CN103884841B - 利用新颖标志物CT‑proADM进行诊断和危险分层 - Google Patents
利用新颖标志物CT‑proADM进行诊断和危险分层 Download PDFInfo
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| EP1628136A1 (en) * | 2004-08-19 | 2006-02-22 | B.R.A.H.M.S. Aktiengesellschaft | Method of diagnosis of disease using copeptin |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| DE102006060112A1 (de) * | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| DE102007009751A1 (de) | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| JP5711131B2 (ja) * | 2008-10-07 | 2015-04-30 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 最初の有害事象の予測のためのバイオマーカー |
| WO2010054810A1 (en) * | 2008-11-11 | 2010-05-20 | B.R.A.H.M.S Ag | Prognosis and risk assessment in patients suffering from heart failure by determining the level of adm and bnp |
| DK2427764T3 (en) * | 2009-05-05 | 2017-09-11 | Brahms Gmbh | VASOACTIVE HORMON-BASED STRATIFICATION OF PATIENTS SUFFERING OF DISEASES RELATED TO ENDOTELIAL FUNCTION / DYSFUNCTION |
| WO2011083145A1 (en) * | 2010-01-08 | 2011-07-14 | Cavadis B.V. | Determination of exosomel biomarkers for predicting cardiovascular events |
| US9709565B2 (en) | 2010-04-21 | 2017-07-18 | Memed Diagnostics Ltd. | Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof |
| US20140051183A1 (en) * | 2010-06-18 | 2014-02-20 | B.R.A.H.M.S Gmbh | Biomarkers for the prediction of incident cancer |
| RU2618437C2 (ru) * | 2010-11-01 | 2017-05-03 | Б.Р.А.Х.М.С Гмбх | Оценка прогноза и риска пациентов с неспецифическими жалобами |
| US9726668B2 (en) | 2012-02-09 | 2017-08-08 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| EP2637023A1 (en) * | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| US10598674B2 (en) * | 2013-03-20 | 2020-03-24 | Sphingotec Gmbh | Adrenomedullin to guide therapy of blood pressure decline |
| CA3190715A1 (en) | 2014-08-14 | 2016-02-18 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| WO2016059636A1 (en) | 2014-10-14 | 2016-04-21 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| CN107209184B (zh) | 2014-12-11 | 2020-04-24 | 米密德诊断学有限公司 | 用于诊断多种感染的标记组合及其使用方法 |
| CN104655849B (zh) * | 2015-02-15 | 2016-08-24 | 河北博海生物工程开发有限公司 | 一种肿瘤靶标的筛选方法 |
| WO2017149548A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| CN108699609A (zh) | 2016-03-03 | 2018-10-23 | 米密德诊断学有限公司 | 分析rna用于诊断感染类型 |
| EP3482208B1 (en) | 2016-07-08 | 2023-04-12 | SphingoTec GmbH | Adrenomedullin for assessing congestion in a subject with acute heart failure |
| EP3482201B1 (en) | 2016-07-10 | 2022-12-14 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| EP4141448A1 (en) | 2016-07-10 | 2023-03-01 | MeMed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| EP3279667A1 (en) * | 2016-08-02 | 2018-02-07 | Abbott Laboratories | Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd) |
| EP3519834A4 (en) | 2016-09-29 | 2020-06-17 | MeMed Diagnostics Ltd. | RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS |
| WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| JP6855118B2 (ja) * | 2017-03-14 | 2021-04-07 | 東ソー株式会社 | 全身状態の良不良を評価するための情報を提供する方法及び測定試薬 |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| EP3438668A1 (en) | 2017-08-04 | 2019-02-06 | B.R.A.H.M.S GmbH | Diagnosis and risk stratification of fungal infections |
| EP3682247B1 (en) | 2017-09-13 | 2022-02-09 | B.R.A.H.M.S GmbH | Proadrenomedullin as a marker for abnormal platelet levels |
| EP3698134A1 (en) * | 2017-10-18 | 2020-08-26 | AdrenoMed AG | Therapy monitoring under treatment with an anti-adrenomedullin (adm) binder |
| EP3502706A1 (en) | 2017-12-20 | 2019-06-26 | B.R.A.H.M.S GmbH | Workflow for risk assessment and patient management using procalcitonin and midregional-proadrenomedullin |
| AU2019219071A1 (en) | 2018-02-08 | 2020-07-30 | Sphingotec Gmbh | Adrenomedullin (ADM) for diagnosis and/or prediction of dementia and anti-adrenomedullin binder for use in therapy or prevention of dementia |
| CN112334773A (zh) * | 2018-06-01 | 2021-02-05 | B.R.A.H.M.S有限公司 | 用于诊断侵袭性真菌感染的生物标记物 |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| EP3914913A1 (en) * | 2019-02-21 | 2021-12-01 | B.R.A.H.M.S GmbH | Method for the diagnosis of macce in patients who underwent gastrointestinal surgery |
| WO2020169819A1 (en) * | 2019-02-21 | 2020-08-27 | B.R.A.H.M.S Gmbh | Diagnosis or prognosis of postsurgical adverse events |
| JP7575400B2 (ja) | 2019-03-29 | 2024-10-29 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | バイオマーカーに基づく遠隔患者管理の処方 |
| EP3715851A1 (en) | 2019-03-29 | 2020-09-30 | B.R.A.H.M.S GmbH | Prescription of remote patient management based on biomarkers |
| CN114556100A (zh) | 2019-08-30 | 2022-05-27 | 4Teen4制药有限公司 | 用于治疗休克的疗法指引和/或疗法监测 |
| EP4023218A1 (en) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Combination therapy for patients having acute and/or persistent dyspnea |
| EP4345109A1 (en) | 2022-09-30 | 2024-04-03 | AdrenoMed AG | Anti-adrenomedullin (adm) binder for use in therapy of pediatric patients with congenital heart disease |
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| DE19847690A1 (de) * | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| AUPR005600A0 (en) * | 2000-09-12 | 2000-10-05 | University Of Sydney, The | Diagnostic assay |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
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| JP4423426B2 (ja) * | 2006-05-29 | 2010-03-03 | 国立大学法人 宮崎大学 | アドレノメデュリン前駆体ｃ末端ペプチドの濃度の上昇を循環器疾患又は炎症性疾患の指標とする方法 |
| DE102006046996A1 (de) * | 2006-10-01 | 2008-04-03 | Brahms Aktiengesellschaft | Diagnose von Infektionen oder Entzündungserkrankungen der Atemwege und Lunge assoziiert mit Herzinsuffizienz |
| US9012151B2 (en) * | 2006-11-09 | 2015-04-21 | B.R.A.H.M.S. Gmbh | Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin |
| DE102007021443A1 (de) * | 2007-05-08 | 2008-11-13 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels NT-proET-1 |
| EP2180322A1 (en) * | 2008-10-22 | 2010-04-28 | BRAHMS Aktiengesellschaft | Prognostic biomarkers for the progression of primary chronic kidney disease |
| CN102317788A (zh) * | 2008-10-31 | 2012-01-11 | B.R.A.H.M.S有限公司 | 用作糖尿病预测生物标志物的精氨酸加压素激素原 |
| WO2011000020A1 (en) * | 2009-06-12 | 2011-01-06 | Sbc Research Pty Ltd | Enhanced method of detection |
| EP2470910B1 (en) * | 2009-08-28 | 2017-01-11 | B.R.A.H.M.S GmbH | Procalcitonin for the prognosis of adverse events |
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- 2006-12-20 DE DE102006060112A patent/DE102006060112A1/de not_active Withdrawn
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2007
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- 2007-12-20 WO PCT/DE2007/002300 patent/WO2008074315A2/de not_active Ceased
- 2007-12-20 AT AT07856143T patent/ATE552504T1/de active
- 2007-12-20 CN CN200780047509.XA patent/CN101611314B/zh active Active
- 2007-12-20 JP JP2009541760A patent/JP5379018B2/ja active Active
- 2007-12-20 CN CN201410026248.5A patent/CN103884841B/zh active Active
- 2007-12-20 US US12/520,159 patent/US8436135B2/en not_active Expired - Fee Related
- 2007-12-20 ES ES07856143T patent/ES2383711T3/es active Active
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2013
- 2013-03-01 US US13/782,027 patent/US8853355B2/en active Active
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2014
- 2014-09-05 US US14/478,639 patent/US9726675B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101611314B (zh) * | 2006-12-20 | 2014-03-05 | 布拉姆斯股份公司 | 利用新颖标志物CT-proADM进行诊断和危险分层 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100035289A1 (en) | 2010-02-11 |
| CN101611314B (zh) | 2014-03-05 |
| US8436135B2 (en) | 2013-05-07 |
| CN103884841A (zh) | 2014-06-25 |
| DE102006060112A1 (de) | 2008-06-26 |
| EP2111552A2 (de) | 2009-10-28 |
| JP5379018B2 (ja) | 2013-12-25 |
| US8853355B2 (en) | 2014-10-07 |
| US20150011017A1 (en) | 2015-01-08 |
| EP2111552B1 (de) | 2012-04-04 |
| WO2008074315A3 (de) | 2008-09-12 |
| WO2008074315A2 (de) | 2008-06-26 |
| US9726675B2 (en) | 2017-08-08 |
| ATE552504T1 (de) | 2012-04-15 |
| CN101611314A (zh) | 2009-12-23 |
| ES2383711T3 (es) | 2012-06-25 |
| JP2010513879A (ja) | 2010-04-30 |
| US20130266961A1 (en) | 2013-10-10 |
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