scrophulariae and the same merit of Radix Rehmanniae.Its scrofula that disappears also is loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." " Records of Tradition Chinese and Western Medicine in Combination ": " many liquid cool in nature was the medicine of the kidney invigorating warp clearly originally for Radix Scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of lung heat clearing man, removing toxic substances quench, is suitable for pneumonopathy tuberculosis most, cough due to lung-heat." " Japan hanako materia medica ": " control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strains, and the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison." there is clearing away heat and cooling blood, eliminating fire and detoxication, effect of YIN nourishing, cure mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.Taste have wet and insufficiency of the spleen loose stool person to avoid clothes.

Rhizoma Corydalis: pungent, bitter, temperature.Return liver, spleen channel.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.

Herba Hyperici Japonici: bitter in the mouth, flat; Return liver, gallbladder meridian." the SHENGCAO property of medicine is standby to be wanted ": " control wine disease, subside a swelling swollen, apply large malignant boil, reason chancre swells." " south of the Five Ridges gather medicinal herbs record ": " remove the yellow fire-toxin of nitre, apply shrimp pincers skin ulcer, reason traumatic injury, snakebite." dampness removing jaundice eliminating, heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Control infectious hepatitis, dysentery, infantile convulsion, infantile malnutrition, throat moth, acute appendicitis, furuncle and phyma, venom.

Cortex Sapii Radicis: bitter, tepor.Gui Jing: enter lung, spleen, kidney, large intestine channel.Slightly poisonous.For schistosomicide, cirrhotic ascites, defecation is unfavorable, venom; Furuncle is controlled in external, clavus, mastitis, traumatic injury, eczema, dermatitis.Parasite killing, removing toxic substances, diuresis, relieving constipation.

Folium Isatidis: bitter, cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, sends out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.

Rhizoma Atractylodis Macrocephalae (parched): sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.

Rhizoma Dioscoreae: sweet, flat, enters spleen, lung, kidney channel.Spleen benefiting and stimulating the appetite, boosting qi and nourishing yin, antidiarrheal arresting seminal emission.Cure mainly diarrhea due to hypofunction of the spleen, asthenia chronic cough, the diseases such as seminal emission, leukorrhagia frequent micturition of quenching one's thirst.

Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel." herbal classic ": " main arthralgia chiefly caused by damp pathogen spinal column gonalgia, invigorating middle warmer is except sudden and violent disease, and beneficial vital essence, Qiang Zhi, makes normal hearing and eyesight." there is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, is with inferior card.Record according to Compendium of Material Medica, Semen Euryales cure mainly arthralgia chiefly caused by damp pathogen, spinal column gonalgia, invigorating middle warmer, except sudden and violent disease, the strong will of beneficial vital essence, make normal hearing and eyesight, appetizing helps gas, quenches the thirst.

Rhizoma Cyperi: the pungent micro-hardship of nature and flavor is sweet, flat.Enter liver, tri-jiao channel.Compendium of Material Medica is said: " gas of Rhizoma Cyperi is flat and do not tremble with fear, fragrant and can alter, and how pungent its taste is can fall apart, and micro-hardship can be fallen, micro-sweet energy with "." Amplification on Materia Medica addendum ": " Rhizoma Cyperi, must soak with urine of baby boys, all vim and vigour medicines must with it, cause edema caused by disorder of QI and hemopoietic, the justice of this Yin grows while yang is generating is also." resolving depression of can regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian.Heat-clearing and toxic substances removing, dispelling wind and heat pathogens, clear skin ulcer is thoroughly malicious." property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti.Stick up greatly leaf long and narrow, as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the Chinese toon person of not opening in fact, sticks up outstanding grass as room.On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi is all carefully little like sticking up greatly, and mountain people from south also uses it.Only with sticking up son greatly under modern capital, without stem flower also." pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, be the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, the symptom such as laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.

Herba Lophatheri: nature and flavor, sweet, be slightly cold.Effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome.Compendium of Material Medica: " go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, and children's's pox poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome." vegetation is side just ": " expectorant is quenched the thirst.Control dysphoria with smothery sensation, cough with asthma, spit blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for calentura excessive thirst, heart stomach-fire is contained.

The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature, enters liver, spleen channel, joint venture of nourishing blood, easing the affected liver to relieve pain, and the effect of suppressing liver-YANG is mainly used in deficiecny of liver-YIN, the headache feeling of fullness in the head of excessive rising of liver-YANG, vertigo and tinnitus, irritable; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of deficiency of the liver stasis dampness; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery is suffered from abdominal pain; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the cards such as the carpopedal spasm pain of supporting.

Radix Clematidis: pungent, salty, temperature.Return urinary bladder channel." Kaibao Bencao ": " main all wind, Xuan Tongwu hides, and go in abdomen cold stagnant, septum cordis expectorant water amasss for a long time, lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, the cold pain of waist knee joint and treatment injured." " herbal classic is met former ": " and varioliform exanthema poison is stopped up and can not be assigned in upper, and under waist, shin knee joint rises and fills with slow person, with under draw." there is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, effect of the loose hypochondriac lump, cures mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, the cards such as all a fishbone or other bone caught in the throat pharynxs.

Semen Arecae: bitter in the mouth, pungent, warm in nature.Return stomach, large intestine channel.Have parasite killing, removing mass, sending down the abnormal ascending QI is capable stagnant, and row aquation wets.Effect.Cure mainly rapid digestion of food to relieve oedema or abdominal distension through diuresis or purgation, kill intestinal volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp nine orifices, relieving restlessness, caking in broken abdomen; Also can control beriberi, edema, chest pain, dysentery, abdominal distention is suffered from abdominal pain, defecation is unfavorable, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases.

Cortex Magnoliae Officinalis: bitter, pungent, temperature.Enter spleen, stomach, lung, large intestine channel.Warming the middle warmer and descending qi, drying dampness to eliminate phlegm, relievings asthma.Cure mainly gastral cavity abdominal distention vexed, stomachache, regurgitation is vomitted, the diseases such as cough with asthma.

Semen Raphani: property is put down, acrid in the mouth, sweet; Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.

Cortex Mori: Gan Han, enters lung meridian.Expelling phlegm for arresting cough, lets out lung diuretic.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly damaging the spleen and stomach, five kinds of over strain, six types of severe debility disease, weakness and emaciation, metrorrhagia, pulse disappeared, tonify deficiency, QI invigorating.Leaf: main except cold and heat, perspires." " Mingyi Bielu ": " nontoxic.Master goes aqueous vapor in lung, only hemoptysis, and heat is thirsty, edema, and abdominal distention, sets out swollen, dredging water passages, goes in vain very little, can stitch gold wound." " Japan hanako materia medica ": " and temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea." function eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.

Periostracum Cicadae: sweet, cold; Return lung, Liver Channel.Relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, relieving sore-throat by clearing away heat, rash is subsided a swelling, and improving acuity of vision and removing nebula, expellings wind and relieving convulsion.Amplification on Canon of Materia Medica: " control blurred vision nebula.Decocting shell juice again, controlling children's, to go out skin ulcer rash unhappy." Compendium of Material Medica: " controls phlegm-accumulating vertigo, skin wind heat, and varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva." loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.

Folium Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dense the boiling of dry person.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and Zheng Hou An; Scolopendra stings snakeworm, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

Embodiments provide a kind of pharmaceutical composition being used for the treatment of cattle urinary stone, be made up of the raw medicinal material of following parts by weight: Herba Adianti 32 weight portion, Herba lygodii 13 weight portion, Herba Cassiae Mimosoidis 29 weight portion, Radix Semiaquilegiae 30 weight portion, Herba Ajugae Lupulinae 16 weight portion, Herba Violae diffusae 15 weight portion, Herba Lysimachiae 28 weight portion, Radix Cudraniae 27 weight portion, Radix Scrophulariae 39 weight portion, Rhizoma Corydalis 16 weight portion, Herba Hyperici Japonici 17 weight portion, Cortex Sapii Radicis 18 weight portion, Folium Isatidis 14 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 37 weight portion, Rhizoma Dioscoreae 25 weight portion, Semen Euryales 26 weight portion, Rhizoma Cyperi 13 weight portion, Fructus Forsythiae 12 weight portion, Herba Lophatheri 11 weight portion, the Radix Paeoniae Alba 41 weight portion and Radix Clematidis 8 weight portion.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 pharmaceutical composition 2

Embodiments provide a kind of pharmaceutical composition being used for the treatment of cattle urinary stone, be made up of the raw medicinal material of following parts by weight: Herba Adianti 32 weight portion, Herba lygodii 13 weight portion, Herba Cassiae Mimosoidis 29 weight portion, Radix Semiaquilegiae 30 weight portion, Herba Ajugae Lupulinae 16 weight portion, Herba Violae diffusae 15 weight portion, Herba Lysimachiae 28 weight portion, Radix Cudraniae 27 weight portion, Radix Scrophulariae 39 weight portion, Rhizoma Corydalis 16 weight portion, Herba Hyperici Japonici 17 weight portion, Cortex Sapii Radicis 18 weight portion, Folium Isatidis 14 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 37 weight portion, Rhizoma Dioscoreae 25 weight portion, Semen Euryales 26 weight portion, Rhizoma Cyperi 13 weight portion, Fructus Forsythiae 12 weight portion, Herba Lophatheri 11 weight portion, the Radix Paeoniae Alba 41 weight portion, Radix Clematidis 8 weight portion, Semen Arecae 16 weight portion, Cortex Magnoliae Officinalis 23 weight portion, Semen Raphani 19 weight portion, Cortex Mori 13 weight portion, Periostracum Cicadae 11 weight portion and Folium Mori 17 weight portion.

Its preparation method is as follows:

The first step, Herba Adianti, Herba lygodii, Herba Cassiae Mimosoidis, Radix Semiaquilegiae, Herba Ajugae Lupulinae and Herba Violae diffusae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 1 times relative to the mixture quality obtained, reflux was extracted after 1 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Cudraniae, Radix Scrophulariae, Rhizoma Corydalis, Herba Hyperici Japonici and Cortex Sapii Radicis are mixed in described ratio, add the ethanol of the determining alcohol 95% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 1 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 1 times relative to the mixture quality obtained, again heat decoction 2 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The toxicity test of pharmaceutical composition:

1, trial drug

Choose Herba Adianti 32g, Herba lygodii 13g, Herba Cassiae Mimosoidis 29g, Radix Semiaquilegiae 30g, Herba Ajugae Lupulinae 16g, Herba Violae diffusae 15g, Herba Lysimachiae 28g, Radix Cudraniae 27g, Radix Scrophulariae 39g, Rhizoma Corydalis 16g, Herba Hyperici Japonici 17g, Cortex Sapii Radicis 18g, Folium Isatidis 14g, Rhizoma Atractylodis Macrocephalae (parched) 37g, Rhizoma Dioscoreae 25g, Semen Euryales 26g, Rhizoma Cyperi 13g, Fructus Forsythiae 12g, Herba Lophatheri 11g, Radix Paeoniae Alba 41g and Radix Clematidis 8g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Model case 1

Have a head of cattle in the cattle of Jining of Shandong Province farm, performance is uneasy, rises and retires peaceful, hogback crouching waist, and hind leg plays abdomen, and frequently stick up tail and to urinate posture, urine dribs and drabs when urinating, urinate not go out for urine, and ostium praeputiale becomes mildewed and above has tiny calculus.Sick cattle body temperature 38.3 DEG C, heart beating is slightly fast, and rumen peristalsis is normal.Through examination per rectum after inquiry poultry raiser, urinary bladder-distention very large, is full of urine, oppresses also difficulty and urinate.Be diagnosed as urinary stone disease.The injectable powder of the injection embodiment of the present invention 1, injectable powder adopts subcutaneous injection, each 60mg/1kg, and once a day, after half an hour, sick cattle starts to urinate, and urinates altogether 3 times in 2 hours, gets rid of calculus number piece.Continuous injection 3 days, cured after 3 days.Follow up a case by regular visits to after 1 year and do not recur.

Model case 2

The a head of cattle of Jining, Inner Mongol animal farm suffers from urinary stone, and rear quarters waves, and hind leg opens, and again and again exerts duty, drips as room leaks to drench for urine sample, urinates not smooth, sick cattle body temperature 38.8 DEG C, with aminophylline 30 milliliters, an intramuscular injection is invalid.Within second day, feed and be added with the feedstuff of the embodiment of the present invention 2 powder, powder is mixed in conventional feed according to 3:100 weight ratio, eats and starts to urinate after 30 minutes, but voided volume is not too large, the 3rd finds to discharge calculus everyday, feeds altogether 2 days, cure, follow up a case by regular visits to after 2 years and do not recur.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. be used for the treatment of the pharmaceutical composition of cattle urinary stone, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Herba Adianti, Herba lygodii, Herba Cassiae Mimosoidis, Radix Semiaquilegiae, Herba Ajugae Lupulinae, Herba Violae diffusae, Herba Lysimachiae, Radix Cudraniae, Radix Scrophulariae, Rhizoma Corydalis, Herba Hyperici Japonici, Cortex Sapii Radicis, Folium Isatidis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, Semen Euryales, Rhizoma Cyperi, Fructus Forsythiae, Herba Lophatheri, the Radix Paeoniae Alba and Radix Clematidis.

2. the pharmaceutical composition being used for the treatment of cattle urinary stone according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 25-35 weight portion, Herba lygodii 10-15 weight portion, Herba Cassiae Mimosoidis 25-35 weight portion, Radix Semiaquilegiae 20-32 weight portion, Herba Ajugae Lupulinae 12-18 weight portion, Herba Violae diffusae 9-18 weight portion, Herba Lysimachiae 25-35 weight portion, Radix Cudraniae 20-32 weight portion, Radix Scrophulariae 32-42 weight portion, Rhizoma Corydalis 10-17 weight portion, Herba Hyperici Japonici 10-19 weight portion, Cortex Sapii Radicis 12-19 weight portion, Folium Isatidis 10-18 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 30-40 weight portion, Rhizoma Dioscoreae 18-26 weight portion, Semen Euryales 19-27 weight portion, Rhizoma Cyperi 9-15 weight portion, Fructus Forsythiae 10-18 weight portion, Herba Lophatheri 10-14 weight portion, Radix Paeoniae Alba 30-42 weight portion and Radix Clematidis 6-12 weight portion.

3. the pharmaceutical composition being used for the treatment of cattle urinary stone according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 32 weight portion, Herba lygodii 13 weight portion, Herba Cassiae Mimosoidis 29 weight portion, Radix Semiaquilegiae 30 weight portion, Herba Ajugae Lupulinae 16 weight portion, Herba Violae diffusae 15 weight portion, Herba Lysimachiae 28 weight portion, Radix Cudraniae 27 weight portion, Radix Scrophulariae 39 weight portion, Rhizoma Corydalis 16 weight portion, Herba Hyperici Japonici 17 weight portion, Cortex Sapii Radicis 18 weight portion, Folium Isatidis 14 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 37 weight portion, Rhizoma Dioscoreae 25 weight portion, Semen Euryales 26 weight portion, Rhizoma Cyperi 13 weight portion, Fructus Forsythiae 12 weight portion, Herba Lophatheri 11 weight portion, the Radix Paeoniae Alba 41 weight portion and Radix Clematidis 8 weight portion.

4. the pharmaceutical composition being used for the treatment of cattle urinary stone according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises Semen Arecae, Cortex Magnoliae Officinalis, Semen Raphani, Cortex Mori, Periostracum Cicadae and Folium Mori.

5. the pharmaceutical composition being used for the treatment of cattle urinary stone according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 25-35 weight portion, Herba lygodii 10-15 weight portion, Herba Cassiae Mimosoidis 25-35 weight portion, Radix Semiaquilegiae 20-32 weight portion, Herba Ajugae Lupulinae 12-18 weight portion, Herba Violae diffusae 9-18 weight portion, Herba Lysimachiae 25-35 weight portion, Radix Cudraniae 20-32 weight portion, Radix Scrophulariae 32-42 weight portion, Rhizoma Corydalis 10-17 weight portion, Herba Hyperici Japonici 10-19 weight portion, Cortex Sapii Radicis 12-19 weight portion, Folium Isatidis 10-18 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 30-40 weight portion, Rhizoma Dioscoreae 18-26 weight portion, Semen Euryales 19-27 weight portion, Rhizoma Cyperi 9-15 weight portion, Fructus Forsythiae 10-18 weight portion, Herba Lophatheri 10-14 weight portion, Radix Paeoniae Alba 30-42 weight portion, Radix Clematidis 6-12 weight portion, Semen Arecae 12-19 weight portion, Cortex Magnoliae Officinalis 15-28 weight portion, Semen Raphani 15-25 weight portion, Cortex Mori 10-15 weight portion, Periostracum Cicadae 10-18 weight portion and Folium Mori 12-19 weight portion.

6. the pharmaceutical composition being used for the treatment of cattle urinary stone according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Adianti 32 weight portion, Herba lygodii 13 weight portion, Herba Cassiae Mimosoidis 29 weight portion, Radix Semiaquilegiae 30 weight portion, Herba Ajugae Lupulinae 16 weight portion, Herba Violae diffusae 15 weight portion, Herba Lysimachiae 28 weight portion, Radix Cudraniae 27 weight portion, Radix Scrophulariae 39 weight portion, Rhizoma Corydalis 16 weight portion, Herba Hyperici Japonici 17 weight portion, Cortex Sapii Radicis 18 weight portion, Folium Isatidis 14 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 37 weight portion, Rhizoma Dioscoreae 25 weight portion, Semen Euryales 26 weight portion, Rhizoma Cyperi 13 weight portion, Fructus Forsythiae 12 weight portion, Herba Lophatheri 11 weight portion, the Radix Paeoniae Alba 41 weight portion, Radix Clematidis 8 weight portion, Semen Arecae 16 weight portion, Cortex Magnoliae Officinalis 23 weight portion, Semen Raphani 19 weight portion, Cortex Mori 13 weight portion, Periostracum Cicadae 11 weight portion, Folium Mori 17 weight portion.

7. the pharmaceutical composition being used for the treatment of cattle urinary stone according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. the pharmaceutical composition being used for the treatment of cattle urinary stone according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, Herba Adianti, Herba lygodii, Herba Cassiae Mimosoidis, Radix Semiaquilegiae, Herba Ajugae Lupulinae and Herba Violae diffusae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Cudraniae, Radix Scrophulariae, Rhizoma Corydalis, Herba Hyperici Japonici and Cortex Sapii Radicis are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.