CN104024272B - 用于浅灰霉素和甲基浅灰霉素的生物合成的基因簇 - Google Patents

用于浅灰霉素和甲基浅灰霉素的生物合成的基因簇 Download PDF

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CN104024272B
CN104024272B CN201280061301.4A CN201280061301A CN104024272B CN 104024272 B CN104024272 B CN 104024272B CN 201280061301 A CN201280061301 A CN 201280061301A CN 104024272 B CN104024272 B CN 104024272B
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protein
nucleic acid
orf
seq
methyl
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Expired - Fee Related
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CN104024272A (zh
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M.布洛恩斯特拉普
C.凯尼格
L.托蒂
J.温克
W.勒希纳
J.加森休伯
R.米勒
S.温策尔
T.宾兹
C.沃尔兹
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Sanofi SA
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Sanofi SA
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
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  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrrole Compounds (AREA)
CN201280061301.4A 2011-10-12 2012-10-11 用于浅灰霉素和甲基浅灰霉素的生物合成的基因簇 Expired - Fee Related CN104024272B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11306321.8 2011-10-12
EP11306321 2011-10-12
EP11306400.0 2011-10-28
EP11306400.0A EP2586791A1 (en) 2011-10-28 2011-10-28 Gene cluster for biosynthesis of griselimycin and methylgriselimycin
PCT/EP2012/070213 WO2013053857A2 (en) 2011-10-12 2012-10-11 Gene cluster for biosynthesis of griselimycin and methylgriselimycin

Publications (2)

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CN104024272A CN104024272A (zh) 2014-09-03
CN104024272B true CN104024272B (zh) 2018-04-20

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CN201280061301.4A Expired - Fee Related CN104024272B (zh) 2011-10-12 2012-10-11 用于浅灰霉素和甲基浅灰霉素的生物合成的基因簇

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US (1) US9422566B2 (enExample)
EP (1) EP2766389B1 (enExample)
JP (1) JP6430250B2 (enExample)
CN (1) CN104024272B (enExample)
EA (1) EA029209B1 (enExample)
IN (1) IN2014CN03414A (enExample)
WO (1) WO2013053857A2 (enExample)

Families Citing this family (7)

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EA029209B1 (ru) 2011-10-12 2018-02-28 Санофи Кластер генов биосинтеза гризелимицина и метилгризелимицина
US10336999B2 (en) 2015-05-29 2019-07-02 Zymergen Inc. Compositions and methods for activating silent gene clusters
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
KR20180084756A (ko) 2015-12-07 2018-07-25 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터
WO2018005793A1 (en) 2016-06-30 2018-01-04 Zymergen Inc. Methods for generating a glucose permease library and uses thereof
WO2018005655A2 (en) 2016-06-30 2018-01-04 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1388252A (zh) * 2002-08-06 2003-01-01 中国医学科学院医药生物技术研究所 吸水链霉菌17997生物合成格尔德霉素的基因簇
CN101016533A (zh) * 2005-11-09 2007-08-15 上海医药工业研究院 一种蒽环类抗生素产生工程菌及其应用
CN101586112A (zh) * 2009-06-19 2009-11-25 中国科学院上海有机化学研究所 诺丝七肽的生物合成基因簇
CN102021187A (zh) * 2003-10-23 2011-04-20 上海交通大学 Fr-008聚酮抗生素生物合成相关的基因簇

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FR2126108B1 (enExample) 1971-02-25 1974-08-02 Rhone Poulenc Sa
FI107053B (fi) 1998-10-23 2001-05-31 Galilaeus Oy Nogalamysiinin biosynteesiin liittyvä geeniryhmittymä ja sen käyttö hybridiantibioottien tuotossa
EP1326983B1 (en) * 2000-10-13 2005-04-06 Ecopia Biosciences Inc. Gene cluster for ramoplanin biosynthesis
AU2002324580A1 (en) * 2001-08-06 2003-02-24 Cubist Pharmaceuticals, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
WO2009019524A1 (en) * 2007-08-03 2009-02-12 Naicons S.C.A.R.L. Genes and proteins for the biosynthesis of the lantibiotic 107891
EA029209B1 (ru) 2011-10-12 2018-02-28 Санофи Кластер генов биосинтеза гризелимицина и метилгризелимицина

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1388252A (zh) * 2002-08-06 2003-01-01 中国医学科学院医药生物技术研究所 吸水链霉菌17997生物合成格尔德霉素的基因簇
CN102021187A (zh) * 2003-10-23 2011-04-20 上海交通大学 Fr-008聚酮抗生素生物合成相关的基因簇
CN101016533A (zh) * 2005-11-09 2007-08-15 上海医药工业研究院 一种蒽环类抗生素产生工程菌及其应用
CN101586112A (zh) * 2009-06-19 2009-11-25 中国科学院上海有机化学研究所 诺丝七肽的生物合成基因簇

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Structure of griselimycin, polypeptide antibiotic extracted from streptomyces cultures. 3.Products related to griselimycin;Terlain B.等;《Bulltein de la societe chimique de France》;19710630;第6卷;第2363-2365页 *

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Publication number Publication date
US9422566B2 (en) 2016-08-23
JP2014530609A (ja) 2014-11-20
JP6430250B2 (ja) 2018-11-28
IN2014CN03414A (enExample) 2015-10-09
EA029209B1 (ru) 2018-02-28
US20140295457A1 (en) 2014-10-02
EP2766389B1 (en) 2017-03-29
CN104024272A (zh) 2014-09-03
EA201490767A1 (ru) 2014-09-30
WO2013053857A2 (en) 2013-04-18
WO2013053857A3 (en) 2013-08-01
EP2766389A2 (en) 2014-08-20

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