The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is illustrated.
Embodiment 1
The present invention is in concrete enforcement, and this traditional Chinese medicine mate is to be made up of the raw material of following weight percent meter: sucrose 55%, sucralose 0.06%, Fructus Citri sinensis fruit powder 3%, citric acid 0.6%, malic acid 0.35%, beta-schardinger dextrin-40.76%, flavoring orange essence 0.2% and orange flavor 0.03%; Wherein, sucrose, citric acid and malic acid are pulverized, sucralose is mixed homogeneously with citric acid, malic acid and Fructus Citri sinensis fruit powder with equivalent incremental method, mix homogeneously with cane sugar powder, beta-schardinger dextrin-again, be dried at 55 ℃, be cooled to 18 ℃ of room temperatures, add flavoring orange essence, orange flavor, mix homogeneously, subpackage, every bag 7g.
Embodiment 2
The present invention is in concrete enforcement, and this traditional Chinese medicine mate also can be made up of the raw material of following weight percent meter: sucrose 60%, sucralose 0.07%, Fructus Citri sinensis fruit powder 4%, citric acid 0.7%, malic acid 0.4%, beta-schardinger dextrin-34.49%, flavoring orange essence 0.3% and orange flavor 0.04%; Wherein, sucrose, citric acid and malic acid are pulverized, sucralose is mixed homogeneously with citric acid, malic acid and Fructus Citri sinensis fruit powder with equivalent incremental method, mix homogeneously with cane sugar powder, beta-schardinger dextrin-again, be dried at 60 ℃, be cooled to 22 ℃ of room temperatures, add flavoring orange essence, orange flavor, mix homogeneously, subpackage, every bag 7g.
Embodiment 3
The present invention is in concrete enforcement, and this traditional Chinese medicine mate also can be made up of the raw material of following weight percent meter: sucrose 65%, sucralose 0.09%, Fructus Citri sinensis fruit powder 5%, citric acid 0.9%, malic acid 0.3%, beta-schardinger dextrin-28.24%, flavoring orange essence 0.45% and orange flavor 0.02%; Wherein, sucrose, citric acid and malic acid are pulverized, sucralose is mixed homogeneously with citric acid, malic acid and Fructus Citri sinensis fruit powder with equivalent incremental method, mix homogeneously with cane sugar powder, beta-schardinger dextrin-again, be dried at 65 ℃, be cooled to 25 ℃ of room temperatures, add flavoring orange essence, orange flavor, mix homogeneously, subpackage, every bag 7g.
Embodiment 4
The present invention is in concrete enforcement, and this traditional Chinese medicine mate also can be made up of the raw material of following weight percent meter: sucrose 70%, sucralose 0.1%, Fructus Citri sinensis fruit powder 5%, citric acid 1%, malic acid 0.5%, beta-schardinger dextrin-22.85%, flavoring orange essence 0.5% and orange flavor 0.05%; Wherein, sucrose, citric acid and malic acid are pulverized, sucralose is mixed homogeneously with citric acid, malic acid and Fructus Citri sinensis fruit powder with equivalent incremental method, mix homogeneously with cane sugar powder, beta-schardinger dextrin-again, be dried at 65 ℃, be cooled to 25 ℃ of room temperatures, add flavoring orange essence, orange flavor, mix homogeneously, subpackage, every bag 7g.
Embodiment 5
The present invention is in concrete enforcement, and this traditional Chinese medicine mate also can be made up of the raw material of following weight percent meter: sucrose 50%, sucralose 0.05%, Fructus Citri sinensis fruit powder 2%, citric acid 0.5%, malic acid 0.25%, beta-schardinger dextrin-47.09%, flavoring orange essence 0.1% and orange flavor 0.01%; Wherein, sucrose, citric acid and malic acid are pulverized, sucralose is mixed homogeneously with citric acid, malic acid and Fructus Citri sinensis fruit powder with equivalent incremental method, mix homogeneously with cane sugar powder, beta-schardinger dextrin-again, be dried at 63 ℃, be cooled to 24 ℃ of room temperatures, add flavoring orange essence, orange flavor, mix homogeneously, subpackage, every bag 7g.
The present invention after tested, protein, aminoacid, sugar and the polysaccharide, fat, mineral and the multivitamin that contain needed by human, edible after following Chinese medicine decoction or Chinese medicinal granule to be in harmonious proportion, can effectively remove the poor taste of Chinese medicine decoction, make taste fragrant and sweet agreeable to the taste, be not only a kind of nutriment that human body is digested and assimilated that is easy to, improve again the bad mouthfeel of Chinese medicine, facilitate patients, relevant experimental data is as follows:
1. Chinese medicine is divided into 5 grades by bitter degree, concrete following table:
The bad flavour hardship of Chinese medicine degree value (
i) qualitative description and quantitative scope
2. the preparation of sample
Get Chinese medicinal granule composition " the stagnant soup of heat clearing awayization " by the clinical conventional prescription of the pharmacist of Chinese medicine " the stagnant soup of heat clearing awayization ", one pair of medicine rushes 120ml solution and obtains bitterness sample " the stagnant soup of heat clearing awayization ".
The stagnant soup formula of heat clearing awayization: Radix Bupleuri 18g, Radix Scutellariae 10g, Radix Puerariae 10g, Gypsum Fibrosum 30g, Rhizoma Anemarrhenae 10g, Cortex Magnoliae Officinalis 6g, Semen Arecae 10g, Semen Coicis 30g, Rhizoma Et Radix Notopterygii 6g, Fructus Aurantii Immaturus 6g, Radix Glycyrrhizae 9g.
3. valuation officer's screening
After the examination and approval of Ethics Committee of No.1 Hospital Attached to He'nan Traditional Chinese Medical College, seminar has carried out including the strict screening bitterness sensitivity etc. the volunteer who recruits, 16 healthy volunteers are as experimenter in final selection, before test, sign Informed Consent Form, through training the qualified valuation officer of being decided to be.
4. test method
First surveying reference liquid first gets the 30 negative reference solutions of mL (purified water) and tastes in dixie cup in mouth, contained in mouth by valuation officer, timing 15s, the oral cavity action of gargling around here, so that the bitterness of sample can be experienced in the bitterness receptive field of the root of the tongue and tongue side, and be apprised of bitter degree classification and the concrete bitter degree value of this solution, spue, gargle 5 times, in oral cavity without bitterness.
The assay method of sample is measured with reference solution.One group of sample to valuation officer, taste impression according to mouth, according to the taste degree to sample, sample is sorted, and in conjunction with the contrast of reference solution, first bitter degree grade is determined in the statement of the bitterness in reference table, gives a concrete bitter degree value to tasted sample, in " the bitter taste of drug description list " recording and design in advance, each sample has been surveyed and has been gargled 5 times, in oral cavity without bitterness, after 2min, measure another sample.In addition,, when subject is to sample test in experiment, adopt random, single blind method to test sample.
The rejecting of 4.2 exceptional values
Now carrying out spearman check according to ranking results according to GBT 12315-2008 method evaluates valuation officer's performance, valuation officer's evaluating data of correlation coefficient r value less than 0.5 is all rejected, and residue valuation officer data adopt Grubbs method of inspection data to be carried out to circular test and the rejecting of exceptional value according to appraisal result.And take two-sided test, the mode of significant level 0.05 is rejected outlier, each is organized each and takes turns and only reject an exceptional value.And after rejecting, no longer carry out interpolation or supplement test.
5. result
" the stagnant soup of heat clearing awayization " bitter degree value average out to 3.2 ± 0.9, after adding the present invention, bitter degree value is reduced to 1.6 ± 0.6(P<0.01), the original bitterness of decoction and strange taste are covered to a great extent, added the sour-sweet mouthfeel of Fructus Citri sinensis simultaneously, make medicine mouthfeel approach orange juice, be more easily accepted.
Therefore, traditional Chinese medicine mate of the present invention and other Chinese medicine decoction or granule and other dosage form are followed and are taken, all obtain good useful technique effect, its experimental technique is with " the stagnant soup of heat clearing awayization ", tired stating no longer one by one, by experimental result and test, the present invention not only has the nutrient substance of needed by human, and have good flavored action, and follow Chinese medicine to take, can increase patient's nutrition, can give full play to again drug effect, being very beneficial for Rehabilitation, is to take the good companion of Chinese medicine, and economic and social benefit is remarkable.