CL2014001278A1 - Compuestos triciclicos, inhibidores de proteina quinasa cdc42 de union a proteina quinasa alfa (cdc42bpa o mrcka); composicion farmaceutica; y su uso para tratar una enfermedad, trastorno o condicion seleccionada de obesidad, sobrepeso, distribucion anormal de grasa o cualquier condicion o enfermedad asociada con el mismo. - Google Patents
Compuestos triciclicos, inhibidores de proteina quinasa cdc42 de union a proteina quinasa alfa (cdc42bpa o mrcka); composicion farmaceutica; y su uso para tratar una enfermedad, trastorno o condicion seleccionada de obesidad, sobrepeso, distribucion anormal de grasa o cualquier condicion o enfermedad asociada con el mismo.Info
- Publication number
- CL2014001278A1 CL2014001278A1 CL2014001278A CL2014001278A CL2014001278A1 CL 2014001278 A1 CL2014001278 A1 CL 2014001278A1 CL 2014001278 A CL2014001278 A CL 2014001278A CL 2014001278 A CL2014001278 A CL 2014001278A CL 2014001278 A1 CL2014001278 A1 CL 2014001278A1
- Authority
- CL
- Chile
- Prior art keywords
- protein kinase
- condition
- disease
- mrcka
- cdc42bpa
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559964P | 2011-11-15 | 2011-11-15 | |
| US201261603508P | 2012-02-27 | 2012-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001278A1 true CL2014001278A1 (es) | 2014-12-26 |
Family
ID=48429067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001278A CL2014001278A1 (es) | 2011-11-15 | 2014-05-14 | Compuestos triciclicos, inhibidores de proteina quinasa cdc42 de union a proteina quinasa alfa (cdc42bpa o mrcka); composicion farmaceutica; y su uso para tratar una enfermedad, trastorno o condicion seleccionada de obesidad, sobrepeso, distribucion anormal de grasa o cualquier condicion o enfermedad asociada con el mismo. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9447040B2 (es) |
| EP (1) | EP2802320B1 (es) |
| JP (1) | JP6087367B2 (es) |
| KR (1) | KR101986272B1 (es) |
| CN (1) | CN104010636B (es) |
| AU (1) | AU2012338362B2 (es) |
| BR (1) | BR112014011641B1 (es) |
| CA (1) | CA2855759C (es) |
| CL (1) | CL2014001278A1 (es) |
| CO (1) | CO7020909A2 (es) |
| DK (1) | DK2802320T3 (es) |
| ES (1) | ES2729713T3 (es) |
| HR (1) | HRP20190927T1 (es) |
| HU (1) | HUE043827T2 (es) |
| IN (1) | IN2014CN03610A (es) |
| MX (1) | MX347570B (es) |
| PE (1) | PE20141940A1 (es) |
| PL (1) | PL2802320T3 (es) |
| PT (1) | PT2802320T (es) |
| RU (1) | RU2624446C9 (es) |
| SG (1) | SG11201402258UA (es) |
| SI (1) | SI2802320T1 (es) |
| WO (1) | WO2013072915A1 (es) |
| ZA (1) | ZA201404065B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016020919A1 (en) | 2014-08-07 | 2016-02-11 | Raziel Therapeutics Ltd. | Compositions comprising tricyclic compounds, and uses thereof |
| EP3307323B1 (en) * | 2015-06-15 | 2022-07-13 | Raziel Therapeutics Ltd. | Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof |
| JP2023503769A (ja) * | 2019-09-15 | 2023-02-01 | ラジエル セラピューティクス エルティーディー． | 固形腫瘍の処置のための組成物 |
| EP4096653A4 (en) * | 2020-01-28 | 2024-02-28 | Raziel Therapeutics Ltd | COMPOSITIONS FOR TREATING ANGIOLIPOMA |
| US20240041827A1 (en) * | 2020-09-16 | 2024-02-08 | Raziel Therapeutics Ltd. | Compositions for the treatment of fat related conditions and disorders |
| EP4213835A1 (en) * | 2020-09-16 | 2023-07-26 | Raziel Therapeutics Ltd. | Compositions and methods for the treatment of lipid-related disorders |
| IL308270A (en) * | 2021-05-06 | 2024-01-01 | Raziel Therapeutics Ltd | Consequence of crystalline carbazole |
| IL310051A (en) * | 2021-07-28 | 2024-03-01 | Raziel Therapeutics Ltd | Compositions and methods for treating lipoma pain |
| CN115073374B (zh) * | 2022-06-14 | 2023-10-27 | 五邑大学 | 一种α-葡萄糖苷酶抑制剂及其制备方法和应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2590125A (en) * | 1952-03-25 | Quaternary-ammonium alkyl | ||
| US2676966A (en) * | 1951-04-04 | 1954-04-27 | Searle & Co | Quaternary salts of 9-carbazolealkylamines and 10-acridanalkylamines and methods forpreparing same |
| US2676971A (en) * | 1951-04-21 | 1954-04-27 | Searle & Co | Quaternary ammonium derivatives of aminoalkylxanthenes and aminoalkylthiaxanthenes |
| FR1186832A (fr) | 1956-08-03 | 1959-09-02 | Etablissements Clin-Byla | Composés hétérocycliques dérivés du pyrrol et des benzopyrrols et leur fabrication |
| GB832568A (en) * | 1956-08-03 | 1960-04-13 | Clin Byla Ets | Heterocyclic compounds and production thereof |
| US2930798A (en) * | 1956-08-03 | 1960-03-29 | Clin Byla Ets | 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof |
| GB866418A (en) * | 1958-01-25 | 1961-04-26 | Bayer Ag | Phenoxazine derivatives |
| US3836587A (en) * | 1969-11-17 | 1974-09-17 | American Cyanamid Co | Organo phosphonium salts |
| AR205331A1 (es) * | 1972-07-24 | 1976-04-30 | Hoffmann La Roche | Procedimiento para la preparacion de carbazoles |
| FR2691459B1 (fr) * | 1992-05-25 | 1995-06-09 | Adir | Nouveaux derives de la phenothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH11504905A (ja) | 1995-05-05 | 1999-05-11 | ノボ ノルディスク アクティーゼルスカブ | 新規複素環の化学 |
| US6440961B1 (en) | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
| EP1094063A1 (en) | 1999-10-18 | 2001-04-25 | Applied Research Systems ARS Holding N.V. | 9-(Piperazinylalkyl)carbazoles as Bax-modulators |
| GB9925880D0 (en) | 1999-11-01 | 1999-12-29 | British Tech Group Int | B-Carboline derivatives |
| EP1395554B1 (en) | 2001-03-28 | 2007-02-14 | Eli Lilly And Company | Substituted carbazoles as inhibitors of spla2 |
| WO2003027084A1 (en) | 2001-09-25 | 2003-04-03 | Dr. Reddy's Laboratories Ltd. | Improved process for the preparation of optically active phenoxazine derivatives as antidiabetic agents |
| US7428091B2 (en) * | 2004-11-15 | 2008-09-23 | Gentex Corporation | Electrochromic compounds and associated media and devices |
| WO2007079239A2 (en) | 2005-12-30 | 2007-07-12 | Acadia Pharmaceuticals Inc. | Bicyclic nitrogen compounds as modulators of ghrelin receptor and uses thereof |
| US20090317372A1 (en) * | 2008-06-20 | 2009-12-24 | Zoltan Kiss | Small molecules for the reduction of high blood glucose level |
| UA107652C2 (en) * | 2008-10-06 | 2015-02-10 | Incuron Llc | Carbazole compounds and therapeutic uses of the compounds |
| US8362277B2 (en) * | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CN102405043B (zh) * | 2009-01-09 | 2017-08-22 | 得克萨斯州大学系统董事会 | 前神经原性化合物 |
| CN103415289B (zh) * | 2010-07-07 | 2017-04-12 | 得克萨斯州大学系统董事会 | 前神经原性化合物 |
-
2012
- 2012-11-15 AU AU2012338362A patent/AU2012338362B2/en active Active
- 2012-11-15 PE PE2014000685A patent/PE20141940A1/es active IP Right Grant
- 2012-11-15 HU HUE12850186A patent/HUE043827T2/hu unknown
- 2012-11-15 CN CN201280060159.1A patent/CN104010636B/zh active Active
- 2012-11-15 PT PT12850186T patent/PT2802320T/pt unknown
- 2012-11-15 DK DK12850186.3T patent/DK2802320T3/da active
- 2012-11-15 CA CA2855759A patent/CA2855759C/en active Active
- 2012-11-15 KR KR1020147016247A patent/KR101986272B1/ko active IP Right Grant
- 2012-11-15 ES ES12850186T patent/ES2729713T3/es active Active
- 2012-11-15 BR BR112014011641-5A patent/BR112014011641B1/pt active IP Right Grant
- 2012-11-15 IN IN3610CHN2014 patent/IN2014CN03610A/en unknown
- 2012-11-15 RU RU2014119711A patent/RU2624446C9/ru active
- 2012-11-15 WO PCT/IL2012/050461 patent/WO2013072915A1/en active Application Filing
- 2012-11-15 JP JP2014540635A patent/JP6087367B2/ja active Active
- 2012-11-15 SG SG11201402258UA patent/SG11201402258UA/en unknown
- 2012-11-15 SI SI201231605T patent/SI2802320T1/sl unknown
- 2012-11-15 EP EP12850186.3A patent/EP2802320B1/en active Active
- 2012-11-15 MX MX2014005765A patent/MX347570B/es active IP Right Grant
- 2012-11-15 PL PL12850186T patent/PL2802320T3/pl unknown
- 2012-11-15 US US14/358,431 patent/US9447040B2/en active Active
-
2014
- 2014-05-14 CL CL2014001278A patent/CL2014001278A1/es unknown
- 2014-05-19 CO CO14107499A patent/CO7020909A2/es unknown
- 2014-06-04 ZA ZA2014/04065A patent/ZA201404065B/en unknown
-
2019
- 2019-05-20 HR HRP20190927TT patent/HRP20190927T1/hr unknown
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