ES2687196T3 - Una síntesis mejorada del tosilato de [18F]-fluoroalquilo - Google Patents

Una síntesis mejorada del tosilato de [18F]-fluoroalquilo Download PDF

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Publication number
ES2687196T3
ES2687196T3 ES14758263.9T ES14758263T ES2687196T3 ES 2687196 T3 ES2687196 T3 ES 2687196T3 ES 14758263 T ES14758263 T ES 14758263T ES 2687196 T3 ES2687196 T3 ES 2687196T3
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ES
Spain
Prior art keywords
improved synthesis
tosylate
fluoroalkyl
fluoroalkyl tosylate
crude
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14758263.9T
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English (en)
Inventor
Sajinder Luthra
Matthias Eberhard Glaser
James Nairne
Jane Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Application granted granted Critical
Publication of ES2687196T3 publication Critical patent/ES2687196T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un método que comprende las etapas de: (a) reacción de distosilato con una fuente de 18F- para formar tosilato de [18F]2-fluoroetilo bruto; y (b) purificar tal tosilato de [18F]2-fluoroetilo bruto con un sistema de SPE; en donde dicha etapa de purificación se realiza en un aparato de radiosíntesis de FASTlab automático.

Description

imagen1
imagen2
imagen3

Claims (1)

  1. imagen1
ES14758263.9T 2013-08-22 2014-08-21 Una síntesis mejorada del tosilato de [18F]-fluoroalquilo Active ES2687196T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361868766P 2013-08-22 2013-08-22
US201361868766P 2013-08-22
PCT/US2014/052002 WO2015027012A1 (en) 2013-08-22 2014-08-21 An improved synthesis of [18f] - fluoroalkyl tosylate

Publications (1)

Publication Number Publication Date
ES2687196T3 true ES2687196T3 (es) 2018-10-24

Family

ID=51453906

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14758263.9T Active ES2687196T3 (es) 2013-08-22 2014-08-21 Una síntesis mejorada del tosilato de [18F]-fluoroalquilo

Country Status (6)

Country Link
US (1) US10087141B2 (es)
EP (1) EP3036209B1 (es)
KR (1) KR102234143B1 (es)
CN (1) CN105452203B (es)
ES (1) ES2687196T3 (es)
WO (1) WO2015027012A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102234143B1 (ko) 2013-08-22 2021-03-31 지이 헬쓰케어 리미티드 [18f]-플루오로알킬 토실레이트의 개선된 합성

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2509637T3 (pl) * 2009-10-08 2016-12-30 Sposób oczyszczania
US9073802B2 (en) * 2010-02-12 2015-07-07 Tokyo Institute Of Technology Method for producing 18F-labeled compound and high molecular compound to be used in the method
GB201021263D0 (en) * 2010-12-15 2011-01-26 Ge Healthcare Ltd Solid phase extraction method
CN103974762A (zh) * 2011-09-30 2014-08-06 通用电气健康护理有限公司 用于多步放射化学的反应器
GB201117785D0 (en) * 2011-10-14 2011-11-30 Ge Healthcare Ltd Improved radiosynthesis method
GB201120586D0 (en) * 2011-11-30 2012-01-11 Ge Healthcare Ltd Solid phase extraction neutralisation
EP2809356A1 (en) * 2012-02-03 2014-12-10 Aarhus Universitet Radiolabeled bile acids and bile acid derivatives
KR102234143B1 (ko) 2013-08-22 2021-03-31 지이 헬쓰케어 리미티드 [18f]-플루오로알킬 토실레이트의 개선된 합성

Also Published As

Publication number Publication date
US20160176807A1 (en) 2016-06-23
KR102234143B1 (ko) 2021-03-31
EP3036209B1 (en) 2018-08-01
CN105452203B (zh) 2019-04-09
EP3036209A1 (en) 2016-06-29
KR20160045691A (ko) 2016-04-27
WO2015027012A1 (en) 2015-02-26
CN105452203A (zh) 2016-03-30
US10087141B2 (en) 2018-10-02

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