CN101611314B - 利用新颖标志物CT-proADM进行诊断和危险分层 - Google Patents
利用新颖标志物CT-proADM进行诊断和危险分层 Download PDFInfo
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- CN101611314B CN101611314B CN200780047509.XA CN200780047509A CN101611314B CN 101611314 B CN101611314 B CN 101611314B CN 200780047509 A CN200780047509 A CN 200780047509A CN 101611314 B CN101611314 B CN 101611314B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6884—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from lung
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410026248.5A CN103884841B (zh) | 2006-12-20 | 2007-12-20 | 利用新颖标志物CT‑proADM进行诊断和危险分层 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006060112A DE102006060112A1 (de) | 2006-12-20 | 2006-12-20 | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| DE102006060112.2 | 2006-12-20 | ||
| PCT/DE2007/002300 WO2008074315A2 (de) | 2006-12-20 | 2007-12-20 | Diagnose und risikostratifizierung mittels dem neuen marker ct-proadm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410026248.5A Division CN103884841B (zh) | 2006-12-20 | 2007-12-20 | 利用新颖标志物CT‑proADM进行诊断和危险分层 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101611314A CN101611314A (zh) | 2009-12-23 |
| CN101611314B true CN101611314B (zh) | 2014-03-05 |
Family
ID=39431425
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780047509.XA Active CN101611314B (zh) | 2006-12-20 | 2007-12-20 | 利用新颖标志物CT-proADM进行诊断和危险分层 |
| CN201410026248.5A Active CN103884841B (zh) | 2006-12-20 | 2007-12-20 | 利用新颖标志物CT‑proADM进行诊断和危险分层 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410026248.5A Active CN103884841B (zh) | 2006-12-20 | 2007-12-20 | 利用新颖标志物CT‑proADM进行诊断和危险分层 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8436135B2 (enExample) |
| EP (1) | EP2111552B1 (enExample) |
| JP (1) | JP5379018B2 (enExample) |
| CN (2) | CN101611314B (enExample) |
| AT (1) | ATE552504T1 (enExample) |
| DE (1) | DE102006060112A1 (enExample) |
| ES (1) | ES2383711T3 (enExample) |
| WO (1) | WO2008074315A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103884841A (zh) * | 2006-12-20 | 2014-06-25 | 布拉姆斯股份公司 | 利用新颖标志物CT-proADM进行诊断和危险分层 |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1628136A1 (en) * | 2004-08-19 | 2006-02-22 | B.R.A.H.M.S. Aktiengesellschaft | Method of diagnosis of disease using copeptin |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| DE102007009751A1 (de) | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| ES2795003T3 (es) * | 2008-10-07 | 2020-11-20 | Brahms Gmbh | Biomarcador para la predicción de los primeros eventos adversos |
| CN102317790B (zh) * | 2008-11-11 | 2014-12-10 | B.R.A.H.M.S有限公司 | Adm在制备用于评估心力衰竭和/或呼吸短促的制剂中的应用 |
| ES2643033T3 (es) * | 2009-05-05 | 2017-11-21 | B.R.A.H.M.S Gmbh | Estratificación basada en la hormona vasoactiva de los pacientes que sufren de enfermedades relacionadas con la función/disfunción endotelial |
| CN102812362B (zh) * | 2010-01-08 | 2015-02-11 | 卡瓦迪斯有限责任公司 | 用于预测心血管事件的外来体生物标志物的确定 |
| CN103119444B (zh) * | 2010-04-21 | 2016-10-26 | 米密德诊断学有限公司 | 区分细菌与病毒感染的标记物和决定因素以及其使用方法 |
| RU2586295C2 (ru) * | 2010-06-18 | 2016-06-10 | Б.Р.А.Х.М.С Гмбх | Биомаркеры для прогнозирования возникновения рака |
| RU2618437C2 (ru) * | 2010-11-01 | 2017-05-03 | Б.Р.А.Х.М.С Гмбх | Оценка прогноза и риска пациентов с неспецифическими жалобами |
| IN2014MN01780A (enExample) | 2012-02-09 | 2015-07-03 | Memed Diagnostics Ltd | |
| EP2637023A1 (en) * | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| WO2014147153A1 (en) * | 2013-03-20 | 2014-09-25 | Sphingotec Gmbh | Adrenomedullin to guide therapy of blood pressure decline |
| CA2954601C (en) | 2014-08-14 | 2023-04-18 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| US20170234873A1 (en) | 2014-10-14 | 2017-08-17 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| US20170269081A1 (en) | 2014-12-11 | 2017-09-21 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
| CN104655849B (zh) * | 2015-02-15 | 2016-08-24 | 河北博海生物工程开发有限公司 | 一种肿瘤靶标的筛选方法 |
| IL294121B2 (en) | 2016-03-03 | 2023-09-01 | Memed Diagnostics Ltd | An RNA test to diagnose the type of infection |
| WO2017149548A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| MX2019000003A (es) | 2016-07-08 | 2019-08-29 | Sphingotec Gmbh | Adrenomodulina para evaluar la congestión en un individuo con insuficiencia cardiaca aguda. |
| US11340223B2 (en) | 2016-07-10 | 2022-05-24 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| WO2018011795A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| EP3279667A1 (en) * | 2016-08-02 | 2018-02-07 | Abbott Laboratories | Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd) |
| CN110073220A (zh) | 2016-09-29 | 2019-07-30 | 米密德诊断学有限公司 | 风险评估和疾病分类的方法 |
| US11385241B2 (en) | 2016-09-29 | 2022-07-12 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| JP6855118B2 (ja) * | 2017-03-14 | 2021-04-07 | 東ソー株式会社 | 全身状態の良不良を評価するための情報を提供する方法及び測定試薬 |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| EP3438668A1 (en) | 2017-08-04 | 2019-02-06 | B.R.A.H.M.S GmbH | Diagnosis and risk stratification of fungal infections |
| JP7346389B2 (ja) | 2017-09-13 | 2023-09-19 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 異常な血小板レベルのマーカーとしてのプロアドレノメジュリン |
| JP2021500548A (ja) * | 2017-10-18 | 2021-01-07 | アドレノメト アクチェンゲゼルシャフト | 抗アドレノメデュリン(adm)結合剤での処置下での治療モニタリング |
| EP3502706A1 (en) | 2017-12-20 | 2019-06-26 | B.R.A.H.M.S GmbH | Workflow for risk assessment and patient management using procalcitonin and midregional-proadrenomedullin |
| WO2019154900A1 (en) | 2018-02-08 | 2019-08-15 | Sphingotec Gmbh | Adrenomedullin (adm) for diagnosis and/or prediction of dementia and anti-adrenomedullin binder for use in therapy or prevention of dementia |
| CN112334773A (zh) * | 2018-06-01 | 2021-02-05 | B.R.A.H.M.S有限公司 | 用于诊断侵袭性真菌感染的生物标记物 |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| CN113439214A (zh) * | 2019-02-21 | 2021-09-24 | 勃拉姆斯有限公司 | 用于诊断经历了胃肠道手术的患者的macce的方法 |
| US20220187313A1 (en) * | 2019-02-21 | 2022-06-16 | B.R.A.H.M.S Gmbh | Diagnosis or Prognosis of Postsurgical Adverse Events |
| EP3715851A1 (en) | 2019-03-29 | 2020-09-30 | B.R.A.H.M.S GmbH | Prescription of remote patient management based on biomarkers |
| WO2020201078A1 (en) | 2019-03-29 | 2020-10-08 | B.R.A.H.M.S Gmbh | Prescription of remote patient management based on biomarkers |
| EP4552649A3 (en) | 2019-08-30 | 2025-06-25 | 4TEEN4 Pharmaceuticals GmbH | Therapy guidance and/or therapy monitoring for treatment of shock |
| EP4023218A1 (en) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Combination therapy for patients having acute and/or persistent dyspnea |
| EP4345109A1 (en) | 2022-09-30 | 2024-04-03 | AdrenoMed AG | Anti-adrenomedullin (adm) binder for use in therapy of pediatric patients with congenital heart disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007316009A (ja) * | 2006-05-29 | 2007-12-06 | Univ Of Miyazaki | アドレノメデュリン前駆体c末端ペプチドの濃度の上昇を指標として循環器疾患又は炎症性疾患を診断する方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2774769B2 (ja) | 1993-04-26 | 1998-07-09 | 賢治 寒川 | アドレノメデュリン |
| DE19847690A1 (de) * | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| AUPR005600A0 (en) | 2000-09-12 | 2000-10-05 | University Of Sydney, The | Diagnostic assay |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| DE10316583A1 (de) | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| GB0401730D0 (en) * | 2004-01-27 | 2004-03-03 | Bioxell Spa | Diagnosis method |
| DE102005036094A1 (de) * | 2005-08-01 | 2007-02-08 | B.R.A.H.M.S Ag | In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| DE102006046996A1 (de) * | 2006-10-01 | 2008-04-03 | Brahms Aktiengesellschaft | Diagnose von Infektionen oder Entzündungserkrankungen der Atemwege und Lunge assoziiert mit Herzinsuffizienz |
| US9012151B2 (en) * | 2006-11-09 | 2015-04-21 | B.R.A.H.M.S. Gmbh | Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin |
| DE102006060112A1 (de) * | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| DE102007021443A1 (de) * | 2007-05-08 | 2008-11-13 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels NT-proET-1 |
| EP2180322A1 (en) * | 2008-10-22 | 2010-04-28 | BRAHMS Aktiengesellschaft | Prognostic biomarkers for the progression of primary chronic kidney disease |
| EP3199951B1 (en) * | 2008-10-31 | 2019-11-20 | B.R.A.H.M.S GmbH | Arginine vasopressin pro-hormone as predicitive biomarker for diabetes |
| WO2011000020A1 (en) * | 2009-06-12 | 2011-01-06 | Sbc Research Pty Ltd | Enhanced method of detection |
| EP2470910B1 (en) * | 2009-08-28 | 2017-01-11 | B.R.A.H.M.S GmbH | Procalcitonin for the prognosis of adverse events |
-
2006
- 2006-12-20 DE DE102006060112A patent/DE102006060112A1/de not_active Withdrawn
-
2007
- 2007-12-20 CN CN200780047509.XA patent/CN101611314B/zh active Active
- 2007-12-20 US US12/520,159 patent/US8436135B2/en not_active Expired - Fee Related
- 2007-12-20 AT AT07856143T patent/ATE552504T1/de active
- 2007-12-20 ES ES07856143T patent/ES2383711T3/es active Active
- 2007-12-20 JP JP2009541760A patent/JP5379018B2/ja active Active
- 2007-12-20 EP EP07856143A patent/EP2111552B1/de active Active
- 2007-12-20 WO PCT/DE2007/002300 patent/WO2008074315A2/de not_active Ceased
- 2007-12-20 CN CN201410026248.5A patent/CN103884841B/zh active Active
-
2013
- 2013-03-01 US US13/782,027 patent/US8853355B2/en active Active
-
2014
- 2014-09-05 US US14/478,639 patent/US9726675B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007316009A (ja) * | 2006-05-29 | 2007-12-06 | Univ Of Miyazaki | アドレノメデュリン前駆体c末端ペプチドの濃度の上昇を指標として循環器疾患又は炎症性疾患を診断する方法 |
Non-Patent Citations (4)
| Title |
|---|
| Gumusel等.Adrenotensin: an ADM gene product with the opposite effects of ADM.《Life Sciences》.1995,第57卷(第8期), * |
| Gumusel等.Adrenotensin: An adrenomedullin gene product contracts pulmonary blood vessels.《Peptides》.1996,第17卷(第3期), * |
| Struck等.Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients.《Peptides》.2004,第25卷(第8期), * |
| Zhou等.Vasoactive effects of adrenotensin and its interactions with adrenomedullin.《Chinese Medical Journal》.2000,第113卷(第3期), * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103884841A (zh) * | 2006-12-20 | 2014-06-25 | 布拉姆斯股份公司 | 利用新颖标志物CT-proADM进行诊断和危险分层 |
| CN103884841B (zh) * | 2006-12-20 | 2018-01-02 | 布拉姆斯有限公司 | 利用新颖标志物CT‑proADM进行诊断和危险分层 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8436135B2 (en) | 2013-05-07 |
| CN103884841A (zh) | 2014-06-25 |
| WO2008074315A2 (de) | 2008-06-26 |
| US20100035289A1 (en) | 2010-02-11 |
| US20130266961A1 (en) | 2013-10-10 |
| US9726675B2 (en) | 2017-08-08 |
| ATE552504T1 (de) | 2012-04-15 |
| CN103884841B (zh) | 2018-01-02 |
| EP2111552A2 (de) | 2009-10-28 |
| WO2008074315A3 (de) | 2008-09-12 |
| EP2111552B1 (de) | 2012-04-04 |
| ES2383711T3 (es) | 2012-06-25 |
| CN101611314A (zh) | 2009-12-23 |
| US8853355B2 (en) | 2014-10-07 |
| US20150011017A1 (en) | 2015-01-08 |
| JP5379018B2 (ja) | 2013-12-25 |
| JP2010513879A (ja) | 2010-04-30 |
| DE102006060112A1 (de) | 2008-06-26 |
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