CN104030967B - 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 - Google Patents
一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 Download PDFInfo
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- CN104030967B CN104030967B CN201310069735.5A CN201310069735A CN104030967B CN 104030967 B CN104030967 B CN 104030967B CN 201310069735 A CN201310069735 A CN 201310069735A CN 104030967 B CN104030967 B CN 104030967B
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- formula
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- dpp
- inhibitor
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- 0 C*(C1)CC(C)(C2)[C@@]1CN2C(N(C)*)=O Chemical compound C*(C1)CC(C)(C2)[C@@]1CN2C(N(C)*)=O 0.000 description 6
- QZUCRNBAELEXMD-AOOOYVTPSA-N CC(C)(C1)C[C@@H](C2)[C@H]1CN2C(N(C)C)=O Chemical compound CC(C)(C1)C[C@@H](C2)[C@H]1CN2C(N(C)C)=O QZUCRNBAELEXMD-AOOOYVTPSA-N 0.000 description 1
- MAOKMKIGLSXYOL-WDSKDSINSA-N NCC(N(C[C@H](C1)F)[C@@H]1C#N)=O Chemical compound NCC(N(C[C@H](C1)F)[C@@H]1C#N)=O MAOKMKIGLSXYOL-WDSKDSINSA-N 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
缩写 | 全称 |
Bn | 苄基 |
Boc | 叔丁氧羰基 |
Cbz | 苄氧羰基 |
Claims (12)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310069735.5A CN104030967B (zh) | 2013-03-05 | 2013-03-05 | 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 |
TW103106002A TW201443017A (zh) | 2013-03-05 | 2014-02-24 | 一種dpp-iv抑制劑的中間體、其製備方法和經由其製備dpp-iv抑制劑的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310069735.5A CN104030967B (zh) | 2013-03-05 | 2013-03-05 | 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104030967A CN104030967A (zh) | 2014-09-10 |
CN104030967B true CN104030967B (zh) | 2018-01-02 |
Family
ID=51461991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201310069735.5A Active CN104030967B (zh) | 2013-03-05 | 2013-03-05 | 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法 |
Country Status (2)
Country | Link |
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CN (1) | CN104030967B (zh) |
TW (1) | TW201443017A (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101050194A (zh) * | 2006-04-05 | 2007-10-10 | 上海恒瑞医药有限公司 | 双环辛烷类衍生物、其制备方法及其在医药上的用途 |
CN101230059A (zh) * | 2007-01-23 | 2008-07-30 | 上海恒瑞医药有限公司 | 双环氮杂烷类衍生物、其制备方法及其在医药上的用途 |
WO2009094866A1 (fr) * | 2008-01-23 | 2009-08-06 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Dérivés de dicycloazaalcane, leurs procédés de préparation et utilisations médicales |
CN101904840A (zh) * | 2009-06-08 | 2010-12-08 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
CN101919851A (zh) * | 2009-06-09 | 2010-12-22 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
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2013
- 2013-03-05 CN CN201310069735.5A patent/CN104030967B/zh active Active
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2014
- 2014-02-24 TW TW103106002A patent/TW201443017A/zh unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101050194A (zh) * | 2006-04-05 | 2007-10-10 | 上海恒瑞医药有限公司 | 双环辛烷类衍生物、其制备方法及其在医药上的用途 |
CN101230059A (zh) * | 2007-01-23 | 2008-07-30 | 上海恒瑞医药有限公司 | 双环氮杂烷类衍生物、其制备方法及其在医药上的用途 |
WO2009094866A1 (fr) * | 2008-01-23 | 2009-08-06 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Dérivés de dicycloazaalcane, leurs procédés de préparation et utilisations médicales |
CN101904840A (zh) * | 2009-06-08 | 2010-12-08 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
CN101919851A (zh) * | 2009-06-09 | 2010-12-22 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
Non-Patent Citations (3)
Title |
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Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes;Tang Peng Cho,等;《Bioorganic & Medicinal Chemistry Letters》;20100518;第20卷;3565-3568 * |
Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes;Tang Peng Cho ,等;《Bioorganic & Medicinal Chemistry Letters》;20100518;第20卷;3521-3525 * |
The synthesis of potential Neramexane metabolites: cis- and trans-3-amino-1,3,5,5-tetramethylcyclohexanecarboxylic acids;Dina Trifanova,等;《Tetrahedron Letters》;20040922;第45卷;8145-8147 * |
Also Published As
Publication number | Publication date |
---|---|
CN104030967A (zh) | 2014-09-10 |
TW201443017A (zh) | 2014-11-16 |
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Effective date of registration: 20170220 Address after: 222200 Jiangsu city of Lianyungang province Guanyun County Harbor Industrial Zone weft seven road No. 1 Applicant after: LIANYUNGANG HENGYUN MEDICAL TECHNOLOGY CO., LTD. Address before: 201203 Shanghai Zhangjiang High Tech Park of Pudong New Area Cailun Road No. 399 Applicant before: UniTris Biopharma Co., Ltd. |
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Effective date of registration: 20170527 Address after: 222200 Guanyun City, Jiangsu province Lingang Industrial Zone, the south side of the weft Road, eight Applicant after: Lianyungang Hengyun Pharmaceutical Co. Ltd. Address before: 222200 Jiangsu city of Lianyungang province Guanyun County Harbor Industrial Zone weft seven road No. 1 Applicant before: LIANYUNGANG HENGYUN MEDICAL TECHNOLOGY CO., LTD. |
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Address after: 222200 Guanyun City, Jiangsu province Lingang Industrial Zone, the south side of the weft Road, eight Applicant after: Lianyungang Hengyun Pharmaceutical Co. Ltd. Address before: 222200 Guanyun City, Jiangsu province Lingang Industrial Zone, the south side of the weft Road, eight Applicant before: Lianyungang Hengyun Pharmaceutical Co. Ltd. |
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