CN103946366B - 细胞培养物的预编程非反馈控制的连续供料 - Google Patents

细胞培养物的预编程非反馈控制的连续供料 Download PDF

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Publication number
CN103946366B
CN103946366B CN201280044589.4A CN201280044589A CN103946366B CN 103946366 B CN103946366 B CN 103946366B CN 201280044589 A CN201280044589 A CN 201280044589A CN 103946366 B CN103946366 B CN 103946366B
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feed
feeding
continuous
cell culture
glucose
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CN103946366A (zh
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H.林
J.贝蔡尔
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280044589.4A 2011-09-16 2012-09-14 细胞培养物的预编程非反馈控制的连续供料 Active CN103946366B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161535809P 2011-09-16 2011-09-16
US61/535,809 2011-09-16
US61/535809 2011-09-16
PCT/US2012/055552 WO2013040444A1 (en) 2011-09-16 2012-09-14 Pre-programmed non-feedback controlled continuous feeding of cell cultures

Publications (2)

Publication Number Publication Date
CN103946366A CN103946366A (zh) 2014-07-23
CN103946366B true CN103946366B (zh) 2017-08-11

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Country Status (16)

Country Link
US (1) US9803166B2 (https=)
EP (1) EP2756069B1 (https=)
JP (4) JP2014526265A (https=)
KR (1) KR101710766B1 (https=)
CN (1) CN103946366B (https=)
AU (1) AU2012308335A1 (https=)
BR (1) BR112014008303A2 (https=)
CA (1) CA2846905A1 (https=)
EA (1) EA201490502A1 (https=)
ES (1) ES2862576T3 (https=)
IL (1) IL231032A0 (https=)
MX (1) MX356956B (https=)
SG (1) SG11201400656SA (https=)
TW (1) TWI583788B (https=)
WO (1) WO2013040444A1 (https=)
ZA (1) ZA201401655B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU765203B2 (en) 1999-04-19 2003-09-11 Shionogi & Co., Ltd. Sulfonamide derivatives having oxadiazole rings
AU2015269365A1 (en) 2014-06-04 2016-12-15 Amgen Inc. Methods for harvesting mammalian cell cultures
PL3865563T3 (pl) 2014-11-25 2024-01-29 Corning Incorporated Materiały i sposoby do przedłużania pożywki do hodowli komórkowej
CA2969225C (en) 2014-12-01 2023-08-22 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
WO2016183016A1 (en) * 2015-05-08 2016-11-17 Flownamics Analytical Instruments, Inc. Method & apparatus for continuous automated perfusion system harvesting from in-situ filtration probe
WO2021097281A1 (en) 2019-11-15 2021-05-20 Lonza Ltd Process and system for producing an inoculum
US20230287335A1 (en) 2020-07-30 2023-09-14 Amgen Inc. Cell culture media and methods of making and using the same
CN112553044A (zh) * 2020-12-10 2021-03-26 上海奥浦迈生物科技股份有限公司 一种生物反应器细胞培养进样口用防堵塞装置
KR20250056246A (ko) * 2022-10-13 2025-04-25 가부시키가이샤 히타치세이사쿠쇼 배양 장치의 제어 방법, 및 세포 배양을 수반하는 배양 장치의 제어 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629202A (en) * 1994-07-19 1997-05-13 Development Center For Biotechnology Computer-controlled bioreactor system for enzymatic synthesis of L-tryptophan
DE102004007658A1 (de) * 2004-02-17 2005-09-01 Bioceuticals Arzneimittel Ag Verfahren zur Herstellung von rekombinanten Proteinen in eukaryontischen Wirtszellen
CN1778903A (zh) * 2005-09-29 2006-05-31 华东理工大学 一种动物细胞高密度连续灌注培养方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE241695T1 (de) * 1996-03-13 2003-06-15 Delta Biotechnology Ltd Gärungs-steuerungssysteme
WO1998041611A1 (en) 1997-03-20 1998-09-24 Regents Of The University Of Minnesota Process for the continuous culture of cells
CN1678731A (zh) * 2002-08-27 2005-10-05 范德比尔特大学 多室生物反应器
WO2007071072A1 (en) * 2005-12-22 2007-06-28 Corporation De L'ecole Polytechnique De Montreal High-rate perfusion bioreactor
JP2007202500A (ja) * 2006-02-03 2007-08-16 Hitachi Ltd 培養槽の運転制御装置
WO2008136398A1 (ja) 2007-04-26 2008-11-13 Chugai Seiyaku Kabushiki Kaisha 高濃度アミノ酸含有培地を用いた細胞の培養方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629202A (en) * 1994-07-19 1997-05-13 Development Center For Biotechnology Computer-controlled bioreactor system for enzymatic synthesis of L-tryptophan
DE102004007658A1 (de) * 2004-02-17 2005-09-01 Bioceuticals Arzneimittel Ag Verfahren zur Herstellung von rekombinanten Proteinen in eukaryontischen Wirtszellen
CN1778903A (zh) * 2005-09-29 2006-05-31 华东理工大学 一种动物细胞高密度连续灌注培养方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHO工程细胞无血清流加培养代谢动力学及转录谱特征研究;刘兴茂;《中国博士学位论文全文数据库》;20090915;第3.7节 *
The Effect of the Dilution Rate on CHO Cell Physiology and Recombinant Interferon-y Production in Glucose- Limited Chemostat Culture;Paul M. Hayter et al;《Biotechnology and Bioengineering》;19931231;第1077-1085页 *

Also Published As

Publication number Publication date
TWI583788B (zh) 2017-05-21
WO2013040444A1 (en) 2013-03-21
AU2012308335A1 (en) 2014-03-13
JP2022058710A (ja) 2022-04-12
EA201490502A1 (ru) 2014-06-30
IL231032A0 (en) 2014-03-31
MX356956B (es) 2018-06-21
SG11201400656SA (en) 2014-04-28
BR112014008303A2 (pt) 2017-04-11
ES2862576T3 (es) 2021-10-07
KR101710766B1 (ko) 2017-02-27
TW201326387A (zh) 2013-07-01
KR20140044396A (ko) 2014-04-14
US20140295545A1 (en) 2014-10-02
US9803166B2 (en) 2017-10-31
EP2756069A1 (en) 2014-07-23
JP2020022492A (ja) 2020-02-13
JP2014526265A (ja) 2014-10-06
EP2756069B1 (en) 2021-01-27
MX2014003134A (es) 2014-04-25
JP2017029162A (ja) 2017-02-09
CA2846905A1 (en) 2013-03-21
ZA201401655B (en) 2014-12-23
CN103946366A (zh) 2014-07-23

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