CN103842515A - 降低糖化过程的粘度的方法 - Google Patents
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107002056A (zh) * | 2014-09-05 | 2017-08-01 | 诺维信公司 | 碳水化合物结合模块变体以及编码它们的多核苷酸 |
| CN107328883A (zh) * | 2017-09-05 | 2017-11-07 | 南京凯通粮食生化研究设计有限公司 | 一种鼠李糖生产企业快速准确测定鼠李糖含量的方法 |
| CN110713998A (zh) * | 2019-11-29 | 2020-01-21 | 江南大学 | 一种阿拉伯木聚糖降解酶系的制备方法及其应用 |
| CN112522117A (zh) * | 2020-12-29 | 2021-03-19 | 中国科学院成都生物研究所 | 一株粪壳菌及其应用 |
| CN120519535A (zh) * | 2025-07-24 | 2025-08-22 | 吉林农业大学 | 一种一步转化法制备槐糖脂的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7056721B2 (en) * | 2001-12-18 | 2006-06-06 | Genencor International, Inc. | EGVI endoglucanase and nucleic acids encoding the same |
| WO2011038019A2 (en) | 2009-09-23 | 2011-03-31 | Danisco Us Inc. | Novel glycosyl hydrolase enzymes and uses thereof |
| IN2012DN03825A (enExample) | 2009-11-20 | 2015-08-28 | Danisco Us Inc | |
| JP2013515482A (ja) | 2009-12-23 | 2013-05-09 | ダニスコ・ユーエス・インク | 同時糖化発酵反応の効率を改善するための方法 |
| CN103080306B (zh) * | 2010-08-20 | 2015-02-18 | 科德克希思公司 | 糖苷水解酶61家族蛋白在纤维素加工中的用途 |
| KR20140017612A (ko) | 2011-03-17 | 2014-02-11 | 다니스코 유에스 인크. | 당화 공정에서 점도를 감소시키는 방법 |
| EP2748317B1 (en) * | 2011-08-22 | 2017-04-19 | Codexis, Inc. | Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity |
| JP2013169154A (ja) * | 2012-02-17 | 2013-09-02 | Toyota Motor Corp | セルロース系バイオマス分解増強活性ポリペプチド |
| CA2868308A1 (en) | 2012-04-27 | 2013-10-31 | Novozymes, Inc. | Gh61 polypeptide variants and polynucleotides encoding same |
| JP2015533293A (ja) * | 2012-10-31 | 2015-11-24 | ダニスコ・ユーエス・インク | 組成物及び使用方法 |
| CA2892054A1 (en) | 2012-12-07 | 2014-06-12 | Ling Hua | Compositions and methods of use |
| DK2943577T3 (da) | 2013-01-11 | 2019-07-29 | Dsm Ip Assets Bv | Fremgangsmåde til enzymatisk hydrolyse af lignocellulosemateriale |
| US9988615B2 (en) * | 2013-02-04 | 2018-06-05 | Dsm Ip Assets B.V. | Carbohydrate degrading polypeptide and uses thereof |
| WO2014138672A1 (en) | 2013-03-08 | 2014-09-12 | Novozymes A/S | Cellobiohydrolase variants and polynucleotides encoding same |
| WO2014140171A1 (en) * | 2013-03-14 | 2014-09-18 | Dsm Ip Assets B.V. | Novel cell wall deconstruction enzymes of thielavia australiensis and uses thereof |
| WO2014182990A1 (en) | 2013-05-10 | 2014-11-13 | Novozymes A/S | Polypeptides having xylanase activity and polynucleotides encoding same |
| EP3027741B1 (en) | 2013-07-29 | 2019-10-23 | Danisco US Inc. | Gh61 enzyme variants |
| JP6325214B2 (ja) * | 2013-08-29 | 2018-05-16 | アサヒグループホールディングス株式会社 | セルラーゼの製造方法及び液体培地 |
| CN105492601A (zh) | 2013-09-04 | 2016-04-13 | 诺维信公司 | 增加对纤维素材料的酶法水解的方法 |
| EP3074513A1 (en) | 2013-11-26 | 2016-10-05 | Novozymes A/S | Enzyme compositions and uses thereof |
| FR3014903B1 (fr) * | 2013-12-17 | 2017-12-01 | Ifp Energies Now | Procede d'hydrolyse enzymatique avec production in situ de glycosides hydrolases par des microorganismes genetiquement modifies (mgm) et non mgm |
| MY205075A (en) | 2014-01-07 | 2024-10-01 | Novozymes As | Process for degrading mannan-containing cellulosic materials |
| EP3152315B1 (en) | 2014-06-06 | 2018-08-15 | Novozymes A/S | Enzyme compositions and uses thereof |
| BR112017003483A2 (pt) | 2014-08-28 | 2018-01-16 | Novozymes As | composição de enzimas para solubilização de resíduos sólidos municipais, e, processo para solubilizar um resíduo sólido municipal, para produzir um produto de fermentação e para fermentar um resíduo sólido municipal |
| MX382637B (es) | 2014-09-23 | 2025-03-13 | Novozymes As | Procesos para producir etanol y organismos fermentadores. |
| KR101719778B1 (ko) * | 2015-01-13 | 2017-04-03 | 대한민국 | 신규 페니실리움 솔리텀 ｍ２４３９ 균주 및 이의 용도 |
| FI3739045T3 (fi) | 2015-02-24 | 2024-11-13 | Novozymes As | Sellobiohydrolaasivariantteja ja niitä koodittavia polynukleotideja |
| TN2017000318A1 (en) | 2015-03-12 | 2019-01-16 | Beta Renewable Spa | Multi-stage enzymatic hydrolysis of lignocellulosic biomass |
| WO2016145358A1 (en) | 2015-03-12 | 2016-09-15 | Novozymes A/S | Enzymatic hydrolysis with hemicellulolytic enzymes |
| WO2016145363A1 (en) | 2015-03-12 | 2016-09-15 | Novozymes A/S | Multi-stage enzymatic hydrolysis of lignocellulosic biomass employing an oxidoreductase with an aa9 polypeptide |
| BR112017021489A2 (pt) | 2015-05-27 | 2018-07-03 | Novozymes A/S | polipeptídeo tendo atividade de celobio-hidrolase, composição, formulação de caldo inteiro ou composição de cultura de células, polinucleotídeo, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, métodos de produção do polipeptídeo. |
| BR112017027729A2 (pt) | 2015-07-07 | 2018-09-11 | Danisco Us Inc | indução de expressão de gene com o uso de uma mistura de açúcar de concentração alta |
| CN108138153A (zh) | 2015-07-24 | 2018-06-08 | 诺维信股份有限公司 | 具有阿拉伯呋喃糖苷酶活性的多肽以及编码它们的多核苷酸 |
| WO2017019491A1 (en) | 2015-07-24 | 2017-02-02 | Novozymes Inc. | Polypeptides having beta-xylosidase activity and polynucleotides encoding same |
| US10479984B2 (en) | 2015-09-22 | 2019-11-19 | Novozymes A/S | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| CN114054481A (zh) | 2015-11-02 | 2022-02-18 | 雷内科学有限公司 | 用混合酶溶解城市固体废物 |
| WO2018053058A1 (en) | 2016-09-14 | 2018-03-22 | Danisco Us Inc. | Lignocellulosic biomass fermentation-based processes |
| WO2018067599A1 (en) | 2016-10-04 | 2018-04-12 | Danisco Us Inc. | Protein production in filamentous fungal cells in the absence of inducing substrates |
| EP4644560A2 (en) | 2016-12-21 | 2025-11-05 | International N&H Denmark ApS | Methods of using thermostable serine proteases |
| WO2019074828A1 (en) | 2017-10-09 | 2019-04-18 | Danisco Us Inc | CELLOBIOSE DEHYDROGENASE VARIANTS AND METHODS OF USE |
| EP3781697A1 (en) | 2018-04-20 | 2021-02-24 | Renescience A/S | Method for determining chemical compounds in waste |
| EP4240543A1 (en) | 2020-11-04 | 2023-09-13 | Renescience A/S | Method for enzymatic and/or microbial processing of waste comprising recirculation of process water |
| EP4015642A1 (en) * | 2020-12-16 | 2022-06-22 | Clariant Produkte (Deutschland) GmbH | Process for the production of a filamentous fungus whole broth enzyme composition with low biomass formation and high protein yield |
| EP4015640A1 (en) * | 2020-12-16 | 2022-06-22 | Clariant Produkte (Deutschland) GmbH | Process for the production of a filamentous fungus whole broth enzyme composition with low viscosity |
| EP4015641A1 (en) * | 2020-12-16 | 2022-06-22 | Clariant Produkte (Deutschland) GmbH | Process for the production of a filamentous fungus whole broth enzyme composition with low biomass formation and high protein yield |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1152025A (zh) * | 1995-12-13 | 1997-06-18 | 高广仁 | 啤酒生产中添加纤维素酶的糖化工艺 |
| WO2005074647A2 (en) * | 2004-01-30 | 2005-08-18 | Novozymes Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| CN101671698A (zh) * | 2009-10-12 | 2010-03-17 | 天津科技大学 | 用木聚糖酶提高淀粉质原料酒精发酵速度和出酒率的方法 |
Family Cites Families (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1358599A (en) | 1970-12-22 | 1974-07-03 | Monacelli Umberto | Gun for firing tacks |
| US5366558A (en) | 1979-03-23 | 1994-11-22 | Brink David L | Method of treating biomass material |
| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| GB2094826B (en) | 1981-03-05 | 1985-06-12 | Kao Corp | Cellulase enzyme detergent composition |
| GB2095275B (en) | 1981-03-05 | 1985-08-07 | Kao Corp | Enzyme detergent composition |
| US4797361A (en) | 1983-10-24 | 1989-01-10 | Lehigh University | Microorganism and process |
| US5776757A (en) | 1988-03-24 | 1998-07-07 | Novo Nordisk A/S | Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof |
| DE68911131T2 (de) | 1988-03-24 | 1994-03-31 | Novonordisk As | Cellulosezubereitung. |
| CA1333777C (en) | 1988-07-01 | 1995-01-03 | Randy M. Berka | Aspartic proteinase deficient filamentous fungi |
| US5536655A (en) | 1989-09-26 | 1996-07-16 | Midwest Research Institute | Gene coding for the E1 endoglucanase |
| DK494089D0 (enExample) | 1989-10-06 | 1989-10-06 | Novo Nordisk As | |
| DK16490D0 (da) | 1990-01-19 | 1990-01-19 | Novo Nordisk As | Enzym |
| DE69107455T3 (de) | 1990-05-09 | 2004-09-23 | Novozymes A/S | Eine ein endoglucanase enzym enthaltende zellulasezubereitung. |
| DK115890D0 (da) | 1990-05-09 | 1990-05-09 | Novo Nordisk As | Enzym |
| US6103464A (en) | 1990-12-10 | 2000-08-15 | Genencor International, Inc. | Method of detecting DNA encoding a β-glucosidase from a filamentous fungus |
| DK1225227T3 (da) | 1990-12-10 | 2009-06-22 | Genencor Int | Forbedret forsukring af cellulose ved kloning og amplifikation af beta-glucosidase genet af trichoderma |
| ES2120428T3 (es) | 1991-03-18 | 1998-11-01 | Gist Brocades Nv | Clonacion y expresion de acetil-xilano esterasas de origen fungico. |
| US5405769A (en) | 1993-04-08 | 1995-04-11 | National Research Council Of Canada | Construction of thermostable mutants of a low molecular mass xylanase |
| DK81293D0 (da) | 1993-07-06 | 1993-07-06 | Novo Nordisk As | Enzym |
| DK83993D0 (enExample) | 1993-07-13 | 1993-07-13 | Novo Nordisk As | |
| US5437992A (en) | 1994-04-28 | 1995-08-01 | Genencor International, Inc. | Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp |
| US6099844A (en) | 1994-08-22 | 2000-08-08 | Triarco Industries, Inc. | Increasing yield of extractable substances from botanicals with an enzyme composition |
| US5705369A (en) | 1994-12-27 | 1998-01-06 | Midwest Research Institute | Prehydrolysis of lignocellulose |
| CN101955921A (zh) | 1995-03-17 | 2011-01-26 | 诺沃奇梅兹有限公司 | 新的内切葡聚糖酶 |
| CA2224624A1 (en) | 1995-06-23 | 1997-01-09 | Leendert Hendrik De Graaff | Novel beta-xylosidase, nucleotide sequence encoding it, and use thereof |
| US7883872B2 (en) | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
| US5811381A (en) | 1996-10-10 | 1998-09-22 | Mark A. Emalfarb | Cellulase compositions and methods of use |
| NZ502277A (en) | 1997-07-11 | 2002-02-01 | Genencor Int | Swollenin protein, encoding DNA sequences and use in detergents, fodder and paper production |
| US20020084046A1 (en) | 1998-09-29 | 2002-07-04 | Jay Chiehlung Hsu | Enzymatic paper and process of making thereof |
| EP1117808B1 (en) | 1998-10-06 | 2004-12-29 | Mark Aaron Emalfarb | Transformation system in the field of filamentous fungal hosts: in chrysosporium |
| US6409841B1 (en) | 1999-11-02 | 2002-06-25 | Waste Energy Integrated Systems, Llc. | Process for the production of organic products from diverse biomass sources |
| US6248535B1 (en) | 1999-12-20 | 2001-06-19 | University Of Southern California | Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens |
| JP4643881B2 (ja) | 1999-12-30 | 2011-03-02 | ジェネンコア インターナショナル インコーポレーテッド | Ｔｒｉｃｈｏｄｅｒｍａｒｅｅｓｅｉのキシラナーゼ |
| US6423145B1 (en) | 2000-08-09 | 2002-07-23 | Midwest Research Institute | Dilute acid/metal salt hydrolysis of lignocellulosics |
| DE10043662A1 (de) | 2000-08-30 | 2001-02-22 | Saechsisches Inst Fuer Angewan | Verfahren zur enzymatischen Aktivierung von lignocellulosen Faserstoffen zur Herstellung von Werkstoffen |
| US20060075519A1 (en) | 2001-05-18 | 2006-04-06 | Novozymes A/S | Polypeptides having cellobiase activity and ploynucleotides encoding same |
| US6982159B2 (en) | 2001-09-21 | 2006-01-03 | Genencor International, Inc. | Trichoderma β-glucosidase |
| US7049125B2 (en) | 2001-12-18 | 2006-05-23 | Genencor International, Inc. | EGVIII endoglucanase and nucleic acids encoding the same |
| US7056721B2 (en) | 2001-12-18 | 2006-06-06 | Genencor International, Inc. | EGVI endoglucanase and nucleic acids encoding the same |
| US7045331B2 (en) | 2001-12-18 | 2006-05-16 | Genencor International, Inc. | EGVII endoglucanase and nucleic acids encoding the same |
| US7005289B2 (en) | 2001-12-18 | 2006-02-28 | Genencor International, Inc. | BGL5 β-glucosidase and nucleic acids encoding the same |
| US7045332B2 (en) | 2001-12-18 | 2006-05-16 | Genencor International, Inc. | BGL4 β-glucosidase and nucleic acids encoding the same |
| US20040005674A1 (en) | 2002-04-30 | 2004-01-08 | Athenix Corporation | Methods for enzymatic hydrolysis of lignocellulose |
| CA2865180A1 (en) | 2002-08-16 | 2004-02-26 | Genencor International, Inc. | Novel variant hyprocrea jecorina cbh1 cellulases |
| ATE493490T1 (de) | 2002-10-04 | 2011-01-15 | Du Pont | Verfahren zur biologischen herstellung von 1,3- propandiol mit hoher ausbeute |
| JP4744879B2 (ja) | 2002-11-07 | 2011-08-10 | ジェネンコー・インターナショナル・インク | ＢＧＬ６β−グルコシダーゼ及びそれをエンコードする核酸 |
| US7407788B2 (en) | 2002-11-21 | 2008-08-05 | Danisco A/S, Genencor Division | BGL7 beta-glucosidase and nucleic acids encoding the same |
| WO2004078919A2 (en) | 2003-02-27 | 2004-09-16 | Midwest Research Institute | Superactive cellulase formulation using cellobiohydrolase-1 from penicillium funiculosum |
| US20040231060A1 (en) | 2003-03-07 | 2004-11-25 | Athenix Corporation | Methods to enhance the activity of lignocellulose-degrading enzymes |
| EP2311942A1 (en) | 2003-03-21 | 2011-04-20 | Genecor International, Inc. | Novel cbh1 homologs and variant cbh1 cellulases |
| SI1627050T1 (sl) | 2003-04-01 | 2014-01-31 | Danisco Us Inc. | Varianta humicola grisea cbh1.1 |
| ES2381207T3 (es) | 2003-05-29 | 2012-05-24 | Danisco Us Inc. | Nuevos genes de trichoderma |
| CN103088001A (zh) | 2003-08-25 | 2013-05-08 | 诺维信股份有限公司 | 糖苷水解酶的变体 |
| BRPI0414370A (pt) * | 2003-09-15 | 2006-11-14 | Genencor Int | enzimas modificadas, processos para produzir enzimas modificadas e usos das mesmas |
| CN1902310B (zh) | 2003-10-28 | 2011-09-21 | 诺维信股份有限公司 | 具有β-葡糖苷酶活性的多肽和编码所述多肽的多核苷酸 |
| WO2005054475A1 (ja) | 2003-12-03 | 2005-06-16 | Meiji Seika Kaisha, Ltd. | エンドグルカナーゼｓｔｃｅおよびそれを含むセルラーゼ調製物 |
| EP1733033B1 (en) * | 2004-02-06 | 2012-06-20 | Novozymes Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| CA2838451C (en) | 2004-03-25 | 2017-10-24 | Novozymes, Inc. | Methods for degrading or converting plant cell wall polysaccharides |
| US8097445B2 (en) | 2004-03-25 | 2012-01-17 | Danisco Us Inc. | Exo-endo cellulase fusion protein |
| EP2354222A1 (en) | 2004-03-25 | 2011-08-10 | Genencor International, Inc. | Cellulase fusion protein and heterologous cellulase fusion construct encoding the same |
| MXPA06013600A (es) | 2004-05-27 | 2007-03-15 | Genencor Int | Alfa amilasas acidoestables con actividad hidrolizante de almidon granular y composiciones enzimaticas. |
| CA2586779A1 (en) | 2004-06-03 | 2005-12-15 | Novozymes A/S | Mashing process and enzyme composition useful therein |
| US20060075522A1 (en) | 2004-07-31 | 2006-04-06 | Jaclyn Cleveland | Genes and uses for plant improvement |
| EP2302049B1 (en) | 2004-12-30 | 2017-01-25 | Danisco US Inc. | Variant hypocrea jecorina cbh2 cellulases |
| CA2593246C (en) | 2005-01-06 | 2016-06-21 | Novozymes, Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| BRPI0612944B1 (pt) | 2005-04-12 | 2017-11-28 | E.I.Du Pont De Nemours And Company | Method of production of target substance |
| US7781191B2 (en) | 2005-04-12 | 2010-08-24 | E. I. Du Pont De Nemours And Company | Treatment of biomass to obtain a target chemical |
| CA2910102A1 (en) | 2005-04-26 | 2006-11-02 | Novozymes A/S | Hydrolysis of arabinoxylan |
| CN104404106A (zh) * | 2005-09-30 | 2015-03-11 | 诺维信股份有限公司 | 用于增强纤维素材料降解或转化的方法 |
| US7256032B2 (en) | 2005-12-22 | 2007-08-14 | Ab Enzymes Oy | Enzymes |
| FI120045B (fi) * | 2005-12-22 | 2009-06-15 | Roal Oy | Selluloosamateriaalin käsittely ja siinä käyttökelpoiset entsyymit |
| NZ595497A (en) * | 2006-02-10 | 2013-09-27 | Verenium Corp | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
| WO2008008793A2 (en) | 2006-07-10 | 2008-01-17 | Dyadic International Inc. | Methods and compositions for degradation of lignocellulosic material |
| US8017373B2 (en) | 2006-08-31 | 2011-09-13 | Iogen Energy Corporation | Process for enzymatic hydrolysis of pretreated lignocellulosic feedstocks |
| US8138321B2 (en) | 2006-09-22 | 2012-03-20 | Danisco Us Inc. | Acetolactate synthase (ALS) selectable marker from Trichoderma reesei |
| US7993884B2 (en) | 2006-10-10 | 2011-08-09 | The United States Of America As Represented By The Secretary Of Agriculture | Beta-xylosidase for conversion of plant cell wall carbohydrates to simple sugars |
| CA2669720C (en) | 2006-11-13 | 2015-07-21 | Danisco Us, Inc., Genencor Division | Method for improving yield of cellulose conversion processes |
| BRPI0811465A2 (pt) | 2007-05-10 | 2014-10-14 | Novozymes Inc | Composição de enzima celulolítica, e, métodos para degradação ou conversão de um material centendo celulose e para produção de um produto de fermentação |
| WO2008153712A2 (en) | 2007-05-21 | 2008-12-18 | Danisco Us, Inc., Genencor Division | Method for introducing nucleic acids into fungal cells |
| BRPI0812035A2 (pt) * | 2007-05-31 | 2014-10-14 | Novozymes Inc | Polipeptídeo isola, polinucleotídeo isolado, construção de ácidos nucleicos, vetor de expressão recombinante, célula hospedeira recombinante, métodos para produzir um polipeptídeo, um mutante de uma célula originária e uma proteína, para inibir a expressão de um polipeptídeo em uma célula, para degradar ou converter um material contendo celulose e para produzir um produto de fermentação, célula mutante, planta, parte de planta ou célula de planta trangênica, e, molécula de rna inibidor de fita dupla |
| JP2010528624A (ja) | 2007-05-31 | 2010-08-26 | ノボザイムス，インコーポレイティド | セルロース物質分解のための組成物 |
| AU2008259986C1 (en) | 2007-05-31 | 2012-07-26 | Novozymes, Inc. | Methods of increasing the cellulolytic enhancing activity of a polypeptide |
| CA2693084A1 (en) | 2007-06-08 | 2008-12-18 | Benjamin S. Bower | Heterologous and homologous cellulase expression system |
| US9399782B2 (en) | 2007-06-27 | 2016-07-26 | Novozymes A/S | Methods for producing fermentation products |
| EP2175714A4 (en) | 2007-07-10 | 2011-01-26 | Monsanto Technology Llc | TRANSGENIC PLANTS WITH IMPROVED AGRONOMIC CHARACTERISTICS |
| US7819976B2 (en) | 2007-08-22 | 2010-10-26 | E. I. Du Pont De Nemours And Company | Biomass treatment method |
| CA2736661A1 (en) | 2007-09-07 | 2009-03-12 | Dyadic International, Inc. | Novel fungal enzymes |
| US20100221784A1 (en) | 2007-09-07 | 2010-09-02 | Fujdala Meredith K | Beta-Glucosidase Enhanced Filamentous Fungal Whole Cellulase Compositions and Methods Of Use |
| NZ584967A (en) | 2007-10-03 | 2012-08-31 | Verenium Corp | Xylanases, nucleic acids encoding them and methods for making and using them |
| US20110039320A1 (en) | 2007-10-12 | 2011-02-17 | Mian Li | Methods and Compositions for Enhanced Production of Organic Substances From Fermenting Microorganisms |
| MY174318A (en) * | 2007-12-12 | 2020-04-07 | Novozymes As | Enzymatic degradation of biomass substrates comprising mannan |
| WO2009076676A2 (en) | 2007-12-13 | 2009-06-18 | Danisco Us Inc. | Compositions and methods for producing isoprene |
| WO2009085859A2 (en) * | 2007-12-19 | 2009-07-09 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| CA2709490A1 (en) * | 2007-12-19 | 2009-07-09 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| EP2260105B1 (en) | 2008-02-29 | 2016-08-17 | The Trustees Of The University Of Pennsylvania | Production and use of plant degrading materials |
| EP2250257A1 (en) | 2008-03-07 | 2010-11-17 | Danisco US Inc. | Expression of catalase in trichoderma |
| WO2009117689A1 (en) | 2008-03-21 | 2009-09-24 | Danisco Us Inc., Genencor Division | Hemicellulase enriched compositions for enhancing hydrolysis of biomass |
| US20110165635A1 (en) | 2008-04-21 | 2011-07-07 | Chromatin, Inc. | Methods and materials for processing a feedstock |
| BRPI0910940A2 (pt) | 2008-04-29 | 2015-10-06 | Danisco Us Inc | composições de swolenina e métodos de aumento da eficiência de uma celulase |
| EP2628796A1 (en) | 2008-06-06 | 2013-08-21 | Danisco US Inc. | Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials |
| WO2010059424A2 (en) * | 2008-11-18 | 2010-05-27 | Novozymes, Inc. | Methods and compositions for degrading cellulosic material |
| US7771983B2 (en) * | 2008-12-04 | 2010-08-10 | Novozymos, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| CN102325889A (zh) * | 2008-12-19 | 2012-01-18 | 诺维信股份有限公司 | 增加纤维素材料水解的方法 |
| RU2560424C2 (ru) | 2009-02-20 | 2015-08-20 | ДАНИСКО ЮЭс ИНК. | Способ получения состава ферментационного бульона |
| CA2750920A1 (en) * | 2009-02-27 | 2010-09-02 | Iogen Energy Corporation | Novel lignin-resistant cellulase enzymes |
| WO2010118257A2 (en) * | 2009-04-08 | 2010-10-14 | Danisco Us Inc. | Endoglucanase for reducing the viscosity of a plant material slurry |
| CN102482680B (zh) * | 2009-04-30 | 2014-09-10 | 诺维信股份有限公司 | 具有木聚糖酶活性的多肽和编码该多肽的多核苷酸 |
| CA2763031A1 (en) * | 2009-05-29 | 2010-12-02 | Novozymes, Inc. | Methods for enhancing the degradation or conversion of cellulosic material |
| US8679816B2 (en) | 2009-06-03 | 2014-03-25 | Danisco Us Inc. | Cellulase variants with improved expression, activity and stability, and use thereof |
| EP2443235A4 (en) | 2009-06-16 | 2013-07-31 | Codexis Inc | ß-glucosidase VARIANTS |
| WO2011038019A2 (en) | 2009-09-23 | 2011-03-31 | Danisco Us Inc. | Novel glycosyl hydrolase enzymes and uses thereof |
| IN2012DN03825A (enExample) | 2009-11-20 | 2015-08-28 | Danisco Us Inc | |
| US8647850B2 (en) * | 2009-12-23 | 2014-02-11 | E I Du Pont De Nemours And Company | Process for simultaneous saccharification and fermentation for production of ethanol |
| JP2013515482A (ja) | 2009-12-23 | 2013-05-09 | ダニスコ・ユーエス・インク | 同時糖化発酵反応の効率を改善するための方法 |
| US8906235B2 (en) | 2010-04-28 | 2014-12-09 | E I Du Pont De Nemours And Company | Process for liquid/solid separation of lignocellulosic biomass hydrolysate fermentation broth |
| US8721794B2 (en) | 2010-04-28 | 2014-05-13 | E I Du Pont De Nemours And Company | Production of high solids syrup from lignocellulosic biomass hydrolysate fermentation broth |
| US8962295B2 (en) | 2010-06-01 | 2015-02-24 | California Institute Of Technology | Stable, functional chimeric cellobiohydrolase class I enzymes |
| EP2397491A1 (en) | 2010-06-21 | 2011-12-21 | Technische Universität Wien | LeaA from Trichoderma reesei |
| WO2012030845A2 (en) | 2010-08-30 | 2012-03-08 | Novozymes A/S | Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same |
| US8476048B2 (en) * | 2010-12-17 | 2013-07-02 | E I Du Pont De Nemours And Company | Xylose utilizing zymomonas mobilis with improved ethanol production in biomass hydrolysate medium |
| KR20140017612A (ko) | 2011-03-17 | 2014-02-11 | 다니스코 유에스 인크. | 당화 공정에서 점도를 감소시키는 방법 |
| CA2829918A1 (en) | 2011-03-17 | 2012-09-20 | Danisco Us Inc. | Cellulase compositions and methods of using the same for improved conversion of lignocellulosic biomass into fermentable sugars |
| WO2012125937A2 (en) | 2011-03-17 | 2012-09-20 | Danisco Us Inc. | Glycosyl hydrolase enzymes and uses thereof for biomass hydrolysis |
| WO2012154735A2 (en) | 2011-05-10 | 2012-11-15 | Danisco Us Inc. | Thermostable carbonic anhydrases and methods of use thereof |
| EP2748317B1 (en) | 2011-08-22 | 2017-04-19 | Codexis, Inc. | Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity |
| DK2791350T3 (da) | 2011-12-13 | 2019-05-06 | Danisco Us Inc | Enzymcocktails fremstillet af blandede kulturer |
| JP2015533293A (ja) | 2012-10-31 | 2015-11-24 | ダニスコ・ユーエス・インク | 組成物及び使用方法 |
| BR112015009237A2 (pt) | 2012-10-31 | 2017-08-22 | Danisco Us Inc | Composição compreendendo beta-glicosidase de magnaporthe grisea, ácido nucleico, célula hospedeira e métodos para produzir beta-glicosidase e para hidrolisar substrato de biomassa lignocelulósica |
| MX2015007234A (es) | 2012-12-12 | 2015-10-29 | Danisco Us Inc | Variantes de celobiohidrolasas. |
| BR112015029081A2 (pt) | 2013-05-20 | 2017-09-19 | Abengoa Bioenergia Nuevas Tecnologias Sa | Célula hospedeira myceliophthora thermophila expressando uma enzima beta-xilosidase recombinante, enzima beta-xilosidase recombinante expressada por meio da mesma, composição, uso de célula hospedeira, enzima beta-xilosidase ou composição e métodos de produção de açúcares fermentescíveis e de produção de bioproduto a partir de biomassa |
| EP3027741B1 (en) | 2013-07-29 | 2019-10-23 | Danisco US Inc. | Gh61 enzyme variants |
| US20160298157A1 (en) | 2013-12-04 | 2016-10-13 | Danisco Us Inc. | Compositions comprising a beta-glucosidase polypeptide and methods of use |
-
2012
- 2012-03-16 KR KR1020137027241A patent/KR20140017612A/ko not_active Withdrawn
- 2012-03-16 MX MX2013010512A patent/MX2013010512A/es unknown
- 2012-03-16 UA UAA201312128A patent/UA115306C2/uk unknown
- 2012-03-16 EP EP12711517.8A patent/EP2686434B1/en active Active
- 2012-03-16 CA CA2830508A patent/CA2830508A1/en not_active Abandoned
- 2012-03-16 US US14/004,877 patent/US20140134677A1/en not_active Abandoned
- 2012-03-16 WO PCT/US2012/029445 patent/WO2012125925A2/en not_active Ceased
- 2012-03-16 DK DK12711517.8T patent/DK2686434T3/da active
- 2012-03-16 BR BR112013023757A patent/BR112013023757A2/pt not_active Application Discontinuation
- 2012-03-16 SG SG2013056122A patent/SG192098A1/en unknown
- 2012-03-16 JP JP2013558209A patent/JP6290626B2/ja not_active Expired - Fee Related
- 2012-03-16 RU RU2013146245/10A patent/RU2013146245A/ru not_active Application Discontinuation
- 2012-03-16 CN CN201280013810.XA patent/CN103842515A/zh active Pending
- 2012-03-16 HK HK14112152.3A patent/HK1198659A1/xx unknown
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1152025A (zh) * | 1995-12-13 | 1997-06-18 | 高广仁 | 啤酒生产中添加纤维素酶的糖化工艺 |
| WO2005074647A2 (en) * | 2004-01-30 | 2005-08-18 | Novozymes Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| CN101671698A (zh) * | 2009-10-12 | 2010-03-17 | 天津科技大学 | 用木聚糖酶提高淀粉质原料酒精发酵速度和出酒率的方法 |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107002056A (zh) * | 2014-09-05 | 2017-08-01 | 诺维信公司 | 碳水化合物结合模块变体以及编码它们的多核苷酸 |
| CN107328883A (zh) * | 2017-09-05 | 2017-11-07 | 南京凯通粮食生化研究设计有限公司 | 一种鼠李糖生产企业快速准确测定鼠李糖含量的方法 |
| CN110713998A (zh) * | 2019-11-29 | 2020-01-21 | 江南大学 | 一种阿拉伯木聚糖降解酶系的制备方法及其应用 |
| CN110713998B (zh) * | 2019-11-29 | 2021-11-02 | 江南大学 | 一种阿拉伯木聚糖降解酶系的制备方法及其应用 |
| CN112522117A (zh) * | 2020-12-29 | 2021-03-19 | 中国科学院成都生物研究所 | 一株粪壳菌及其应用 |
| CN112522117B (zh) * | 2020-12-29 | 2022-06-28 | 中国科学院成都生物研究所 | 一株粪壳菌及其应用 |
| CN120519535A (zh) * | 2025-07-24 | 2025-08-22 | 吉林农业大学 | 一种一步转化法制备槐糖脂的方法 |
| CN120519535B (zh) * | 2025-07-24 | 2025-09-26 | 吉林农业大学 | 一种一步转化法制备槐糖脂的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140017612A (ko) | 2014-02-11 |
| JP2018075020A (ja) | 2018-05-17 |
| WO2012125925A2 (en) | 2012-09-20 |
| EP2686434B1 (en) | 2021-07-14 |
| US20170096651A1 (en) | 2017-04-06 |
| CA2830508A1 (en) | 2012-09-20 |
| HK1198659A1 (en) | 2015-05-22 |
| DK2686434T3 (da) | 2021-10-11 |
| SG192098A1 (en) | 2013-08-30 |
| ZA201305619B (en) | 2014-10-29 |
| US10190108B2 (en) | 2019-01-29 |
| EP2686434A2 (en) | 2014-01-22 |
| JP2014511673A (ja) | 2014-05-19 |
| US20140134677A1 (en) | 2014-05-15 |
| UA115306C2 (uk) | 2017-10-25 |
| BR112013023757A2 (pt) | 2017-06-06 |
| WO2012125925A3 (en) | 2012-12-27 |
| MX2013010512A (es) | 2013-10-07 |
| RU2013146245A (ru) | 2015-04-27 |
| JP6290626B2 (ja) | 2018-03-14 |
| US20190249160A1 (en) | 2019-08-15 |
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