CN103816484B - A kind of Chinese medicine composition treating cancer of the stomach and preparation method thereof - Google Patents
A kind of Chinese medicine composition treating cancer of the stomach and preparation method thereof Download PDFInfo
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- CN103816484B CN103816484B CN201410082416.2A CN201410082416A CN103816484B CN 103816484 B CN103816484 B CN 103816484B CN 201410082416 A CN201410082416 A CN 201410082416A CN 103816484 B CN103816484 B CN 103816484B
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Abstract
The invention belongs to field of medicaments, be specifically related to treat the pharmaceutical preparation of cancer of the stomach, particularly relate to a kind of Chinese medicine composition treating cancer of the stomach and preparation method thereof.Described Chinese medicine composition is prepared from by the Chinese medicine of following weight portion: the banksia rose 30 50, oldenlandia diffusa 30 60, Herba Andrographitis 25 40, frankincense 20 40, pseudo-ginseng 15 30, tribulus terrestris 15 30, curcuma zedoary 10 20, the achene of Siberian cocklebur 5 15, dried orange peel 5 15.The present invention treats cancer of the stomach effect substantially, has no side effect, difficulty in relapse after healing, and efficient 94%, cure rate 70%.Open the road of the hope for the treatment of cancer of the stomach for prior art.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine preparation treating cancer of the stomach.
Background technology
Cancer of the stomach (Gastric cancer) is the most commonly seen malignant tumor of digestive tract of harm human health, originates from
Skin, the incidence of disease of cancer of the stomach is widely different in country variant different regions.China belongs to high incidence area of gastric cancer, occupies each at its incidence of disease of China
The first place of class tumour, there are about 170,000 people every year and dies from cancer of the stomach, almost close to the 1/4 of whole mortality of malignant tumors numbers, and every year
More than 20,000 new Patients with Gastric Cancer are also had to generate, serious threat people's health.
The pathogenic factor of cancer of the stomach is failed to understand, may be with many factors, such as habits and customs, dietetic variety, environmental factor, heredity element
Matter, mental element etc. are relevant, also with chronic gastritis, polyp of stomach, stomach lining special-shaped hyperplasia and intestinal metaplasia, the residual stomach of Post operation,
And helicobacter pylori (HP) infection etc. for a long time has certain relation.Treatment to cancer of the stomach, operation, chemotherapy are still treatment at present
The main method of cancer of the stomach.But operation can damage internal organs organ, causes traumatic bleeding;Lacking selectivity, toxic and side effect
Relatively big, many bad reactions such as apocleisis, pain, blood item index reduction occur, and body's immunity is had damage, no
Can well improve the life quality of Patients with Gastric Cancer.If cancer stove is not yet utterly destroyed, even if reaching to alleviate for the moment, still can be rapid
Recurrence or transfer.Traditional Chinese medicine is the exclusive medical advantages of China, and traditional Chinese medicine, in treatment cancer of the stomach, not only can promote that health is extensive
Multiple, strengthen immunologic function, and antitumaous effect can be played, prevent recurrence and transfer, improve survival rate.Therefore, exploitation and development
Effective Chinese medicine preparation treats cancer of the stomach, is of great significance the hygiene medical treatment cause tool of China.
The traditional Chinese medical science think this disease be that chronic dietary does not saves, feelings will is unsuccessful, overstrain internal injury or being invaded by exogenous pathogen,invasion of exogenous pathogen, cause liver dysfunction, stomach
Become estranged fall, or prolonged illness taste are impaired, the wet interior life of phlegm, qi depression to blood stasis, are condensed in stomach and form.As " General Treatise on the Cause and Symptoms of Diseases " is said: " negative and positive
Discord, then three burnt isolations, three burnt isolations, then body fluid is unfavorable, therefore makes vent plug uncomfortable, is to become to choke.Caused by this is angerd by sorrow, sorrow angers gas
Knot, depressed, do not declare stream, and the plug that makes to choke is obstructed also "." special effect good recipe regurgitation door " is called: " husband gastric disorder causing nausea person, this stomach.Many because of stomach
Gas choosing is satisfied, wound of drinking, or long-pending chill, or because of sad calamity of being worried or depressed because storing anger, and the stagnant addiction in place is gathered cold phlegm, moved and disturb spleen
Stomach, stomach is weak can not wear down paddy food, then becomes this disease ".The traditional Chinese medical science is often with clearing heat and detoxicating, and strengthening vital QI to eliminate pathogenic factors, strengthening the spleen and stomach, tonifying Qi and blood are
Method, reaches the purpose for the treatment of.The present invention is groped by substantial amounts of experiment, have found a kind of Chinese medicine composition treating cancer of the stomach, medicine
It is extremely notable that effect learns experiment effect, and we are made for granule, tablet, hard capsule, soft capsule, dripping pill by corresponding technique
The formulation such as agent, oral liquid.
Content of the invention
The present invention is from the rules for the treatment of of Chinese traditional treatment cancer of the stomach, through development test, by the banksia rose, oldenlandia diffusa, Herba Andrographitis,
Frankincense, pseudo-ginseng, tribulus terrestris, curcuma zedoary, the achene of Siberian cocklebur, dried orange peel nine taste medicine, through suitable processing, the process of preparing Chinese medicine, extract, make one and treat stomach
The good Chinese medicine preparation of the effect of cancer.
On the one hand, the present invention provides a kind of Chinese medicine composition treating cancer of the stomach, is prepared from by the Chinese medicine of following weight portion:
Banksia rose 30-50, oldenlandia diffusa 30-60, Herba Andrographitis 25-40, frankincense 20-40, pseudo-ginseng 15-30, tribulus terrestris 15-30, curcuma zedoary 10-
20th, achene of Siberian cocklebur 5-15, dried orange peel 5-15.
In a preferred embodiment, described Chinese medicine composition is preferably prepared from by the Chinese medicine of following weight portion:
The banksia rose the 40th, oldenlandia diffusa the 45th, Herba Andrographitis the 35th, frankincense the 30th, pseudo-ginseng the 25th, tribulus terrestris the 25th, curcuma zedoary the 15th, the achene of Siberian cocklebur the 10th, dried orange peel 10.
On the other hand, the invention provides the preparation method of described Chinese medicine composition, specifically comprise the following steps that and claim according to proportioning
Take the banksia rose, oldenlandia diffusa, Herba Andrographitis, frankincense, pseudo-ginseng, tribulus terrestris, curcuma zedoary, the achene of Siberian cocklebur, dried orange peel nine traditional Chinese medicines, be added thereto to
The water of 6-12 times amount, decocts three times, each 1-3 hour, collecting decoction, filters, and it is 1.10-that filtrate is condensed into relative density
The clear cream (80 DEG C) of 1.25, adds ethanol to alcohol content 60-80% (v/v), and stirring stands 12-24 hour, filters, and filtrate subtracts
Push back receipts ethanol, to obtain final product.
In a preferred embodiment, can be appropriate auxiliary by adding according to the conventional preparation method in this area
The present composition is made the preparations such as granule, tablet or capsule, soft extract, pill, medicinal tea, powder, dripping pill by material.
Described auxiliary material includes the general conventional auxiliary material of various medical standards, sugar-free sweetener, preservative etc., and conventional is sweet
Taste agent includes sucrose etc..Sugar-free sweetener includes the sweetener such as stevioside and protein sugar, xylitol, high fructose and honey element, anti-
Rotten agent includes Sodium Benzoate, benzoic acid, nipagin esters etc..
Another further aspect, present invention also offers the medical usage of described Chinese medicine composition, and the Chinese medicine composition of the present invention is controlled
Treat cancer of the stomach effect obvious, have no side effect, difficulty in relapse after healing, efficient 94%, cure rate 70%.The typically patient to morbidity
Take medicine and can reach the purpose of healing in 1-5 the course for the treatment of, and difficulty in relapse after healing.Open the hope for the treatment of cancer of the stomach for prior art
Road.
The relevant meridian distribution of property and flavor of Chinese traditional medicine of the present invention, effect situation as follows:
This preparation has beneficial gas tonifying spleen, promoting blood circulation and removing blood stasis, nourishing the liver and kidney, invigorating the spleen disappear long-pending effect, can be used for the treatment of cancer of the stomach.
The banksia rose: taste is pungent, mildly bitter flavor, warm in nature, gas fragrance, enter spleen, stomach, large intestine, gallbladder channel, there is the work(of promoting qi circulation and relieving pain.Oldenlandia diffusa taste
Bitter, light, cold in nature.Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness.Herba Andrographitis, bitter, cold in nature.The thoughts of returning home, lung, big
Intestines, bladder warp, have clearing heat and detoxicating, cool blood, detumescence, effect of eliminating dampness.Frankincense is arduous, warm, enters the heart, liver, the spleen channel, and regulating the qi flowing in the channels is lived
Blood, analgesic therapy, chase after poison.Pseudo-ginseng, warm in nature, taste is pungent, has scattered silt hemostasis, effect of detumescence ding-tong.Tribulus terrestris toil, temperature, enter liver, lung
Warp, has scattered wind, improving eyesight, lower gas, effect of promoting circulation of blood.Curcuma zedoary bitter is pungent, temperature, and broken blood gas, disappear long-pending pain relieving.Achene of Siberian cocklebur bitter;
Sweet;Pungent;Warm in nature, enter lung, Liver Channel, dispersing wind and cold;Clearing the nasal passage;Wines used as antirheumatic;Antipruritic.Dried orange peel is warm in nature, and taste is pungent, bitter, enters the spleen channel, stomach
Warp, lung channel, have regulating qi-flowing for strengthening spleen, in tune, and eliminating dampness, the work(reducing phlegm.
All medicines share above, play strengthening the spleen and replenishing qi altogether, blood circulation promoting nourishing kidney, promoting blood circulation and removing blood stasis, invigorating the spleen disappear long-pending work(, for controlling of cancer of the stomach
Treat.Additionally, the Chinese medicine composition preparation technology of the present invention is simple, substantially having no side effect, patient compliance is higher, has very well
Development and application prospect.
Detailed description of the invention
Further describe technical scheme by implementation below.It is pointed out that following explanation
It is only the illustration to claimed technical scheme, the not any restriction to these technical schemes.This
The content that bright protection domain is recorded with appended claims is as the criterion.
Embodiment 1
Composition: banksia rose 30g oldenlandia diffusa 45g Herba Andrographitis 25g
Frankincense 40g pseudo-ginseng 15g tribulus terrestris 30g
Curcuma zedoary 10g achene of Siberian cocklebur 10g dried orange peel 15g
Preparation method: by formula ratio weigh the banksia rose, oldenlandia diffusa, Herba Andrographitis, frankincense, pseudo-ginseng, tribulus terrestris, curcuma zedoary, the achene of Siberian cocklebur,
Dried orange peel is got the raw materials ready, and adds 8 times of water, decocts three times, and 2 hours every time, collecting decoction, filtration, it was 1.10-that filtrate is condensed into relative density
The clear cream (80 DEG C) of 1.15, adds ethanol to alcohol content 60% (v/v), and stirring stands 24 hours, filters, filtrate decompression recovery second
Alcohol, to obtain final product.
Embodiment 2
Composition: banksia rose 50g oldenlandia diffusa 30g Herba Andrographitis 40
Frankincense 20g pseudo-ginseng 30g tribulus terrestris 20g
Curcuma zedoary 20g achene of Siberian cocklebur 15g dried orange peel 10g.
Preparation method: by formula ratio weigh the banksia rose, oldenlandia diffusa, Herba Andrographitis, frankincense, pseudo-ginseng, tribulus terrestris, curcuma zedoary, the achene of Siberian cocklebur,
Dried orange peel is got the raw materials ready, and adds the water of 12 times, decocts three times, and 1 hour every time, collecting decoction, filtration, filtrate was condensed into relative density and is
The clear cream (80 DEG C) of 1.10-1.12, adds ethanol to alcohol content 70% (v/v), and stirring stands 12 hours, filtration, filtrate decompression
Reclaim ethanol, to obtain final product.
Embodiment 3
Banksia rose 40g oldenlandia diffusa 45g Herba Andrographitis 35g
Frankincense 30g pseudo-ginseng 25g tribulus terrestris 25g
Curcuma zedoary 15g achene of Siberian cocklebur 10g dried orange peel 10g.
Preparation method: by formula ratio weigh the banksia rose, oldenlandia diffusa, Herba Andrographitis, frankincense, pseudo-ginseng, tribulus terrestris, curcuma zedoary, the achene of Siberian cocklebur,
Dried orange peel is got the raw materials ready, and adds the water of 10 times, decocts three times, and 1.5 hours every time, collecting decoction, filtration, filtrate was condensed into relative density and is
The clear cream (80 DEG C) of 1.10-1.15, adds ethanol to alcohol content 60% (v/v), and stirring stands 18 hours, filtration, filtrate decompression
Reclaim ethanol, to obtain final product.
Embodiment 4
Banksia rose 50g oldenlandia diffusa 60g Herba Andrographitis 30g
Frankincense 40g pseudo-ginseng 15g tribulus terrestris 25g
Curcuma zedoary 15g achene of Siberian cocklebur 10g dried orange peel 15g.
Preparation method: by formula ratio weigh the banksia rose, oldenlandia diffusa, Herba Andrographitis, frankincense, pseudo-ginseng, tribulus terrestris, curcuma zedoary, the achene of Siberian cocklebur,
Dried orange peel is got the raw materials ready, and adds the water of 8 times, decocts three times, and 1 hour every time, collecting decoction, filtration, it was 1.10-that filtrate is condensed into relative density
The clear cream (80 DEG C) of 1.15, adds ethanol to alcohol content 80% (v/v), and stirring stands 24 hours, filters, filtrate decompression recovery second
Alcohol, to obtain final product.
The Clinical observation of embodiment 5 Chinese medicine composition of the present invention
Instructions of taking: take day 2 times, sooner or later after meal respectively once.
Treat the course for the treatment of: within 30 days, being 1 course for the treatment of, the lighter can cure 2-3 the course for the treatment of, and severe one 3-6 can be cured, after healing the course for the treatment of
It is difficult to recurrence.
Medication effect of the present invention: treatment cancer of the stomach effect is obvious, has no side effect, difficulty in relapse after healing is efficient
94%, cure rate 70%.
The medicine of the present invention cures mainly cancer of the stomach, and disease is seen: stomach can touch enclosed mass, abdominal distension, and feed is few, and stomach occurs scorching hot, stool
Constipation, has blood in stool greatly, and after breastbone, hidden pain, uncomfortable in chest, and food difficulty is swallowed, abdominal fullness and distention, belch, thirst with desire to drink, and urine is yellow, colourless of breathing hard,
Puffiness of the face and dropsy of the feet, becomes thin.
The clinical observation of drug therapy cancer of the stomach of the present invention:
1st, data is treated
Take treatment patient 50 case, wherein male 30 cases, female 20 case, the age 40-60 year.Above patient is all by CT and disease
Reason cut sections for microscopic examination are advanced gastric carcinoma.
2nd, diagnostic criteria
Stomach sharp ache, can touch and see that bag is fast, n and V, abdominal distension, feed is few, and stomach occurs scorching hot, dry feces, stool
Blood, food difficulty swallow, abdominal fullness and distention, belch, or pharynx thing unfavorable, when have retrosternal pain, uncomfortable in chest, or food after spue, thirst with desire to drink,
Urine is yellow, colourless of breathing hard, and puffiness of the face and dropsy of the feet is become thin, weak, and spirit is poor.
3rd, treatment method
Take the medicine of the embodiment of the present invention 3 preparation, take 2 day, early, after supper each once.
4th, treat the course for the treatment of
Within 30 days, being 1 course for the treatment of, the lighter can cure 2-3 the course for the treatment of, and severe one 3-6 can be cured the course for the treatment of, controls difficulty in relapse after healing.
5th, efficacy assessment standard
Effective: pain relief, appetite increases, and spirit recovered, tumor regression or be not in progress, and the state of an illness can be stably.
Taking a turn for the better: pain disappears, and tumour is obviously reduced, appetite is normal, and spirit takes a turn for the better, and when has repeatedly, still needs to treatment.
Recovery from illness: tumour body disappears, pain disappears, and appetite is normal, energetic, recovers normal work or physical labor.
Invalid: symptom art mitigates, the state of an illness continues to deteriorate.
6th, treatment results
The above-mentioned patients with gastric cancer of drug therapy through being prepared by the embodiment of the present invention 3, through treating 3 courses for the treatment of, wherein recovery from illness 35
Example, take a turn for the better 10 cases, effective 2 cases, invalid 3 cases, and efficient 94%, cure rate 70%, inefficiency 6%.
Model case
1st, relative, man, 49 years old, people from Anshan, in November, 2008 is cancer of the stomach by hospital diagnosis, through take western medicines in treatment without
Effect, after withdrawing other drug, according to instructions of taking of the present invention, takes 2 day, early, after supper each once, take the present invention and implement
The medicine after 10 days of example 3 preparation, patient's stomach pain, stomach occurs scorching hot, dry feces, abdominal fullness and distention, belch, colourless of breathing hard,
The symptoms such as puffiness of the face and dropsy of the feet gradually mitigate.Taking 3 courses for the treatment of continuously by above-mentioned instructions of taking, symptom all disappears, and tumour does not exists,
Physical recovery is normal, does not recurs so far.
2nd, bavin, female, 55 years old, people from Hebei, in October, 2007 is cancer of the stomach by hospital diagnosis, according to instructions of taking of the present invention,
Day takes 2 times, early, each after supper once takes the medicine of the embodiment of the present invention 3 preparation after 15 days, epigastric distending pain, vomiting band blood, just
Blood, the symptom such as puffiness of the face and dropsy of the feet has taken a turn for the better, takes 4 courses for the treatment of continuously by above-mentioned instructions of taking, and above-mentioned symptom all disappears, and CT shows swollen
Knurl does not exists, and physical recovery is normal, does not recurs so far.
3rd, Lee so-and-so, man, 65 years old, in July, 2009 was cancer of the stomach by hospital diagnosis, presses instructions of taking immediately, took day 2 times,
Early, each after supper once the medicine of the embodiment of the present invention 3 preparation is taken after 7 days, patient's stomach pain, heartburn, have blood in stool, gastral cavity
The symptoms such as distention and fullness in the abdomen, breathes hard, puffiness of the face and dropsy of the feet have taken a turn for the better, and take 5 courses for the treatment of continuously by above-mentioned instructions of taking, and above-mentioned symptom all disappears
Losing, CT display tumour does not exists, and physical recovery is normal, does not recurs so far.
Present invention merely illustrates some claimed specific embodiments, one of them or more skill
Technical characteristic described in art scheme can be combined with arbitrary one or more technical schemes, and these are combined and obtain
Technical scheme also in the application protection domain, just as obtained from these are combined, technical scheme is open in the present invention
In content as concrete record.
Claims (4)
1. the Chinese medicine composition treating cancer of the stomach, it is characterised in that it is prepared from by the Chinese medicine of following weight portion: the banksia rose
40th, oldenlandia diffusa the 45th, Herba Andrographitis the 35th, frankincense the 30th, pseudo-ginseng the 25th, tribulus terrestris the 25th, curcuma zedoary the 15th, the achene of Siberian cocklebur the 10th, dried orange peel 10;
Specifically comprising the following steps that of the preparation method of wherein said Chinese medicine composition
By formula ratio weigh the banksia rose, oldenlandia diffusa, Herba Andrographitis, frankincense, pseudo-ginseng, tribulus terrestris, curcuma zedoary, the achene of Siberian cocklebur, dried orange peel are got the raw materials ready,
Being added thereto to the water of 10 times amount, decocting three times, 1.5 hours every time, collecting decoction, filtration, filtrate was condensed into relative density and is
The clear cream of 1.10-1.15 at 80 DEG C, adds ethanol to containing alcohol 60% (v/v), and stirring stands 18 hours, and filtration, filtrate decompression is returned
Receive ethanol, to obtain final product.
2. the pharmaceutical preparation containing the Chinese medicine composition described in claim 1, it is characterised in that by described Chinese medicine composition
It is prepared as tablet, granule, capsule, soft extract, pill, medicinal tea, powder or dripping pill with pharmaceutically acceptable auxiliary material.
3. pharmaceutical preparation according to claim 2, it is characterised in that described pharmaceutical preparation is tablet or granule.
4. application in the medicine of preparation treatment cancer of the stomach for the Chinese medicine composition described in claim 1.
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CN1238985A (en) * | 1999-07-09 | 1999-12-22 | 张振海 | Exterior-applied medicine for treating cold symptoms type gastroenteropathy and its preparing process |
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CN1238985A (en) * | 1999-07-09 | 1999-12-22 | 张振海 | Exterior-applied medicine for treating cold symptoms type gastroenteropathy and its preparing process |
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中医抗癌处方组成探析;徐 力等;《江苏中医药》;20031231;第24卷(第12期);4-6 * |
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