CN103930127B - 治疗性核酸酶组合物和方法 - Google Patents

治疗性核酸酶组合物和方法 Download PDF

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CN103930127B
CN103930127B CN201280032451.2A CN201280032451A CN103930127B CN 103930127 B CN103930127 B CN 103930127B CN 201280032451 A CN201280032451 A CN 201280032451A CN 103930127 B CN103930127 B CN 103930127B
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polypeptide
hybrid nuclease
molecule
certain embodiments
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CN103930127A (zh
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J·A·莱德贝特
M·海登-莱德贝特
K·艾肯
孙锡章
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University of Washington
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University of Washington
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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CN201280032451.2A 2011-04-29 2012-04-27 治疗性核酸酶组合物和方法 Active CN103930127B (zh)

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US201161480961P 2011-04-29 2011-04-29
US61/480,961 2011-04-29
US201261617241P 2012-03-29 2012-03-29
US61/617,241 2012-03-29
PCT/US2012/035614 WO2012149440A2 (en) 2011-04-29 2012-04-27 Therapeutic nuclease compositions and methods

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CN107964539A (zh) * 2011-04-29 2018-04-27 华盛顿大学 治疗性核酸酶组合物和方法

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EP3919505B1 (en) 2013-01-16 2023-08-30 Emory University Uses of cas9-nucleic acid complexes
WO2015066550A1 (en) 2013-10-31 2015-05-07 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
ES2700149T3 (es) * 2014-02-24 2019-02-14 Takeda Gmbh Proteínas de fusión de UTI
US9599606B2 (en) * 2014-06-10 2017-03-21 The Board Of Regents Of The University Of Texas System ADP-ribose detection reagents
WO2016069889A1 (en) * 2014-10-31 2016-05-06 Resolve Therapeutics, Llc Therapeutic nuclease-transferrin fusions and methods
US10117911B2 (en) 2015-05-29 2018-11-06 Agenovir Corporation Compositions and methods to treat herpes simplex virus infections
EP3328881B1 (en) 2015-09-08 2019-08-28 Theripion, Inc. Apoa-1 fusion polypeptides and related compositions and methods
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WO2018136163A2 (en) 2016-12-09 2018-07-26 Theripion, Inc. Tandem apoa-1 fusion polypeptides
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US10988746B2 (en) * 2018-10-08 2021-04-27 Neutrolis, Inc. Manufacturing and engineering of DNASE enzymes for therapy
MX2021004022A (es) * 2018-10-08 2021-09-10 Neutrolis Inc Modificacion genetica de enzimas dnasas para elaboracion y terapia.
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US20230062096A1 (en) * 2020-01-11 2023-03-02 Yale University Compositions and methods for treating, ameliorating, and/or preventing diseases or disorders caused by or associated with dnase1 and/or dnase1l3 deficiency
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