CN103826657A - 改进疫苗免疫原性的方法 - Google Patents

改进疫苗免疫原性的方法 Download PDF

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CN103826657A
CN103826657A CN201280027239.7A CN201280027239A CN103826657A CN 103826657 A CN103826657 A CN 103826657A CN 201280027239 A CN201280027239 A CN 201280027239A CN 103826657 A CN103826657 A CN 103826657A
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epi
antigen
antibody
compound
cells
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G.比肖普
T.范登布什
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University of Iowa Research Foundation UIRF
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CN201280027239.7A 2011-04-04 2012-04-04 改进疫苗免疫原性的方法 Pending CN103826657A (zh)

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US201161471553P 2011-04-04 2011-04-04
US61/471,553 2011-04-04
PCT/US2012/032190 WO2012138774A2 (en) 2011-04-04 2012-04-04 Methods of improving vaccine immunogenicity

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US (1) US10059746B2 (enExample)
EP (1) EP2694102A4 (enExample)
JP (2) JP2014512182A (enExample)
KR (1) KR20140027211A (enExample)
CN (1) CN103826657A (enExample)
AU (2) AU2012240231B2 (enExample)
CA (1) CA2834734A1 (enExample)
MX (1) MX356426B (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472350A (zh) * 2016-01-08 2018-08-31 瓦西博迪公司 新表位rna癌症疫苗

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014120941A1 (en) 2013-02-01 2014-08-07 University Of Iowa Research Foundation Tumor vaccines and methods of use thereof
AR095425A1 (es) 2013-03-15 2015-10-14 Glaxosmithkline Biologicals Sa Vacuna, uso y procedimiento para prevenir una infección por picornavirus
JP2018058812A (ja) * 2016-06-01 2018-04-12 パナソニックIpマネジメント株式会社 インフルエンザウィルス核内蛋白質に結合する抗体、複合体、それを用いた検出装置及び検出方法
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3927372A4 (en) * 2019-02-21 2023-01-25 Centivax, Inc. OPTIMIZED VACCINE COMPOSITIONS AND METHODS OF PRODUCTION

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070026502A1 (en) * 1994-04-28 2007-02-01 Matti Sallberg Specificity exchangers that redirect antibodies to a pathogen
US20080090225A1 (en) * 2006-06-16 2008-04-17 Kirkegaard Karla A Methods of identifying anti-viral agents
US20080118530A1 (en) * 2004-10-08 2008-05-22 Kew Olen M Modulation of Replicative Fitness By Deoptimization of Synonymous Codons

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US5204096A (en) 1984-03-07 1993-04-20 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5374426A (en) * 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
ES2284161T3 (es) 1990-01-12 2007-11-01 Amgen Fremont Inc. Generacion de anticuerpos xenogenicos.
CA2109602C (en) 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1992014489A1 (en) * 1991-02-14 1992-09-03 Repligen Corporation Poliovirus-based vaccines
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
PT1696031E (pt) 1991-12-02 2010-06-25 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
AU3328493A (en) 1991-12-17 1993-07-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AU685047B2 (en) * 1992-02-11 1998-01-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Dual carrier immunogenic construct
JP3507073B2 (ja) 1992-03-24 2004-03-15 ケンブリッジ アンティボディー テクノロジー リミティド 特異的結合対の成員の製造方法
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
CA2125344A1 (en) * 1993-07-01 1995-01-02 Casey D. Morrow Encapsidated recombinant poliovirus nucleic acid and methods of making and using same
WO1995015388A1 (en) 1993-12-03 1995-06-08 Medical Research Council Recombinant binding proteins and peptides
US6660842B1 (en) * 1994-04-28 2003-12-09 Tripep Ab Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
CA2194907A1 (en) 1994-07-13 1996-02-01 Kouji Matsushima Reshaped human antibody against human interleukin-8
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
CN1044092C (zh) * 1997-02-26 1999-07-14 上海医科大学 抗原-抗体-重组dna复合型疫苗
US6232082B1 (en) 1998-12-01 2001-05-15 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
US20020131953A1 (en) 2001-03-14 2002-09-19 Ut Southwestern Medical Center In situ langerhans cell vaccine
FR2827605B1 (fr) 2001-07-20 2004-07-16 Pf Medicament Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin
KR101228376B1 (ko) 2002-07-18 2013-01-31 사이토스 바이오테크놀로지 아게 합텐-캐리어 컨쥬게이트 및 그의 용도
CA2548180C (en) 2003-12-04 2014-02-04 Vaccinex, Inc. Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells
US20080311147A1 (en) * 2004-04-19 2008-12-18 Thomas Jeffeson University Rhabdoviral N-Fusion Proteins as Carrier for Foreign Antigens
US7078179B2 (en) 2004-05-04 2006-07-18 Newlink Genetics Corporation Selectable gene marker system based on expression of N-acetyllactosaminide 3-α galactosyltransferase
GB0428394D0 (en) 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
AU2006235364A1 (en) * 2005-04-08 2006-10-19 Marina Biotech, Inc. RNAi therapeutic for respiratory virus infection
WO2007052238A2 (en) * 2005-11-07 2007-05-10 University Of Pretoria Chimeric antigens and vaccines
WO2008118487A2 (en) * 2007-03-26 2008-10-02 University Of Massachusetts Medical School Compositions and methods for incresing immunogenicity of glycoprotein vaccines
EP2164511A1 (en) * 2007-05-22 2010-03-24 Baylor College Of Medicine Immune complex vaccination as a strategy to enhance immunity in the elderly and other immune compromised populations
EP2223934B1 (en) 2007-11-14 2012-10-03 Institute Of Microbiology, Chinese Academy Of Sciences Polypeptides for inhibiting influenza virus infection
US20090324630A1 (en) 2008-04-21 2009-12-31 Jensen Michael C Fusion multiviral chimeric antigen
WO2011041691A1 (en) 2009-10-02 2011-04-07 University Of Iowa Research Foundation Methods of improving vaccine immunogenicity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070026502A1 (en) * 1994-04-28 2007-02-01 Matti Sallberg Specificity exchangers that redirect antibodies to a pathogen
US20080118530A1 (en) * 2004-10-08 2008-05-22 Kew Olen M Modulation of Replicative Fitness By Deoptimization of Synonymous Codons
US20080090225A1 (en) * 2006-06-16 2008-04-17 Kirkegaard Karla A Methods of identifying anti-viral agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KINGSMAN S M: "多价重组抗原: 一种新的疫苗策略", 《国外医学.预防.诊断.治疗用生物制品分册》 *
董明: "1 型脊髓灰质炎病毒中和抗原决定簇在白喉病毒融合蛋白中的表达", 《国外医学.预防.诊断.治疗用生物制品分册》 *

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN108472350A (zh) * 2016-01-08 2018-08-31 瓦西博迪公司 新表位rna癌症疫苗

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NZ617303A (en) 2016-07-29
MX356426B (es) 2018-05-29
AU2017218957A1 (en) 2017-10-19
JP2017158556A (ja) 2017-09-14
US20140134204A1 (en) 2014-05-15
EP2694102A2 (en) 2014-02-12
AU2012240231B2 (en) 2017-05-25
EP2694102A4 (en) 2015-03-04
KR20140027211A (ko) 2014-03-06
US10059746B2 (en) 2018-08-28
JP2014512182A (ja) 2014-05-22
AU2012240231A1 (en) 2013-11-14
CA2834734A1 (en) 2012-10-11
WO2012138774A2 (en) 2012-10-11
MX2013011689A (es) 2014-07-14

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Application publication date: 20140528