CN104030967A - 一种dpp-iv抑制剂的中间体、其制备方法和通过其制备dpp-iv抑制剂的方法 - Google Patents
一种dpp-iv抑制剂的中间体、其制备方法和通过其制备dpp-iv抑制剂的方法 Download PDFInfo
- Publication number
- CN104030967A CN104030967A CN201310069735.5A CN201310069735A CN104030967A CN 104030967 A CN104030967 A CN 104030967A CN 201310069735 A CN201310069735 A CN 201310069735A CN 104030967 A CN104030967 A CN 104030967A
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- China
- Prior art keywords
- compound
- formula
- suc
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- 0 *N1C[C@@](CC(C2)=*)[C@@]2C1 Chemical compound *N1C[C@@](CC(C2)=*)[C@@]2C1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
缩写 | 全称 |
Bn | 苄基 |
Boc | 叔丁氧羰基 |
Cbz | 苄氧羰基 |
Claims (14)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310069735.5A CN104030967B (zh) | 2013-03-05 | 2013-03-05 | 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 |
TW103106002A TW201443017A (zh) | 2013-03-05 | 2014-02-24 | 一種dpp-iv抑制劑的中間體、其製備方法和經由其製備dpp-iv抑制劑的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310069735.5A CN104030967B (zh) | 2013-03-05 | 2013-03-05 | 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104030967A true CN104030967A (zh) | 2014-09-10 |
CN104030967B CN104030967B (zh) | 2018-01-02 |
Family
ID=51461991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310069735.5A Active CN104030967B (zh) | 2013-03-05 | 2013-03-05 | 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN104030967B (zh) |
TW (1) | TW201443017A (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101050194A (zh) * | 2006-04-05 | 2007-10-10 | 上海恒瑞医药有限公司 | 双环辛烷类衍生物、其制备方法及其在医药上的用途 |
CN101230059A (zh) * | 2007-01-23 | 2008-07-30 | 上海恒瑞医药有限公司 | 双环氮杂烷类衍生物、其制备方法及其在医药上的用途 |
WO2009094866A1 (fr) * | 2008-01-23 | 2009-08-06 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Dérivés de dicycloazaalcane, leurs procédés de préparation et utilisations médicales |
CN101904840A (zh) * | 2009-06-08 | 2010-12-08 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
CN101919851A (zh) * | 2009-06-09 | 2010-12-22 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
-
2013
- 2013-03-05 CN CN201310069735.5A patent/CN104030967B/zh active Active
-
2014
- 2014-02-24 TW TW103106002A patent/TW201443017A/zh unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101050194A (zh) * | 2006-04-05 | 2007-10-10 | 上海恒瑞医药有限公司 | 双环辛烷类衍生物、其制备方法及其在医药上的用途 |
CN101230059A (zh) * | 2007-01-23 | 2008-07-30 | 上海恒瑞医药有限公司 | 双环氮杂烷类衍生物、其制备方法及其在医药上的用途 |
WO2009094866A1 (fr) * | 2008-01-23 | 2009-08-06 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Dérivés de dicycloazaalcane, leurs procédés de préparation et utilisations médicales |
CN101904840A (zh) * | 2009-06-08 | 2010-12-08 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
CN101919851A (zh) * | 2009-06-09 | 2010-12-22 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
Non-Patent Citations (3)
Title |
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DINA TRIFANOVA,等: "The synthesis of potential Neramexane metabolites: cis- and trans-3-amino-1,3,5,5-tetramethylcyclohexanecarboxylic acids", 《TETRAHEDRON LETTERS》 * |
TANG PENG CHO ,等: "Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
TANG PENG CHO,等: "Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Also Published As
Publication number | Publication date |
---|---|
TW201443017A (zh) | 2014-11-16 |
CN104030967B (zh) | 2018-01-02 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20170220 Address after: 222200 Jiangsu city of Lianyungang province Guanyun County Harbor Industrial Zone weft seven road No. 1 Applicant after: LIANYUNGANG HENGYUN MEDICAL TECHNOLOGY CO., LTD. Address before: 201203 Shanghai Zhangjiang High Tech Park of Pudong New Area Cailun Road No. 399 Applicant before: UniTris Biopharma Co., Ltd. |
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TA01 | Transfer of patent application right |
Effective date of registration: 20170527 Address after: 222200 Guanyun City, Jiangsu province Lingang Industrial Zone, the south side of the weft Road, eight Applicant after: Lianyungang Hengyun Pharmaceutical Co. Ltd. Address before: 222200 Jiangsu city of Lianyungang province Guanyun County Harbor Industrial Zone weft seven road No. 1 Applicant before: LIANYUNGANG HENGYUN MEDICAL TECHNOLOGY CO., LTD. |
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CB02 | Change of applicant information |
Address after: 222200 Guanyun City, Jiangsu province Lingang Industrial Zone, the south side of the weft Road, eight Applicant after: Lianyungang Hengyun Pharmaceutical Co. Ltd. Address before: 222200 Guanyun City, Jiangsu province Lingang Industrial Zone, the south side of the weft Road, eight Applicant before: Lianyungang Hengyun Pharmaceutical Co. Ltd. |
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