CN103977458A - 多羟基聚合体栓塞微球及其制备工艺 - Google Patents
多羟基聚合体栓塞微球及其制备工艺 Download PDFInfo
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- CN103977458A CN103977458A CN201410232150.5A CN201410232150A CN103977458A CN 103977458 A CN103977458 A CN 103977458A CN 201410232150 A CN201410232150 A CN 201410232150A CN 103977458 A CN103977458 A CN 103977458A
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410232150.5A CN103977458B (zh) | 2014-05-28 | 2014-05-28 | 多羟基聚合体栓塞微球及其制备工艺 |
PCT/CN2014/000571 WO2015179997A1 (zh) | 2014-05-28 | 2014-06-10 | 多羟基聚合体栓塞微球及其制备工艺 |
Applications Claiming Priority (1)
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CN201410232150.5A CN103977458B (zh) | 2014-05-28 | 2014-05-28 | 多羟基聚合体栓塞微球及其制备工艺 |
Publications (2)
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CN103977458A true CN103977458A (zh) | 2014-08-13 |
CN103977458B CN103977458B (zh) | 2016-10-05 |
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CN201410232150.5A Active CN103977458B (zh) | 2014-05-28 | 2014-05-28 | 多羟基聚合体栓塞微球及其制备工艺 |
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CN (1) | CN103977458B (zh) |
WO (1) | WO2015179997A1 (zh) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106110334A (zh) * | 2016-08-08 | 2016-11-16 | 江南大学 | 一种表面功能化可载药洗脱微球的制备方法 |
CN106693040A (zh) * | 2016-12-12 | 2017-05-24 | 江南大学 | 一种可载药聚乙烯醇洗脱微球的制备方法 |
CN106729953A (zh) * | 2016-12-29 | 2017-05-31 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种功能化改性聚乙烯醇栓塞微球及其制备方法 |
CN106822983A (zh) * | 2016-12-29 | 2017-06-13 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种用于微创介入疗法治疗肿瘤疾病的可显影栓塞微球及其制备方法 |
CN107050501A (zh) * | 2016-12-29 | 2017-08-18 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种可视化多羟基聚合体栓塞微球及其制备方法 |
CN107854720A (zh) * | 2017-12-28 | 2018-03-30 | 苏州恒瑞迦俐生生物医药科技有限公司 | 具有造影功能的可载药多羟基聚合物栓塞微球及其制备方法 |
CN107899066A (zh) * | 2017-12-01 | 2018-04-13 | 苏州恒瑞迦俐生生物医药科技有限公司 | 阳离子多羟基聚合物栓塞微球及其制备方法 |
CN108114308A (zh) * | 2017-12-28 | 2018-06-05 | 苏州恒瑞迦俐生生物医药科技有限公司 | 具有高密度元素的自显影栓塞微球及其制备方法 |
CN108686259A (zh) * | 2018-07-12 | 2018-10-23 | 中国人民解放军总医院 | 用于血管内栓塞x线下可显影的载药微球及其制备方法 |
CN108744020A (zh) * | 2018-06-12 | 2018-11-06 | 杭州艾力康医药科技有限公司 | 一种离子交换型聚乙烯醇微球的制备方法 |
CN109667170A (zh) * | 2018-12-29 | 2019-04-23 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种高分子微球的着色工艺 |
CN111202206A (zh) * | 2020-03-03 | 2020-05-29 | 武汉轻工大学 | 呕吐毒素脱毒剂及其制备方法、及呕吐毒素的脱除方法 |
CN112316199A (zh) * | 2020-11-16 | 2021-02-05 | 江南大学 | 一种改性羧甲基壳聚糖微球及其制备方法和应用 |
CN113694248A (zh) * | 2021-09-13 | 2021-11-26 | 中山大学 | 一种基于可溶性淀粉的栓塞微球及其制备和应用 |
CN114478927A (zh) * | 2022-01-26 | 2022-05-13 | 科睿驰(深圳)医疗科技发展有限公司 | 一种栓塞微球及梯度交联制备方法 |
CN114621491A (zh) * | 2022-03-23 | 2022-06-14 | 克林纳奇(荆州)高分子科技有限公司 | 一种聚乙烯醇类多孔栓塞微球的制作方法 |
CN114790661A (zh) * | 2022-05-30 | 2022-07-26 | 上海益思妙医疗器械有限公司 | 一种高分子微球的染色方法 |
WO2023035384A1 (zh) * | 2021-09-10 | 2023-03-16 | 苏州浩微生物医疗科技有限公司 | 水凝胶栓塞微球及其制备方法 |
CN116444734A (zh) * | 2023-04-04 | 2023-07-18 | 苏州浩微生物医疗科技有限公司 | 一种可降解水凝胶微球及其制备方法和应用 |
WO2023226141A1 (zh) * | 2022-05-27 | 2023-11-30 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种载药微球及其制备方法 |
US11925708B1 (en) | 2022-09-23 | 2024-03-12 | Jiangnan University | Method for making modified polyvinyl alcohol embolic microsphere |
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US4663410A (en) * | 1985-08-06 | 1987-05-05 | Air Products And Chemicals, Inc. | Polymers of self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers |
CN1156411A (zh) * | 1994-08-10 | 1997-08-06 | 因捷尔拂勒小夫涅德列娜契斯卡耶公司 | 生物相容性水凝胶 |
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CN101125225A (zh) * | 2007-08-10 | 2008-02-20 | 苏州迦俐生生物医药科技有限公司 | 微球型栓塞剂及其制备工艺 |
CN101670095A (zh) * | 2009-04-13 | 2010-03-17 | 北京大学 | 一种用于栓塞治疗的药物组合物及其制备方法 |
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US7838035B2 (en) * | 2006-04-11 | 2010-11-23 | E. I. Du Pont De Nemours And Company | Microsphere powder of high density, swellable, deformable, durable occlusion-forming microspheres |
CN101716349B (zh) * | 2009-12-16 | 2012-02-08 | 北京大学 | 一种用于栓塞治疗和止痛的药物组合物及其制备方法 |
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Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106110334A (zh) * | 2016-08-08 | 2016-11-16 | 江南大学 | 一种表面功能化可载药洗脱微球的制备方法 |
CN106110334B (zh) * | 2016-08-08 | 2019-11-15 | 江南大学 | 一种表面功能化可载药洗脱微球的制备方法 |
CN106693040A (zh) * | 2016-12-12 | 2017-05-24 | 江南大学 | 一种可载药聚乙烯醇洗脱微球的制备方法 |
CN106729953A (zh) * | 2016-12-29 | 2017-05-31 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种功能化改性聚乙烯醇栓塞微球及其制备方法 |
CN106822983A (zh) * | 2016-12-29 | 2017-06-13 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种用于微创介入疗法治疗肿瘤疾病的可显影栓塞微球及其制备方法 |
CN107050501A (zh) * | 2016-12-29 | 2017-08-18 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种可视化多羟基聚合体栓塞微球及其制备方法 |
CN107899066A (zh) * | 2017-12-01 | 2018-04-13 | 苏州恒瑞迦俐生生物医药科技有限公司 | 阳离子多羟基聚合物栓塞微球及其制备方法 |
WO2019129237A1 (zh) * | 2017-12-28 | 2019-07-04 | 苏州恒瑞迦俐生生物医药科技有限公司 | 具有造影功能的可载药多羟基聚合物栓塞微球及其制备方法 |
CN107854720A (zh) * | 2017-12-28 | 2018-03-30 | 苏州恒瑞迦俐生生物医药科技有限公司 | 具有造影功能的可载药多羟基聚合物栓塞微球及其制备方法 |
CN108114308B (zh) * | 2017-12-28 | 2021-08-06 | 苏州恒瑞迦俐生生物医药科技有限公司 | 具有高密度元素的自显影栓塞微球及其制备方法 |
CN108114308A (zh) * | 2017-12-28 | 2018-06-05 | 苏州恒瑞迦俐生生物医药科技有限公司 | 具有高密度元素的自显影栓塞微球及其制备方法 |
CN108744020A (zh) * | 2018-06-12 | 2018-11-06 | 杭州艾力康医药科技有限公司 | 一种离子交换型聚乙烯醇微球的制备方法 |
CN108686259A (zh) * | 2018-07-12 | 2018-10-23 | 中国人民解放军总医院 | 用于血管内栓塞x线下可显影的载药微球及其制备方法 |
CN109667170A (zh) * | 2018-12-29 | 2019-04-23 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种高分子微球的着色工艺 |
CN111202206A (zh) * | 2020-03-03 | 2020-05-29 | 武汉轻工大学 | 呕吐毒素脱毒剂及其制备方法、及呕吐毒素的脱除方法 |
CN112316199A (zh) * | 2020-11-16 | 2021-02-05 | 江南大学 | 一种改性羧甲基壳聚糖微球及其制备方法和应用 |
WO2023035384A1 (zh) * | 2021-09-10 | 2023-03-16 | 苏州浩微生物医疗科技有限公司 | 水凝胶栓塞微球及其制备方法 |
CN113694248B (zh) * | 2021-09-13 | 2023-03-17 | 中山大学 | 一种基于可溶性淀粉的栓塞微球及其制备和应用 |
CN113694248A (zh) * | 2021-09-13 | 2021-11-26 | 中山大学 | 一种基于可溶性淀粉的栓塞微球及其制备和应用 |
CN114478927A (zh) * | 2022-01-26 | 2022-05-13 | 科睿驰(深圳)医疗科技发展有限公司 | 一种栓塞微球及梯度交联制备方法 |
CN114621491A (zh) * | 2022-03-23 | 2022-06-14 | 克林纳奇(荆州)高分子科技有限公司 | 一种聚乙烯醇类多孔栓塞微球的制作方法 |
CN114621491B (zh) * | 2022-03-23 | 2023-03-10 | 克林纳奇(荆州)高分子科技有限公司 | 一种聚乙烯醇类多孔栓塞微球的制作方法 |
WO2023226141A1 (zh) * | 2022-05-27 | 2023-11-30 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种载药微球及其制备方法 |
CN114790661A (zh) * | 2022-05-30 | 2022-07-26 | 上海益思妙医疗器械有限公司 | 一种高分子微球的染色方法 |
US11925708B1 (en) | 2022-09-23 | 2024-03-12 | Jiangnan University | Method for making modified polyvinyl alcohol embolic microsphere |
CN116444734A (zh) * | 2023-04-04 | 2023-07-18 | 苏州浩微生物医疗科技有限公司 | 一种可降解水凝胶微球及其制备方法和应用 |
CN116444734B (zh) * | 2023-04-04 | 2024-01-30 | 苏州浩微生物医疗科技有限公司 | 一种可降解水凝胶微球及其制备方法和应用 |
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WO2015179997A1 (zh) | 2015-12-03 |
CN103977458B (zh) | 2016-10-05 |
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