CN103974762A - 用于多步放射化学的反应器 - Google Patents

用于多步放射化学的反应器 Download PDF

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Publication number
CN103974762A
CN103974762A CN201280058676.5A CN201280058676A CN103974762A CN 103974762 A CN103974762 A CN 103974762A CN 201280058676 A CN201280058676 A CN 201280058676A CN 103974762 A CN103974762 A CN 103974762A
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CN
China
Prior art keywords
reaction vessel
opening
valve
reactor
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280058676.5A
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English (en)
Chinese (zh)
Inventor
A.杰克逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN103974762A publication Critical patent/CN103974762A/zh
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792—One or more tube-shaped elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00799—Cup-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00813—Fluidic connections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00844—Comprising porous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B01J2219/00876—Insulation elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201280058676.5A 2011-09-30 2012-09-28 用于多步放射化学的反应器 Pending CN103974762A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161541159P 2011-09-30 2011-09-30
US61/541,159 2011-09-30
PCT/US2012/057683 WO2013049431A2 (en) 2011-09-30 2012-09-28 Reactor for multi-step radiochemistry

Publications (1)

Publication Number Publication Date
CN103974762A true CN103974762A (zh) 2014-08-06

Family

ID=47116342

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280058676.5A Pending CN103974762A (zh) 2011-09-30 2012-09-28 用于多步放射化学的反应器

Country Status (6)

Country Link
US (1) US20140256970A1 (enExample)
EP (1) EP2760577A2 (enExample)
JP (1) JP2014534896A (enExample)
CN (1) CN103974762A (enExample)
AU (1) AU2012315883A1 (enExample)
WO (1) WO2013049431A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013049783A1 (en) * 2011-09-30 2013-04-04 Ge Healthcare Limited Partitioned reaction vessels
KR101326000B1 (ko) * 2012-01-30 2013-11-07 재단법인 아산사회복지재단 수소이온 농도가 조절된 플루오린-18의 용리액 제조 및 이를 이용한 플루오린-18의 표지방법
ES2687196T3 (es) 2013-08-22 2018-10-24 Ge Healthcare Limited Una síntesis mejorada del tosilato de [18F]-fluoroalquilo
NL2014828B1 (en) * 2015-05-20 2017-01-31 Out And Out Chemistry S P R L Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
EP3967674A1 (en) 2020-09-11 2022-03-16 Precirix N.V. Reactions of radioactive compounds facilitated by a solid phase
CA3247109A1 (en) 2022-04-06 2023-10-12 Univ Pennsylvania Compositions and treatment methods for metastatic breast cancer that is human epidermal growth factor receptor 2 positive and other cancers
CN121127599A (zh) 2022-12-17 2025-12-12 宾夕法尼亚州大学信托人 具有心肌和骨骼肌特异性靶向基序的重组aav突变载体及含有其的组合物
WO2024130070A2 (en) 2022-12-17 2024-06-20 The Trustees Of The University Of Pennsylvania Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603114A (en) * 1980-09-23 1986-07-29 California Institute Of Technology Method for the sequential performance of chemical processes
US6136555A (en) * 1993-07-09 2000-10-24 Cambridge Molecular Technologies Limited Purification method and apparatus
CN101061130A (zh) * 2004-11-19 2007-10-24 通用电气健康护理有限公司 用于合成2－[18f]氟－2－脱氧－d－葡萄糖的氟化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2084899B (en) * 1980-09-23 1985-05-30 California Inst Of Techn Apparatus and method for the sequential performance of chemical processes
US4610847A (en) * 1980-09-23 1986-09-09 California Institute Of Technology Conversion flask for sequential performance apparatus
US5080868A (en) * 1990-05-16 1992-01-14 Elgas David H Sparger assembly
US8333952B2 (en) * 2009-09-23 2012-12-18 Abt Molecular Imaging, Inc. Dose synthesis module for biomarker generator system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603114A (en) * 1980-09-23 1986-07-29 California Institute Of Technology Method for the sequential performance of chemical processes
US6136555A (en) * 1993-07-09 2000-10-24 Cambridge Molecular Technologies Limited Purification method and apparatus
CN101061130A (zh) * 2004-11-19 2007-10-24 通用电气健康护理有限公司 用于合成2－[18f]氟－2－脱氧－d－葡萄糖的氟化方法

Also Published As

Publication number Publication date
AU2012315883A1 (en) 2014-04-17
US20140256970A1 (en) 2014-09-11
WO2013049431A2 (en) 2013-04-04
JP2014534896A (ja) 2014-12-25
WO2013049431A3 (en) 2013-06-27
EP2760577A2 (en) 2014-08-06

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Application publication date: 20140806