CN108324916A

CN108324916A - Treat the Chinese medicine and preparation method thereof of tumour

Info

Publication number: CN108324916A
Application number: CN201810384637.3A
Authority: CN
Inventors: 潘烨杰; 胡学东
Original assignee: Huzhou Herbaceous Bio Technology Co Ltd
Current assignee: Huzhou Herbaceous Bio Technology Co Ltd
Priority date: 2018-04-24
Filing date: 2018-04-24
Publication date: 2018-07-27

Abstract

The invention discloses the Chinese medicines and preparation method thereof for the treatment of tumour.The Chinese medicine of the treatment tumour is prepared by bulk pharmaceutical chemicals Radix Astragali, hairyvein agrimony, radix bupleuri, pinellia, cimicifugae foetidae, Radix Angelicae Sinensis, rhizoma atractylodis macrocephalae, dried orange peel, honey-fried licorice root, Fructus Aurantii, rhizoma cyperi processed, fructus corni, Radix Ophiopogonis, Schisandra chinensis, Radix Notoginseng, tag processed, baked ginger, Radix Rehmanniae, radix rehmanniae preparata, ganoderma lucidum, Poria cocos.The Chinese medicine for the treatment of tumour of the present invention, it directly can destroy or kill tumour cell, the toxicity of chemicotherapy can be mitigated, it strengthens the body resistance to consolidate the constitution, softening and resolving hard mass is adapted to the treatment of all kinds of malignant tumours, improve the clinical symptoms of tumor patient, the growth for inhibiting tumour improves the quality of life of patient and extends life cycle, has good clinical efficacy.

Description

Traditional Chinese medicine for treating tumor and preparation method thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine for treating tumors and a preparation method thereof.

Background

Tumors are diseases which cause discoloration of human bodies, and the number of people dying from tumors per year in China is more than 160 million, and the annual cost for treating the tumors is up to 1500 million yuan, which is still rising. Tumors become important reasons for the damage of labor force and the rise of medical expenses in China. However, the prevention and treatment of tumors in domestic medical departments are not standardized, and the prevention and treatment targets of 'early discovery, early diagnosis and early treatment' of tumors are not yet achieved in China.

At present, three main treatment means are commonly used for tumor clinically: chemotherapy, radiotherapy and operation, and their curative effect on tumor is definite and obvious. However, chemotherapy and radiotherapy kill tumor cells and damage normal and healthy cells indiscriminately, while surgical treatment can only remove visible lesions, and tumor cells are easy to metastasize after surgery. The mental and economic pressure on patients caused by chemotherapy, radiotherapy or operation is difficult to bear, and particularly, physical injury causes the patients to be difficult to bear.

Tumor cells are primarily transmitted through 70% of the body fluids (i.e., blood and lymph) in humans. The effective components in the traditional Chinese medicine can improve the double immunity of human body, namely cellular immunity and humoral immunity, activate T, B lymphocytes to arouse the immune recognition of the organism to tumors, enhance the natural killing function of NK cells and macrophages, further eliminate the tumor cells in blood and lymph fluid, and block the metastasis and diffusion of the tumor cells. Moreover, patients with malignant tumor often have weak constitution and low immune function, and particularly have the toxic and side effects of anemia, leukopenia, anorexia, nausea, vomiting and the like after operation, radiotherapy and chemotherapy. The traditional Chinese medicine can strengthen the body, improve anemia, promote the increase of white blood cells and improve the quality of life by the regulation and the nourishing of the traditional Chinese medicine for strengthening the body resistance and consolidating the constitution.

Chinese patent CN101897869A discloses a medicine for treating tumor, which is prepared from black nightshade, semiaquilegia root, nong Jili, rhizoma paridis, toad skin, pangolin scales, scorpion and centipede. However, the absorption effect of the drug is not good, and the raw materials are expensive.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: the traditional Chinese medicine for treating the tumor can directly destroy or kill tumor cells, can relieve toxic and side effects of radiotherapy and chemotherapy, strengthen the body resistance, consolidate the constitution and soften hardness and dissipate stagnation, and is suitable for treating various malignant tumors.

In order to solve the technical problems, the invention adopts the technical scheme that:

the invention provides a traditional Chinese medicine for treating tumors, which is prepared from raw material medicines of astragalus, hairyvein agrimony, radix bupleuri, ginger processed pinellia tuber, rhizoma cimicifugae, angelica, fried bighead atractylodes rhizome, dried orange peel, honey-fried licorice root, fructus aurantii, prepared rhizoma cyperi, jujube peel, radix ophiopogonis, schisandra chinensis, pseudo-ginseng, prepared aconite, baked ginger, radix rehmanniae, prepared rehmannia root, lucid ganoderma and poria cocos.

According to the traditional Chinese medicine for treating tumors, the traditional Chinese medicine for treating tumors is prepared from 20-30 g of bulk drugs of astragalus membranaceus, 25-30 g of hairyvein agrimonia herb and bud, 12-15 g of radix bupleuri, 6-12 g of ginger processed pinellia tuber, 10-20 g of rhizoma cimicifugae, 5-15 g of angelica sinensis, 10-15 g of fried bighead atractylodes rhizome, 10-20 g of dried orange peel, 10-12 g of honey-fried licorice root, 10-12 g of fructus aurantii, 10-15 g of prepared rhizoma cyperi, 15-20 g of jujube peel, 10-15 g of radix ophiopogonis, 10-15 g of schisandra chinensis, 5-7 g of pseudo-ginseng, 20-30 g of prepared aconite, 10-20 g of baked ginger, 20-30 g of radix rehmanniae, 10-30 g of prepared rehmannia root.

As a preferred technical scheme, the traditional Chinese medicine for treating tumors is prepared from 30g of bulk drugs of astragalus, 30g of hairyvein agrimony, 12g of radix bupleuri, 10g of ginger processed pinellia tuber, 15g of rhizoma cimicifugae, 10g of angelica, 12g of fried bighead atractylodes rhizome, 10g of dried orange peel, 10g of honey-fried licorice root, 10g of fructus aurantii, 10g of prepared rhizoma cyperi, 15g of Chinese date peel, 10g of radix ophiopogonis, 10g of schisandra chinensis, 5g of pseudo-ginseng, 20g of prepared radix aconiti lateralis preparata, 10g of baked ginger, 20g of radix rehmanniae, 20g of prepared rhizome of rehmannia, 15.

The baked ginger is obtained by the following method: drying fresh ginger in the sun, and slicing; putting the sand grains into a pot, frying to 180-220 ℃, adding ginger slices, frying for 6-8 minutes, taking out, screening out the sand grains, and spreading and drying in the air to obtain the ginger tea;

the honey-fried licorice root is obtained by the following method: adding refined honey accounting for 25-30% of the weight of the liquorice into the liquorice, uniformly stirring, and standing for 40-60 minutes; spreading the liquorice subjected to honey absorption into a material layer with the thickness of 1-3 cm, drying for 5-7 minutes in microwave with the power of 210-350W and the working frequency of 200-300 MHz, taking out, and spreading and airing to obtain the liquorice honey-dried powder;

the fried bighead atractylodes rhizome is obtained by the following method: adding refined honey accounting for 30-50% of the weight of the bran into the bran, uniformly stirring, standing for 30-60 minutes, and then frying for 10-15 minutes at 70-80 ℃ by using a medicine frying machine to obtain honey-fried bran; putting the bran fried with honey into a medicine frying machine, and frying for 2-5 minutes at 150-160 ℃; adding white atractylodes rhizome accounting for 4-6 times of the weight of the honey-fried bran, frying at 150-160 ℃ for 8-12 minutes, and pouring out; sieving to remove bran processed with honey, and spreading and air drying.

The ginger processed pinellia can be obtained by the existing processing method. Preferably, the pinellia ternata is obtained by adopting the following steps:

(1) adding 300-600 g of water into 30-50 g of liquorice, heating to 80-90 ℃, decocting at 80-90 ℃ for 40-50 minutes, and cooling to 40-50 ℃ to obtain a liquorice water decoction;

(2) uniformly mixing 80-120 g of raw pinellia ternate and 300-500 g of licorice decoction in the step (1), soaking in a sealed condition at 40-50 ℃ for 24-48 hours, and respectively collecting soak solution and soaked pinellia ternate;

(3) slicing 20-30 g of ginger, adding 10-15 g of water, heating to boil, naturally cooling to 60-70 ℃, decocting for 30-60 minutes at 60-70 ℃, filtering, and taking a decoction; squeezing the decocted rhizoma Zingiberis recens, and collecting the juice; mixing the juice and the decoction, and adding 10-15 g of alum to dissolve to obtain alum ginger juice;

(4) mixing alum ginger juice and the pinellia ternate soaked in the step (2) according to the weight ratio of 1: (3-4) mixing, adding water which is 5-10 times of the weight of the alum ginger juice, soaking for 20-40 minutes, heating to boil, and decocting for 40-60 minutes in a boiling state; stopping heating, cooling to 40-45 ℃, sealing, preserving heat, soaking for 24-48 hours, removing the soaking solution, and taking the soaked pinellia ternata;

(5) and (4) adding water which is 1-3 times of the weight of the pinellia ternate into the pinellia ternate soaked in the step (4), washing off alum, taking out the pinellia ternate, and drying to obtain the ginger processed pinellia ternate.

As a first technical scheme for preparing the refined honey, the preparation process of the refined honey comprises the following steps: weighing 20-30 g of honey, adding 1-5 mL of 0.4-0.7 g/mL sodium glutamate solution, mixing uniformly, heating and refining at 110-120 ℃ for 2-3 hours, and taking out to obtain the honey.

As a second technical scheme for preparing the refined honey, the preparation process of the refined honey comprises the following steps: taking 25-30 g of honey, adding 1-5 mL of 0.4-0.7 g/mL sodium glutamate solution, mixing uniformly, heating and refining at 110-120 ℃ for 2-3 hours, taking out, adding 0.025-0.03 g of zymocyte under an aseptic condition, mixing uniformly, sealing, and fermenting at 35-37 ℃ for 36-48 hours to obtain the honey.

Preferably, 5-10 g of pollen is added while the zymophyte is added.

The zymocyte is one or more of yeast, lactobacillus acidophilus and acetic acid bacteria. Preferably, the zymocyte is yeast and lactobacillus acidophilus in a mass ratio of 2.5: 1 in a mixed strain.

The traditional Chinese medicine for treating tumors is in the form of decoction, pills or granules.

The second technical problem to be solved by the invention is to provide a preparation method of the traditional Chinese medicine for treating tumors.

The preparation method of the traditional Chinese medicine for treating the tumor comprises the following steps:

s1, weighing the raw materials according to the weight ratio of the formula;

s2, crushing, sieving and uniformly mixing the raw material medicines to obtain a raw material medicine mixture;

s3, adding water into the bulk drug mixture obtained in the step S2, wherein the weight ratio of the bulk drug mixture to the water is 1: (10-15), decocting with strong fire at 300-450 ℃ until boiling, and then decocting with slow fire at 150-170 ℃ for 40-60 minutes to obtain a decoction type traditional Chinese medicine for treating tumors;

or,

s1, weighing the raw materials according to the weight ratio of the formula;

s2 pulverizing radix astragali, herba et Gemma Agrimoniae, radix bupleuri, Chinese date peel, radix Notoginseng, radix rehmanniae, and radix rehmanniae Preparata, and sieving to obtain fine powder A; adding ethanol with the volume fraction of 70-80%, wherein the solid-to-liquid ratio of the raw material medicine fine powder A to the ethanol is 1: (8-10) (g/mL), extracting at 50-80 ℃ for 2-5 hours; collecting the alcohol extract, concentrating and drying to obtain a dry extract I;

s3 pulverizing rhizoma cimicifugae, pericarpium Citri Reticulatae, rhizoma Cyperi preparata, and fructus Schisandrae chinensis to obtain fine powder B; adding water, wherein the solid-to-liquid ratio of the raw material medicine fine powder B to the water is 1: (8-10) (g/mL), extracting for 8 hours by steam distillation with the steam pressure of 0.12-0.13 MPa, and collecting volatile oil and mother liquor; embedding the volatile oil with cyclodextrin by conventional method, and drying at low temperature to obtain cyclodextrin embedded substance;

s4 pulverizing rhizoma Pinelliae preparata, radix Angelicae sinensis, rhizoma Atractylodis Macrocephalae preparata, radix Glycyrrhizae Preparata, fructus Aurantii, radix Ophiopogonis, radix Aconiti lateralis Preparata, rhizoma Zingiberis Preparata, Ganoderma, and Poria to obtain fine powder C; adding water, wherein the solid-to-liquid ratio of the raw material powder C to the water is 1: (6-8) (g/mL), extracting at 70-90 ℃ for 1-3 hours, and collecting water extract;

s5, combining the water extract obtained in the step S4 and the mother liquor obtained in the step S3, concentrating under reduced pressure until the relative density is 1.10-1.35, cooling, adding absolute ethyl alcohol until the concentration of the ethyl alcohol reaches 65-70%, refrigerating overnight, and filtering to obtain an alcohol precipitation solution; concentrating and drying the alcohol precipitation solution to obtain a dry extract II;

s6, mixing the dry extract I obtained in the step S2, the cyclodextrin inclusion obtained in the step S3 and the dry extract II obtained in the step S5 to obtain the granular traditional Chinese medicine for treating tumors;

or,

s1, weighing the raw materials according to the weight ratio of the formula;

s2 pulverizing the raw materials, mixing, and sieving; adding pharmaceutically acceptable adjuvants, stirring, and making into pill according to conventional method to obtain the pill for treating tumor.

The traditional Chinese medicine for treating tumors can directly destroy or kill tumor cells, can relieve toxic and side effects of radiotherapy and chemotherapy, strengthen the body resistance, soften hardness and dissipate stagnation, is suitable for treating various malignant tumors, improves the clinical symptoms of tumor patients, inhibits the growth of tumors, improves the life quality of the patients and prolongs the life cycle of the patients, and has good clinical curative effect.

The efficacy and source of the various raw materials of the present invention are described below:

astragalus, latin scientific name: leguminosae, also known as astragali or tragacanth. Is root of Leguminosae herbaceous plant Astragalus membranaceus bge. Has effects in enhancing immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure, and inhibiting bacteria. In the examples, Astragalus membranaceus was supplied by Baichun pharmaceutical Co., Ltd, Bozhou.

Agrimony, Latin school name: agrimonia eupatoria, also known as western agrimony. Has effects in astringing, stopping bleeding, relieving inflammation, relieving dysentery, removing toxic materials, killing parasite, invigorating qi, and tonifying heart. Can be used for treating hematemesis, hemoptysis, epistaxis, hematuria, functional metrorrhagia, dysentery, gastroenteritis, trichomonas vaginalis, fatigue, asthenia, contusion, lumbago, carbuncle, and sore. Has strong anticancer effect. In the examples, Agrimonia pilosa is provided by Xiangguang medicinal materials, Inc. in Xidoman county.

Bupleurum, Latin scientific name: bupleurum chinense, also known as peruvian. Is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia. In the embodiment, the bupleurum is provided by the traditional Chinese medicine plant Limited company of Yuyan Chinese medicine workshop in the Annational city.

The rhizoma Pinelliae is tuber of rhizoma Pinelliae of perennial herb of Araceae, has effects of eliminating dampness and phlegm, lowering adverse qi, relieving vomit, relieving distention and fullness, and resolving hard mass, and can be used for treating excessive phlegm cough and asthma, phlegm retention and dizziness, wind phlegm giddiness, phlegm syncope headache, emesis regurgitation, chest and abdominal fullness and distress, plum nuclear qi, etc. Raw half of Xia is used for external treatment of abscess, swelling and phlegm nodule, and Jiang ban Xia is mostly used for checking adverse rise of qi and relieving vomiting. The tuber of pinellia contains volatile oil, small amount of fat, starch, nicotine, mucus, and amino acids. In the embodiment, the raw pinellia ternate is provided by traditional Chinese medicine material limited company of Yuyan Chinese medicine Fang in Anguo city.

Cimicifugae foetidae, the scientific name of latin: RHIZOMA Ligustici under the same name as longan root and folium Sesami. Is dried rhizome of Cimicifuga dahurica Kom, Cimicifuga dahurica (Turcz.) Maxim, or Cimicifuga foetida L. Seasonal pestilence, headache, cold and heat, laryngalgia, aphtha and macula impetigo; sinking of middle qi, chronic diarrhea, dysentery, rectocele, metrorrhagia, leukorrhagia, and metrostaxis; abscess, swelling and sore. Examples cimicifuga foetida is provided by forest pharmaceutical sales, Inc. in Bozhou.

Angelica, latin scientific name: angelica sinensis, also known as Christian, Qinlian. Is root of Angelica gigas nakai of Umbelliferae. Enriching the blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The main symptoms are blood deficiency; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling. Examples angelica is provided by Baichun pharmaceutical Co., Ltd, Bozhou city.

The fried rhizoma atractylodis macrocephalae has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. Record of "medical enlightenment": the traditional Chinese medicine composition has the effects of removing dampness and benefiting dryness, regulating the middle warmer and replenishing qi, warming the middle warmer, removing dampness in the spleen and stomach, removing stomach heat, strengthening the spleen and stomach, promoting appetite, quenching thirst and preventing miscarriage. In the embodiment, the bighead atractylodes rhizome is provided by traditional Chinese medicine material limited company of Yuyan Chinese medicine Fang in Anguo city.

Tangerine peel, also called orange peel. Is dried mature pericarp of Citrus reticulata blanco of Rutaceae and its cultivar. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm. In the embodiment, the dried orange peel is provided by traditional Chinese medicine material limited company of Yuan Yan Chinese medicine Fang in An national city.

Prepared licorice, Latin scientific name: RADIX Glycyrrhizae PREPARATA. Is baked with honey. The honey-fried licorice root is a round-like or oval slice, the surface is reddish brown or grayish brown, the honey-fried licorice root is slightly glossy, the section is yellow to dark yellow, the cambium ring is obvious, and the rays are radial. Has the treatment effects of tonifying qi, nourishing yin, activating yang and recovering pulse. In the examples, licorice was provided by Baichun pharmaceutical Co., Ltd, Bozhou.

Fructus aurantii, Latin school name: FRUCTUS AURANTII. Is dried immature fruit of Citrus aurantium L.of Rutaceae and its cultivars. The bitter orange is bitter, pungent, sour and warm in nature, has the effects of regulating qi, relieving epigastric distention, activating stagnancy and relieving distension, and is mainly used for treating qi stagnation in chest and hypochondrium, fullness and pain, indigestion and retention of food, and phlegm and fluid retention; gastroptosis, proctoptosis, uterine prolapse, etc. In an embodiment, the fructus aurantii is provided by Baichun pharmaceutical Co., Ltd.

The prepared rhizoma cyperi is pungent, slightly bitter and sweet in taste and neutral in nature, has the effects of soothing liver, regulating qi, regulating menstruation and relieving pain, and mainly comprises volatile oil, β -pinene and camphene.

Jujube peel, Latin school name: fructus Lycii, also known as fructus Lycii. Is pulp of Corni fructus of Cornaceae. Tonify liver and kidney, astringe essence and qi, and strengthen deficiency. It is used to treat soreness of waist and knees, vertigo, tinnitus, sexual impotence, spermatorrhea, frequent micturition, liver deficiency, cold and heat, sweating, and heart shaking pulse powder. Tonify liver and kidney, astringe essence and relieve depletion. Can be used for treating vertigo, tinnitus, soreness of waist and knees, sexual impotence, spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, sweating, asthenia, internal heat, and diabetes. Warming liver and tonifying kidney, dispelling all wind, stopping menorrhagia, treating frequent micturition of the elderly. In the examples, the date peel was provided by forest pharmaceutical sales, Inc. in Bozhou.

Ophiopogon root, Latin scientific name: ophiopogonjaponica (Linn.f.) Ker-Gawl. The book of the medical science Zhongzhao xi Lu says that: it can enter stomach to nourish gastric juice, stimulate appetite, and enter spleen to help spleen to disperse essence in lung, relieve asthma and relieve cough. According to the traditional Chinese medicine, the dwarf lilyturf tuber is sweet and slightly bitter in taste and slightly cold in nature, enters the stomach, lung and heart channels, has the effects of nourishing yin and moistening lung, tonifying stomach and promoting fluid production, and clearing away heart fire and relieving restlessness, and is used for treating dry cough due to lung dryness, phthisis cough due to yin deficiency, pharyngitis and pharyngalgia, thirst due to body fluid consumption, internal heat and diabetes, insomnia due to vexation, constipation due to intestinal dryness and the like. In an embodiment, radix Ophiopogonis is provided by Xin Yuan Chinese medicine science and technology, Inc. of Bozhou city.

Schisandra chinensis, Latin's academic name: schisandra chinensis (Turcz.) Baill. Is dried mature fruit of Schisandra chinensis of Magnoliaceae or Schisandra Sphenhera Rehd. et Wils. Tang et al, in the book of Xin Xiu Ben Cao, carry that "Wu Wei Pi gan sui and He Zi is pungent and bitter in the kernel and salty in flavor", so it is named as Wu Wei Zi. The schisandra fruit is divided into two kinds of south and north. The ancient medical book called him 33614c, mysterious union 34127, mysterious union, confluence, the earliest listed in the Shennong herbal meridian top-grade traditional Chinese medicines can nourish and strengthen the strength, has extremely high medicinal value and the effect of strengthening the body, and is used together with Qiongzhen lucid ganoderma to treat insomnia. In the examples, Schizandra chinensis is provided by Baichun pharmaceutical industries, Inc., Bozhou.

Pseudo-ginseng, Latin scientific name: panax Notogeneng, also known as pseudo-ginseng. Is root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae. Can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain. In the examples, pseudo-ginseng was provided by Guimao industries, Ltd, of Dongguan city.

Prepared into Fu pian with the functions of restoring yang to restore collapse, warming and invigorating spleen and kidney, dispelling cold to stop pain, warming yang and expelling cold, and is used in treating diseases of exuberant yin, excessive sweating, vomiting, cold syncope, cold pain in heart and abdomen, diarrhea and dysentery of spleen, impotence, cold womb, ulcer and other diseases of cold pertinence. Examples the coupons were prepared in accordance with the first inventive patent example of patent application No. 201210090653.4.

Baked ginger, Latin's scientific name: rhizoma Zingiensis prepadata. Is processed product of dried rhizome of Zingiber officinale Roscoe of Zingiberaceae, such as peel of Zingiber officinale Roscoe and processed product of Zingiber officinale Roscoe. Has effects of warming spleen and stomach, dispelling cold, warming channels and stopping bleeding. The pungent and dry property of Pao Jiang is weaker than that of gan Jiang, the action of warming the interior is not as rapid as that of gan Jiang, but the action is mild and lasting, and it is good at warming the middle energizer to alleviate pain, checking diarrhea and warming meridians to stop bleeding. Can be used for treating abdominal pain, diarrhea and hemorrhage due to deficiency-cold of middle-warmer energy. In the examples ginger was purchased from farmer markets.

Radix rehmanniae, Latin school name: rehmannia glutinosa Libosch, also known as Sheng Di Huang, Ye Di Huang. Is root tuber of rehmannia glutinosa Libosch of Scrophulariaceae. Clear heat and cool blood, nourish yin, promote the production of body fluid. Can be used for treating fever with deep-red tongue, polydipsia, yin deficiency, internal heat, bone steaming, internal heat, diabetes, hematemesis, epistaxis, macula, and eruption. In the examples, the living land is provided by Xinyuan Chinese medicine science and technology limited, Bozhou.

Prepared rehmannia root, Latin scientific name: chinese Foxglove, also known as rehmanniae radix Preparata or Fugu. Is root tuber of Rehmannia Rehmannia glutinosa of Scrophulariaceae family. Has effects of replenishing blood and nourishing yin, and can be used for treating blood deficiency and chlorosis, giddiness, cardiopalmus and insomnia, menoxenia, metrorrhagia, etc., and can also be used for treating hectic fever and bone steaming due to kidney yin deficiency, night sweat, spermatorrhea, diabetes, etc. In the examples, prepared rehmannia glutinosa is provided by Xinyuan Chinese medicine science and technology limited, Bozhou city.

Ganoderma lucidum, latin scientific name: ganoderma Lucidum Karst, also known as Ganoderma Lucidum and Ganoderma Lucidum. Is fruiting body of Ganoderma lucidum belonging to Polyporaceae. Has effects of invigorating qi, tranquilizing mind, relieving cough and asthma, and prolonging life. Can be used for treating vertigo, insomnia, palpitation, short breath, neurasthenia, and cough with asthma due to asthenia. In the examples, Ganoderma lucidum is provided by Xiangguang medicinal materials, Inc. in Xi Domain.

Tuckahoe, Latin science name: wolfiporia cocos, also known as Yuling and Fuling. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. In an example, Poria cocos (Schw.) wolf is offered by the Kyoho pharmaceutical sales Co., Ltd.

Bran, provided by Zhangjiakou naked oat sprout food Co.

Alumen provided by Imperial Chinese medicinal materials Limited of America

Honey is obtained from various flowers of Hefeiyumao food Co.

Sodium glutamate, food grade sodium glutamate supplied by Yeshang food trade Co., Ltd, Guangzhou city, was used.

Yeast, provided by Cangzhou Huayu Biotech Inc., has 100 hundred million viable bacteria/g.

As the pollen, rape pollen provided by Bao Ji bee industry Co., Ltd, Yongyang county was used.

Lactobacillus acidophilus, provided by Shaanxi Sen fluorine natural products Co., Ltd, the number of viable bacteria is 100 hundred million/g.

Detailed Description

Example 1

The traditional Chinese medicine for treating tumor is prepared from 30g of bulk drugs of astragalus root, 30g of agrimony, 12g of radix bupleuri, 10g of ginger processed pinellia tuber, 15g of cimicifuga foetida, 10g of angelica, 12g of fried bighead atractylodes rhizome, 10g of dried orange peel, 10g of honey-fried licorice root, 10g of bitter orange, 10g of prepared nutgrass galingale rhizome, 15g of Chinese date peel, 10g of dwarf lilyturf tuber, 10g of Chinese magnoliavine fruit, 5g of pseudo-ginseng, 20g of prepared aconite, 10g of baked ginger, 20g of rehmannia root, 20g of prepared rehmannia.

s1, weighing the raw materials according to the weight ratio of the formula;

s2, crushing the raw material medicines, sieving the crushed raw material medicines by a 300-mesh sieve, and uniformly mixing the crushed raw material medicines to obtain a raw material medicine mixture;

s3, adding water into the bulk drug mixture obtained in the step S2, wherein the weight ratio of the bulk drug mixture to the water is 1: 10, decocting with strong fire at 400 ℃ until boiling, and then decocting with slow fire at 170 ℃ for 40 minutes to obtain the traditional Chinese medicine for treating tumors.

The rhizoma pinelliae preparata is obtained by the following steps:

(1) adding water into 80g of raw pinellia ternate, wherein the weight ratio of the raw pinellia ternate to the water is 1: 6, heating to 40 ℃ at the speed of 5 ℃/min, sealing, preserving heat, soaking for 24 hours, and removing the soaking solution to obtain soaked pinellia ternata;

(2) cutting 20g of ginger into ginger slices with the thickness of 2mm, adding 10g of water, heating to boil, naturally cooling to 70 ℃, decocting for 30 minutes at 70 ℃, filtering by a 200-mesh filter cloth, and taking a decoction; squeezing the decocted rhizoma Zingiberis recens, and collecting the juice; mixing the decoction with the juice, and dissolving with 12g Alumen to obtain Alumen-rhizoma Zingiberis recens juice;

(3) mixing alum ginger juice and the pinellia ternate soaked in the step (1) according to the weight ratio of 1: 3, mixing, adding water with the weight 5 times that of the alum ginger juice, soaking for 30 minutes, heating to boil, and decocting for 40 minutes in a boiling state; stopping heating, cooling to 40 deg.C, sealing, soaking for 48 hr, removing the soaking solution, and collecting soaked rhizoma Pinelliae;

(4) adding water 2 times the weight of the pinellia ternate into the pinellia ternate soaked in the step (3), washing off alum, taking out the pinellia ternate, and drying at 70 ℃ for 6 hours to obtain the ginger processed pinellia ternate.

The baked ginger is obtained by the following method: drying fresh ginger in the sun, and cutting into ginger slices with the thickness of 3 mm; and putting the sand grains into a pot, frying to 200 ℃, adding the ginger slices, frying for 8 minutes, taking out, sieving by a 10-mesh sieve to remove the sand grains, and spreading and airing for 3 hours to obtain the baked ginger for later use.

The honey-fried licorice root is obtained by the following method: adding refined honey accounting for 25% of the weight of the liquorice into the liquorice, uniformly stirring, and standing for 60 minutes; spreading the honey-absorbed liquorice into a material layer with the thickness of 2cm, baking for 5 minutes by using microwave with the power of 350W and the working frequency of 245MHz, taking out, spreading and airing for 3 hours to obtain the liquorice for later use.

The fried bighead atractylodes rhizome is obtained by the following method: adding refined honey accounting for 30% of the weight of the bran into the bran, uniformly stirring, standing for 40 minutes, and frying for 15 minutes at 70 ℃ by using a medicine frying machine to obtain honey-fried bran; putting the bran fried with honey into a medicine frying machine, frying for 3 minutes at 160 ℃, and discharging green smoke; adding Atractylodis rhizoma 5 times of the weight of testa Tritici processed with honey, parching at 160 deg.C for 12 min, and pouring out; removing bran from the honey-fried white atractylodes rhizome by using a sieve with 10 meshes, spreading and airing for 3 hours to obtain the fried white atractylodes rhizome for later use.

The preparation process of the refined honey comprises the following steps: weighing 30g of honey, adding 2mL of water, uniformly mixing, heating and refining at 110 ℃ for 3 hours, and taking out to obtain the honey.

Example 2

s1, weighing the raw materials according to the weight ratio of the formula;

The rhizoma pinelliae preparata is obtained by the following steps:

(1) adding 600g of water into 50g of liquorice, heating to 80 ℃ at a speed of 5 ℃/min, decocting for 50 min at 80 ℃, and cooling to 40 ℃ to obtain liquorice water decoction;

(2) uniformly mixing 80g of raw pinellia ternate and 480g of liquorice decoction in the step (1), soaking for 24 hours at 40 ℃ in a closed heat-preservation manner, and respectively collecting soak solution and soaked pinellia ternate;

(3) cutting 20g of ginger into ginger slices with the thickness of 2mm, adding 10g of water, heating to boil, naturally cooling to 70 ℃, decocting for 30 minutes at 70 ℃, filtering by a 200-mesh filter cloth, and taking a decoction; squeezing the decocted rhizoma Zingiberis recens, and collecting the juice; mixing the decoction with the juice, and dissolving with 12g Alumen to obtain Alumen-rhizoma Zingiberis recens juice;

(4) mixing alum ginger juice and the pinellia ternate soaked in the step (2) according to the weight ratio of 1: 3, mixing, adding water with the weight 5 times that of the alum ginger juice, soaking for 30 minutes, heating to boil, and decocting for 40 minutes in a boiling state; stopping heating, cooling to 40 deg.C, sealing, soaking for 48 hr, removing the soaking solution, and collecting soaked rhizoma Pinelliae;

(5) adding water 2 times the weight of the pinellia ternate into the pinellia ternate soaked in the step (4), washing off alum, taking out the pinellia ternate, and drying at 70 ℃ for 6 hours to obtain the ginger processed pinellia ternate.

Example 3

s1, weighing the raw materials according to the weight ratio of the formula;

The rhizoma pinelliae preparata is obtained by the following steps:

The preparation process of the refined honey comprises the following steps: weighing 30g of honey, adding 2mL of 0.7g/mL sodium glutamate solution, mixing uniformly, heating and refining at 110 ℃ for 3 hours, and taking out to obtain the honey.

Example 4

s1, weighing the raw materials according to the weight ratio of the formula;

The rhizoma pinelliae preparata is obtained by the following steps:

The preparation process of the refined honey comprises the following steps: weighing 30g of honey, adding 2mL of 0.7g/mL sodium glutamate solution, mixing, heating and refining at 110 ℃ for 3 hours, taking out, adding 0.028g of yeast under the aseptic condition, mixing uniformly, sealing, and fermenting at 35 ℃ for 48 hours to obtain the honey.

Example 5

s1, weighing the raw materials according to the weight ratio of the formula;

The rhizoma pinelliae preparata is obtained by the following steps:

The preparation process of the refined honey comprises the following steps: weighing 30g of honey, adding 2mL of 0.7g/mL sodium glutamate solution, mixing, heating and refining at 110 ℃ for 3 hours, taking out, adding 5g of pollen and 0.028g of yeast under the aseptic condition, mixing uniformly, sealing, and fermenting at 35 ℃ for 48 hours to obtain the honey.

Example 6

Essentially the same as example 5, except that: the yeast is replaced by lactobacillus acidophilus.

Example 7

Essentially the same as example 5, except that: replacing saccharomycetes with saccharomycetes and lactobacillus acidophilus according to a mass ratio of 2.5: 1 in a mixed strain.

The DPPH radical clearance of the refined honey of examples 2-6 was measured.

Preparing a solution to be detected: adding 10mL of distilled water into the refined honey, uniformly mixing, centrifuging for 10 minutes at 4000 rpm, and taking the supernatant for later use.

Diluting the solution to be detected by a proper amount with distilled water, mixing 0.5mL with 0.5mL of LDPPH solution, reacting for 30 minutes under the dark condition, and measuring the absorbance value at the wavelength of 517 nm. Absolute ethyl alcohol was used as a sample control instead of DPPH, and distilled water was used as a DPPH control instead of DPPH.

The DPPH clearance equation is as follows:

S(％)＝[A₀-(A₁-A₂)]/A0×100％。

s represents clearance, a0 is DPPH control absorbance, a1 represents sample absorbance, and a2 represents sample control absorbance. The test results are shown in Table 1.

TABLE 1 DPPH radical scavenging Rate test results Table

Clinical observation test

The curative effect of the traditional Chinese medicine for treating tumor is further illustrated by clinical observation tests.

Clinical liver cancer patients were selected, aged 30-80 years, and randomly divided into 7 groups. The basic data of the severity, course and age of the liver cancer patients in each group are compared, and the difference has no statistical significance (P is more than 0.05) and is comparable.

The Chinese medicament for treating the tumor is taken three times a day. The dosage of the patient in late stage of tumor is 50mL, the dosage of the patient in middle stage of tumor is 40mL, and the dosage of the patient in early stage of tumor is 30 mL.

The traditional Chinese medicine for treating the tumor and plain boiled water are only taken without eating during the taking period. Seven days are a treatment course, and patients can drink light food after seven days and can enter the next treatment course after seven days. The treatment period is one year.

The therapeutic effect judgment standard is as follows:

the effect is shown: the lump disappears, the cancer cells are reduced, the immunity is improved, the spirit is full, and no pain is caused;

the method has the following advantages: the effective mass becomes small, the cancer cells are basically inhibited, the spirit is poor, and the pain is relieved;

and (4) invalidation: the cancer cells are unchanged, the mental condition is poor, pain still exists, and the symptoms are obvious.

The difference in therapeutic effect between the groups was statistically significant (P < 0.05). The specific test results are shown in table 2.

Table 2: observation results of curative effect

	Show effect	Is effective	Invalidation
				Example 1	169	91	0
Example 2	173	97	0
				Example 3	185	75	0
Example 4	191	69	0
				Example 5	206	54	0
Example 6	221	39	0
				Example 7	239	21	0

Conclusions were drawn from the above treatments: the traditional Chinese medicine for treating tumors has an obvious treatment effect on tumors.

Specific examples of the applications

Li Shi, female, 48 years old, with lung cancer, under the doctor's advice, started to do radiotherapy, after 6 courses of radiotherapy, the disease was not alleviated, and symptoms of hoarseness and neck edema appeared. After the traditional Chinese medicine for treating the tumor is taken for 4 courses of treatment, the sound returns to normal, and the phenomenon of neck edema disappears. After the traditional Chinese medicine for treating the tumor is continuously taken for 8 courses of treatment, the disease condition is basically controlled, and the tumor cells are not spread any more after the examination.

Xuan, male, 25 years old, with esophageal cancer, after the poor treatment effect of many hospitals, it is accompanied by the side effects of radiotherapy, general weakness, emaciation, anorexia, irregular fever. After the traditional Chinese medicine for treating the tumor is taken for 3 courses, normal diet can be realized, general weakness and irregular fever symptoms disappear, and after the traditional Chinese medicine for treating the tumor is continuously taken for 6 courses, the body is recovered to be normal, and tumor cells disappear after examination.

Zhangqi, female, 53 years old, with primary liver cancer. After receiving chemotherapy for three courses in the hospital, the condition of the disease is relieved. But ascites, cirrhosis and other symptoms appear soon, and the body weight is obviously reduced. After the Chinese medicament for treating the tumor is introduced by people to be taken for 6 treatment courses, the ascites disappears and the liver function index is recovered to be normal.

The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. All obvious changes and modifications which are obvious to the technical scheme of the invention are covered by the protection scope of the invention.

Claims

1. The traditional Chinese medicine for treating tumors is characterized by being prepared from raw material medicines of astragalus membranaceus, hairyvein agrimony, radix bupleuri, ginger processed pinellia tuber, rhizoma cimicifugae, angelica sinensis, fried bighead atractylodes rhizome, dried orange peel, honey-fried licorice root, fructus aurantii, prepared rhizoma cyperi, jujube peel, radix ophiopogonis, schisandra chinensis, pseudo-ginseng, prepared radix aconiti lateralis preparata, baked ginger, radix rehmanniae, prepared rehmannia root, lucid ganoderma and poria cocos.

2. The traditional Chinese medicine for treating tumors according to claim 1, which is prepared from 20-30 g of bulk drugs including astragalus membranaceus, 25-30 g of agrimony, 12-15 g of radix bupleuri, 6-12 g of ginger processed pinellia tuber, 10-20 g of cimicifuga foetida, 5-15 g of angelica sinensis, 10-15 g of fried bighead atractylodes rhizome, 10-20 g of pericarpium citri reticulatae, 10-12 g of honey-fried licorice root, 10-12 g of fructus aurantii, 10-15 g of prepared rhizoma cyperi, 15-20 g of jujube peel, 10-15 g of radix ophiopogonis, 10-15 g of schisandra chinensis, 5-7 g of pseudo-ginseng, 20-30 g of prepared radix aconiti lateralis preparata, 10-20 g of baked ginger, 20-30 g of radix rehmanniae, 10-30 g of prepared rehmannia glutinosa, 15-20 g of ganoderma lucidum and 10-15.

3. The traditional Chinese medicine for treating tumors according to claim 2, wherein the baked ginger is obtained by the following method: drying fresh ginger in the sun, and slicing; putting the sand grains into a pot, frying to 180-220 ℃, adding ginger slices, frying for 6-8 minutes, taking out, screening out the sand grains, and spreading and drying in the air to obtain the ginger tea;

4. The traditional Chinese medicine for treating tumors according to claim 2, wherein the pinellia ternata is obtained by adopting the following steps:

5. The traditional Chinese medicine for treating tumors as claimed in claim 3, wherein the preparation process of the refined honey comprises the following steps: weighing 20-30 g of honey, adding 1-5 mL of 0.4-0.7 g/mL sodium glutamate solution, mixing uniformly, heating and refining at 110-120 ℃ for 2-3 hours, and taking out to obtain the honey.

6. The traditional Chinese medicine for treating tumors as claimed in claim 3, wherein the preparation process of the refined honey comprises the following steps: taking 25-30 g of honey, adding 1-5 mL of 0.4-0.7 g/mL sodium glutamate solution, mixing uniformly, heating and refining at 110-120 ℃ for 2-3 hours, taking out, adding 0.025-0.03 g of zymocyte under an aseptic condition, mixing uniformly, sealing, and fermenting at 35-37 ℃ for 36-48 hours to obtain the honey.

7. The traditional Chinese medicine for treating tumors according to claim 6, wherein 5-10 g of pollen is added at the same time as the zymocyte is added.

8. The traditional Chinese medicine for treating tumors according to claim 6, wherein the fermentation bacteria is one or a mixture of yeast, lactobacillus acidophilus and acetic acid bacteria.

9. The traditional Chinese medicine for treating tumor according to claim 2, wherein the dosage form of the traditional Chinese medicine for treating tumor is one of decoction, pills and granules.

10. The method for preparing a Chinese medicine for treating tumor according to any one of claims 2 to 9,

s1, weighing the raw materials according to the weight ratio of the formula;

or,

s1, weighing the raw materials according to the weight ratio of the formula;

or,

s1, weighing the raw materials according to the weight ratio of the formula;