CN114903960A

CN114903960A - Traditional Chinese medicine composition for treating chronic gastritis and preparation method thereof

Info

Publication number: CN114903960A
Application number: CN202210513424.2A
Authority: CN
Inventors: 刘德喜; 戴好富; 刘建浩; 刘海涛; 梅文莉; 蔡翠珠; 汪洁; 刘莹
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-05-12
Filing date: 2022-05-12
Publication date: 2022-08-16
Anticipated expiration: 2042-05-12
Also published as: CN114903960B

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic gastritis and a preparation method thereof. The Chinese medicinal composition comprises lignum Aquilariae Resinatum, herba Agastaches, fructus Amomi rotundus, semen Arecae Preparatum, fructus Aurantii Immaturus, herba Taraxaci, radix Curcumae, and Glycyrrhrizae radix. And the like. The invention also provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention is mainly used for treating chronic gastritis.

Description

Traditional Chinese medicine composition for treating chronic gastritis and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating chronic gastritis and a preparation method thereof.

Background

Chronic gastritis is a common disease of the digestive tract, a chronic gastric mucositis disease caused by a variety of different etiologies. In the later period, atrophy and metaplasia of the glands of the inherent layer of the gastric mucosa can occur in part of patients, and then intraepithelial neoplasia appears, which is closely related to the occurrence of gastric cancer. Chronic gastritis can be divided into chronic superficial gastritis (non-atrophic gastritis) and chronic atrophic gastritis.

The most common symptoms of chronic gastritis are upper abdominal pain and fullness. Compared with ulcer, it is comfortable in fasting state and uncomfortable after meal, and may feel less but full due to diastolic dysfunction. Patients often complain of "weak stomach" or "stomach weakness". Symptoms are often caused or exacerbated by cold meals, hard meals, spicy or other irritating foods. These symptoms are not easily relieved by antacids and spasmolytics. Most patients complain of poor appetite.

Moreover, bleeding is also one of the symptoms of chronic gastritis, especially with erosions. It may be repeated small bleeding or large bleeding. The emergency gastroscopy indicates that the acute and chronic gastritis accounts for 20 to 40 percent of the causes of the upper gastrointestinal hemorrhage. Bleeding is usually seen in the dark, and is usually stopped automatically after 3 to 4 days, and can be released after months or years.

At present, the existing chronic gastritis medicines are not positive enough in effect, and relapse easily after treatment. Therefore, the development of a medicament for treating chronic gastritis with definite curative effect and good curative effect is urgently needed.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating chronic gastritis;

the invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating chronic gastritis.

The purpose of the invention is realized by the following technical scheme:

the traditional Chinese medicine composition for treating chronic gastritis is prepared from the following traditional Chinese medicine raw materials in parts by weight:

5-12 parts of agilawood, 10-30 parts of wrinkled gianthyssop herb, 10-25 parts of fructus amomi, 10-25 parts of amomum cardamomum, 8-16 parts of scorched areca seed, 8-16 parts of immature bitter orange, 5-15 parts of dandelion, 5-15 parts of radix curcumae and 3-10 parts of liquorice.

In a preferred scheme, the active ingredients of the traditional Chinese medicine composition for treating chronic gastritis are prepared by the following method: drying the above materials, mixing, pulverizing into fine powder, stirring, and mixing.

In a preferred scheme II, the active ingredients of the traditional Chinese medicine composition for treating chronic gastritis are prepared by adopting the following method: is prepared by water extraction or ethanol extraction with the concentration of 40-80 percent by volume.

In a preferred scheme, the active ingredients of the traditional Chinese medicine composition for treating chronic gastritis are prepared by the following method: mixing all the medicinal materials, reflux-extracting with 40-80% ethanol for 2-3 times, each time the ethanol amount is 4-10 times of the total amount of the medicinal materials, extracting for 1-4 hr, mixing extractive solutions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.15-1.20 at 70-80 deg.C.

In a preferred scheme, the active ingredients of the traditional Chinese medicine composition for treating chronic gastritis are prepared by the following method: mixing all the medicinal materials, adding water for extraction for 2-3 times, adding water amount 6-12 times of the total weight of the medicinal materials each time, extracting for 1-3 hr each time, mixing extractive solutions, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.15-1.20 at 70-80 deg.C, adding ethanol to obtain extract with ethanol content of 40-70%, standing for 12-24 hr, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.10-1.25 at 70-80 deg.C.

The traditional Chinese medicine composition for treating chronic gastritis can be matched with a medically acceptable carrier to prepare a traditional Chinese medicine preparation for improving metabolism and regulating functions.

Pharmaceutically acceptable carriers of the present invention include, but are not limited to, the following:

oral preparation:

diluent agent: starch, powdered sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, sugar alcohols, and the like.

Wetting agent and binder: purified water, ethanol, gelatin, polyethylene glycol, cellulose derivatives, and the like.

Disintegrating agent: starch, sodium carboxymethyl starch, cellulose derivatives, crospovidone, and the like.

Lubricant: magnesium stearate, aerosil, talcum powder, polyethylene glycol and the like.

Cosolvent: water, ethanol, glycerol, propylene glycol, liquid paraffin, vegetable oil, etc.

Flavoring agent: sucrose, monosaccharide, aromatic, etc.

Preservative: benzoic acid, sorbic acid, methyl esters, ethyl esters, propyl esters, and the like.

The method comprises the following steps: tablet formulation

Taking one of the active ingredients obtained in the first to fourth preferred schemes, adding common auxiliary materials of the tablets, and preparing the tablets by a conventional production method.

The common auxiliary materials of the tablets comprise one or all of diluent, wetting agent, adhesive, disintegrant and lubricant.

The method 2 comprises the following steps: capsule preparation

And (3) adding common auxiliary materials for capsules into one of the active ingredients obtained in the first to fourth optimization schemes, and preparing the capsules according to a conventional production method.

The common adjuvants for the capsule include one or all of diluent, wetting agent, binder, disintegrant, and lubricant.

The method 3 comprises the following steps: syrup preparation

And (3) adding common auxiliary materials for syrup into one of the active ingredients obtained in the second to fourth preferred schemes, and preparing the syrup according to the conventional production method.

The syrup common adjuvants comprise one or all of correctant, antiseptic, and cosolvent.

The method 4 comprises the following steps: mixture agent

And (3) adding common auxiliary materials of the mixture into one of the active ingredients obtained in the second to fourth preferred schemes, and preparing the mixture according to a conventional production method.

The mixture common auxiliary materials comprise one or all of flavoring agent and preservative.

The method 5 comprises the following steps: oral liquid

And (4) dissolving one of the active ingredients obtained in the schemes two to four, purifying and concentrating, adding common auxiliary materials of the oral liquid, and preparing the oral liquid according to a conventional production method.

The inventor thinks that chronic gastritis is mainly caused by improper diet, overeating, being addicted to spicy stimulating food, drinking, uncooked diet or stagnation of qi due to liver depression, dysfunction of spleen and stomach in ascending and descending and pivoting, endogenous dampness, and damp turbidity in tropical areas in southern sea, coastal areas around the sea, corresponding heaven, and easy generation of damp-heat evil, and depression of middle-jiao qi, and the symptoms are mainly stomach cavity pain or distending pain, tiredness and hypodynamia, frequent accompanying with inappetence, eructation, nausea and vomiting, dry mouth and bitter taste, and stool viscosity.

The invention has the following advantages:

the formula is designed aiming at the etiology and pathogenesis of the chronic gastritis, the agilawood in the formula promotes qi circulation and relieves pain, the wrinkled gianthyssop herb is aromatic and eliminates dampness and regulates the stomach to arrest vomiting, and the wrinkled gianthyssop herb has good curative effect when being used for a patient with positive helicobacter pylori. Both Chenxiang and Huoxiang contain volatile oil, Chenxiang has the action of lowering stomach qi and regulating middle energizer, Huoxiang has the action of raising spleen and enlivening spleen, and the two are combined to raise and lower one to make the normal transportation and transformation function of spleen and stomach to eliminate damp turbidity and eliminate abdominal distention and stuffiness, which are the monarch drugs.

Fructus amomi has the efficacies of resolving dampness, promoting qi circulation and arresting vomiting, has aromatic smell, is warm but not dry, promotes qi circulation without destroying qi, and is the key medicine for activating spleen and harmonizing stomach. The amomum cardamomum has the functions of eliminating dampness, promoting qi circulation, stimulating appetite and helping digestion, and modern pharmacological research proves that the amomum cardamomum contains volatile oil, has an antibacterial effect, particularly has a remarkable inhibiting effect on dysentery bacillus, can invigorate the stomach with aromatics, dispel wind, promote gastric secretion and intestinal peristalsis, expel intestinal pneumatosis, inhibit intestinal abnormal fermentation, and has good effects of strengthening the spleen and stomach and preventing vomiting. Both the amomum fruit and the amomum cardamomum contain volatile oil, and the amomum fruit and the amomum cardamomum are respectively added into the spleen and the stomach, and are used together to further assist the monarch drug in resolving dampness and harmonizing stomach, and regulating qi and harmonizing the middle as the ministerial drug.

Hainan Jia Bing enters stomach and large intestine to promote digestion and remove food stagnation, so it is indicated for indigestion. Immature bitter orange enters spleen, stomach and large intestine meridians to break qi and remove food retention, resolve phlegm and remove mass. Hainan Jia Bing and Zhishi enter spleen, stomach and large intestine meridians, and are combined to enhance gastrointestinal motility and further eliminate gastrointestinal stagnation, resulting in abdominal fullness and pain. Dandelion has the effects of clearing heat and removing toxicity, relieving swelling and dissipating stagnation, and clearing damp-heat toxin of stomach and intestine. The radix curcumae enters heart, liver and gallbladder channels, soothes liver, regulates qi, relieves depression, clears heat, promotes diuresis and relieves pain. The four drugs are used together to help digestion, remove food stagnation, clear away damp-heat, sooth the liver and regulate qi. Modern pharmacological researches find that dandelion has a certain bactericidal effect on staphylococcus, hemolytic streptococcus, pseudomonas aeruginosa, diphtheria bacillus, dysentery bacillus and typhoid bacillus, and the effect of killing helicobacter pylori is reported. Licorice root, radix Glycyrrhizae is used as a guiding drug with the actions of clearing heat and removing toxicity, relieving spasm and alleviating pain, and moderating the property of herbs. The whole formula has the effects of regulating qi, resolving dampness, clearing turbid and harmonizing stomach.

The traditional Chinese medicine composition disclosed by the invention is scientific and reasonable in formula, simple in preparation method, good in effect as proved by an efficacy experiment, and has a large popularization value.

Detailed Description

The invention is further illustrated by the following examples. It should be understood that the examples of the present invention are for illustrative purposes and not intended to limit the present invention. Simple modifications of the invention in accordance with its spirit fall within the scope of the claimed invention. Unless otherwise indicated, the percentages of the amount of ethanol in the present invention are volume percentages, and v/v represents the volume ratio of the solution.

Example 1

The traditional Chinese medicine composition for treating chronic gastritis comprises the following components:

5 kg of agilawood, 10 kg of wrinkled gianthyssop herb, 10 kg of fructus amomi, 10 kg of amomum cardamomum, 8 kg of scorched areca nut, 8 kg of immature bitter orange, 5 kg of dandelion, 5 kg of radix curcumae and 3 kg of liquorice.

The preparation method comprises the following steps:

drying the above materials, mixing, pulverizing into fine powder, stirring, and mixing.

Example 2

12 kg of agilawood, 30 kg of wrinkled gianthyssop herb, 25 kg of fructus amomi, 25 kg of amomum cardamomum, 16 kg of scorched areca nut, 16 kg of immature bitter orange, 5 kg of dandelion, 15 kg of radix curcumae and 10 kg of liquorice.

The preparation method comprises the following steps:

Example 3

8 kg of agilawood, 20 kg of wrinkled gianthyssop herb, 16 kg of villous amomum fruit, 16 kg of round cardamom fruit, 12 kg of scorched areca seed, 12 kg of immature bitter orange, 10 kg of dandelion, 10 kg of turmeric root-tuber and 6 kg of liquorice.

The preparation method comprises the following steps:

Example 4

6 kg of agilawood, 18 kg of wrinkled gianthyssop herb, 15 kg of fructus amomi, 15 kg of amomum cardamomum, 8 kg of scorched areca nut, 8 kg of immature bitter orange, 10 kg of dandelion, 0 kg of radix curcumae and 5 kg of liquorice.

The preparation method comprises the following steps:

mixing all the medicinal materials, reflux-extracting with 40% ethanol for 2 times, wherein the amount of ethanol is 4 times of the total amount of the medicinal materials each time, the extraction time is 1 hr, mixing extractive solutions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.15 at 70 deg.C.

Example 5

7 kg of agilawood, 13 kg of wrinkled gianthyssop herb, 12 kg of fructus amomi, 18 kg of amomum cardamomum, 9 kg of scorched areca nut, 9 kg of immature bitter orange, 12 kg of dandelion, 13 kg of radix curcumae and 4 kg of liquorice.

The preparation method comprises the following steps:

mixing all the medicinal materials, extracting with 80% ethanol under reflux for 3 times, wherein the amount of ethanol is 10 times of the total amount of the medicinal materials each time, the extraction time is 4 hr, mixing extractive solutions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.20 at 80 deg.C.

Example 6

10 kg of agilawood, 25 kg of wrinkled gianthyssop herb, 15 kg of fructus amomi, 15 kg of amomum cardamomum, 15 kg of scorched areca nut, 15 kg of immature bitter orange, 13 kg of dandelion, 8 kg of radix curcumae and 9 kg of liquorice.

The preparation method comprises the following steps:

mixing all the medicinal materials, reflux-extracting with 60% ethanol for 2 times, each time the ethanol amount is 6 times of the total amount of the medicinal materials, extracting for 3 hr, mixing extractive solutions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.18 at 75 deg.C.

Example 7

11 kg of agilawood, 27 kg of wrinkled gianthyssop herb, 13 kg of fructus amomi, 13 kg of amomum cardamomum, 13 kg of scorched areca nut, 13 kg of immature bitter orange, 9 kg of dandelion, 6 kg of radix curcumae and 8 kg of liquorice.

The preparation method comprises the following steps:

mixing all the medicinal materials, adding water for extraction for 2 times, wherein the water amount is 6 times of the total weight of the medicinal materials, the extraction time is 1 hour, mixing the extractive solutions, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.15 at 70 deg.C, adding ethanol to make the ethanol content 40%, standing for 12 hours, filtering, and concentrating the filtrate to obtain extract with relative density of 1.10 at 70 deg.C.

Example 8

8 kg of agilawood, 12 kg of wrinkled gianthyssop herb, 12 kg of fructus amomi, 12 kg of amomum cardamomum, 13 kg of scorched areca nut, 14 kg of immature bitter orange, 11 kg of dandelion, 11 kg of radix curcumae and 8 kg of liquorice.

The preparation method comprises the following steps:

mixing all the medicinal materials, adding water, extracting for 3 times, wherein the amount of water added each time is 12 times of the total weight of the medicinal materials, the extraction time each time is 3 hours, mixing the extractive solutions, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.20 at 80 deg.C, adding ethanol to make the ethanol content 70%, standing for 24 hours, filtering, and concentrating the filtrate to obtain extract with relative density of 1.25 at 80 deg.C.

Example 9

9 kg of agilawood, 16 kg of wrinkled gianthyssop herb, 22 kg of fructus amomi, 21 kg of amomum cardamomum, 10 kg of scorched areca nut, 13 kg of immature bitter orange, 7 kg of dandelion, 7 kg of radix curcumae and 5 kg of liquorice.

The preparation method comprises the following steps:

mixing all the medicinal materials, adding water, extracting for 3 times, each time adding water amount 8 times of the total weight of the medicinal materials, each time extracting for 2 hours, mixing the extractive solutions, filtering, concentrating the filtrate to obtain fluid extract with relative density of 1.16 at 80 deg.C, adding ethanol to make ethanol content 55%, standing for 18 hours, filtering, and concentrating the filtrate to obtain extract with relative density of 1.20 at 80 deg.C.

Example 10

Summary of clinical trials

1. General data: the study was approved by the ethical Commission of the department of TCM, Suiyuan (lot No. ZYFY 20160536). 160 patients in the study are taken as study objects, and all the patients come from the clinic of digestive department of Hospital, TCM, and the study time is 6 months from 2019 to 6 months from 2021. The random number table method is adopted, and the control group and the observation group are divided into 80 cases according to the ratio of 1: 1. The control group comprises 48 male cases and 32 female cases, wherein the age is 31-65 years, the average (46.79 +/-8.27) year, the course is 6 months-12 years, the average is 4.87 +/-0.52) year, the pathological atrophic gastritis is 30 cases, and the non-atrophic gastritis is 50 cases. 6 cases are dropped and lost during the test, 3 cases are rejected contrary to the scheme, and 71 cases are completed. The observation group comprises 45 males and 35 females, the age is 30-64 years, the average (46.05 +/-9.58) year, the course is 9 months-14 years, the average (5.15 +/-0.64) year, 32 pathological atrophic gastritis and 48 non-atrophic gastritis. 4 cases of falling and missing visit during the test period are rejected by violating the scheme, and 75 cases are completed. The comparison of the baseline data of more than two groups of patients has no statistical significance and is comparable.

2. The diagnostic standard (I) for chronic gastritis refers to the Chinese consensus of chronic gastritis (2017, Shanghai). Can have nonspecific dyspepsia symptoms, and can be CAG or CNAG by endoscope and pathological examination. Hp detection A biopsy was taken under gastroscope according to the fifth national consensus report on helicobacter pylori infection treatment, and a rapid urease test was performed, along with a 14C-urea breath test. ② the syndrome differentiation standard of traditional Chinese medicine refers to syndrome of dampness-heat in spleen and stomach in Chinese medicine diagnosis and treatment expert consensus for chronic gastritis (2017). The principal symptoms are epigastric pain or fullness and stuffy pain, weakness and constipation. ② the secondary symptoms are bitter taste and halitosis, bad appetite, nausea and vomiting. ③ Red tongue with yellow coating, slippery or rapid pulse.

3. Bringing in the standard, diagnosing as a chronic gastritis patient with obvious dyspepsia symptoms through endoscopy and pathological examination, detecting as a positive Hp patient through a rapid urease test and a 14C-urea breath test, meeting the differentiation standard of the spleen and stomach damp-heat syndrome, aging for 20-65 years, and obtaining a signed informed consent.

4. The method comprises the steps of eliminating the standard that gastritis caused by long-term taking of non-steroidal anti-inflammatory drugs and ethanol, other types of gastritis such as autoimmune gastritis and the like, merging patients with gastrointestinal surgery history, patients with peptic ulcer, gastric polyp and gastrointestinal tumor, patients with serious liver, kidney, heart and lung dysfunction, merging patients with other internal and external diseases and needing emergency treatment, women in gestation or lactation, patients with psychosis and depression accompanied by cognitive dysfunction, patients with severe allergic constitution and allergic to known medicinal ingredients in the research are merged, and patients with clinical efficacy evaluation are affected by treating with other traditional Chinese medicines in the same period.

5. The treatment method comprises the following steps: the control group of treatment methods employed the Hp eradication protocol, referring to the literature oral Esseomeprazole magnesium enteric-coated tablet, Aslicon pharmaceutical Co., Ltd, Chinese drug Standard H20046379, 20 mg/dose, 1 dose/dose, and bismuth potassium citrate tablet (0.3 g/dose, Lizhu group Lizhu pharmaceutical factory, Chinese drug Standard H10900084), 1 tablet/dose, 2 doses/dose, and amoxicillin capsule (0.5 g/dose, Hayao group pharmaceutical Co., Ltd, Chinese drug Standard H23020932), 2 tablets/dose, 2 doses/dose, and furazolidone tablet (0.1 g/dose, Beijing Erythroculter pharmaceutical Co., Ltd, Chinese drug Standard H11020698), 1 tablet/dose, 2 doses/dose. The treatment course is 14 days of continuous treatment. The observation group is administered with lignum Aquilariae Resinatum and stomach harmonizing pill (preparation of san city TCM institute) based on the control group, which comprises lignum Aquilariae Resinatum 8 g, herba Agastaches 20 g, fructus Amomi 16 g, fructus Amomi rotundus 16 g, semen Arecae Preparata 12 g, fructus Aurantii Immaturus 12 g, herba Taraxaci 10 g, radix Curcumae 10 g, and Glycyrrhrizae radix 6 g; 6 g/time and 3 times/d, and is orally taken.

6. The curative effect standard includes that firstly, the evaluation of the curative effect of the syndrome refers to 'Chinese medicine diagnosis and treatment expert consensus observation for chronic gastritis (2017)' the main symptoms and the physical signs disappear or substantially disappear, the curative effect index is more than or equal to 95 percent, the main symptoms and the physical signs are obviously improved, the curative effect index is more than or equal to 70 percent and less than 95 percent, the main symptoms and the physical signs are obviously improved, the curative effect index is more than or equal to 30 percent and less than 70 percent, the main symptoms and the physical signs are not obviously improved or even aggravated, and the curative effect index is less than 30 percent. And secondly, evaluating the clinical curative effect, namely judging according to results of gastroscopy and pathological examination by referring to 'consensus opinion of combined traditional Chinese and western medicine diagnosis and treatment for chronic gastritis (2011 Tianjin)', and classifying the results into 4 grades of cure, obvious effect, effectiveness and ineffectiveness.

7. Results

The negative conversion of Hp in two groups of patients is compared: the Hp negative conversion rate of the observed group was 93.33% (70/75), which is higher than 81.69% (58/71) of the control group, and the comparative difference between the groups was statistically significant.

The traditional Chinese medicine syndrome curative effects of two groups of patients are compared, and 75 cases of the patients are observed: cure 58 is significant, 10 is effective, 6 is ineffective 1. Control group 71 cases: cure 43 is significant 14 is effective 10 is ineffective 4. After treatment, the curative effect of the traditional Chinese medicine syndromes of the two groups of patients is analyzed by rank sum test, and the observed group is superior to the control group.

The two groups of patients are compared in the four aspects of Hp negative conversion condition, traditional Chinese medicine syndrome curative effect, clinical curative effect and spleen and stomach damp-heat syndrome integral, and the observation group is superior to the control group, so that the curative effect of the agilawood and the gastritis on treating the Hp gastritis by matching with the four-combination therapy is exact.

Although the invention has been described in detail hereinabove by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that many modifications and improvements can be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. The traditional Chinese medicine composition for treating chronic gastritis is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight:

5-12 parts of agilawood, 10-30 parts of wrinkled gianthyssop herb, 10-25 parts of fructus amomi, 10-25 parts of amomum cardamomum, 8-16 parts of scorched areca nut, 8-16 parts of immature bitter orange, 5-15 parts of dandelion, 5-15 parts of radix curcumae and 3-10 parts of liquorice.

2. The traditional Chinese medicine composition for treating chronic gastritis as claimed in claim 1, wherein the active ingredients are prepared by the following method:

3. The traditional Chinese medicine composition for treating chronic gastritis as claimed in claim 1, wherein the active ingredients are prepared by the following method:

is prepared by water extraction or ethanol extraction with the concentration of 40-80 percent by volume.

4. The traditional Chinese medicine composition for treating chronic gastritis as claimed in claim 3, wherein the active ingredients are prepared by the following method: mixing all the medicinal materials, reflux-extracting with 40-80% ethanol for 2-3 times, each time the ethanol amount is 4-10 times of the total amount of the medicinal materials, extracting for 1-4 hr, mixing extractive solutions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.15-1.20 at 70-80 deg.C.

5. The traditional Chinese medicine composition for treating chronic gastritis as claimed in claim 3, wherein the active ingredients are prepared by the following method: mixing all the medicinal materials, adding water, extracting for 2-3 times, each time adding water amount 6-12 times of the total weight of the medicinal materials, each time extracting for 1-3 hr, mixing extractive solutions, filtering, concentrating the filtrate to fluid extract with relative density of 1.15-1.20 at 70-80 deg.C, adding ethanol to make ethanol content 40-70%, standing for 12-24 hr, filtering, and concentrating the filtrate to extract with relative density of 1.10-1.25 at 70-80 deg.C.

6. A preparation for treating chronic gastritis, which is prepared by matching the traditional Chinese medicine composition for treating chronic gastritis in any one of claims 1 to 5 with a pharmaceutically acceptable carrier.