MA30402B1 - Acides carboxyliques substitues par des phenylamino-benzoxazoles, leur procede de production et leur utilisation comme medicaments - Google Patents

Acides carboxyliques substitues par des phenylamino-benzoxazoles, leur procede de production et leur utilisation comme medicaments

Info

Publication number
MA30402B1
MA30402B1 MA31362A MA31362A MA30402B1 MA 30402 B1 MA30402 B1 MA 30402B1 MA 31362 A MA31362 A MA 31362A MA 31362 A MA31362 A MA 31362A MA 30402 B1 MA30402 B1 MA 30402B1
Authority
MA
Morocco
Prior art keywords
phenylamino
carboxylic acids
medicaments
production
substituted carboxylic
Prior art date
Application number
MA31362A
Other languages
English (en)
Inventor
Elisabeth Defossa
Markus Follmann
Thomas Klabunde
Viktoria Drosou
Gerhard Hessler
Siegfried Stengelin
Guido Haschke
Andreas Herling
Stefan Bartoschek
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA30402B1 publication Critical patent/MA30402B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES ACIDES CARBOXYLIQUES SUBSTITUÉS PAR DES PHÉNYLAMINO-BENZOXAZOLES ET LEURS SELS PHYSIOLOGIQUEMENT COMPATIBLES. L'INVENTION CONCERNE ÉGALEMENT LES COMPOSÉS DE FORMULE (I), DANS LAQUELLE R1, R2, R6, R7, R8, R9, R10, M ET X SONT DÉFINIS COMME DANS LA DESCRIPTION, ET LEURS SELS PHYSIOLOGIQUEMENT COMPATIBLES. LESDITS COMPOSÉS CONVIENNENT, PAR EXEMPLE, AU TRAITEMENT DU DIABÈTE.
MA31362A 2006-05-11 2008-11-05 Acides carboxyliques substitues par des phenylamino-benzoxazoles, leur procede de production et leur utilisation comme medicaments MA30402B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006021878A DE102006021878A1 (de) 2006-05-11 2006-05-11 Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
MA30402B1 true MA30402B1 (fr) 2009-05-04

Family

ID=38371048

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31362A MA30402B1 (fr) 2006-05-11 2008-11-05 Acides carboxyliques substitues par des phenylamino-benzoxazoles, leur procede de production et leur utilisation comme medicaments

Country Status (31)

Country Link
US (2) US20090149519A1 (fr)
EP (1) EP2024347B1 (fr)
JP (1) JP2009536629A (fr)
KR (1) KR20090006846A (fr)
CN (1) CN101437805B (fr)
AR (1) AR060990A1 (fr)
AU (1) AU2007250213B2 (fr)
BR (1) BRPI0711448A2 (fr)
CA (1) CA2651660A1 (fr)
CO (1) CO6241107A2 (fr)
CY (1) CY1113177T1 (fr)
DE (1) DE102006021878A1 (fr)
DK (1) DK2024347T3 (fr)
ES (1) ES2391203T3 (fr)
HK (1) HK1131978A1 (fr)
HR (1) HRP20120829T1 (fr)
IL (1) IL195179A0 (fr)
MA (1) MA30402B1 (fr)
MX (1) MX2008014102A (fr)
MY (1) MY148258A (fr)
NO (1) NO20085068L (fr)
NZ (1) NZ572692A (fr)
PL (1) PL2024347T3 (fr)
PT (1) PT2024347E (fr)
RS (1) RS52450B (fr)
RU (1) RU2434003C2 (fr)
SI (1) SI2024347T1 (fr)
TW (1) TW200812987A (fr)
UY (1) UY30338A1 (fr)
WO (1) WO2007131622A1 (fr)
ZA (1) ZA200808490B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
AU2006291234A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
CA2662305C (fr) 2006-09-07 2012-04-17 Amgen Inc. Modulateurs heterocycliques du recepteur couple a la proteine g (gpr40)
EP2061760A1 (fr) 2006-09-07 2009-05-27 Amgen, Inc Composés benzo-fusionnés destinés à être utilisés dans le traitement de troubles métaboliques
EP2139843B1 (fr) 2007-04-16 2013-12-25 Amgen, Inc Modulateurs de gpr40 des acides biphényle phénoxy, thiophényle et aminophénylpropanoïque substitués
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
KR20100090249A (ko) 2007-10-10 2010-08-13 암젠 인크 치환된 비페닐 ｇｒｐ４０ 조절제
WO2009145829A1 (fr) * 2008-04-01 2009-12-03 University Of Massachusetts Inhibiteurs de sécrétion de type iii, leurs analogues et utilisation de ceux-ci
JP2011515341A (ja) 2008-03-06 2011-05-19 アムジエン・インコーポレーテツド 代謝障害の治療に有用な立体配座的に制限されたカルボン酸誘導体
EP2358656B1 (fr) 2008-10-15 2014-01-01 Amgen, Inc Modulateurs spirocycliques de gpr40
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
WO2011140190A1 (fr) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Tétrazolones utilisés en tant qu'inhibiteurs d'acide gras synthase (fasn)
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
JP2013538215A (ja) 2010-08-31 2013-10-10 エスエヌユー アールアンドディービー ファウンデーション ＰＰＡＲδアゴニストの胎児再プログラミング用途
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013039140A1 (fr) * 2011-09-14 2013-03-21 第一三共株式会社 Dérivé hétérocyclique condensé
EP2760862B1 (fr) 2011-09-27 2015-10-21 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
EP2911655A1 (fr) 2012-10-24 2015-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibiteurs de la kinase tpl2 pour prévenir ou traiter le diabète et favoriser la survie de cellules
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
EP3102198B1 (fr) 2014-02-06 2020-08-26 Merck Sharp & Dohme Corp. Composés antidiabétiques
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
AU2019222644B2 (en) 2018-02-13 2021-04-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN112041311B (zh) 2018-04-19 2023-10-03 吉利德科学公司 Pd-1/pd-l1抑制剂
EP4234030A3 (fr) 2018-07-13 2023-10-18 Gilead Sciences, Inc. Inhibiteurs de pd-1/pd-l1
WO2020086556A1 (fr) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Inhibiteurs de pd-1/pd-l1
AU2020206036A1 (en) 2019-01-11 2021-08-05 Naegis Pharmaceuticals Inc. Leukotriene synthesis inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
US4025637A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2,5 OR 2,6 Disubstituted benzoxazoles
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
EP0664792B1 (fr) * 1992-10-14 2000-01-05 Merck & Co. Inc. Antagonistes des recepteurs du fibrinogene
ES2201452T3 (es) * 1997-03-14 2004-03-16 Vertex Pharmaceuticals Incorporated Inhibidores de la enzima impdh.
EP1133484A2 (fr) * 1998-07-23 2001-09-19 AstraZeneca AB Composes chimiques
DE60027700T2 (de) * 1999-02-16 2007-05-03 Aventis Pharma Ltd., West Malling Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden
GB0001346D0 (en) * 2000-01-21 2000-03-08 Astrazeneca Uk Ltd Chemical compounds
WO2002036553A2 (fr) * 2000-11-04 2002-05-10 Aventis Pharma Limited Acides alcanoiqies substitues
IL156064A0 (en) * 2000-12-28 2003-12-23 Daiichi Seiyaku Co Vla-4 inhibitors
JP4805552B2 (ja) * 2003-05-30 2011-11-02 武田薬品工業株式会社 縮合環化合物
GB0401334D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
JP2006056830A (ja) * 2004-08-20 2006-03-02 Dai Ichi Seiyaku Co Ltd ２−アリールアミノベンゾオキサゾール誘導体

Also Published As

Publication number Publication date
HK1131978A1 (en) 2010-02-12
JP2009536629A (ja) 2009-10-15
EP2024347B1 (fr) 2012-08-01
US20090149519A1 (en) 2009-06-11
EP2024347A1 (fr) 2009-02-18
IL195179A0 (en) 2009-08-03
PT2024347E (pt) 2012-10-09
NZ572692A (en) 2011-03-31
SI2024347T1 (sl) 2012-11-30
US20130303578A1 (en) 2013-11-14
NO20085068L (no) 2009-02-04
AR060990A1 (es) 2008-07-30
WO2007131622A1 (fr) 2007-11-22
CA2651660A1 (fr) 2007-11-22
CO6241107A2 (es) 2011-01-20
KR20090006846A (ko) 2009-01-15
AU2007250213A1 (en) 2007-11-22
CN101437805B (zh) 2012-05-30
RU2008148838A (ru) 2010-06-20
US8748465B2 (en) 2014-06-10
PL2024347T3 (pl) 2013-01-31
UY30338A1 (es) 2008-01-02
DK2024347T3 (da) 2012-10-29
MY148258A (en) 2013-03-29
AU2007250213B2 (en) 2013-04-11
MX2008014102A (es) 2008-11-14
HRP20120829T1 (hr) 2012-11-30
ES2391203T3 (es) 2012-11-22
TW200812987A (en) 2008-03-16
RS52450B (en) 2013-02-28
CN101437805A (zh) 2009-05-20
DE102006021878A1 (de) 2007-11-15
BRPI0711448A2 (pt) 2011-11-08
ZA200808490B (en) 2009-10-28
RU2434003C2 (ru) 2011-11-20
CY1113177T1 (el) 2016-04-13

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