CN105194510A - Traditional Chinese medicine composition for treating duodenal bulbar ulcer with qi-stagnation syndrome of liver and stomach - Google Patents
Traditional Chinese medicine composition for treating duodenal bulbar ulcer with qi-stagnation syndrome of liver and stomach Download PDFInfo
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Abstract
A traditional Chinese medicine composition for treating duodenal bulbar ulcer with the qi-stagnation syndrome of liver and stomach comprises the following Chinese medicinal plants by mass: 10 to 30 parts of Chinese angelica, 8 to 15 parts of radix bupleuri, 12 to 30 parts of radix paeoniae alba, 8 to 15 parts of cuttlebone, 8 to 20 parts of immature bitter orange, 8 to 15 parts of radix linderae, 10 to 20 parts of bletilla striata, 10 to 20 parts of poria cocos, 8 to 15 parts of amomum cardamomum, 10 to 15 parts of serrate rabdosia herb, 10 to 15 parts of dandelion, 5 to 10 parts of liquorice, 8 to 15 g of raw malt, 10 to 20 g of elecampane and 8 to 20 g of fructus amomi. The traditional Chinese medicine composition has a remarkable curative effect on duodenal bulbar ulcer with the qi-stagnation syndrome of liver and stomach; a large quantity of clinical treatment cases show that the effective rate can reach up to 98 percent; after a patient takes the traditional Chinese medicine composition, the liver qi circulation is promoted, the circulation of qi and blood is smooth, the spleen and the stomach are conditioned, vital-qi is recovered, pathogenic factors are eliminated, the disease is cured, the symptom is eliminated, both symptoms and root causes are treated, and the rate of relapse is low. The traditional Chinese medicine composition is safe, free of toxic, side and adverse effects, and acceptable to patients, thereby creating favorable economic benefits and wide social benefits.
Description
Technical field
The invention belongs to treatment by Chinese herbs taste-blindness rate field, relate to a kind of Chinese medicine composition being used for the treatment of hepatogastric vital energy stagnation type duodenal bulbar ulcer.
Background technology
Pyloric cap is burst and is belonged to the one of peptic ulcer, and the traditional Chinese medical science is classified as gastric abscess category, all very common in China each department.According to bibliographical information, Beijing's recall rate is 13.83%, Tianjin 17.03%, Chongqing City 25.30%, Shanghai City 29.05%.Scholars think, gastric acid is the deciding factor of all kinds of peptic ulcers comprising duodenal bulbar ulcer; It is closely related that helicobacter pylori and digestibility present sick generation, and duodenal bulbar ulcer Helicobacter Pylori Infection In Patients rate is 90% ~ 100%.
Modern medicine gets Comprehensive Treatment to the general Bian of duodenal bulbar ulcer, and these medicines all have good therapeutic effect, but also there is many weak points.(1) eradicate helicobacter pylori, treatment is based on colloidal bismuth combined with antibiotic at present, but needs prolonged application, easily produces drug resistance, and toxic and side effects is comparatively large, and the state of an illness easily repeatedly.(2) use antacid or acid suppression medicine, the former needs repeatedly large dose oral administration, easily produces metabolic alkalosis, renal damage, increases the weight of the complication such as hypertension or heart failure; The latter makes some difference renal function, the liver function that makes some difference and gastrointestinal function, exists and brings out gastric cancer and ARR risk.(3) take gastric mucosal protection medicine, but diarrhoea can be caused, cause the untoward reaction such as uterine contraction.
So many clinical workers explore and use Chinese medicine peptic ulcer, although take Chinese medicine to need the long period, by treating both the principal and secondary aspects of a disease, most of patient can effect a radical cure, and Chinese medicine does not exist toxic and side effects.But what be seen in document is the report using traditional Chinese medicine composition for treating gastric ulcer mostly, and the retrospective summary of many genus, observation case is on the low side, and effect reliability needs further discussion.
There is the symptoms such as gastralgia, belch, acid regurgitation, bitter taste for duodenal bulbar ulcer patient in us, and carries out classifying according to the different pattern of syndrome of patient and be mainly divided into hepatogastric vital energy stagnation type and intense stomach-heat type; Alter the side of body back of the body for the swollen pain of gastral cavilty painful abdominal mass or attack, belch, acid regurgitation, white and thin fur, stringy pulse, dialectical is hepatogastric vital energy stagnation type.At present, not yet there is the Patents for the Chinese medicine composition of hepatogastric vital energy stagnation type duodenal bulbar ulcer open.
Summary of the invention
The object of this invention is to provide one group of important composition, easily producing drug resistance to solve existing medicine to overcome prior art, and toxic and side effects is comparatively large, the state of an illness easily shortcoming repeatedly with not enough.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of hepatogastric vital energy stagnation type duodenal bulbar ulcer, is made up of following Chinese crude drug by quality proportioning: Radix Angelicae Sinensis 10-30 part, Radix Bupleuri 8-15 part, Radix Paeoniae Alba 12-30 part, Endoconcha Sepiae 8-15 part, Fructus Aurantii Immaturus 8-20 part, Radix Linderae 8-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Poria 10-20 part, Fructus Amomi Rotundus 8-15 part, Herba Rabdosiae Lophanthoidis 10-15 part, Herba Taraxaci 10-15 part, Radix Glycyrrhizae 5-10 part, Fructus Hordei Germinatus 8-15g, Radix Inulae 10-20g, fructus amomi 8-20g.
Preferably, the preferred mass number of described Chinese crude drug is: Radix Angelicae Sinensis 12 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 15 parts, Endoconcha Sepiae 10 parts, Fructus Aurantii Immaturus 10 parts, the Radix Linderae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, 12 parts, Poria, Fructus Amomi Rotundus 10 parts, Herba Rabdosiae Lophanthoidis 12 parts, Herba Taraxaci 12 parts, 6 parts, Radix Glycyrrhizae, Fructus Hordei Germinatus 10g, Radix Inulae 12g, fructus amomi 10g.
Second aspect present invention provides a kind of Chinese medicine extract for the treatment of hepatogastric vital energy stagnation type duodenal bulbar ulcer, for above-mentioned Chinese medicine composition for raw material effective component extracting obtain.
Further, the preparation method of described Chinese medicine extract is decocting method.
Further, the step of described decocting method is: take Chinese medicine composition in proportion, soak, decoct, filter, and repeats 2 ~ 3 times, merges each filtrate decocted.
Preferably, described decocting method is: deployed Chinese medicine composition is put into crock, adds drinking water and soaks 15 minutes, and the depth of water is advisable to cover medical material 3cm.First with high heat medicine is decocted to boiling, then with 30 minutes at a simmer, medicine juice is poured in container.And then drinking water is added in crock, the depth of water is advisable just to cover medical material, first decocts to boiling by medicine with high heat, then with after 15 minutes at a simmer, medicine juice is poured into medicine juice in container with primary and mixes.
Third aspect present invention provides a kind of Chinese medicine preparation for the treatment of hepatogastric vital energy stagnation type duodenal bulbar ulcer, containing above-mentioned Chinese medicine extract and pharmaceutically acceptable adjuvant.
Pharmaceutically acceptable adjuvant is various pharmaceutically conventional adjuvant and/or excipient, include, but is not limited to saccharide (as lactose, dextrose plus saccharose), starch (as corn starch and potato starch), cellulose and its derivates is (as sodium carboxymethyl cellulose, ethyl cellulose and methylcellulose), tragacanth gum powder, Fructus Hordei Germinatus, gelatin, Talcum, kollag (as stearic acid and magnesium stearate), calcium sulfate, vegetable oil, as Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, Oleum sesami, olive oil, Semen Maydis oil and cupu oil, polyhydric alcohol is (as propylene glycol, glycerol, Sorbitol, mannitol and Polyethylene Glycol), alginic acid, emulsifying agent (as Tween), wetting agent (as sodium lauryl sulfate), coloring agent, flavoring agent, tablet agent, stabilizing agent, antioxidant, antiseptic, apirogen water, isotonic saline solution and phosphate buffer etc., this carrier can improve stability, the activity and biological effectiveness etc. of formula as required, or when oral, produce acceptable mouthfeel or abnormal smells from the patient.
Chinese medicine preparation of the present invention can make the dosage form of any routine according to the universal method on pharmaceutics, comprise oral formulations; Preferably tablet, granule, pill, powder, syrup and decoction; Be more preferably granule, pill and powder.
Content of the present invention also comprises the application in the medicine of preparation treatment hepatogastric vital energy stagnation type duodenal bulbar ulcer of above-mentioned Chinese medicine composition, Chinese medicine extract and Chinese medicine preparation.
In Chinese medicine composition of the present invention, Radix Bupleuri, Fructus Aurantii Immaturus, the Radix Linderae are monarch drug, soothing the liver circulation of qi promoting; Radix Angelicae Sinensis, the Radix Paeoniae Alba are ministerial drug, nourishing blood to suppress the hyperactive liver; Poria, Fructus Amomi Rotundus, Radix Glycyrrhizae are ministerial drug, invigorating the spleen to clear away damp pathogen; Help with Endoconcha Sepiae antacid sore, Pseudobulbus Bletillae (Rhizoma Bletillae) expelling pus and promoting granulation; Herba Rabdosiae Lophanthoidis, Herba Taraxaci for making medicine, expel the heat-evil be amusing, eliminating evil sterilization.Main gather effect that soothing the liver circulation of qi promoting, stomach function regulating expel the heat-evil altogether.As the stagnation of QI is obvious, add Fructus Hordei Germinatus, Radix Inulae, fructus amomi, soothing liver and strengthening spleen, promoting the circulation of QI to relieve pain.
The invention has the beneficial effects as follows, the Chinese medicine composition provided possess soothing the liver circulation of qi promoting, effect that stomach function regulating expels the heat-evil, have significant curative effect to duodenal bulbar ulcer, a large amount of clinical treatment cases shows that effective percentage reaches 98%.Irritability row after patient consumes and QI and blood are smooth, and taste are in harmonious proportion, and healthy energy is multiple and pathogenic factor disappears, disease removing of recovering, treating both the principal and secondary aspects of a disease, and relapse rate is low.Safe without toxic side effect, does not have untoward reaction, and patient gladly accepts, and creates good economic benefit and social benefit widely.
In order to understand better and implement, the following detailed description of the present invention.
Specific embodiment
Crude drug of the present invention (or medical material) all can be bought from common pharmacy or Chinese crude drug sales company and obtain, and its specification meets national medical standards or meets the pertinent regulations such as Chinese Pharmacopoeia.The medical material adopted unless otherwise indicated, is tcm and herbal slice, and this tcm and herbal slice also can be through processing after obtaining.
Compositions of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, or the dosage form that the final extracting solution through extracting said composition gained can be prepared into further through common process, comprises capsule, tablet, granule, powder, oral liquid, soft capsule, pill, mixture, syrup, gel and sustained-release preparation etc.For enabling above-mentioned dosage form realize, pharmaceutically acceptable adjuvant need be added, as filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc. when preparing these dosage forms.
Set forth the present invention further below in conjunction with specific embodiment, should be understood that following examples are only not used in for illustration of the present invention and limit the scope of the invention.
The preparation method of [embodiment 1] Chinese medicine extract
Prescription 1: Radix Angelicae Sinensis 12g, Radix Bupleuri 12g, Radix Paeoniae Alba 15g, Endoconcha Sepiae 10g, Fructus Aurantii Immaturus 10g, Radix Linderae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Poria 12g, Fructus Amomi Rotundus 10g, Herba Rabdosiae Lophanthoidis 12g, Herba Taraxaci 12g, Radix Glycyrrhizae 6g, Fructus Hordei Germinatus 10g, Radix Inulae 12g, fructus amomi 10g.
Prescription 2: Radix Angelicae Sinensis 10g, Radix Bupleuri 8g, Radix Paeoniae Alba 12g, Endoconcha Sepiae 8g, Fructus Aurantii Immaturus 8g, Radix Linderae 8g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Poria 10g, Fructus Amomi Rotundus 8g, Herba Rabdosiae Lophanthoidis 10g, Herba Taraxaci 10g, Radix Glycyrrhizae 5g, Fructus Hordei Germinatus 8g, Radix Inulae 10g, fructus amomi 8g.
Prescription 3: Radix Angelicae Sinensis 30g, Radix Bupleuri 15g, Radix Paeoniae Alba 30g, Endoconcha Sepiae 15g, Fructus Aurantii Immaturus 20g, Radix Linderae 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Poria 20g, Fructus Amomi Rotundus 15g, Herba Rabdosiae Lophanthoidis 15g, Herba Taraxaci 15g, Radix Glycyrrhizae 10g, Fructus Hordei Germinatus 15g, Radix Inulae 20g, fructus amomi 20g.
Usage and consumption:
Deployed Chinese medicine composition is put into crock, adds drinking water and soak 15 minutes, the depth of water is advisable to cover medical material 3cm.First with high heat medicine is decocted to boiling, then with 30 minutes at a simmer, medicine juice is poured in container.And then drinking water is added in crock, the depth of water is advisable just to cover medical material, first decocts to boiling by medicine with high heat, then with after 15 minutes at a simmer, medicine juice is poured into medicine juice in container with primary and mixes.Whole medicine juice be divided into twice after the meal clothes under, take night and morning.4 weeks were a course for the treatment of.
[embodiment 2] case study on implementation
1. rely so-and-so, man, 38 years old, Zhaoqing Mu Gang people from town, because of gastralgia repeatedly 20 years, increase the weight of companion's belch, acid regurgitation 10 days, medical in December in 1994 15 days.Patient is frequent gastralgia from 1975, and time hungry, aggravation, accompanies two distending pain over the hypochondrium, belch, acid regurgitation, half congealed time hard during stool, and when chance emotion is smooth, pain increases the weight of.Once interval took western medicine repeatedly, bad during state of an illness fashion, did not heal always.Nearly 10 days above-mentioned exacerbation of symptoms, with to hospital admission, body of the tongue is light red, white and thin fur, stringy pulse; Dialectical is hepatogastric vital energy stagnation type.Gastroscopy prompting duodenal bulbar ulcer (active stage), ulcer diameter 9mm, helicobacter pylori checks positive.Then give prescription 1 in the embodiment of the present invention 1 to treat, every day 1 dose.After 3 days, symptom alleviates, transference cure after 6 days; Gastroscope check after 4 week, prompting ulcer all healed enters the white scar phase, and helicobacter pylori checks negative, and the state of an illness is fully recovered, and does not recur always again.
2. king so-and-so, female, 38 years old.Gastralgia 13 years, is diagnosed as duodenal bulbar ulcer, eats Western medicine, Chinese medicine in other Duo Jia hospitals, but do not fully recover, recurrent exerbation, whenever tired or increase the weight of when feeling blue, then give prescription 2 in the embodiment of the present invention 1 to treat, after 1 course for the treatment of, patient's recovery from illness, does not recur again.
3. coil certain, man, 42 years old.Repeatedly occur over 15 years that epigastrium pain is uncomfortable, with acid regurgitation phenomenon, pain is many when hunger or night-time attack, increases the weight of after tired or time unhappy.Take the Drug therapys such as omeprazole, effect still can always.The symptom such as Without dysphagia, Nausea and vomiting; Deny the phenomenon such as hematemesis, melena; Body weight is without obviously alleviating.Due to emotional distress, nearly one month pain, acid regurgitation exacerbation of symptoms, take food and namely occur insufferable upper abdominal pain in about 1 hour, attacks and alter the side of body back of the body.Defecate uncomfortable, white and thin fur, stringy pulse.Dialectically then give prescription 1 in the embodiment of the present invention 1 and treat, every day 1 dose for hepatogastric vital energy stagnation type.After 7 days, symptom alleviates, transference cure after 15 days; Gastroscope check after January, prompting ulcer healing, does not recur always again.
4. practice certain, man, 59 years old.In more than 10 years of epigastrium repeated relapsing pain, companion acid regurgitation, belch, night and autumn and winter season are easily sent out, and take food or take antacid pain to alleviate.3 days causes and other people be difficulet and sulky, epigastrium, breast side of body portion attack support and have a pain, acid regurgitation water, companioned with headache, weak, insomnia.Gastroscopy: pyloric cap antetheca and curvedly greatly respectively see the ulcer that a size is about 3X5 ㎜ and 8X5 ㎜, attached white fur at the bottom of ulcer, mucosa congestion and edema around, helicobacter pylori checks positive, diagnosis of duodenal bulb multiple ulcer.White and thin fur, stringy and thready pulse.Dialectical is hepatogastric vital energy stagnation type, then gives prescription 1 in the embodiment of the present invention 1 and treats, every day 1 dose.After 10 days, symptom alleviates, transference cure after 15 days; Gastroscope check after February, prompting ulcer healing.
5. Zhu, man, 43 years old.Without obvious inducement sensuously abdominal pain before 1 week, accompany acid regurgitation, belch in hunger pain, take the poor effect such as omeprazole.Patient's readme because of epigastrium pain repeatedly, was done barium meal examination and is diagnosed " duodenal bulbar ulcer " before 10 years, took remission after western medicine, repeatedly occurred again epigastrium pain companion acid regurgitation misery afterwards, and all had alleviation each serving after Western medicine.Gastroscopy: the visible size of pyloric cap rear wall is about the ulcer of 11X10 ㎜, has white fur and blood crusts bottom ulcer, around mucosa congestion and edema is obvious.Diagnosis of duodenal duodenal bulbar ulcer.White and thin fur, stringy and thready pulse.Dialectical is hepatogastric vital energy stagnation type.Then give prescription 3 in the embodiment of the present invention 1 to treat, every day 1 dose.After first quarter moon, symptom alleviates, transference cure after January.Gastroscope check after February, prompting ulcer healing, follows up a case by regular visits to and has no recurrence in 2 years.
[embodiment 3] clinical effectiveness statistics
Inventor added up from January, 1994 in December ,-2013 Zhaoqing institute of traditional Chinese medicine use traditional Chinese medicine composition for treating duodenal bulbar ulcer patient 4762 of the present invention example.According to " People's Republic of China's traditional Chinese medicine industry standard-Chinese medical disease Standardization of diagnosis and curative effect " gastric abscess CM syndrome differentiation criterion, cure 3951 examples, effective 715 examples, invalid 96 examples, total effective rate reaches 97.98%.To wherein 1246 examples before the treatment, all have Endoscopic patient to carry out scope efficacy determination afterwards, adopt Forrest classification method to evaluate hemorrhage symptom, by treating, front I (a, b) level, II (patient that a, b, c) level transfer latter III grade for the treatment of to accounts for 92.25%
The present invention is not limited to above-mentioned embodiment, if do not depart from the spirit and scope of the present invention to various change of the present invention or distortion, if these are changed and distortion belongs within claim of the present invention and equivalent technologies scope, then the present invention is also intended to comprise these changes and distortion.
Claims (9)
1. treat a Chinese medicine composition for hepatogastric vital energy stagnation type duodenal bulbar ulcer, it is characterized in that, be made up of following Chinese crude drug by quality proportioning: Radix Angelicae Sinensis 10-30 part, Radix Bupleuri 8-15 part, Radix Paeoniae Alba 12-30 part, Endoconcha Sepiae 8-15 part, Fructus Aurantii Immaturus 8-20 part, Radix Linderae 8-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part, Poria 10-20 part, Fructus Amomi Rotundus 8-15 part, Herba Rabdosiae Lophanthoidis 10-15 part, Herba Taraxaci 10-15 part, Radix Glycyrrhizae 5-10 part, Fructus Hordei Germinatus 8-15g, Radix Inulae 10-20g, fructus amomi 8-20g.
2. Chinese medicine composition according to claim 1, is characterized in that, the mass fraction of described Chinese crude drug is: Radix Angelicae Sinensis 12 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 15 parts, Endoconcha Sepiae 10 parts, Fructus Aurantii Immaturus 10 parts, the Radix Linderae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, 12 parts, Poria, Fructus Amomi Rotundus 10 parts, Herba Rabdosiae Lophanthoidis 12 parts, Herba Taraxaci 12 parts, 6 parts, Radix Glycyrrhizae, Fructus Hordei Germinatus 10g, Radix Inulae 12g, fructus amomi 10g.
3. the application of the Chinese medicine composition described in claim 1 or 2 in the medicine of preparation treatment hepatogastric vital energy stagnation type duodenal bulbar ulcer.
4. treat a Chinese medicine extract for hepatogastric vital energy stagnation type duodenal bulbar ulcer, for the Chinese medicine composition described in claim 1 or 2 for raw material effective component extracting obtain.
5. Chinese medicine extract according to claim 4, is characterized in that, the preparation method of described Chinese medicine extract is decocting method.
6. Chinese medicine extract according to claim 5, is characterized in that, the step of described decocting method is: take Chinese medicine composition in proportion, soak, decoct, filter, and repeats 2 ~ 3 times, merges each filtrate decocted.
7. the application of the Chinese medicine extract in claim 4-6 described in arbitrary claim in the medicine of preparation treatment hepatogastric vital energy stagnation type duodenal bulbar ulcer.
8. treat a Chinese medicine preparation for hepatogastric vital energy stagnation type duodenal bulbar ulcer, containing the Chinese medicine extract described in claim arbitrary in claim 4-6 and pharmaceutically acceptable adjuvant.
9. the application of Chinese medicine preparation according to claim 8 in the medicine of preparation treatment hepatogastric vital energy stagnation type duodenal bulbar ulcer.
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Cited By (1)
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CN113546133A (en) * | 2021-06-24 | 2021-10-26 | 无锡济煜山禾药业股份有限公司 | Preparation and application of compound preparation for treating gastric ulcer |
Citations (2)
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CN1114900A (en) * | 1995-05-12 | 1996-01-17 | 蒋东北 | Recovery medicine for duodenal ulcer |
CN1218685A (en) * | 1998-10-30 | 1999-06-09 | 阎作礼 | Capsule for enterogastric disease |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1114900A (en) * | 1995-05-12 | 1996-01-17 | 蒋东北 | Recovery medicine for duodenal ulcer |
CN1218685A (en) * | 1998-10-30 | 1999-06-09 | 阎作礼 | Capsule for enterogastric disease |
Non-Patent Citations (1)
Title |
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《实用医学杂志》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113546133A (en) * | 2021-06-24 | 2021-10-26 | 无锡济煜山禾药业股份有限公司 | Preparation and application of compound preparation for treating gastric ulcer |
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Application publication date: 20151230 |