CA2834734A1 - Methods of improving vaccine immunogenicity - Google Patents
Methods of improving vaccine immunogenicity Download PDFInfo
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- CA2834734A1 CA2834734A1 CA2834734A CA2834734A CA2834734A1 CA 2834734 A1 CA2834734 A1 CA 2834734A1 CA 2834734 A CA2834734 A CA 2834734A CA 2834734 A CA2834734 A CA 2834734A CA 2834734 A1 CA2834734 A1 CA 2834734A1
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- C12N2760/16011—Orthomyxoviridae
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- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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| WO2014120941A1 (en) | 2013-02-01 | 2014-08-07 | University Of Iowa Research Foundation | Tumor vaccines and methods of use thereof |
| AR095425A1 (es) | 2013-03-15 | 2015-10-14 | Glaxosmithkline Biologicals Sa | Vacuna, uso y procedimiento para prevenir una infección por picornavirus |
| WO2017118702A1 (en) * | 2016-01-08 | 2017-07-13 | Vaccibody As | Neoepitope rna cancer vaccine |
| JP2018058812A (ja) * | 2016-06-01 | 2018-04-12 | パナソニックＩｐマネジメント株式会社 | インフルエンザウィルス核内蛋白質に結合する抗体、複合体、それを用いた検出装置及び検出方法 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3927372A4 (en) * | 2019-02-21 | 2023-01-25 | Centivax, Inc. | OPTIMIZED VACCINE COMPOSITIONS AND METHODS OF PRODUCTION |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US5204096A (en) | 1984-03-07 | 1993-04-20 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| ES2284161T3 (es) | 1990-01-12 | 2007-11-01 | Amgen Fremont Inc. | Generacion de anticuerpos xenogenicos. |
| CA2109602C (en) | 1990-07-10 | 2002-10-01 | Gregory P. Winter | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992014489A1 (en) * | 1991-02-14 | 1992-09-03 | Repligen Corporation | Poliovirus-based vaccines |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| PT1696031E (pt) | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU685047B2 (en) * | 1992-02-11 | 1998-01-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Dual carrier immunogenic construct |
| JP3507073B2 (ja) | 1992-03-24 | 2004-03-15 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的結合対の成員の製造方法 |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| CA2125344A1 (en) * | 1993-07-01 | 1995-01-02 | Casey D. Morrow | Encapsidated recombinant poliovirus nucleic acid and methods of making and using same |
| WO1995015388A1 (en) | 1993-12-03 | 1995-06-08 | Medical Research Council | Recombinant binding proteins and peptides |
| US6933366B2 (en) * | 1996-12-27 | 2005-08-23 | Tripep Ab | Specificity exchangers that redirect antibodies to bacterial adhesion receptors |
| US6660842B1 (en) * | 1994-04-28 | 2003-12-09 | Tripep Ab | Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen |
| CA2194907A1 (en) | 1994-07-13 | 1996-02-01 | Kouji Matsushima | Reshaped human antibody against human interleukin-8 |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| CN1044092C (zh) * | 1997-02-26 | 1999-07-14 | 上海医科大学 | 抗原－抗体－重组dna复合型疫苗 |
| US6232082B1 (en) | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| US20020131953A1 (en) | 2001-03-14 | 2002-09-19 | Ut Southwestern Medical Center | In situ langerhans cell vaccine |
| FR2827605B1 (fr) | 2001-07-20 | 2004-07-16 | Pf Medicament | Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin |
| KR101228376B1 (ko) | 2002-07-18 | 2013-01-31 | 사이토스 바이오테크놀로지 아게 | 합텐-캐리어 컨쥬게이트 및 그의 용도 |
| CA2548180C (en) | 2003-12-04 | 2014-02-04 | Vaccinex, Inc. | Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells |
| US20080311147A1 (en) * | 2004-04-19 | 2008-12-18 | Thomas Jeffeson University | Rhabdoviral N-Fusion Proteins as Carrier for Foreign Antigens |
| US7078179B2 (en) | 2004-05-04 | 2006-07-18 | Newlink Genetics Corporation | Selectable gene marker system based on expression of N-acetyllactosaminide 3-α galactosyltransferase |
| EP1797173B1 (en) | 2004-10-08 | 2014-05-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Modulation of replicative fitness by using less frequently used synonymous codons |
| GB0428394D0 (en) | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
| AU2006235364A1 (en) * | 2005-04-08 | 2006-10-19 | Marina Biotech, Inc. | RNAi therapeutic for respiratory virus infection |
| WO2007052238A2 (en) * | 2005-11-07 | 2007-05-10 | University Of Pretoria | Chimeric antigens and vaccines |
| US7476499B2 (en) * | 2006-06-16 | 2009-01-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of identifying anti-viral agents |
| WO2008118487A2 (en) * | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
| EP2164511A1 (en) * | 2007-05-22 | 2010-03-24 | Baylor College Of Medicine | Immune complex vaccination as a strategy to enhance immunity in the elderly and other immune compromised populations |
| EP2223934B1 (en) | 2007-11-14 | 2012-10-03 | Institute Of Microbiology, Chinese Academy Of Sciences | Polypeptides for inhibiting influenza virus infection |
| US20090324630A1 (en) | 2008-04-21 | 2009-12-31 | Jensen Michael C | Fusion multiviral chimeric antigen |
| WO2011041691A1 (en) | 2009-10-02 | 2011-04-07 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
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| MX356426B (es) | 2018-05-29 |
| AU2017218957A1 (en) | 2017-10-19 |
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| EP2694102A2 (en) | 2014-02-12 |
| AU2012240231B2 (en) | 2017-05-25 |
| EP2694102A4 (en) | 2015-03-04 |
| KR20140027211A (ko) | 2014-03-06 |
| US10059746B2 (en) | 2018-08-28 |
| JP2014512182A (ja) | 2014-05-22 |
| AU2012240231A1 (en) | 2013-11-14 |
| WO2012138774A2 (en) | 2012-10-11 |
| MX2013011689A (es) | 2014-07-14 |
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