CN104010636B - 三环化合物、包含它们的组合物及其用途 - Google Patents
三环化合物、包含它们的组合物及其用途 Download PDFInfo
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- CN104010636B CN104010636B CN201280060159.1A CN201280060159A CN104010636B CN 104010636 B CN104010636 B CN 104010636B CN 201280060159 A CN201280060159 A CN 201280060159A CN 104010636 B CN104010636 B CN 104010636B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559964P | 2011-11-15 | 2011-11-15 | |
| US61/559,964 | 2011-11-15 | ||
| US201261603508P | 2012-02-27 | 2012-02-27 | |
| US61/603,508 | 2012-02-27 | ||
| PCT/IL2012/050461 WO2013072915A1 (en) | 2011-11-15 | 2012-11-15 | Tricyclic compounds, compositions comprising them and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104010636A CN104010636A (zh) | 2014-08-27 |
| CN104010636B true CN104010636B (zh) | 2017-04-12 |
Family
ID=48429067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280060159.1A Active CN104010636B (zh) | 2011-11-15 | 2012-11-15 | 三环化合物、包含它们的组合物及其用途 |
Country Status (25)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016020919A1 (en) | 2014-08-07 | 2016-02-11 | Raziel Therapeutics Ltd. | Compositions comprising tricyclic compounds, and uses thereof |
| WO2016203468A1 (en) * | 2015-06-15 | 2016-12-22 | Raziel Therapeutics Ltd. | Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof |
| EP4031130A4 (en) * | 2019-09-15 | 2023-10-11 | Raziel Therapeutics Ltd. | COMPOSITIONS FOR THE TREATMENT OF SOLID TUMORS |
| AU2021213469B2 (en) * | 2020-01-28 | 2026-06-04 | Raziel Therapeutics Ltd. | Compositions for the treatment of angiolipoma |
| WO2022058792A1 (en) * | 2020-09-16 | 2022-03-24 | Raziel Therapeutics Ltd. | Compositions for the treatment of fat related conditions and disorders |
| EP4213835A4 (en) * | 2020-09-16 | 2024-10-02 | Raziel Therapeutics Ltd. | COMPOSITIONS AND METHODS FOR TREATING LIPID-RELATED DISORDERS |
| WO2022234337A2 (en) * | 2021-05-06 | 2022-11-10 | Raziel Therapeutics Ltd. | Crystalline carbazole derivative |
| US20240335424A1 (en) * | 2021-07-28 | 2024-10-10 | Raziel Therapeutics Ltd. | Compositions and methods for treating lipoma pain |
| CN115073374B (zh) * | 2022-06-14 | 2023-10-27 | 五邑大学 | 一种α-葡萄糖苷酶抑制剂及其制备方法和应用 |
| WO2024100533A1 (en) * | 2022-11-07 | 2024-05-16 | Raziel Therapeutics Ltd. | Crystalline carbazole derivative and methods of making thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2676966A (en) * | 1951-04-04 | 1954-04-27 | Searle & Co | Quaternary salts of 9-carbazolealkylamines and 10-acridanalkylamines and methods forpreparing same |
| US2930798A (en) * | 1956-08-03 | 1960-03-29 | Clin Byla Ets | 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2590125A (en) * | 1952-03-25 | Quaternary-ammonium alkyl | ||
| US2676971A (en) * | 1951-04-21 | 1954-04-27 | Searle & Co | Quaternary ammonium derivatives of aminoalkylxanthenes and aminoalkylthiaxanthenes |
| FR1186832A (fr) | 1956-08-03 | 1959-09-02 | Etablissements Clin-Byla | Composés hétérocycliques dérivés du pyrrol et des benzopyrrols et leur fabrication |
| GB832568A (en) | 1956-08-03 | 1960-04-13 | Clin Byla Ets | Heterocyclic compounds and production thereof |
| GB866418A (en) * | 1958-01-25 | 1961-04-26 | Bayer Ag | Phenoxazine derivatives |
| US3836587A (en) * | 1969-11-17 | 1974-09-17 | American Cyanamid Co | Organo phosphonium salts |
| AR205331A1 (es) * | 1972-07-24 | 1976-04-30 | Hoffmann La Roche | Procedimiento para la preparacion de carbazoles |
| FR2691459B1 (fr) * | 1992-05-25 | 1995-06-09 | Adir | Nouveaux derives de la phenothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH11504905A (ja) | 1995-05-05 | 1999-05-11 | ノボ ノルディスク アクティーゼルスカブ | 新規複素環の化学 |
| US6440961B1 (en) * | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
| EP1094063A1 (en) | 1999-10-18 | 2001-04-25 | Applied Research Systems ARS Holding N.V. | 9-(Piperazinylalkyl)carbazoles as Bax-modulators |
| GB9925880D0 (en) | 1999-11-01 | 1999-12-29 | British Tech Group Int | B-Carboline derivatives |
| DE60218155D1 (de) | 2001-03-28 | 2007-03-29 | Lilly Co Eli | Substituierte carbazole als inhibitoren von spla2 |
| WO2003027084A1 (en) | 2001-09-25 | 2003-04-03 | Dr. Reddy's Laboratories Ltd. | Improved process for the preparation of optically active phenoxazine derivatives as antidiabetic agents |
| US7428091B2 (en) * | 2004-11-15 | 2008-09-23 | Gentex Corporation | Electrochromic compounds and associated media and devices |
| US20070213359A1 (en) | 2005-12-30 | 2007-09-13 | Acadia Pharmaceuticals Inc. | Bicyclic-nitrogen compounds as modulators of ghrelin receptor and uses thereof |
| US20090317372A1 (en) * | 2008-06-20 | 2009-12-24 | Zoltan Kiss | Small molecules for the reduction of high blood glucose level |
| UA107652C2 (en) * | 2008-10-06 | 2015-02-10 | Incuron Llc | Carbazole compounds and therapeutic uses of the compounds |
| CA2748813C (en) * | 2009-01-09 | 2018-07-10 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US8362277B2 (en) * | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9095572B2 (en) * | 2009-01-09 | 2015-08-04 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
-
2012
- 2012-11-15 WO PCT/IL2012/050461 patent/WO2013072915A1/en not_active Ceased
- 2012-11-15 HU HUE12850186A patent/HUE043827T2/hu unknown
- 2012-11-15 SI SI201231605T patent/SI2802320T1/sl unknown
- 2012-11-15 DK DK12850186.3T patent/DK2802320T3/da active
- 2012-11-15 CA CA2855759A patent/CA2855759C/en active Active
- 2012-11-15 HR HRP20190927TT patent/HRP20190927T1/hr unknown
- 2012-11-15 EP EP12850186.3A patent/EP2802320B1/en active Active
- 2012-11-15 BR BR112014011641-5A patent/BR112014011641B1/pt active IP Right Grant
- 2012-11-15 PL PL12850186T patent/PL2802320T3/pl unknown
- 2012-11-15 PT PT12850186T patent/PT2802320T/pt unknown
- 2012-11-15 PE PE2014000685A patent/PE20141940A1/es active IP Right Grant
- 2012-11-15 IN IN3610CHN2014 patent/IN2014CN03610A/en unknown
- 2012-11-15 SG SG11201402258UA patent/SG11201402258UA/en unknown
- 2012-11-15 PH PH1/2014/501061A patent/PH12014501061B1/en unknown
- 2012-11-15 CN CN201280060159.1A patent/CN104010636B/zh active Active
- 2012-11-15 JP JP2014540635A patent/JP6087367B2/ja active Active
- 2012-11-15 KR KR1020147016247A patent/KR101986272B1/ko active Active
- 2012-11-15 AU AU2012338362A patent/AU2012338362B2/en active Active
- 2012-11-15 RU RU2014119711A patent/RU2624446C9/ru active
- 2012-11-15 MX MX2014005765A patent/MX347570B/es active IP Right Grant
- 2012-11-15 US US14/358,431 patent/US9447040B2/en active Active
- 2012-11-15 ES ES12850186T patent/ES2729713T3/es active Active
-
2014
- 2014-05-14 CL CL2014001278A patent/CL2014001278A1/es unknown
- 2014-05-19 CO CO14107499A patent/CO7020909A2/es unknown
- 2014-06-04 ZA ZA2014/04065A patent/ZA201404065B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2676966A (en) * | 1951-04-04 | 1954-04-27 | Searle & Co | Quaternary salts of 9-carbazolealkylamines and 10-acridanalkylamines and methods forpreparing same |
| US2930798A (en) * | 1956-08-03 | 1960-03-29 | Clin Byla Ets | 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof |
Non-Patent Citations (1)
| Title |
|---|
| Polystyrene nanocomposites based on carbazole-containing surfactants;Grace Chigwada et al.;《Thermochimica Acta》;20051231;第436卷;113–121 * |
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