CN103768398A - Traditional Chinese medicine composition for treating advanced lung tumors - Google Patents

Abstract

The invention discloses a medicament and particularly discloses a traditional Chinese medicine composition for treating advanced lung tumors. The traditional Chinese medicine composition for treating advanced lung tumors is characterized by comprising the following components in parts by weight: 20-30 parts of codonopsis pilosula, 20-30 parts of radix astragali, 10-15 parts of alcohol processed radix angelica sinensis, 20-30 parts of roasted rhizoma atractylodis macrocephalae, 20-30 parts of tuckahoe, 10-15 parts of grifola, 10-20 parts of ginger processed pinellia, 10-20 parts of dried orange peel, 6-12 parts of white mustard seed, 10-15 parts of radix glehniae, 6-9 parts of pseudo-ginseng, 10-15 parts of pseudobulbus cremastrae seu pleiones, 15-30 parts of oldenlandia diffusa, 15-30 parts of sculellaria barbata, 15-30 parts of dandelion, 20-30 parts of hairyvein agrimonia herb, 15-30 parts of cordate houttuynia, 20-30 parts of salvia chinensis, 20-30 parts of winged euonymus twig, 10-30 parts of radix ranunculi ternate, 6-12 parts of ganoderma lucidum, 3-6 parts of cordyceps taishanensis powder and 3 centipedes. The traditional Chinese medicine composition has the effects of benefiting the lung and tonifying the spleen, eliminating dampness and reducing phlegm, clearing heat and removing toxicity, counteracting toxic substances and removing stasis, treating qi, blood, phlegm and toxic substances, strengthening the body resistance and eliminating pathogenic factors as well as purging and tonifying jointly so as to achieve the purposes of eliminating or stabilizing a tumor nidus, improve syndromes, improve the life quality of patients and prolong the lifetime. The traditional Chinese medicine composition disclosed by the invention is remarkable in curative effects, safe and free of side effects, and the effective rate reaches 92%.

Description

A kind of Chinese medicine composition for the treatment of lung tumor in late period

Technical field

The present invention relates generally to the field of Chinese medicines, relates in particular to a kind of Chinese medicine composition for the treatment of lung tumor in late period.

Background technology

Lung tumor is that M & M growth is the fastest, and population health and life are threatened to one of maximum malignant tumor.Over nearly 50 years, many countries all report that the M & M of lung tumor all obviously increases, and male's lung tumor M & M all accounts for first of all malignant tumor, and women's sickness rate accounts for second, and mortality rate accounts for second.The many morbidities more than 40 years old of primary disease, age of onset peak is between 60-79 year.Men and women's prevalence is 2.3:1.Race, family members' history and smoking all have impact to the morbidity of lung tumor.

At present in the method for the treatment of lung tumor: doctor trained in Western medicine has operative treatment, radiotherapy, chemotherapy, immunization therapy, laser therapy, cold therapy, high hot micro-wave therapeutic etc.But operative treatment has very large wound, and Low patient is difficult for bearing, and postoperative easy generation complication, often relapse and metastasis.Toxic and side effects of chemoradiotherapy is large, must Long-term taking medicine, expensive, infringement patient normal body function, and easily develop immunity to drugs and occur repeatedly, can not obtain the therapeutic effect of expection.Especially for lung tumor patient in late period, cannot adopt excision and cannot tolerate chemicotherapy side effect, adopting traditional Chinese medicine conservative treatment is a kind of desirable Therapeutic Method.

Traditional Chinese Medicine have the organic conception of emphasizing, strengthening vital QI to eliminate pathogenic factors, regulating yin and yang, table this doublely control, the advantage such as toxic and side effects is little, more and more approved by people.But, lack clinically at present the significant Chinese patent medicine for the treatment of lung tumor effect in late period.

Summary of the invention

The object of the invention is exactly the defect in order to make up prior art, and a kind of Chinese medicine composition for the treatment of lung tumor in late period is provided, and it is obvious for the curative effect for the treatment of lung tumor in late period, safe ready, and side effect is little.

The present invention is achieved by the following technical solutions:

A kind of Chinese medicine composition for the treatment of lung tumor in late period, it is characterized in that: the weight proportion of its each crude drug is: Radix Codonopsis 20-30, Radix Astragali 20-30, Radix Angelicae Sinensis (processed with wine) 10-15, Rhizoma Atractylodis Macrocephalae (parched) 20-30, Poria 20-30, Polyporus 10-15, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-20, Pericarpium Citri Reticulatae 10-20, Bulbus Fritillariae Thunbergii 10-20, Radix Peucedani 15-20, honey Radix Asteris 6-12, honey Flos Farfarae 6-12, Semen Armeniacae Amarum (parched) 10-20, Semen Sinapis Albae 6-12, Radix Glehniae 10-15, Radix Notoginseng 6-9, Pseudobulbus Cremastrae Seu Pleiones 10-15, Herba Hedyotidis Diffusae 15-30, Herba Scutellariae Barbatae 15-30, Herba Taraxaci 15-30, Herba Agrimoniae 20-30, Herba Houttuyniae 15-30, Herba Salviae Chinensis 20-30, Ramulus Euonymi 20-30, Radix Ranunculi Ternati 10-30, Ganoderma 6-12, Cordyceps powder 3-6, 3 of Scolopendras.

A Chinese medicine composition for the treatment of lung tumor in late period, it is preferably: the weight proportion of its each raw material is: 3 of Radix Codonopsis 30, the Radix Astragali 30, Radix Angelicae Sinensis (processed with wine) 12, Rhizoma Atractylodis Macrocephalae (parched) 30, Poria 30, Polyporus 12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Pericarpium Citri Reticulatae 15, Bulbus Fritillariae Thunbergii 15, Radix Peucedani 18, sweet Radix Asteris 12, sweet Flos Farfarae 12, Semen Armeniacae Amarum (parched) 16, Semen Sinapis Albae 9, Radix Glehniae 12, Radix Notoginseng 9, Pseudobulbus Cremastrae Seu Pleiones 12, Herba Hedyotidis Diffusae 30, Herba Scutellariae Barbatae 30, Herba Taraxaci 30, Herba Agrimoniae 30, Herba Houttuyniae 30, Herba Salviae Chinensis 30, Ramulus Euonymi 30, Radix Ranunculi Ternati 30, Ganoderma 12, Cordyceps powder 6, Scolopendra.

Compound method of the present invention is as follows: above-mentioned herbal medicine immersion was decocted after 1 hour, and when decoction, moisture content exceedes 5 centimeters, Chinese medicine, after water boiling, uses slow fire boiling after 30 minutes, and filtration is poured out medicinal liquid and can be taken, and Scolopendra is dried to grind into powder and takes after mixing it with water.Divide sooner or later twice on the one.

Effect and mechanism:

Radix Astragali compatibility honey Radix Asteris, sweet Flos Farfarae, treatment lung qi deficient syndrome.With the passing of time disease sees cough with asthma, shortness of breath and tired spirit, and expectorant harmony brings up in lung is unable.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can lung benefiting consolidating superficial resistance.Honey Radix Asteris, nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm, also has the merit of antitumor.Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Poria, Radix Angelicae Sinensis compatibility, strengthen spleen and stomach function and QI invigorating, and QI invigorating can promote to enrich blood, and spleen invigorating can help hemopoietic, therefore energy enhancing human body immunity power improves hemopoietic function, improves vital sign.Polyporusum bellatus composition in Polyporus, has the immunity of enhancing, tumor inhibition effect.According to document, polyporus extract (being mainly polyporusum bellatus) has more significant inhibitory action to mice transplanted tumor S-180.Inhibitory rate 50-70%, the heavy suppression ratio of tumor reaches more than 30%.In the tumor-bearing mice of extract for treating, approximately there is 6-7% tumor to disappear completely.The mice that tumor is disappeared completely inoculates tumor cell after the 1-6 month, the tumor of all not growing.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI master, controls cough with copious phlegm, nausea and vomiting.Pericarpium Citri Reticulatae, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Bulbus Fritillariae Thunbergii, removing heat-phlegm, powder detoxifcation.Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.Semen Armeniacae Amarum (parched), cough-relieving is coughed, expectorant lung moistening.Semen Sinapis Albae, reduces phlegm by drink; Mass dissipating and swelling eliminating Radix Glehniae, nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough Pseudobulbus Cremastrae Seu Pleiones, dispersing swelling and dissipating binds, reduces phlegm, heat-clearing and toxic substances removing.Herba Hedyotidis Diffusae, cures mainly dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal inflammation; Jaundice due to damp-heat; Be good at treatment kinds of tumors swollen.Herba Salviae Chinensis, blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating.Ramulus Euonymi, bitter, pungent, row spills into blood, both kind drastically removing blood stasis and resolving static bloods, kind promoting blood circulation and detumescence pain relieving again, the efficacy of a drug is stronger.Herba Scutellariae Barbatae, heat clearing away, removing toxic substances, method wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.According to document, to treating the late tumor of weary art, the effect that be also improved symptom, suppresses tumor proliferation and extend patient's life.Radix Ranunculi Ternati, dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling, antitumor.According to document, the ethanol extract of Radix Ranunculi Ternati has the stronger effect that induces to tumor necrosis factor (TNF), and in 36 kinds of screened Chinese herbal medicine, Radix Ranunculi Ternati (70% ethanol extract) production of TNF induced effect is the strongest.Radix Notoginseng, warm in nature, acrid in the mouth, has scattered silt hemostasis, and effect of subduing swelling and relieving pain, cures mainly spitting of blood, spits blood, and epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.Ganoderma, cures mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.There is enhancing immunity, antitumor action.Promote the generation that waits endogenous antitumorigenic substance of interleukin II, promote mononuclear phagocyte phagocytic function, promote the especially leukocytic index level of hematopoietic potential of human body, wherein the effective ingredient such as ganoderan has inhibitory action to tumor cell.Cordyceps powder, has that kidney tonifying tonifying the lung, hemostasis and phlegm, cough-relieving are coughed, benefit is deficient, supports vital essence, relievings asthma, the function of antitumor.Scolopendra, dispels the wind, arresting convulsion, counteracting toxic substances, eliminating stagnation, antitumor.

The traditional Chinese medical science thinks that lung tumors is vital QI being weakened and pathogen being violent, weakened body resistance with the deficiency of vital energy, the deficiency of YIN, and deficiency of both QI and YIN, the domination of pathogen is with the stagnation of QI, blood stasis, expectorant is solidifying, and it is main that poison gathers, and is that a kind of whole body entirety belongs to empty, local true, or the disease of simulataneous insufficiency and excessive.The present invention is reduced phlegm by lung benefiting spleen reinforcing, dehumidifying, heat-clearing and toxic substances removing, dispersing pathogen accumulation.Gas, blood, expectorant, poison are controlled altogether, with strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination.

the specific embodiment:

A Chinese medicine composition for the treatment of lung tumor in late period, it is preferably: (unit is g): 3 of Radix Codonopsis 30, the Radix Astragali 30, Radix Angelicae Sinensis (processed with wine) 12, Rhizoma Atractylodis Macrocephalae (parched) 30, Poria 30, Polyporus 12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Pericarpium Citri Reticulatae 15, Bulbus Fritillariae Thunbergii 15, Radix Peucedani 18, sweet Radix Asteris 12, sweet Flos Farfarae 12, Semen Armeniacae Amarum (parched) 16, Semen Sinapis Albae 9, Radix Glehniae 12, Radix Notoginseng 9, Pseudobulbus Cremastrae Seu Pleiones 12, Herba Hedyotidis Diffusae 30, Herba Scutellariae Barbatae 30, Herba Taraxaci 30, Herba Agrimoniae 30, Herba Houttuyniae 30, Herba Salviae Chinensis 30, Ramulus Euonymi 30, Radix Ranunculi Ternati 30, Ganoderma 12, Cordyceps powder 6, Scolopendra for the weight proportion of its each raw material.

The raw material components that takes above corresponding group, according to the routine fashion of decoction, adds water and boil decoction and takes, and Scolopendra is dried levigation and takes after mixing it with water, potion every day (600ml), and potion divides sub-service sooner or later.

clinical observation:

(1) physical data:

The inventor in 2005 so far, carries out clinical observation treatment to 100 routine patients.Wherein male's 70 examples, women's 30 examples, the age 48 is to 75 years old, small cell lung tumor 38 examples, non-small cell lung tumor 62 examples.All belong to lung tumor patient in late period, part is treated through chemicotherapy early stage, and side effect is excessive, thinks patients with terminal when immune function depression or discovery.

(2) Therapeutic Method:

?with being decocted in water for oral dose, sooner or later respectively once, it within 30 days, is a course for the treatment of with medicine of the present invention, according to the state of an illness and do not recover speed treatment 6 months to 3 years not etc.

(3) efficacy assessment standard:

The present invention is mainly used in treating lung tumor in late period, thus according to late period lung tumor symptom to improve situation and life span be criterion, be divided into following three kinds:

Effective: cardinal symptom is obviously improved, survive 3 years or more than, tumor cell without shift without diffusion, or eliminate.

Effective: cardinal symptom is improved substantially; Existence 1-3, growth of tumour cell is inhibited.

Invalid: symptom is improved not obvious, tumor cell shifts diffusion, death.

(4) therapeutic effect:

?clinical effective 18 examples, effective 74 examples, invalid 8 examples, all cases all have no adverse reaction.

(5) sum up: effective percentage 92%,

For proving that the present invention has good curative effect, enumerate model case as follows:

Case 1: Wang, man, 55 years old, patient is diagnosed as lung cancer in non-cellule type, four diagnostic methods data from May, 2005: chest distress, cough with copious phlegm, clear rare color is white, abdominal distention and anorexia, spiritlessness and weakness, moving tachypnea, enlarged tongue, indentations at the margin of the tongue, lip and nail are dark violet, and pale tongue is partially dark, thin fur, sublingual vein is blue or green black and anger is opened, stringy and thready pulse.Do not do any operation and take other treatment scheme.Give the made decoction of the present invention, every day twice, take after January, symptom is obviously improved, and after 6 months, above-mentioned symptom disappears substantially, normal through examination in hospital indices, CT examination foci disappearance.Existing patient can participate in Activities and physical work, and no abnormal phenomenon, follows up a case by regular visits to so far.

Case 2: Liu, man, 66 years old.When patient's in December, 2008 health check-up, find that there is lung posterior lobe and have a 3CM*4CM lump.Make a definite diagnosis rear row resection operation, postoperative pathological shows: right lung squamous cell carcinoma.Afterwards again through chemotherapy four times and repeatedly radiotherapy.While check after three months, find that left lung shifts.Disease is seen: cough uncomfortable in chest, expectorant are yellow and glue, time and hemoptysis is out of breath uncomfortable in chest, thirsty vexed, hectic fever night sweat, dry pharynx celostomia, red tongue lacks tongue, stringy,thready and rapid pulse.Give the made decoction of the present invention, every day twice, take after January, symptom is obviously improved, take 3 months, and CT examination, the swollen thing of left lung has no diffusion, without transfer case.Continue and take 6 months, swollen thing focus is stable, and the every vital sign of patient is good.

Claims (2)

1. treat the Chinese medicine composition of lung tumor in late period for one kind, it is characterized in that: the weight proportion of its each raw material is: Radix Codonopsis 20-30, Radix Astragali 20-30, Radix Angelicae Sinensis (processed with wine) 10-15, Rhizoma Atractylodis Macrocephalae (parched) 20-30, Poria 20-30, Polyporus 10-15, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-20, Pericarpium Citri Reticulatae 10-20, Bulbus Fritillariae Thunbergii 10-20, Radix Peucedani 15-20, honey Radix Asteris 6-12, honey Flos Farfarae 6-12, Semen Armeniacae Amarum (parched) 10-20, Semen Sinapis Albae 6-12, Radix Glehniae 10-15, Radix Notoginseng 6-9, Pseudobulbus Cremastrae Seu Pleiones 10-15, Herba Hedyotidis Diffusae 15-30, Herba Scutellariae Barbatae 15-30, Herba Taraxaci 15-30, Herba Agrimoniae 20-30, Herba Houttuyniae 15-30, Herba Salviae Chinensis 20-30, Ramulus Euonymi 20-30, Radix Ranunculi Ternati 10-30, Ganoderma 6-12, Cordyceps powder 3-6, 3 of Scolopendras.

2. Chinese medicine composition as claimed in claim 1, is characterized in that: the weight proportion of its each raw material is: 3 of Radix Codonopsis 30, the Radix Astragali 30, Radix Angelicae Sinensis (processed with wine) 12, Rhizoma Atractylodis Macrocephalae (parched) 30, Poria 30, Polyporus 12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Pericarpium Citri Reticulatae 15, Bulbus Fritillariae Thunbergii 15, Radix Peucedani 18, sweet Radix Asteris 12, sweet Flos Farfarae 12, Semen Armeniacae Amarum (parched) 16, Semen Sinapis Albae 9, Radix Glehniae 12, Radix Notoginseng 9, Pseudobulbus Cremastrae Seu Pleiones 12, Herba Hedyotidis Diffusae 30, Herba Scutellariae Barbatae 30, Herba Taraxaci 30, Herba Agrimoniae 30, Herba Houttuyniae 30, Herba Salviae Chinensis 30, Ramulus Euonymi 30, Radix Ranunculi Ternati 30, Ganoderma 12, Cordyceps powder 6, Scolopendra.