CN106728912A

CN106728912A - Treat the composition of lung cancer and the application for preparing treatment lung-cancer medicament

Info

Publication number: CN106728912A
Application number: CN201710010908.4A
Authority: CN
Inventors: 林丽珠
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-01-06
Filing date: 2017-01-06
Publication date: 2017-05-31
Anticipated expiration: 2037-01-06
Also published as: CN106728912B

Abstract

A kind of application the invention discloses composition for treating lung cancer and for preparing treatment lung-cancer medicament, composition includes the following components containing therapeutically effective amount：Any one in radix ranunculi ternati, selfheal or two kinds；Any one in stiff silkworm, house lizard or two kinds；Glabrous Sarcandra Herb, black nightshade grass in it is any one or two kinds；Any one in edible tulip, Sculellaria barbata or two kinds；Any one in fritillaria thunbergii, northern apricot or two kinds；Ganoderma lucidum；Rhizoma pinellinae praeparata, dried orange peel any one or two kinds；Any one in American Ginseng, Radix Codonopsis or two kinds；Composition is provided with the component proportion less than toxic dose.Composition can also further combine chemotherapeutant or targeted drug is used.The present composition and application can be effectively improved lung cancer related symptoms, delay tumour progression, antagonism tumor drug resistance, mitigate chemical therapy toxic side effect, so as to improve Patients with Advanced Lung Cancer life quality, and for patients with lung cancer bring existence benefit, and definitely, objective curative effect.

Description

Treat the composition of lung cancer and the application for preparing treatment lung-cancer medicament

Technical field

The present invention relates to field of medicaments, more particularly, to a kind of Chinese medicine for treating lung cancer as raw material with traditional Chinese medical science animal and plant medicine Composition, and its for preparing the application for the treatment of lung-cancer medicament.

Background technology

Primary bronchogenic carcinoma of lung is one of global incidence highest malignant tumour, and its incidence of disease and the death rate are still in Ascendant trend, seriously threatens the health and life of the mankind year by year.The incidence of disease and case fatality rate of China's lung cancer are occupied in male The 1st of malignant tumour, is only second to breast cancer in women, occupies the 2nd.The statistics table of the World Health Organization in 2005 Bright, annual whole world lung cancer new cases are 1,350,000, account for the 12.4% of whole malignant tumours, dead 11.8 ten thousand, account for tumour All death 17.6%.Wherein, Chinese new cases of lung cancer there are about 500,000 (male about 330,000, women about 170,000), lung cancer oneself turn into The common disease of people's life and health is endangered increasingly severely.

At present, the cause of disease of lung cancer is not yet fully apparent from, and its possible cause is removed to be had outside the Pass with body internal factor, social environment Factor is also a very important problem, it is considered that lung cancer is relevant with following factors：

(1) smoking：It is now recognized that smoking is the most important high risk factor of lung cancer, 3000 kinds of chemicals are had more than in tobacco Matter, wherein multichain compound fragrant hydrocarbon are (such as：BaP) and nitrosamine have very strong carcinogenic activity.Multichain arene Compound and nitrosamine can cause bronchial epithelial cell DNA damage by number of mechanisms so that oncogene (such as Ras genes) is activated Inactivated with tumor suppressor gene (such as p53, FHIT gene etc.), and then cause transformation, final canceration.

(2) occupation and environment contact：Lung cancer is most important one kind in occupational cancer, and the patients with lung cancer for estimating about 10% has environment With Exposed history.Have been demonstrated that following 9 kinds of occupational environment carcinogenic substances increase the incidence of lung cancer：The byproduct of aluminum products, arsenic, Asbestos, chromium compound, coke-fired furnace, mustard gas, nickeliferous impurity, vinyl chloride.The materials such as Long Term Contact beryllium, cadmium, silicon, formalin Also the incidence of disease of lung cancer can be increased, air pollution, particularly industrial waste gas can trigger lung cancer.

(3) ionising radiation：Lungs are the organs more sensitive to radioactive ray.Ionising radiation causes the initial evidence of lung cancer to come from The data in Schneeberg-joakimov mines, radon and its daughter concentration are high in the mine air, and the mostly of induction are small bronchuses Cell cancer.The U.S. once has been reported that the miner 70%~80% of exploitation atomic ore dies from radioactive occupational lung cancer, with It it is 10~45 years from disease time is come into contact with based on squamous carcinoma, average time is 25 years, and average age of onset is 38 years old.Radon And its daughter by amount accumulation more than 120 working waters on ordinary days (WLM) when the incidence of disease start to increase, it is and then more aobvious more than 1800WLM Writing increases up to 20~30 times.By mouse in the gas and dust in these mines, lung neoplasm can be induced.Japan Atomic bullet is quick-fried Suffer from lung cancer person in fried survivor to dramatically increase.Beebe has found in follow-up lifelong to hiroshima bomb blast survivor, away from the quick-fried heart Compared with the survivor beyond quick-fried 1400~1900m of the heart and 2000m, it dies from lung cancer person substantially increases survivor less than 1400m.

(4) the past lung's chronic infection：Such as pulmonary tuberculosis, bronchiectasis patient, bronchiolar epithelium is in chronic infection During may metaplasia cause canceration for scaly epithelium, it is but more rare.

(5) factor such as heredity：The reduction of Familial aggregation, genetic predisposition and immunologic function, metabolism, endocrine function imbalance Etc. being likely to be played an important role in the generation of lung cancer.Many studies demonstrate that, inherent cause may be susceptible to environmental carcinogen Crowd and/or individuality in play an important role.

(6) atmosphere pollution：The incidence of disease of developed country's lung cancer is high, is primarily due to industry and traffic developed regions, The harmful substances such as the carcinogenic hydrocarbon of BaP that contain produced with bituminous highway dust after the burning such as oil, coal and internal combustion engine pollute air It is relevant.Atmosphere pollution may promote mutually the incidence of disease of lung cancer with smoking, play synergy.

The clinical manifestation of lung cancer is more complicated, the morning and evening of the presence or absence of sings and symptoms, weight and appearance, depending on tumour Happening part, histological type, whether there is transfer and whether there is complication, and reaction degree and tolerance difference.Lung cancer Early symptom is often relatively slight, or even can be without any discomfort.There is early and weight in central type carcinoma of lung symptom, and peripheral type carcinoma of lung symptom occurs It is late and relatively light or even asymptomatic, often it is found in physical examination.

The cardinal symptom of lung cancer early stage can have cough, hemoptysis, heating, pain over the chest and back, uncomfortable in chest, shortness of breath or weak etc..Cough and be Onset symptoms person accounts for 45%, and central type carcinoma of lung cough symptom occurs relatively early, is often choked in paroxysmal, excitant and coughed, amount of expectoration compared with Less or without phlegm.Blood-stained sputum or hemoptysis account for 20% for starting symptom, and hemoptysis is the symptom for easily attracting people's attention, and is lung The symptom for relatively having characteristic of cancer, often repeatedly with blood silk or small clot in phlegm, early stage does not typically cause big hemoptysis.Chest The position of pain can be in disperse, unfixed or in continuation dull pain in early stage.Small number of patients can have to breathe heavily suppresses or occurs wheezing sound. Medium and advanced lung cancer patient except general common low-heat, become thin, in addition to the constitutional symptom such as anaemia, still there is neck surface oedema, pain, sound The symptom and signs such as hoarse, pleural effusion, expiratory dyspnea.

At present, both at home and abroad for the treatment of lung cancer, also there is following thorny technical problem：

(1) surgical intervention is the first-selected and topmost treatment method of lung cancer, is also the only treatment side that can cure lung cancer Method.Operative treatment is primarily suitable for early metaphase patients with lung cancer, only has 20% patient when medical and is adapted to surgical intervention, and 30%~ 70% patient is postoperative to be there is recurrence or shifts.End-stage patients' has a delicate constitution, and cannot even more be treated surgically.For late period Or have the patients with lung cancer of extensive transfer, it is impossible to radical surgery is carried out, Experience of Combined Treatment of Internal Medicine often turns into essential therapeutic arsenals.

(2) chemotherapy of lung cancer includes radical-ability chemotherapy, palliative chemotherapy, new adjuvant chemotherapy, NACT, local chemotherapy And Chemotherapy.At present, chemotherapy is the main treatment means of advanced lung cancer.Lung cancer is included completely to the effecting reaction of chemotherapy Alleviate and part alleviate two kinds of situations, but Most patients showed be only part alleviate, only 10%~15% office Portion's patients with terminal, the IV phase patients less than 5% can reach CCR.In recent years, the own extensive use of third generation chemotherapeutic In clinic, with two prescription cases such as docetaxel+cis-platinum that they and platinum class are combined, gemcitabine+cis-platinum, taxol+cis-platinum with And vinorelbine+cis-platinum etc. turns into the main flow for the treatment of-line scheme.The Combination chemotherapy of platiniferous new drug causes that late period is non-small thin The treated effect of born of the same parents' lung cancer is improve by about one time earlier above, but total survival rate is not significantly improved, it means that tumour Alleviate and be not equal to the extension of life cycle.Meanwhile, chemotherapy has certain limitation, and high cost, also there is marrow Various toxic and side effects such as suppression, neurotoxicity, cardiac toxic, liver damage, side effect of digestive tract, implement chemotherapy for a long time Serious resistance situation can be also produced afterwards, and this can also influence effective control of the chemotherapeutics to tumour.

(3) tumor cells targeted therapy is a kind for the treatment of means for quickly growing in recent years.By using tumour cell with Difference between normal cell on molecular biology, so that disabling signal conduction path, closing acceptor, suppression angiogenesis, accurately The specific target spot of tumour cell is acted on, is suppressed its growing multiplication, invasion and attack and is shifted, promote the tune of tumour cell to die.At present, should Molecular targeted therapy for lung cancer includes epidermal growth factor recipient tyrosine kinase inhibitor, and antineoplastic vascular Newborn target therapeutic agent.The former Common drugs have Gefitinib and Erlotinib, and the latter includes that Cetuximab, shellfish cut down pearl The medicine such as monoclonal antibody and Victibix.Compared with traditional chemotherapeutics, molecular targeted agents have Small side effects, convenient to take and treatment The advantage imitated, but its expensive and applicable crowd is limited, it is had a greatly reduced quality in the popularity of clinical application.

(4) radiotherapy is one of critical treatment method of lung cancer, it is adaptable to which the early stage of lung cancer or a variety of causes are reluctant operation Person.Radiotherapy can be divided into radical radiation therapy, palliative radiation therapy and comprehensive radiotherapy on lung cancer therapy.Lung cancer list 5 years survival rates are between 6%~8.7% after pure radiotherapy, therefore need to carry out multidisciplinary synthesis treatment to improve survival rate.Palliative is put Treat can relief of symptoms, improve the quality of living and prevent and treat and acute complicationses occur, such as superior vena cava stress disorders and spinal cord infringement cause Paraplegia.Because knub position relatively limits in the early stage of lung cancer, the advantage using radiotherapy is can to reduce tumour to be easy to operation, but radiotherapy Normal cell is also killed while tumour cell is killed, immunity of organisms is reduced rapidly, therefore effect clinically is simultaneously It is uncertain.And radiotherapy is almost without with because it cannot be accurately positioned to cancer cell, taking and put extensively in Advanced cancers treatment Treatment is lost more than gain.Meanwhile, in addition to ED-SCLC, squamous carcinoma is not high to radiotherapy susceptibility with gland cancer, therefore clinically less use Radiotherapy.

(5) tumor immunotherapy immunization therapy is applied immunology principle and method, improves the immunogenicity of tumour cell With the sensitiveness of pairing effect cell killing, antitumor immunity of organism response, and application immunocyte and effect point are excited and strengthened In son infusion host, collaboration body immune system kills tumour, suppresses tumour growth.In recent years, immunotherapy of tumors was good Message constantly, at present in some tumor types such as melanoma, is illustrated powerful in the treatment of non-small cell lung cancer etc. Antitumor activity, and have immunotherapy of tumors medicine acquisition U.S. FDA (Food and Drug Administration, food Product drug administration) approval clinical practice.Immunotherapy of tumors due to its remarkable curative effect and novelty, in quilt in 2013《Section Learn》Magazine is chosen as annual most important scientific breakthrough.Immunotherapy of tumors is expected to turn into and is controlled after operation, chemotherapy, radiotherapy and targeting An innovation of therapeutic field of tumor after treatment.Yet with not having particular organisms mark, immunization therapy beneficiaries are imprecise, Its medical expense is of a relatively high, and clinical efficacy is limited, and promoting immunization therapy on a large scale at this stage wouldn't be actual.

(6) it is the oncotherapy mode with tcm characteristic that traditional Chinese medicine is antitumor, has caused increasing researcher's Oneself has progressively shown its unique advantage in the treatment of lung cancer for attention, Chinese medicine and the combination of Chinese tradiational and Western medicine.But with regard to present case From the point of view of, the antineoplastic research direction of traditional Chinese medicine is concentrated mainly on cooperation western medical treatment aspect, coordinates chemicotherapy to mitigate with Chinese medicine Based on its toxic and side effect, the drug effect of its independent role is not obvious, and it is less from stablize tumorous size, delay resistance, extension suffer from The angle of person's life cycle is studied.Meanwhile, the research of Lung Cancer with Integrated Traditonal Chinese Westren Medicine lacks Basic pharmacology research and looks forward to the prospect The comparative study of property, the mechanism of action is uncertain, and result of study lacks persuasion.Also, constituent parts, the cooperating research at each center are opened Exhibition is few, also not enough unified, clinical observation case sample is on the low side for diagnosis and treatment standard, lacks statistical significance.Some research is not set up sternly The control group of lattice, result of study lacks evidence-based medical, has severely impacted popularization of the traditional Chinese medicine in oncotherapy.

The content of the invention

In view of this, it is an object of the invention to provide a kind of composition for treating lung cancer and for preparing treatment lung The application of cancer drug, can be effectively improved lung cancer related symptoms, delay tumour progression, antagonism tumor drug resistance, mitigate chemotherapy poison pair Effect, is that patients with lung cancer brings existence to benefit, and definitely, objectively treat so as to improve the life quality of Patients with Advanced Lung Cancer Effect.

Solution of the invention is to refer and synthesize forefathers based on modern doctor to recognize and clinical experience, and developed lung cancer Etiology and pathogenesis are theoretical, more highlight the important function of " phlegm, poison, the stasis of blood, void " in lung cancer morbidity.

Lung governing qi, department's breathing, main a surname sends out drop respectful, and skin is closed outside regulating fluid apssage, has one's ideas straightened out in nose, in large intestine phase table.《Plain Questions The five internal organs generate a piece》Meaning " all gas persons, come under lung ".As lung qi is happy, can accessory heart pass through Xuemaitong up to whole body, the respectful drop of lung qi Can with regulating fluid apssage, impairment of purifying and descending function of the lung then superinverse and be to breath with cough.TCM Oncology thinks that tumour is evil poison accumulation, and poison hair the five internal organs are empty The systemic disease being mingled with fact.The generation of lung cancer, development, differentiation are that various inside and outside paathogenic factors act on body in multiple stages Pathologic process.Wherein, internal cause is Main Etiological Factors, external cause in thus work.《Required Readings for Medical Professionals》Meaning " product into , positive unsaturated vapor, then perverse trend crouch it." if native endowment is not enough or healthy tendency internal weakness, lung qi virtual loss, function is not enough, and a surname's drop is lost Often, disease and evil is taken advantage of a weak point, and lung qi anger is strongly fragrant, stops in aqueous, and train of thought obstruction, phlegm and blood stasis form lung product；Or exopathogen violates lung, " lung is It is tender dirty, happiness profit and dislike dry ", scorching most easily to hinder lung, long-term smoking in addition, cigarette is hot chief, dry to hinder lung yin, fire-evil punishment gold, lung The moon is impaired, and precise and tiny not cloth involves kidney yin, raw in abnormal heat, and the liquid that burns is phlegm, and phlegm heat is fought knot, is formed and gathered or inernal injuries caused by seven emotions, then mechanism of qi Disturbance in ascending and descending, the part of the body cavity above the diaphragm housing the heart and lungs must not declare logical, and qi as the commander of blood, qi disease involving blood, then the blood stasis of blood is stagnant, local knot and it is blocking, such as《Plain Questions is lifted Pain is discussed》Say " remaining to know hundreds of diseases resulting from disorder.Rage leading to qi ascending, then gas delays for happiness, and excessive sorrow leading to qi consumption ... is sad then feels concerned about urgency, and lung cloth leaf is lifted, and The part of the body cavity above the diaphragm housing the heart and lungs is obstructed, and Rong Wei does not dissipate, and hot gas is in, therefore gas disappears." or injury due to diet,《Plain Questions numbness opinion》Say：Eating twice as usual, stomach It is wound.Phlegm coming from spleen, dysfunction of the spleen then essence of water and grain can not biochemical defeated cloth, cause it is wet be polymerized to phlegm, lung being reservoir of phlegm, lung it A surname's drop, it is logical adjust mistake department then phlegm be turbid stay the source on water, lump is gradually formed or evil poison invades lung, and the lung being the dominator of QI passes through larynx, has one's ideas straightened out In nose, directly communicated with external environment, such as industrial waste gas, mine dust, asbestos and radioactive substance evil poison attack lung, and lung qi stasis is not OK, the stagnation of the circulation of vital energy and blood addiction, drug addiction knot gather, and with the passing of time form carcinoma.

In a word, lung cancer because healthy tendency it is deficient, it is all it is evil in invade, cause lung qi anger is strongly fragrant, and body fluid is lost in defeated cloth, and it is phlegm that Tianjin is gathered, and phlegm coagulates gas Stagnant, stasis blocking channels causes phlegm, the stasis of blood, poison to be cemented to product, therefore, " phlegm, poison, the stasis of blood, void " is that the pathogen and pathology of tcm of lung cancer is crucial.

Solution of the invention combines doctor's recognizing and referring to modern pharmacological research to lung cancer etiology and pathogenesis at all times, The natural plants herbal medicine and insect medicine of reducing phlegm and resolving masses, removing toxicity for detumescence, nourishing lung and kidney are filtered out, according to prescription theory, according to certain Proportioning be prepared from, there is provided one kind can improve lung cancer related symptoms, delay tumour progression, antagonism tumor drug resistance, control swollen Knurl recurs and/or shifts, chemotherapeutic sensitivity is attenuated, improves the composition of immunologic function and its for preparing treatment lung-cancer medicament Using, thus improve Patients with Advanced Lung Cancer life quality, extension patient survival, be patients with lung cancer bring existence benefit and really Cut, objective curative effect.

A kind of composition for treating lung cancer, including the following components containing therapeutically effective amount：

Component A) any one or two kinds in radix ranunculi ternati and selfheal；

Component B) any one or two kinds in stiff silkworm and house lizard；

Component C) any one or two kinds in Glabrous Sarcandra Herb and black nightshade grass；

Component D) any one or two kinds in edible tulip and Sculellaria barbata；

Component E) any one or two kinds in fritillaria thunbergii and northern apricot；

Component F) ganoderma lucidum；

Component G) any one or two kinds in rhizoma pinellinae praeparata and dried orange peel；

Component H) any one or two kinds in American Ginseng and Radix Codonopsis；

The composition is provided with the component proportion less than toxic dose.

On each Chinese medicine crude drug component used in the present composition, " therapeutically effective amount " used by the present invention It refer to the raw medicinal herbs amount of the antitumor activity energy that composition is provided.

In the middle of the prescription of composition, radix ranunculi ternati play reducing phlegm and resolving masses, removing toxicity for detumescence the effect of, be monarch drug in a prescription；Stiff silkworm, swollen section The effect of wind, edible tulip and fritillaria thunbergii play facilitaing lung dissipating bind, removing toxicity for eliminating carbuncles, is ministerial drug；The effect of rhizoma pinellinae praeparata plays eliminating dampness and eliminating phlegm, It is adjutant；The effect of ganoderma lucidum, American Ginseng play nourishing lung and kidney, to make medicine.As corresponding alternative, in the prescription of composition In, selfheal play reducing phlegm and resolving masses, removing toxicity for detumescence the effect of, be monarch drug in a prescription；House lizard, black nightshade grass, Sculellaria barbata and northern apricot play facilitaing lung The effect of dissipating bind, removing toxicity for eliminating carbuncles, be ministerial drug；The effect of dried orange peel plays eliminating dampness and eliminating phlegm, is adjutant；Ganoderma lucidum, Radix Codonopsis play help lung The effect of kidney, to make medicine.Lung cancer is deficient because of healthy tendency, is invaded in all heresies, and cause lung qi anger is strongly fragrant, and body fluid is lost in defeated cloth, and it is phlegm that Tianjin is gathered, and phlegm coagulates The stagnation of the circulation of vital energy, stasis blocking channels causes phlegm, the stasis of blood, poison to be cemented to product, and " phlegm, poison, the stasis of blood, void " is that the pathogen and pathology of tcm of lung cancer is crucial.The present invention The prescription of composition is ventilatingd the lung and resolving phlegm by performance, removing toxicity for eliminating carbuncles, it is relieving cough and asthma the effect of, mainly curing cancer of lung and metastatic cancers of lung, disease See that coughing with a lot of sputum, pectoralgia are unfavorable, burnout is tired, the indigestion and loss of appetite person of dry.

The introduction of traditional Chinese medicinal components：

Radix ranunculi ternati：It is the dried root of ranunculaceae plant Seynuns Kugelann (Ranunculus ternatus Thunb).It is distributed in The ground such as Guangxi, Taiwan, Jiangsu, Zhejiang, Jiangxi, Hunan, Anhui, Hubei, Henan, sweet, pungent, warm in nature, Return liver, lung channel.Have The effect of reducing phlegm and resolving masses, removing toxicity for detumescence, it is usually used in scrofula subcutaneous nodule, furuncle swelling toxin, snake bite and insect sting.

Selfheal：Fruit ear is dried for labiate selfheal Prunella vulgaris L..All parts of the country are produced, Main product is in Jiangsu, Zhejiang, Anhui, Henan and other places.Harvested when summer fruit ear is in brownish red, remove impurity, dried or raw use.Property Pungent, hardship, trembles with fear.Return liver, gallbladder channel.The effect of with clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.

Liver Channel, the temperature one of nature and flavor one are cool with entering for radix ranunculi ternati and selfheal, and both can both be substituted for each other, also can compatibility use, pin Neoplastic disease to different constitutions can be applied per capita.Selfheal can clear liver dissipating bind, be that treatment scrofula goiter and tumor is dizzy with acute mastitis breast cancer, the head The medicine of the diseases such as dizzy, arthralgia and myalgia, pulmonary tuberculosis.There is radix ranunculi ternati reducing phlegm and resolving masses, removing toxicity for detumescence to be used, and also be treatment scrofula, lung The medicine of tuberculosis, malaria.For clinical concrete condition, such as need medicine warm in nature, and play the reducing phlegm and resolving masses of medicine, removing toxicity for detumescence work( Effect, then lay particular emphasis on addition radix ranunculi ternati；Such as need medicine cool in nature, and play the clearing liver mass-dissipating efficacy of medicine, then lay particular emphasis on the addition summer withered Grass；Such as patient symptom may be used alone or in combination without fever and chills bias, then any two medicine.

Stiff silkworm：For the larva in Bombycidae insect silkworm Bombyx mori Linnaeus4~5 ages infects (or artificial infection) Muscardine Beauveria bassiana (Bals.) Vuillant and lethal hirudo leech.It is distributed in Jiangsu, Zhejiang, Sichuan, wide The ground such as east, taste is salty, pungent, mild-natured, Return liver, lung, stomach.The effect of with Inflammation Zhijing, wind-expelling pain-stopping, reducing phlegm and resolving masses.It is usually used in Liver wind folder phlegm, twitch, acute infantile convulsion, lockjaw, middle air portHeadache due to pathogenic wind-heat, hot eyes pharyngalgia, rubella itch, hair chin or cheek Zha The cheek.

House lizard：It is the entirety of animal Gekkonidae leopard line house lizard Eublepharis macularius.Alias sky dragon, gecko, Ward off remaining piece.Nature and flavor are salty, cold, slightly poisonous.The effect of with eliminating stagnation to stop pain, dispelling wind and relieving convulsion.

House lizard equally belongs to animal drugs with stiff silkworm, and both of which taste is salty, there is the effect of dispelling, collateral-activating dissipating bind, and both both can mutually replace Generation, also can compatibility use.Clinically many patients with lung cancer also have chest tightness bitterly except cough and expectoration, the situation that the glutinous difficulty of phlegm is coughed up, And with constitutional symptom, such as heating, it is vexed, people becomes thin very much, falling asleep at night after easily perspiration etc., the traditional Chinese medical science is it is thought that heat toxin Pathogenic result.House lizard, stiff silkworm are cold in nature, can clearing heat and detoxicating anticancer, its taste is salty, moreover it is possible to soften dissipation lump.

Glabrous Sarcandra Herb：Complete stool is dried for Chloranthaceae plant Chloranthus glaber.Also known as sarcandra, ring tea, elder.Bitter, It is pungent, mild-natured, the thoughts of returning home, Liver Channel.The effect of with clearing heat and detoxicating, blood circulation promoting and dispersing pathogen accumulation.It is used for heat toxin and stops up Sheng patient, and rheumatism numbness Bitterly, the auxiliary treatment of injury from falling down, tumour.

Black nightshade grass：It is Solanaceae nightshade black nightshade Solanum nigrum L., with all herbal medicine.Alias Soda-apple Night-shade Herb, night My god, bitter certain herbaceous plants with big flowers, wild Fructus Capsici, black eggplant, bryony.It is bitter in taste, cold, it is slightly poisonous, the effects such as with clearing heat and detoxicating, inducing diuresis for removing edema.

Edible tulip：Pseudobulb is dried for orchid Cremastra appendiculata, pleione bulbocodioides or Pleione yunnanensis.The former practises title, and " hair is kind Mushroom ", the latter two are practised and claim " pleionebulbocodioides rolfe ", alias gold lamp, aunt Zhu, wintergreen, nonsense grass etc..Sweet, micro-pungent, it is cool in nature.With heat-clearing The effects such as removing toxic substances, carbuncle that disappears dissipating bind, it is usually used in carbuncle swells serious case of furuncle, scrofula subcutaneous nodule, snake bite and insect sting, lame lump in the abdomen lump in the abdomen.

Sculellaria barbata：Alias Herba hyperici attenuati, the thin root of large-flowered skullcap, toothbrush grass, Tian Jicao, the water root of large-flowered skullcap, narrow leaf indian skullcap herb with root, Latin literary fame Scutellaria barbata D.Don., are tubular flower mesh, Labiatae, root of large-flowered skullcap platymiscium.The dry aerial parts of Sculellaria barbata, The effects such as having clearing heat and detoxicating, promoting blood circulation, swelling and pain relieving.

Black nightshade grass and Glabrous Sarcandra Herb, and Sculellaria barbata and edible tulip, this two groups of medicines to being clinically conventional antitumor compatibility, Every group of medicine to can both be substituted for each other, also can compatibility use.Four property of medicine tastes are respectively provided with clearing heat and detoxicating, Huoxue San " based on bitter cold The effect of knot.

Fritillaria thunbergii：Fritillaria thunbergii, herbaceos perennial.Also known as Zhejiang shellfish, alias Bulbus Fritillariae Thunbergii, great Bei or Pearl shellfish.Bulb and flower hyoscine.Main product Zhejiang Province, China province Yinxian County Zhang Cun, has centuries to plant history.Bitter, cold in nature, return lung, the heart Through.With clearing heat, eliminating phlegm, relieving cough, detoxicating and resolving a mass disappear carbuncle the effect of.It is usually used in cough due to wind-heat evil, phlegm-fire cough, lung carbuncle, acute mastitis, scrofula Scrofula, sore.

Northern apricot：It is rosaceous plant ansu apricot (bitter apricot) Prunus armeniaca L.var.ansu Maxim., western Berli Sub- apricot (ansu apricot) Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshu rica (Maxim.) Koehne or apricot The dry mature seed of Prunus armeniaca L..Summer harvests ripening fruits, removes pulp and nucleocapsid, takes out seed, shines It is dry.Northern almond also known as semen armeniacae amarae, are rosaceous plant ansu apricot, and summer harvesting ripening fruits removes pulp and nucleocapsid, takes out and plant Son, dries.Rather coughed with eliminating the phlegm, ease constipation the effects such as.

Northern apricot and the medicine of fritillaria thunbergii two all return lung warps, belong to expectorants, antitussives and anti-asthmatics medicine, and both can both be substituted for each other, also can compatibility Use.In lung cancer patient, abundant expectoration and stick, some patientss are difficult to bring up, prevent qi-blood-body fluid operation, it is strongly fragrant and change heat, gradually give birth to cancer Knurl, the two medicine property of medicine are relatively gentle, and northern apricot is slightly warm, and Zhejiang shellfish slightly trembles with fear, and two medicine phases mutually restrict balance, concurrence its clearing heat and eliminating phlegm, wide Chest qi-regulating, it is relieving cough and asthma the effect of.For clinical concrete condition, such as need medicine warm in nature, then lay particular emphasis on the northern apricot of addition；Such as need medicine It is cold in nature, then lay particular emphasis on addition fritillaria thunbergii；If patient symptom may be used alone or in combination without fever and chills bias, any two medicine.

Ganoderma lucidum：Lucid Ganoderma, are the fructification of porous castor section fungi glossy ganoderma.Originate in Anhui, Jiangxi, Fujian, wide East, Guangxi, it is lightly seasoned slight bitter, warm in nature.With tonifying Qi and blood, mental-tranquilization, it is relieving cough and asthma the effect of.It is used for dizziness egersis, the heart Throb with fear shortness of breath, consumptive disease cough and asthma.

Rhizoma pinellinae praeparata：Rhizoma pinellinae praeparata is the stem tuber of the aroid tuber of pinellia (Pinellia ternata (Thunb) Breit.). Most of China area has.Main product is in the ground such as Sichuan, Hubei, Jiangsu, Anhui, taste is pungent, warm in nature, returns spleen, stomach, lung channel.Have Eliminating dampness and eliminating phlegm the effect of.It is usually used in abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache.

Dried orange peel：PERICARPIUM CITRI RETICULATAE, alias：Orange peel, expensive old, red skin, yellow orange peel, wide orange peel, PERICARPIUM CITRI RETICULATAE, orange peel, citrus chachiensis hortorum.It is rutaceae orange and its dry mature skin of variety.Warm in nature, taste is pungent, bitter.Return The spleen channel, stomach, lung channel.With regulating qi-flowing for strengthening spleen, adjust in, eliminating dampness, resolving sputum the effects such as.

Dried orange peel is passed through with rhizoma pinellinae praeparata with return lung spleen two, and from " reinforcing earth to generate metal " this theory medication, both of which is started with from taste, Treatment abundant expectoration cough and asthma for causing of lung cancer etc., both can both be substituted for each other, also can compatibility use.Patients with lung cancer because of insufficiency of the spleen weary source, no Can semen deposition in lung, then deficiency and damage of lung-QI, exopathogen is easily taken advantage of a weak point, in clinical common shortness of breath, faint low voice, pale tongue with white fur, deficient and weak pulse Etc. the deficiency of vital energy as.And lung cancer with the passing of time, child-organ disease involving its motherorgan, spleen soil must be caused more empty, transporting loses strong, the biochemical weary source of qi and blood, so that spleen and lung is all It is empty.Both all control suitable replenishing and restoring lung qi, and with the work(of multiple its transporting, clinically application effect is notable.

American Ginseng：It is the dry root of Araliaceae American Ginseng (Panax quinquefolium L).Originate in Canada Big Quebec and the U.S. Wisconsin State, also there is plantation on the ground such as BeiJing, China Huairou and Changbai Mountain, and sweet, slight bitter is cool in nature. With boosting qi and nourishing yin, the effect of clearing heat and promoting fluid.Be usually used in deficiency of vital energy yin deficiency, interior heat, cough and asthma phlegm blood, abnormal heat be tired of it is tired, quench one's thirst, the dry pharynx of mouth It is dry.

Radix Codonopsis：Codonopsis radix, the dry root of Campanulaceae Radix Codonopsis, codonopsis pilosula var. modesta or radix codonpsis tangshen.It is main to produce In Shanxi, Shaanxi, Gansu, agents area is dry root.Its is mild-natured, sweet, enters spleen, lung channel, has tonifying middle-Jiao and Qi and stomach blood-nourishing etc. Effect.

Both Radix Codonopsis and American Ginseng belong to Qi-tonifying drug, and with the effect that tonifying Qi is promoted the production of body fluid, both can both be substituted for each other, and also might be used Compatibility is used.Radix Codonopsis, American Ginseng can be used in treating spleen-lung Qi deficiency, wherein, Radix Codonopsis can be qi-blood tonifying, and American Ginseng is mainly used in Lung Qi deficiency and syndrome of deficiency of lung yin, have effect of heat-clearing concurrently.When disease is faced, according to the specific state of an illness of patient, and medicine can be needed Effect of performance is flexibly used, and can obviously improve the symptoms such as weak patient fatigue, shortness of breath, lazy speech.

Chinese herbal medicine used by the present invention can be bought from general shop of Chinese medicines, and its specification meets Chinese Pharmacopoeia standard.

Used as a kind of preferred mix proportion scheme of the present invention, the composition further includes the component of following weight portion：

Component A) radix ranunculi ternati, any one or two kinds, 15~40 parts in selfheal；

Component B) stiff silkworm, any one or two kinds, 5~15 parts in house lizard；

Component C) Glabrous Sarcandra Herb, any one or two kinds, 10~30 parts in black nightshade grass；

Component D) edible tulip, any one or two kinds, 10~30 parts in Sculellaria barbata；

Component E) fritillaria thunbergii, any one or two kinds, 10~30 parts in northern apricot；

Component F) ganoderma lucidum, 10~40 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 10~30 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 10~40 parts in Radix Codonopsis.

Used as a kind of more preferably mix proportion scheme of the invention, the weight proportion of the various components is further as follows：

Component A) radix ranunculi ternati, any one or two kinds, 15~30 parts in selfheal；

Component E) fritillaria thunbergii, any one or two kinds, 15~30 parts in northern apricot；

Component F) ganoderma lucidum, 15~30 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 10~20 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 10~30 parts in Radix Codonopsis.

Component C) Glabrous Sarcandra Herb, any one or two kinds, 15~30 parts in black nightshade grass；

Component D) edible tulip, any one or two kinds, 15~30 parts in Sculellaria barbata；

Component E) fritillaria thunbergii, any one or two kinds, 10~20 parts in northern apricot；

Component F) ganoderma lucidum, 15~30 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 10~15 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 15~30 parts in Radix Codonopsis.

Component B) stiff silkworm, any one or two kinds, 10~15 parts in house lizard；

Component E) fritillaria thunbergii, any one or two kinds, 10~15 parts in northern apricot；

Component F) ganoderma lucidum, 15~30 parts；

Component A) radix ranunculi ternati, any one or two kinds, 20~30 parts in selfheal；

Component C) Glabrous Sarcandra Herb, any one or two kinds, 15~20 parts in black nightshade grass；

Component D) edible tulip, any one or two kinds, 15~20 parts in Sculellaria barbata；

Component F) ganoderma lucidum, 15~20 parts；

Component H) American Ginseng, any one or two kinds, 15~20 parts in Radix Codonopsis.

Component A) radix ranunculi ternati, any one or two kinds, 30 parts in selfheal；

Component B) stiff silkworm, any one or two kinds, 10 parts in house lizard；

Component C) Glabrous Sarcandra Herb, any one or two kinds, 20 parts in black nightshade grass；

Component D) edible tulip, any one or two kinds, 20 parts in Sculellaria barbata；

Component E) fritillaria thunbergii, any one or two kinds, 15 parts in northern apricot；

Component F) ganoderma lucidum, 30 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 15 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 20 parts in Radix Codonopsis.

Component A) radix ranunculi ternati, any one or two kinds, 15 parts in selfheal；

Component B) stiff silkworm, any one or two kinds, 10 parts in house lizard；

Component C) Glabrous Sarcandra Herb, any one or two kinds, 30 parts in black nightshade grass；

Component D) edible tulip, any one or two kinds, 10 parts in Sculellaria barbata；

Component E) fritillaria thunbergii, any one or two kinds, 10 parts in northern apricot；

Component F) ganoderma lucidum, 40 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 20 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 30 parts in Radix Codonopsis.

Component A) radix ranunculi ternati, any one or two kinds, 20 parts in selfheal；

Component B) stiff silkworm, any one or two kinds, 5 parts in house lizard；

Component C) Glabrous Sarcandra Herb, any one or two kinds, 10 parts in black nightshade grass；

Component D) edible tulip, any one or two kinds, 30 parts in Sculellaria barbata；

Component F) ganoderma lucidum, 15 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 30 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 40 parts in Radix Codonopsis.

Component B) stiff silkworm, any one or two kinds, 10 parts in house lizard；

Component C) Glabrous Sarcandra Herb, any one or two kinds, 15 parts in black nightshade grass；

Component E) fritillaria thunbergii, any one or two kinds, 20 parts in northern apricot；

Component F) ganoderma lucidum, 20 parts；

Component A) radix ranunculi ternati, any one or two kinds, 40 parts in selfheal；

Component B) stiff silkworm, any one or two kinds, 15 parts in house lizard；

Component D) edible tulip, any one or two kinds, 15 parts in Sculellaria barbata；

Component E) fritillaria thunbergii, any one or two kinds, 30 parts in northern apricot；

Component F) ganoderma lucidum, 30 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 10 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 15 parts in Radix Codonopsis.

Component B) stiff silkworm, any one or two kinds, 5 parts in house lizard；

Component E) fritillaria thunbergii, any one or two kinds, 25 parts in northern apricot；

Component F) ganoderma lucidum, 10 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds, 25 parts in dried orange peel；

Component H) American Ginseng, any one or two kinds, 10 parts in Radix Codonopsis.

As of the invention a kind of more preferably prescription and mix proportion scheme, a kind of composition for treating lung cancer, including containing controlling Treat the following components of effective dose：

Component A) radix ranunculi ternati；

Component B) stiff silkworm；

Component C) Glabrous Sarcandra Herb；

Component D) edible tulip；

Component E) fritillaria thunbergii；

Component F) ganoderma lucidum；

Component G) rhizoma pinellinae praeparata；

Component H) American Ginseng；

The composition is provided with the component proportion less than toxic dose.

Used as a kind of more preferably prescription and mix proportion scheme of the invention, the various components of the prescription, and its weight proportion enters One step is as follows：

Component A) radix ranunculi ternati, 15~40 parts；

Component B) stiff silkworm, 5~15 parts；

Component C) Glabrous Sarcandra Herb, 10~30 parts；

Component D) edible tulip, 10~30 parts；

Component E) fritillaria thunbergii, 10~30 parts；

Component F) ganoderma lucidum, 10~40 parts；

Component G) rhizoma pinellinae praeparata, 10~30 parts；

Component H) American Ginseng, 10~40 parts.

Component A) radix ranunculi ternati, 15~30 parts；

Component B) stiff silkworm, 5~15 parts；

Component C) Glabrous Sarcandra Herb, 10~30 parts；

Component D) edible tulip, 10~30 parts；

Component E) fritillaria thunbergii, 15~30 parts；

Component F) ganoderma lucidum, 15~30 parts；

Component G) rhizoma pinellinae praeparata, 10~20 parts；

Component H) American Ginseng, 10~30 parts.

Component A) radix ranunculi ternati, 15~30 parts；

Component B) stiff silkworm, 5~15 parts；

Component C) Glabrous Sarcandra Herb, 15~30 parts；

Component D) edible tulip, 15~30 parts；

Component E) fritillaria thunbergii, 10~20 parts；

Component F) ganoderma lucidum, 15~30 parts；

Component G) rhizoma pinellinae praeparata, 10~15 parts；

Component H) American Ginseng, 15~30 parts.

Component A) radix ranunculi ternati, 15~30 parts；

Component B) stiff silkworm, 10~15 parts；

Component C) Glabrous Sarcandra Herb, 15~30 parts；

Component D) edible tulip, 15~30 parts；

Component E) fritillaria thunbergii, 10~15 parts；

Component F) ganoderma lucidum, 15~30 parts；

Component G) rhizoma pinellinae praeparata, 10~15 parts；

Component H) American Ginseng, 15~30 parts.

Component A) radix ranunculi ternati, 20~30 parts；

Component B) stiff silkworm, 10~15 parts；

Component C) Glabrous Sarcandra Herb, 15~20 parts；

Component D) edible tulip, 15~20 parts；

Component E) fritillaria thunbergii, 10~15 parts；

Component F) ganoderma lucidum, 15~20 parts；

Component G) rhizoma pinellinae praeparata, 10~15 parts；

Component H) American Ginseng, 15~20 parts.

Component A) radix ranunculi ternati, 30 parts；

Component B) stiff silkworm, 10 parts；

Component C) Glabrous Sarcandra Herb, 20 parts；

Component D) edible tulip, 20 parts；

Component E) fritillaria thunbergii, 15 parts；

Component F) ganoderma lucidum, 30 parts；

Component G) rhizoma pinellinae praeparata, 15 parts；

Component H) American Ginseng, 20 parts.

Component A) radix ranunculi ternati, 15 parts；

Component B) stiff silkworm, 10 parts；

Component C) Glabrous Sarcandra Herb, 30 parts；

Component D) edible tulip, 10 parts；

Component E) fritillaria thunbergii, 10 parts；

Component F) ganoderma lucidum, 40 parts；

Component G) rhizoma pinellinae praeparata, 20 parts；

Component H) American Ginseng, 30 parts.

Component A) radix ranunculi ternati, 20 parts；

Component B) stiff silkworm, 5 parts；

Component C) Glabrous Sarcandra Herb, 10 parts；

Component D) edible tulip, 30 parts；

Component E) fritillaria thunbergii, 15 parts；

Component F) ganoderma lucidum, 15 parts；

Component G) rhizoma pinellinae praeparata, 30 parts；

Component H) American Ginseng, 40 parts.

Component A) radix ranunculi ternati, 30 parts；

Component B) stiff silkworm, 10 parts；

Component C) Glabrous Sarcandra Herb, 15 parts；

Component D) edible tulip, 30 parts；

Component E) fritillaria thunbergii, 20 parts；

Component F) ganoderma lucidum, 20 parts；

Component G) rhizoma pinellinae praeparata, 20 parts；

Component H) American Ginseng, 20 parts.

Component A) radix ranunculi ternati, 40 parts；

Component B) stiff silkworm, 15 parts；

Component C) Glabrous Sarcandra Herb, 10 parts；

Component D) edible tulip, 15 parts；

Component E) fritillaria thunbergii, 30 parts；

Component F) ganoderma lucidum, 30 parts；

Component G) rhizoma pinellinae praeparata, any one or two kinds 10 parts in dried orange peel；

Component H) American Ginseng, 15 parts.

Component A) radix ranunculi ternati, 40 parts；

Component B) stiff silkworm, 5 parts；

Component C) Glabrous Sarcandra Herb, 30 parts；

Component D) edible tulip, 20 parts；

Component E) fritillaria thunbergii, 25 parts；

Component F) ganoderma lucidum, 10 parts；

Component G) rhizoma pinellinae praeparata, 25 parts；

Component H) American Ginseng, 10 parts.

Composition of the invention can be arbitrarily appropriate formulation oral administration, the formulation includes, dynamic is planted for example, whole Thing, decoction, pulvis, pill, capsule, granula, tablet, supensoid agent or syrup etc..Composition can use hot water or ethanol Extracted, composition can be prepared into the formulation of any effective form by the active ingredient after extraction, including, but do not limit In decoction, tablet, pill, pulvis, capsule, supensoid agent, syrup or other conventional formulations.It is extraction or concentrate composition In active ingredient, generally contact animal-plant material with appropriate solvent such as water, ethanol or other solvents or mixed solvent.It is molten The selection of agent can be completed routinely, for example, molten to select based on the characteristic for needing the active component by solvent extraction or concentration Agent.In certain embodiments, can be extracted by following method：By composition grind into powder.By powder in mesh Solvent in soak a period of time with from said composition effectively extract activating agent.Solution is filtered and is concentrated to produce containing high The paste of the solvent extraction composition of concentration.In some cases, paste drying can be produced the powder extracts of composition.Carry The content for taking active component in thing can utilize HPLC (High-Performance Liquid Chromatography, efficient liquid Phase chromatography), UV (Ultraviolet, the abbreviation of ultraviolet spectrometry) and other spectrometric methods determine.

Composition of the invention can be applied with arbitrary form by any effective approach, route of administration include for example, through Mouthful, parenteral, intestines, intraperitoneal, local, percutaneous (such as using any standard patch), eye, nose, it is local , parenteral, such as aerosol, subcutaneous, intramuscular, oral cavity, rectum, intra-arterial routes etc..It can be independent Or be included in medicinal forms and apply with any activity or non-active ingredient.

Composition of the invention can be used in combination with chemotherapeutant and targeted drug, and the chemotherapeutant includes alkanisation Agent, antimetabolite antagonist, antitumor antibiotic, anticancer of plant origin etc..

Composition of the invention includes the native compound for showing and suppressing cytological effect, for suppressing pre-existing cancer cells Further growth, the compound shows following one or more characteristic：(i) strengthen immunologic function, (ii) it is antitumor or (iii) lung cancer tumor Apoptosis is induced, especially for two kinds of lung cancer tumor cells of A549 and Lewis.

Composition of the invention can be co-administered with chemotherapeutant, radiotherapy and operation.In some embodiments In, before and after radiotherapy, chemotherapy or surgical operation, composition of the invention is applied to subject.In other embodiment party In case, composition is administered simultaneously with other anti-cancer therapies.These compositions are except showing foregoing characteristic：I () increases Outside strong immunologic function and (ii) are antitumor, one or more characteristic is also showed：A () (increases with chemotherapeutic synergy The strong sensitiveness to chemotherapeutant), the synergy of (b) and radiotherapy and surgical operation is (by suppressing to be radiated or outward The growth of the cancer cell of the previous presence that section's operation is omitted strengthens validity).Anti- mutagenic character (and the increasing caused by collaboration Strong sensitiveness) level for treating necessary chemotherapeutant is reduced, so as to cause the mitigation to patient toxicities.The present invention Composition can be used to include the anti-of alkylating agent, antimetabolite antagonist, antitumor antibiotic and plant origin with chemotherapeutant Cancer agent is combined.

The example of " alkylating agent " includes mustargen, mustron, Chlorambucil, endoxan, ifosfamide, triamine Sulphur phosphorus, carboquone, Bis amine, busulfan, Nimustine Hydrochloride, dibromannitol, melphalan, dacarbazine, Reynolds nitrogen Mustard, estramustine phosphate sodium, tretamine, carmustine, lomustine, streptozotocin, pipobroman, ethoglucid, card ripple Platinum, cis-platinum, Miboplatin (miboplatin), Nedaplatin, oxaliplatin, hexamethyl melamine, Ambamustine, dibrospidium (dibromos Spiral shell oronain) hydrochloride, Fotemustine, prednimustine, fast rice tongue pool, ribomustin (bendamustine), Temozolomide, Treosulphan (NSC-39069, also known as Treosulfan), trofosfamide, Zinostatin Stimalamer, carboquone, A Duolai Newly, cystemustine (cystemustine) and Bizelesin (bizelesin).

The example of " antimetabolite " include purinethol, Ismipur riboside, NSC-40774, methotrexate, according to promise His guest, cytarabine, Cytarbine Ocfostate, Ancitabine, 5-FU medicines is (for example, fluorouracil, tegafur, UFT (excellent good fortune It is fixed), FUDR, Carmofur, gallocitabine (card coughs up its guest), emmitefur (E meter Te Fu)), aminopterin-induced syndrome, Calcium leucovorin, thioguanine, butocin, Calciumlevofolinate, Calcium Levofolinate, Cladribine, Emitefur (emitefur), fludarabine, gemcitabine, hydroxycarbamide, Pentostatin, piritrexim, iodoxuridine, Methyl GAG, Thiazophrine (this Zhong Fei) and Ambamustine etc..

The example of " antitumor antibiotic " includes actinomycin D, Actinomycin-C, Mitomycin-C, chromomycin-A3, hydrochloric acid Bleomycin, Bleomycin Sulphate, Peplomycin Sulfate, daunorubicin hydrochloride, ADMh, aclarubicin hydrochloride, salt Sour Perarubicin, Farmorubine Hydrochloride, neoearcinostain, mithramycin, sarcomycin, cardinophyllin, mitotane, hydrochloric acid assistant It is soft than star, mitoxantrone hydrochloride and Idarubicin Hydrochloride etc..

The example of " anticancer of plant origin " includes etoposide phosphate, vinblastine sulfate, vincristine sulphate, sulfuric acid Eldisine, Teniposide, taxol, docetaxel and vinorelbine etc..

The example of " targeted drug " includes：Imatinib, Gefitinib, gram azoles for Buddhist nun, Sorafenib, Tarceva, relax Buddhist nun is for Buddhist nun, Rituximab, Cetuximab and Herceptin etc..

These chemotherapeutants and targeted drug both can be used alone or can be combined and used.Meanwhile, it is effective except treatment is applied The combination beyond the region of objective existence of amount, it is effective also comprising treatment is applied using the method that cytotoxic composition carries out anticancer therapy according to the present invention One or more standard anti-cancer of amount is treated (for example, one or more radiotherapy, chemotherapy, surgical operation, immunotherapy And PDT).Herein in alternative preferred embodiment, except the combination beyond the region of objective existence for applying therapeutically effective amount, methods described is also Comprising one or more standard chemotherapeutic drugs thing for applying therapeutically effective amount.One or more standard chemical of therapeutically effective amount The combination of the cytotoxic composition of medicine and therapeutically effective amount can cause tumor suppression (including degeneration of existing tumour) In cooperative effect.

Composition of the invention can also be used in combination with immunotherapeutic agent, and the immunotherapeutic agent includes Streptococcus hemolyticus Su, Kerstin, Sizofiran, lentinan, ubenimex, interferon, interleukins, macrophage colony stimulate because Son, granulocyte colony stimulating factor, erythropoietin(EPO), lymphocytotoxin, BCG vaccine, CBP (Corynebacteriumparvum), levamisol, polysaccharide K and procodazole.

Although each component shows health benefits when being administered alone in known composition of the invention, the present invention is related to And the Combination nova of various ingredients, when as particular combination using when the composition show the new features of composition.Can be by group Compound is combined with any pharmaceutically acceptable carrier.Phrase " pharmaceutically acceptable carrier " represents that any medicine is carried Body, such as Remington ' s Pharmaceutical Science, the 18th edition, Mack Publishing company (1990 Year) described in standard vector.The example of suitable carrier is well known in the art, it may include but it is not limited to any mark Quasi- pharmaceutical carrier, such as PBS, the PBS containing Polysorb 80 (polysorbate80), Water, emulsion such as oil/water emulsion and polytype wetting agent.Other carriers may also include sterile solution, coating and capsule etc.. Usual examples of such carriers contains excipient, such as starch, milk, sugar, certain form of clay, gelatin, stearic acid or its salt, stearic acid Magnesium or calcium, talcum, plant fat or oil, natural gum, dihydroxylic alcohols.Prepared comprising examples of such carriers by well-known conventional method Composition.The excipient generally prepared together with composition is suitable for oral administration and does not produce with itself or other active components Harmful reaction.

Suitable pharmaceutically acceptable carrier include but is not limited to water, salting liquid, alcohol, gum arabic, vegetable oil, Phenmethylol, gelatin, sugar, such as lactose, amylose or starch, magnesium stearate, talcum, silicic acid, viscous paraffin, aromatic oil, fat Fat monoglyceride and diglyceride, pentaerythritol fatty ester, hydroxy-methyl cellulose etc..Other additives include, example Such as：Antioxidant and preservative, colouring agent, flavor enhancement and diluent, emulsifying agent and suspending agent, gum arabic, agar, algae Acid, mosanom, bentonite, Carbomer, carrageenan, carboxymethylcellulose calcium, cellulose, cholesterol, gelatin, hydroxy ethyl fiber Element, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methylcellulose, octoxynol 9 (octoxynol 9), oleyl alcohol, poly- dimension Ketone, propylene glycolmonostearate, lauryl sodium sulfate, sorbitan ester, stearyl alcohol, bassora gum, xanthans, and its it is derivative Thing, solvent and Miscellaneous ingredients, such as microcrystalline cellulose, citric acid, dextrin, glucose, liquid glucose, lactic acid, lactose, chlorination Magnesium, potassium metaphosphate, starch etc..

Composition can be prepared with other active components, and the active component is, for example：Antioxidant, vitamin are (A, C, anti- Bad hematic acid, B races, such as B1, thiamine, B6, pyridoxol, B compounds, biotin, choline, nicotinic acid, pantothenic acid, B12, vitamin B12, and/or B2, D, D2, D3, ergocalciferol, E, such as tocopherol, riboflavin, K, K1, K2).Preferred compound, bag Include, such as a creatine monohydrate, acetonate, VBT, alpha-lipoic acid, phytin or phytic acid, Co-Q10, NADH (reduced forms Coenzyme), NAD (diphosphopyridine nucleotide, a kind of basic redox coenzyme), D-ribose, amino acid such as L- glutamy Amine, lysine, Chrysin, prohormone, such as 4-AD, 5- androstenedione, 4 (or 5-) androstenediols, 19- go first -4 (or 5-)-androstenedione, 19- remove first -4 (or 5-)-androstenediol, β-ecdysterone, 5- Methyl-7-methoxy-isoflavones.It is excellent The active component of choosing includes, for example, pollen pini, the fruit of Chinese wolfberry (Fructus Lycii), sea-buckthorn, Radix Angelicae Sinensis (ligusticum), thorn five Plus (Acanthopanax), astragalus (astragalus), Chinese ephedra (ephedra), Radix Codonopsis (Codonopsis), polygala (polygola tenuifolia Willd), lily (Lilium), rhizoma scirpi (Sparganium), ginseng, panax Notogiseng, gamboge (Garcinia), Guggle, grape seed extract or powder, and/or ginkgo (Ginkgo is not in the mood for it Biloba).Other the animals and plants medicinal materials that can be prepared with composition of the invention include various textbooks and publication, such as ES Ayensu, Medicinal Plants of West Africa, ReferencePublications, Algonac, Mich. (1978)；L.Boulos, Medicinal Plants of NorthAfrica, Reference Publications Inc., Algonac, Mich. (1983)；And N.C.Shah, Botanical Folk Medicines in Northern India, J.Ethnopharm, 6：Those mentioned in 294-295 (1982).

Other active components include, for example：Antioxidant, anticancer, antiinflammatory, hormone, hormone antagonist, antibiotic (for example, amoxycillin) and other bacteria preparations, and other pharmaceutically useful medicines, for example those are for example Remington ' s Pharmaceutical Sciences, the 18th edition, in Mack Publishing Company (nineteen ninety) The medicine identified.

Present invention also offers a kind of application that above-mentioned composition is used to prepare treatment lung-cancer medicament.

Preferably, application of the hot water extract of the composition in treatment lung-cancer medicament is prepared.

Preferably, application of the ethanol extract of the composition in treatment lung-cancer medicament is prepared.

Preferably, prepared by least one chemotherapeutant or targeted drug of the composition therapeutic alliance effective dose Application in treatment lung-cancer medicament.

Preferably, at least one chemotherapeutant or targeted drug are selected from platinum medicine (cis-platinum, carboplatin, Ao Shali Platinum etc.), vinorelbine, taxol, gemcitabine, pemetrexed, Gefitinib, Tarceva, gram azoles is for any one in Buddhist nun Kind.

Preferably, the composition realizes the treatment of lung cancer by following at least one characteristic, and it is selected from：Alleviate lung cancer disease Shape, delay tumour progression, antagonism tumor drug resistance, improve immunologic function, improve life quality, extension patient survival, to chemotherapy The effect of Synergy and attenuation.

By implementing composition for treating lung cancer that the invention described above provides and for preparing treatment lung-cancer medicament The technical scheme of application, has the advantages that：

The present invention is directed to the treatment of lung cancer for treating the composition of lung cancer and the application for preparing treatment lung-cancer medicament Certain effect is respectively provided with, drug effect can be farthest played together by various bulk drugs are mutually coordinated, patient can be improved weary Power, cough and asthma, the symptom such as cough up phlegm, are effectively improved after postoperative chemicotherapy cause tired weak, prevent cancer return and/or transfer, Life quality, the life cycle of extension patient for be obviously improved lung cancer related symptoms, improving patient, additionally with delaying tumour to enter Exhibition, antagonism tumor drug resistance, have no toxic side effect, the advantages of medical expense is relatively low.

Brief description of the drawings

In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing The accompanying drawing to be used needed for having technology description is briefly described.It should be evident that drawings in the following description are only this Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, can be with Other embodiments are obtained according to these accompanying drawings.

Fig. 1 is the signal that control group (blank serum group) influences on A549 Apoptosis of Lung Adenocarcinoma Cell in Basic pharmacology experiment Figure；

Fig. 2 is the present composition of the low dosage in Basic pharmacology experiment on showing that A549 Apoptosis of Lung Adenocarcinoma Cell influences It is intended to；

Fig. 3 is the present composition of the high dose in Basic pharmacology experiment on showing that A549 Apoptosis of Lung Adenocarcinoma Cell influences It is intended to；

Fig. 4 is the fluidic cell that control group (blank serum group) influences on apoptosis of tumor cells in Basic pharmacology experiment Figure；

Fig. 5 is the fluidic cell that is influenceed on apoptosis of tumor cells of the present composition of the low dosage in Basic pharmacology experiment Figure；

Fig. 6 is the fluidic cell that is influenceed on apoptosis of tumor cells of the present composition of the high dose in Basic pharmacology experiment Figure；

Fig. 7 is the survivorship curve contrast schematic diagram in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Fig. 8 is the disease developing time contrast schematic diagram in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Fig. 9 is the health integration change schematic diagram in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Figure 10 is the society/family status integration change schematic diagram in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Figure 11 is the emotional status integration change schematic diagram in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Figure 12 is the function status integration change schematic diagram in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Figure 13 is the additional concern situation integration change schematic diagram in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Figure 14 is the efficient change schematic diagram of PS scorings in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Figure 15 is the body weight change schematic diagram before and after the treatment of clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group；

Figure 16 is III, IV degree haematics toxicity incidence contrast in clinical test traditional Chinese and western medicine group, traditional Chinese medical science group and doctor trained in Western medicine group Schematic diagram.

Specific embodiment

To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention In accompanying drawing, clear, complete description is carried out to the technical scheme in the embodiment of the present invention.Obviously, described embodiment is only Only it is a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the present invention claimed Scope.

As shown in accompanying drawing 1 to accompanying drawing 16, the composition for treating lung cancer of the invention is given and for preparing treatment lung The specific embodiment of the application of cancer drug, the invention will be further described with specific embodiment below in conjunction with the accompanying drawings.

Embodiment 1：A kind of preparation () for treating the composition of lung cancer

Radix ranunculi ternati, stiff silkworm, Glabrous Sarcandra Herb, edible tulip, fritillaria thunbergii, ganoderma lucidum, rhizoma pinellinae praeparata, American Ginseng are with the weight containing therapeutically effective amount Amount part is provided, and conventional method is decocted, and composition is provided with the component proportion less than toxic dose.

" therapeutically effective amount " used refers to the raw medicinal herbs amount of the antitumor properties for providing composition in the present invention.

Embodiment 2：A kind of preparation (two) for treating the composition of lung cancer

15~40g of radix ranunculi ternati, 5~15g of stiff silkworm, 10~30g of Glabrous Sarcandra Herb, 10~30g of edible tulip, 10~30g of fritillaria thunbergii, spirit 10~40g of sesame, 0~30g of rhizoma pinellinae praeparata, 10~40g of American Ginseng, conventional method are decocted.

Embodiment 3：A kind of preparation (three) for treating the composition of lung cancer

15~30g of radix ranunculi ternati, 5~15g of stiff silkworm, 10~30g of Glabrous Sarcandra Herb, 10~30g of edible tulip, 15~30g of fritillaria thunbergii, spirit 15~30g of sesame, 10~20g of rhizoma pinellinae praeparata, 10~30g of American Ginseng, conventional method are decocted.

Embodiment 4：A kind of preparation (four) for treating the composition of lung cancer

15~30g of radix ranunculi ternati, 5~15g of stiff silkworm, 15~30g of Glabrous Sarcandra Herb, 15~30g of edible tulip, 10~20g of fritillaria thunbergii, spirit 15~30g of sesame, 10~15g of rhizoma pinellinae praeparata, 15~30g of American Ginseng, conventional method are decocted.

Embodiment 5：A kind of preparation (five) for treating the composition of lung cancer

15~30g of radix ranunculi ternati, 10~15g of stiff silkworm, 15~30g of Glabrous Sarcandra Herb, 15~30g of edible tulip, 10~15g of fritillaria thunbergii, 15~30g of ganoderma lucidum, 10~15g of rhizoma pinellinae praeparata, 15~30g of American Ginseng, conventional method are decocted.

Embodiment 6：A kind of preparation (six) for treating the composition of lung cancer

20~30g of radix ranunculi ternati, 10~15g of stiff silkworm, 15~20g of Glabrous Sarcandra Herb, 15~20g of edible tulip, 10~15g of fritillaria thunbergii, 15~20g of ganoderma lucidum, 10~15g of rhizoma pinellinae praeparata, 15~20g of American Ginseng, conventional method are decocted.

Embodiment 7：A kind of preparation (seven) for treating the composition of lung cancer

Radix ranunculi ternati 30g, stiff silkworm 10g, Glabrous Sarcandra Herb 20g, edible tulip 20g, fritillaria thunbergii 15g, ganoderma lucidum 30g, rhizoma pinellinae praeparata 15g, west American ginseng 20g, conventional method is decocted.

Embodiment 8：A kind of preparation (eight) for treating the composition of lung cancer

Radix ranunculi ternati 15g, stiff silkworm 10g, Glabrous Sarcandra Herb 30g, edible tulip 10g, fritillaria thunbergii 10g, ganoderma lucidum 40g, rhizoma pinellinae praeparata 20g, west American ginseng 30g, conventional method is decocted.

Embodiment 9：A kind of preparation (nine) for treating the composition of lung cancer

Radix ranunculi ternati 20g, stiff silkworm 5g, Glabrous Sarcandra Herb 10g, edible tulip 30g, fritillaria thunbergii 15g, ganoderma lucidum 15g, rhizoma pinellinae praeparata 30g, the West Ginseng 40g, conventional method is decocted.

Embodiment 10：A kind of preparation (ten) for treating the composition of lung cancer

Radix ranunculi ternati 30g, stiff silkworm 10g, Glabrous Sarcandra Herb 15g, edible tulip 30g, fritillaria thunbergii 20g, ganoderma lucidum 20g, rhizoma pinellinae praeparata 20g, west American ginseng 20g, conventional method is decocted.

Embodiment 11：A kind of preparation (11) for treating the composition of lung cancer

Radix ranunculi ternati 40g, stiff silkworm 15g, Glabrous Sarcandra Herb 10g, edible tulip 15g, fritillaria thunbergii 30g, ganoderma lucidum 30g, rhizoma pinellinae praeparata 10g, west American ginseng 15g, conventional method is decocted.

Embodiment 12：A kind of preparation (12) for treating the composition of lung cancer

Radix ranunculi ternati 40g, stiff silkworm 5g, Glabrous Sarcandra Herb 30g, edible tulip 20g, fritillaria thunbergii 25g, ganoderma lucidum 10g, rhizoma pinellinae praeparata 25g, the West Ginseng 10g, conventional method is decocted.

In above traditional Chinese medicinal components, radix ranunculi ternati can be substituted using selfheal, and stiff silkworm can be substituted using house lizard, and Glabrous Sarcandra Herb can Substituted with using black nightshade grass, edible tulip can be substituted using Sculellaria barbata, fritillaria thunbergii can be substituted using northern apricot, and rhizoma pinellinae praeparata can be adopted Substituted with dried orange peel, American Ginseng can be substituted using Radix Codonopsis.Meanwhile, every kind of component can also be a kind of medicine and its alternative medicine Consumption sum is total dose of component.Such as：Can be 15~30g of radix ranunculi ternati for a kind of 15~30g of component radix ranunculi ternati, Can also be 15~30g of selfheal, can also be the mixture of radix ranunculi ternati and selfheal totally 15~30g.And for example：For another kind For component American Ginseng 20g, or Radix Codonopsis 20g, the common 20g of the mixture of American Ginseng and Radix Codonopsis, other components are can also be The rest may be inferred.

It should be noted that it is the conventional preparation method of traditional Chinese herbal decoction that the conventional method described in embodiment 1-12 is decocted, i.e., Described bulk drug is added water to cook into decoction.A kind of typical conventional decocting method is：With (generally 20 DEG C~60 DEG C of cold water Between) composition that will be made up of said components raw medicinal herbs soaks 25 minutes (can be 20~30 minutes), water is higher by powder 4 Centimetre (general water is advisable with being higher by 3~5 centimetres of powder).The principle of " first force is hereinafter " is followed during decoction, that is, is useed force before boiling Fiery (very hot oven), is changed to slow fire (slow fire) after boiling.Decocted at twice.For the first time decoct after boiling again decoct 20 minutes (with It is advisable within 20~25 minutes).Decoct for second after the filter to the greatest extent of first time liquid, then add cold water to be decocted the dregs of a decoction.Decoct for second Boil and decoct 15 minutes (being advisable with 15~20 minutes) again after boiling.After the completion of decocting every time, the dregs of a decoction are drained, liquid is tried one's best filter Only.Finally, will be taken at twice after merging mixing decocting liquid twice.Decocting liquid amount is 500~600ml, divides 2~3 times and takes.

Additionally, the composition of above-mentioned each embodiment is prepared in addition to using the hot water extracting mode for decocting, as this Another preferred specific embodiment of invention, can also use ethanol extracting mode.

Embodiment 13：Preparation for treating the composition tablet/capsule of lung cancer

Take radix ranunculi ternati 30g, stiff silkworm 10g, Glabrous Sarcandra Herb 15g, edible tulip 15g, fritillaria thunbergii 15g, ganoderma lucidum 30g, rhizoma pinellinae praeparata 15g, American Ginseng 15g, plus 8~10 times of amount water, decocts 3 hours, leaches concoction.Again plus 10 times amount water, decoct 2.5 hours, leach concoction, Merge secondary decocting liquid, stand, leaching supernatant, concentration is let cool, and alcohol is measured again with concentrate, stirs precipitates overnight.Take supernatant Liquid, is concentrated into thick medicinal extract；Plus appropriate pharmaceutical aids, granulation, dry, whole grain, 20g particles are obtained, dispense 10g/ bags.

Any described composition of Example 1~12, plus 9 times of water of amount (can be 8~11 times of amounts), decoct 3 hours (can be 2~3.5 hours), leaches concoction.Again plus 10 times of water of amount (can be 8~11 times amount), decocting 2.5 hours (can be with It is 2~3.5 hours), concoction is leached, merge secondary decocting liquid, standing, leaching supernatant are concentrated, let cool, with 3 times of amount wine of concentrate Essence, stirs precipitates overnight.Supernatant is taken, thick medicinal extract is concentrated into.Add appropriate pharmaceutical aids, vacuum drying, crushing granulation, compacting Piece agent is filled encapsulated.

Embodiment 14：Preparation for treating the composition granule of lung cancer

Any described composition of Example 1~12, plus 9 times of water of amount (can be 8~10 times of amounts), decoct 3 hours (can be 2~3.5 hours), leaches concoction.Again plus 10 times of water of amount (can be 8~11 times amount), decocting 2.5 hours (can be with It is 2~3.5 hours), concoction is leached, merge secondary decocting liquid, standing, leaching supernatant are concentrated, let cool, and wine is measured again with concentrate Essence, stirs precipitates overnight.Supernatant is taken, thick medicinal extract is concentrated into.Plus appropriate pharmaceutical aids, granulation, dry, whole grain, obtain 20g Grain, dispenses 10g/ bags.

Embodiment 15：Preparation for treating the composition mixture/oral liquid/syrup of lung cancer

Any described composition of Example 1~12, plus 9 times of water of amount (can be 8~10 times of amounts), decoct 3 hours (can be 2~3.5 hours), leaches concoction.Again plus 10 times of water of amount (can be 8~11 times amount), decocting 2.5 hours (can be with It is 2~3.5 hours), concoction is leached, merge secondary decocting liquid, standing, leaching supernatant are concentrated, let cool, and wine is measured again with concentrate Essence, stirs precipitates overnight.Supernatant is taken, thick medicinal extract is concentrated into.Plus appropriate pharmaceutical aids, it is made mixture, oral liquid or syrup.

Embodiment 16：Composition for treating lung cancer combines the specific of chemotherapeutant or targeted drug scheme composition Square medicine is as follows：

Radix ranunculi ternati 30g, stiff silkworm 10g, Glabrous Sarcandra Herb 20g, edible tulip 20g, fritillaria thunbergii 15g, ganoderma lucidum 30g, rhizoma pinellinae praeparata 15g, west American ginseng 20g, above traditional Chinese medicinal components conventionally decoct into decoction, and daily 1 dose, 21 days as one therapeutic course takes 6 courses for the treatment of altogether.

Chemotherapeutant scheme uses platiniferous (NP, GP, TP, DP) scheme, and every 21 days repeatedly, totally 4 cycles.As this hair Bright preferred specific embodiment, chemotherapeutant or targeted drug are also selected from vinorelbine, taxol, gemcitabine, training Beautiful Qu Sai, Gefitinib, Tarceva, gram azoles are for any one or more in Buddhist nun.

NP schemes

NVB 25mg/m2 ivdrip d1, d8

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

GP schemes

GEM 1000mg/m2 ivdrip d1, d8

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

TP schemes

Taxol 135mg/m2 ivdrip d1 (routinely reducing anaphylactoid generation using dexamethasone before chemotherapy)

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

DP schemes

Taxotere 75mg/m2 ivdrip d1 (routinely reduce anaphylactoid hair before chemotherapy using dexamethasone It is raw)

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

For a better understanding of the present invention, below with the infrastest and clinical test results of the specific embodiment of the invention come Illustrate its effect.

Embodiment 17：Basic pharmacology is tested

The specific embodiment of the invention, as raw material, is specified, using each from natural plant in accordance with the compound pharmaceutical control law of country The comprehensive function treatment lung cancer of taste Chinese medicine.

A large amount of (specific) clinical researches of specific embodiment of the invention premenstruum (premenstrua), having proven to it has improvement lung cancer correlation disease Shape, delay tumour progression, antagonism tumor drug resistance, control tumor recurrence and/or transfer, to chemotherapeutic sensitivity attenuation, improve immune work( Can etc. effect, it is possible to increase Patients with Advanced Lung Cancer life quality, extension patient survival, be patients with lung cancer bring existence benefit and Definitely, objective curative effect, and with operative treatment, radiation and chemotherapy coordinates has synergy, now further to its drug effect and The mechanism of action is described in detail.

It is prepared by culture medium：

1. the Chinese medicine of each component is purchased from general pharmacy in composition, meets Chinese Pharmacopoeia standard, and be prepared as pulvis Standby, composition includes the following components containing therapeutically effective amount, wherein, " therapeutically effective amount " refers to that provided composition can Play the amount of effective antitumor characteristic.For example：A kind of typical composition prescription and weight proportion are：

Radix ranunculi ternati 30g, stiff silkworm 10g, Glabrous Sarcandra Herb 20g, edible tulip 20g, fritillaria thunbergii 15g, ganoderma lucidum 30g, rhizoma pinellinae praeparata 15g, west American ginseng 20g will above-mentioned weight each component mix after be ground into fine powder and cross required pulvis is obtained final product after 1500 mesh sieves.

2. the above-mentioned pulvis of 10g will be taken at room temperature to be dissolved in the DMEM culture mediums of 500ml, 4 DEG C of refrigerator overnights, then carry out vacuum Filtering.It is standby that the final nutrient solution for being diluted to 20mg/ml is stored in 80 DEG C of refrigerator freezings.

A549 lung carcinoma cells are tested：

(1) MTT colorimetric tests detect influence of this Chinese medicine compound prescription to tumor cell activity

Single cell suspension is diluted with complete culture solution, about 3000/hole cell is taken and is seeded to 96 well culture plates.Culture 24h Afterwards, when cell is in exponential phase, original fluid is abandoned, is separately added into blank control group (30% NBCS, volume integral Number, similarly hereinafter), blank serum group (30% blank serum), 5% Contained Serum group, 15% Contained Serum group, 25% Contained Serum Group, 30% Contained Serum tissue culture nutrient solution.Nutrient solution collocation method is volume fraction 70%RPMI-1640 serum-free mediums+x% Contained Serum+(30-x) % blank serums, wherein x% refers to Contained Serum concentration.Each group sets 4 multiple holes respectively, in putting incubator After continuing culture 24,48,72h；The μ L of 5mg/mL MTT solution 20 are added per hole, supernatant is abandoned after 37 DEG C of incubation 4h, add 100 μ L/ Hole dimethyl sulfoxide (DMSO) (DMSO), lucifuge room temperature shaker vibration 20min.Each hole absorbance is determined in ELIASA 490nm unicasts strong point (D) value, and record result.Experiment 3 times is repeated, is averaged.P_{Cell viability}/ %=D_{Administration group}/D_{Blank control group}× 100%.

A549 cells are processed using the pastille culture medium of various concentrations, respectively after observation treatment 24h, 48h, 72h to swollen The influence of oncocyte activity.

Discovery rat blank serum is on A549 cell viabilities substantially without influence in the detection, and each Contained Serum group is thin to A549 Born of the same parents have growth inhibition effect, wherein 25%, 30% Contained Serum is notable to cyto-inhibition (P ＜ 0.01), and with the time Extension, inhibitory action is more obvious；5%th, after 15% Contained Serum treatment A549 cells 48,72h, A549 cells can also be significantly inhibited Growth (P ＜ 0.05 or P ＜ 0.01).In the detection it was additionally observed that after 10%, 20% Contained Serum group treatment A549 cells 48h, Apoptosis can be remarkably promoted, (P ＜ 0.05 or P ＜ 0.01) statistically significant with blank serum group comparing difference, knot It is really as shown in table 1 below.

Influence of each group of table 1 to A549 cytoactivesP_{Cell viability}/ %

1. P ＜ 0.05,2. P ＜ 0.01, compare with blank control group

(2) influence of the Flow Cytometry Assay Chinese medicine compound prescription to apoptosis of tumor cells rate

Take the logarithm growth period cell, digested with pancreatin after counting, with 1 × 10⁵Individual/hole is inoculated in 24 well culture plates.Cell After adherent, with serum free medium starvation synchronizing them of 24h.Original fluid is abandoned after culture 24h, blank serum group is separately added into (20% blank serum), Chinese medicine low dose group (10% Contained Serum), Chinese medicine high dose group (20% Contained Serum) nutrient solution, training Nutrient solution collocation method is volume fraction 80%RPMI-1640 serum-free medium+x% Contained Serums+(20-x) % blank serums (x% refers to Contained Serum concentration), each group sets 3 multiple holes respectively, is placed in incubator and continues to collect cell after cultivating 48h, uses body The cold ethanol of fraction 75% is fixed, and PI carries out fluorescent staining, and flow cytometer is detected, records result, and apoptosis rate is G0 phase cell proportions, are represented in flow cytometer with %Tot.Experiment is repeated 3 times, and averages.

Using blank serum group (20% blank serum), Chinese medicine low dose group (10% Contained Serum) and Chinese medicine high dose Group (20% Contained Serum) pastille culture medium processes A549 cells, and flow cytometer is detected, records result, apoptosis rate It is G0 phase cell proportions, represents that experiment is repeated 3 times with %Tot in flow cytometer, averages.

Such as accompanying drawing 1~3, and shown in table 2 below：10% (low dose group), the treatment of 20% (high dose group) Contained Serum group After A549 cells 48h, Apoptosis can be remarkably promoted, (P ＜ 0.05 statistically significant with blank serum group comparing difference Or P ＜ 0.01).

Influence of the Chinese medicine compound prescription of table 2 to A549 Apoptosis of Lung Adenocarcinoma Cell

1. P ＜ 0.05,2. P ＜ 0.01, compare with blank control group

Lewis lung carcinoma cells are tested：

Tumor-bearing mice is randomly divided into 3 groups：Chinese medicine high and low dose group, model group, every group 16.According to small in preliminary experiment The Survival of mouse, Chinese medicine high and low dose group is respectively the 1 of clinical application amount, 3 times (9.1,27.3gkg-1).According to prerun Modeling 7d (my god) can substantially lay one's hand on and tumour.8th day gastric infusion after modeling, once a day, is administered 7d altogether, and model group gives physiology Salt solution, once a day, continuous 7d.After administration terminates, continue to observe 7d.

Knurl body histocyte apoptosis is detected：Knurl body tissue about 0.5g is cut, is ground on 100 mesh stainless steel filtering nets, culture Ware is collected, and flushing 10 times is filtered repeatedly with PBS liquid, and filtrate is filtered into streaming pipe through 300 mesh filter paper, 1200rmin-1 centrifugations 5min, abandons supernatant.300L binding buffer+5L annexin-v-fitc are added in sample, concussion is mixed, lucifuge After being incubated 30min, 2mL PBS liquid 1200rmin-1 centrifugation 5min are added, after abandoning supernatant, add 300L binding Buffer+5L PI, concussion is mixed, and after lucifuge is incubated 30min, adds 2mL PBS liquid 1200rmin-1 centrifugation 5min, is abandoned Machine testing on 1mL PBS is added after clear.

Influence such as accompanying drawing 4~6 to apoptosis of tumor cells, and shown in table 3 below.Model group apoptosis rate is (3.89 ± 2.67) %, Chinese medicine compound prescription low dose group is (8.06 ± 2.74) %, and high dose group is (8.66 ± 1.34) %, with model group Compare and can effectively improve apoptosis of tumor cells rate (P ＜ 0.05, P ＜ 0.01).

Influence of the Chinese medicine compound prescription of table 3 to apoptosis of tumor cells

Group	Dosage/gkg-1	Apoptosis rate %
			Model group	-	3.89±2.67
Chinese medicine low dose group	9.1	8.06±2.74*
			Chinese medicine high dose group	27.3	8.66±1.34**

From the point of view of cell experiment result, Apoptosis is the suicide machinery that body is actively engaged in, and is that antineoplastic suppresses One of mechanism of growth of tumour cell, is considered as assessing an index of curative effect of medication.Because antineoplastic is mostly by drawing Play tumor cell necrosis and apoptosis and have an effect, therefore the technical scheme of specific embodiment of the invention description is induced by trying Apoptosis of tumor cells realizes that the method for lung cancer therapy will turn into new orientation treatment.In this experiment, Chinese medicine compound prescription to A549 and The apoptosis of two kinds of lung cancer tumor cells of Lewis has inducing action, and has statistical significance with blank control group contrast.Cause This, states " therapeutically effective amount " of part proposition before this invention, specifically refers to provide composition to lung cancer tumor cell (especially Two kinds of lung cancer tumor cells of A549 and Lewis) apoptosis produce inducing action raw medicinal herbs amount, that is, provide composition it is antitumor The raw medicinal herbs amount of characteristic.

Embodiment 18：Clinical test

1. physical data

In on March 1,1 day to 2014 March in 2011,798 patients are included altogether, wherein come off 54, Eligibility 744 Example, wherein traditional Chinese medical science group 276, traditional Chinese and western medicine group 240, doctor trained in Western medicine group 228.Three groups of patients in age, sex, physical situation, face Bed by stages, histological type aspect there is preferably harmonious and comparativity (P ＞ 0.05), it is as shown in table 4 below.

Baseline Data compares before 4 three groups of treatments of table

2. inclusive criteria

Meet what Department of Medical Administration of the People's Republic of China (PRC) write《Common cancer diagnosis and treatment specification》In diagnostic criteria, by generation The TNM stage of boundary's health organization, through pathology or the NCSLC patient of cytodiagnosis；Estimate life cycle more than 3 months；General shape Condition PS ＜＜ 2；60~80 years old age；Every Index for examination meets chemotherapy idicatio；Stop chemicotherapy ＞ 1 month；Patient is ready Receive this programme treatment；Medication, the good person of compliance can be adhered to by doctor's advice.

3. exclusion standard

Without clear and definite tumor focus (including measurable and immeasurablel)；Inclusive criteria is not met；Merge the serious heart The geriatric diseases such as the cerebrovascular, or the disease such as phrenoblabia；Compliance difference person.

4. implementation

4.1 traditional Chinese medical science groups：Based on dissolving stasis removing toxic substances, clearing heat and expelling damp, specific side's medicine is selected from following prescription for treatment：

Daily 1 dose of decoction, 30 days as one therapeutic course takes 3 courses for the treatment of altogether.

4.2 traditional Chinese and western medicine groups：With traditional Chinese medical science group, western medical treatment uses chemotherapy for Chinese traditional treatment, and chemotherapy selects platiniferous side Case (NP, GP, TP, DP scheme), every 21 days repeatedly, totally 4 cycles.

NP schemes

NVB 25mg/m2 ivdrip d1, d8

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

GP schemes

GEM 1000mg/m2 ivdrip d1, d8

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

TP schemes

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

DP schemes

DDP 20mg/m2 ivdrip d1-5 or 30mg/m2 ivdrip d1-3 q21d

4.3 doctor trained in Western medicine groups (comparative example)：Chemotherapy regimen is with traditional Chinese and western medicine group, repetition in every 21 days, 4 cycles.

5. curative effect index

With median survival interval, life quality as MAIN OUTCOME MEASURES, secondary index includes knurl body remission rate, Progression free survival Phase, KPS scale (PS), clinical symptoms, body weight, CEA, toxic and side effect are secondary observation index.

Each group patient carries out knurl body, cardinal symptom, PS scorings, body weight, every biochemical indicator and life from being admitted to hospital first day Deposit the evaluation of quality.Treatment starts rear biochemical indicator, CEA etc. and evaluates once for every three weeks, and tumorous size is evaluated once for every six weeks, main Symptom, KPS scale, body weight is wanted to evaluate weekly once, life quality is evaluated once for (3 weeks) per the course for the treatment of.Continue follow-up, to the greatest extent Amount still based on former Regimen Chemotherapy, follow up time monthly, with phone or letter form, until terminal, finally counts middle position Life cycle.Observation item and information gathering time flow are as shown in table 5 below.

The Clinical observation project of table 5 and information gathering time flow table

Note：(D84) carries out follow-up after terminating with D1 interval time ＜＜ 24h, the course for the treatment of before the treatment of QOL scales Investigation requirements, Monthly, carried out in first day monthly.

6. the standard of curative effect evaluation

6.1 tumour short-term evaluations：RECIST 1.1 editions, it is as shown in table 6 below.

The tumour short-term evaluation of table 6：RECIST 1.1 editions

6.2 ECOG standards of grading, it is as shown in table 7 below.

The ECOG standards of grading tables of table 7

Evaluation method：

It is effective：Than improving two ranks or more before treatment after treatment；

Effectively：It is more one level higher than treatment premise after treatment；

Stabilization：Compare no significant change with before treatment after treatment；

It is invalid：Than declining rank or more before treatment after treatment.

6.3 Evaluation on quality of life

Using lung cancer therapy functional evaluation table (Functinoal Assessment of cancer Therapy-Lung, FACT-L), it is as shown in table 8 below.FACT-L relatively can comprehensively and accurately evaluate Patients with Advanced Lung Cancer life quality.The scale is by two Part is constituted, and Part I includes 31 projects related to general health, from health, social family, mood, work( Energy 4 aspects of situation are evaluated；Part II evaluates the special module (additional concern situation) of lung cancer life quality, has 10 projects stress to evaluate influence of the lung cancer related symptoms to life quality.The measure scale compares with the third edition, has subtracted doctor Suffer from 3 entries of relation plate, be divided into 5 41, field entries, i.e.,：Health (8), society/family status (8 Bar), emotional status (7), function status (8) and additional concern situation (10).Wherein each part last Mesh is all a total evaluation of the patient to the part, and these entries are not included when each several part score is calculated.

The quality of life in patients with lung cancer of table 8 determines scale (FACT-L)

Methods of marking：Each plate overall merit entry is removed, totally 37, using Pyatyi point system, i.e.,：Not at all, have Point, some, quite, very five grades, in scoring, positive entry directly counts 0-4 points, and reverse entry is then reversely scored, that is, fill out Write first grade person to count 4 points, fill in second 3 points of grade person's meter, the rest may be inferred.If having default value in the answer of entry (not Answer), then the point system in corresponding field is：The actual answers of entry number ÷ in each entry score sum × field in the field Entry number.Entry score included by each field is added can obtain the score in the field, and the score in each field is added and obtains The score of total scale.

Acquisition time：It is 21 days per the course for the treatment of, treatment cycle is 4 courses for the treatment of.With treatment the before the treatment of QOL scales Investigation requirements One ＜ 24h hours interval time ＜, the course for the treatment of starts latter every 3 weeks once, in every course for the treatment of collection data on the firstth.

6.4 clinical symptoms evaluations：With reference to Lung Cancer Symptoms classification as shown in table 9 below and methods of marking.

The Lung Cancer Symptoms hierarchical table of table 9

Evaluation method：

1st, with 5 points of meterings

0 degree：Without any manifest symptom.

I degree：There is mild, be resistant to, without treatment.

II degree：Symptom is heavier, is often difficult to tolerate, and must make proper treatment.

III degree：Serious symptom, it is impossible to tolerate, must symptomatic treatment.

IV degree：Symptom is extremely serious, threat to life, must make particular treatment.

2nd, the grade assessment of clinical symptoms

Scoring × 100% before clinical symptoms integration=(being scored after scoring-treatment before treatment)/treatment

It is effective：Symptom disappears, or symptom integral reduces ＞＞ 75%；

Effectively：Symptom mitigation, symptom integral reduces ＞＞ 50%；

Stabilization：25% one-tenth symptom integral reduces ＜ 50%；

It is invalid：Symptom reduces ＜ 50% without mitigation or symptom integral.

6.5 haematics toxicities and biochemical indicator：Quantitative criteria referring to WHO antineoplastics toxicity grading standard, it is as follows Shown in table 10.

The indexing standard of the acute and subacute chemotherapy toxic side effect of table 10 presses the indexing standard scale of WHO

7. data preparation and statistical analysis

7.1 measurement datas

Test of normality is first carried out, meeting normal distribution person carries out t inspections or variance analysis, and variance is carried out before variance analysis Test of homogeneity.

Compare between two groups using t inspections, do not meet normality distribution person then using rank test between two groups；In group before treatment Itself compare afterwards and use paired t-test, do not meet normality distribution person then using pairing rank test；Multigroup comparison operators two-by-two Close normality distribution, the neat person of variance and use variance analysis.

7.2 enumeration datas

Using rank test, compare use rank test two-by-two；Compare between two or more group and checked with Kruskal-Wallis. Compare between two population rates (or constituting ratio), with inspection or exact method method is expanded, multiple sample rates or composition than between compare, Using contingency table X²Inspection.

7.3 survival analysises

Single factor test survival analysis is carried out using the product method of limits (Kaplan-Meier), each group median survival interval, life is calculated Deposit rate, median follow-up time time and mean survival time (MST), and by Log rank check carry out survival rate curve ratio compared with.

8. therapeutic efficacy assessment is set up

All case follow-ups were on March 1st, 2014.After off-test, the clinical data that will be collected into is counted Analysis, evaluates curative effect.Understand Survival according to Follow-up results, calculate median survival interval.

9. Contrast on effect

9.1 3 groups of life cycles compare

11 3 groups of life cycle comparison sheets of table

12 3 groups of survival rate comparison sheets of table

Such as upper table 11,12, and shown in accompanying drawing 7, three groups of median survival intervals with traditional Chinese medical science group highest, next to that the combination of Chinese tradiational and Western medicine Group, doctor trained in Western medicine group is minimum, and three groups are compared that there was no significant difference (P ＞ 0.05).Three groups of half a year survival rates with traditional Chinese medical science group highest, next to that Traditional Chinese and western medicine group, doctor trained in Western medicine group is minimum, and three groups are compared that there was no significant difference.Three groups of annual rates of depositing with traditional Chinese and western medicine group highest, next to that Traditional Chinese medical science group, doctor trained in Western medicine group is minimum, and three groups are compared that there was no significant difference.

9.2 3 groups of comparings of disease developing time

13 3 groups of disease developing time comparison sheets of table

14 3 groups of progression of disease rate comparison sheets of table

Note：Log rank are checked, χ²=1.53, P=0.4661；Breslow is checked, χ²=2.55, P=0.2795

Such as upper table 13,14, and shown in accompanying drawing 8, three groups of mean disease evolution times and middle position disease developing time are in Doctor's group is most long, is secondly traditional Chinese and western medicine group, and doctor trained in Western medicine group is most short, but no significant difference.

9.3 life qualities compare

9.3.1 health plate

The health plate comparison sheet of table 15

Variance analysis " time effect " the Greenhouse-Geisser coefficient corrections inspection of duplicate measurements, F=11.745, P=0.000；" packet effect " checks F=20.874, P=0.000；" interaction of packet and time " Greenhouse- Geisser coefficient corrections are checked, F=9.931, P=0.000.

* with compare P ＜ 0.005 before treatment, △ compares P ＜ 0.05 with traditional Chinese medical science group, and ★ compares P ＜ 0.05 with traditional Chinese and western medicine group.

As shown in upper table 15 and accompanying drawing 9, in health plate, the life quality integral contrast of different time of measuring is poor It is different to have conspicuousness (P ＜ 0.01)；The integral contrast difference of different groups has conspicuousness (P ＜ 0.01)；Integration is between different groups The trend comparison difference for changing over time has conspicuousness (P ＜ 0.01).

Compare in group：The 42nd, 63 and 84 days integrations of traditional Chinese medical science group " health " have rising compared with pre-treatment, and difference has Conspicuousness (P ＜ 0.01)；Traditional Chinese and western medicine group because by chemical therapy toxic side effect influenceed the 21st, 42 days integration compared with pre-treatment under Drop, difference has conspicuousness (P ＜ 0.01), and integration gos up within the 63rd, 84 days, compares with before treatment, no significant difference；Doctor trained in Western medicine group " health " four measurement integrations have decline compared with pre-treatment, and difference has conspicuousness (P ＜ 0.01).

Compare between group：Respectively compared with traditional Chinese and western medicine group, doctor trained in Western medicine group, four times measurement integration has significantly traditional Chinese medical science group compared to difference Property (P ＜ 0.01)；The difference compared with doctor trained in Western medicine group of traditional Chinese and western medicine group the 63rd, 84 days has conspicuousness (P ＜ 0.01).

9.3.2 society/family status plate

16 societies of table/family status plate comparison sheet

Variance analysis " time effect " the Greenhouse-Geisser coefficient corrections inspection of duplicate measurements, F=0.414, P =0.879；" packet effect " checks F=0.733, P=0.483；" interaction of packet and time " Greenhouse- Geisser coefficient corrections are checked, F=1.282, P=0.220.

As shown in upper table 16 and accompanying drawing 10, in social family status plate, life quality is integrated in different time, difference Between group and the trend comparison difference that changes over time of different group there are no significant.

Compare in group：Three groups of " society/family status " each acquisition times compared with pre-treatment difference there are no significant.

Compare between group：There are no significant for comparing difference between three groups of " society/family status " each acquisition time groups.

9.3.3 emotional status plate

The emotional status plate comparison sheet of table 17

Variance analysis " time effect " the Greenhouse-Geisser coefficient corrections inspection of duplicate measurements, F=14.347, P=0.000；" packet effect " checks F=28.273, P=0.000；" interaction of packet and time " Greenhouse- Geisser coefficient corrections are checked, F=3.630, P=0.000.

As shown in upper table 17 and accompanying drawing 11, in emotional status plate, the life quality integral contrast of different time of measuring Difference has conspicuousness (P ＜ 0.01)；The integral contrast difference of different groups has conspicuousness (P ＜ 0.01)；Integration is in different groups Between the trend comparison difference that changes over time have conspicuousness (P ＜ 0.01).

Compare in group：The 63rd day integration of traditional Chinese medical science group " emotional status " has rising compared with pre-treatment, and difference has conspicuousness (P ＜ 0.01)；The 21st day integration of traditional Chinese and western medicine group is slightly decreased compared with pre-treatment, but no significant difference, the 42nd, 63,84 days products Divide has rising compared with pre-treatment, and difference has conspicuousness (P ＜ 0.01)；The integration of doctor trained in Western medicine group " emotional status " the 21st, 84 days with Compared to there is decline before treatment, difference has conspicuousness (P ＜ 0.01).

Compare between group：Four measurement integration differences compared with traditional Chinese and western medicine group of doctor trained in Western medicine group have conspicuousness (P ＜ 0.05), the 21st, 42,84 days integration difference compared with traditional Chinese medical science group also has conspicuousness (P ＜ 0.05).The 63rd day integration of traditional Chinese medical science group and traditional Chinese and western medicine group There is conspicuousness (P ＜ 0.05) compared to difference.

9.3.4 function status plate

The function status plate comparison sheet of table 18

Variance analysis " time effect " the Greenhouse-Geisser coefficient corrections inspection of duplicate measurements, F=37.323, P=0.000；" packet effect " checks F=17.568, P=0.000；" interaction of packet and time " Greenhouse- Geisser coefficient corrections are checked, F=12.528, P=0.000.

* with compare P ＜ .005, △ before treatment and compare P ＜ 0.05 with traditional Chinese medical science group, ★ compares P ＜ 0.05 with traditional Chinese and western medicine group.

As shown in upper table 18 and accompanying drawing 12, in function status plate, the life quality integral contrast of different time of measuring Difference has conspicuousness (P ＜ 0.01)；The integral contrast difference of different groups has conspicuousness (P ＜ 0.01)；Integration is in different groups Between the trend comparison difference that changes over time have conspicuousness (P ＜ 0.01).

Compare in group：Four measurement integrations of traditional Chinese medical science group " function status " have rising compared with pre-treatment, and difference has significantly Property (P ＜ 0.05)；Traditional Chinese and western medicine group had rising compared with pre-treatment in the 42nd, 63,84 days integrations, and difference has conspicuousness (P ＜ 0.05)；Doctor trained in Western medicine group " function status " has rising on the 42nd day compared with pre-treatment, and difference has conspicuousness (P ＜ 0.05), the 21st, 84 Its integration has decline compared with pre-treatment, and difference has conspicuousness (P ＜ 0.05).

Compare between group：Traditional Chinese medical science group difference compared with the 21st day integration of traditional Chinese and western medicine group has conspicuousness (P ＜ 0.05)：With doctor trained in Western medicine group Integration has conspicuousness (P ＜ 0.05) compared to difference within 21st, 63,84 days；The 21st, 63,84 days integrations of traditional Chinese and western medicine group and doctor trained in Western medicine group phase There is conspicuousness (P ＜ 0.01) than difference.

9.3.5 the concern situation plate for adding

The additional concern situation plate comparison sheet of table 19

Variance analysis " time effect " the Greenhouse-Geisser coefficient corrections inspection of duplicate measurements, F=16.293, P=0.000；" packet effect " checks F=12.867, P=0.000；" interaction of packet and time " Greenhouse- Geisser coefficient corrections are checked, F=7.043, P=0.000.

As shown in upper table 19 and accompanying drawing 13, in additional concern situation plate, the life quality integration of different time of measuring Comparing difference has conspicuousness (P ＜ 0.01)；The integral contrast difference of different groups has conspicuousness (P ＜ 0.01)；Integration is in difference The trend comparison difference changed over time between group has conspicuousness (P ＜ 0.01).

Compare in group：The 42nd, 63,84 days integrations of traditional Chinese medical science group " additional conditions " have rising compared with pre-treatment, and difference has Conspicuousness (P ＜ 0.05)；Traditional Chinese and western medicine group had rising compared with pre-treatment in the 42nd, 63,84 days integrations, and difference has conspicuousness (P ＜ 0.05)；Doctor trained in Western medicine group " additional conditions " has decline for the 21st, 84 days compared with pre-treatment, and difference has conspicuousness (P ＜ 0.05).

Compare between group：Four measurement integration differences compared with traditional Chinese medical science group and doctor trained in Western medicine group of doctor trained in Western medicine group have conspicuousness (P ＜ 0.05)；Traditional Chinese and western medicine group each time point, there are no significant for difference (P ＞ 0.05) compared with traditional Chinese medical science group.

9.4 Tumor response situations compare

Tumor response situation comparison sheet (REC1ST) of table 20

ORR mono- traditional Chinese medical science group vs traditional Chinese and western medicine group P=0.012, traditional Chinese medical science group vs doctor trained in Western medicine group P=0.146, traditional Chinese and western medicine group vs doctor trained in Western medicine groups P=0.283.

OSD mono- traditional Chinese medical science group vs traditional Chinese and western medicine group P=0.877, traditional Chinese medical science group vs doctor trained in Western medicine group P=0.197, traditional Chinese and western medicine group vs doctor trained in Western medicine groups P=0.165.

Tumor response situation is evaluated by RECIST, and as shown in upper table 20, traditional Chinese and western medicine group Overall response rate is high compared with traditional Chinese medical science group, difference Statistically significant (P=0.012), but traditional Chinese and western medicine group compares with doctor trained in Western medicine group, doctor trained in Western medicine group with traditional Chinese medical science group, no significant difference (P ＞ 0.05), three groups of comparing differences of total coefficient of stabilization are not statistically significant (P ＞ 0.05).

9.5 Cattells scoring situation of change

The 42nd day PS scoring comparison sheet of table 21

Cattell scoring in the 42nd day is compared after three groups of treatments, three groups of no significant differences (P ＞ 0.05).

The 84th day PS scoring comparison sheet of table 22

△ compares P=0.000 with doctor trained in Western medicine group, and * compares P=0.001 with doctor trained in Western medicine group.

Cattell scoring in the 84th day is compared after three groups of treatments, and traditional Chinese medical science group and traditional Chinese and western medicine group effective percentage, coefficient of stabilization are better than doctor trained in Western medicine group (P ＜ 0.05).

From upper table 21,22, and shown in accompanying drawing 14, traditional Chinese medical science group PS scorings are evaluated good before relatively treating for the 42nd, 84 days twice Turn, difference is statistically significant (P ＜ 0.05)；Traditional Chinese and western medicine group the 84th day take a favorable turn with comparing before treatment, and difference has statistics to anticipate Adopted (P ＜ 0.05)；Three measurements of doctor trained in Western medicine group are showed no notable difference (P ＞ 0.05) with comparing before treatment.

9.6 changes of weight situations

Changes of weight table after 23 3 groups of treatments of table

From shown in upper table 23 and accompanying drawing 15, traditional Chinese medical science group is measured and there are no significant (the P ＞ of comparing difference before treatment twice 0.05).Traditional Chinese and western medicine group is declined slightly before the 42nd day measurement body weight is relatively treated, and difference has conspicuousness (P ＜ 0.05), subsequent body weight Go up, compare with before treatment, no significant difference (P ＞ 0.05).The 42nd, 84 days body weight of doctor trained in Western medicine group compare with before treatment, have It is decreased obviously, difference has conspicuousness (P ＜ 0.01).There are no significant (P ＞ 0.05) for comparing difference between each time point group.

9.7 tumor-related symptoms improve situation

The 42nd day symptom improves degree comparison sheet after 24 3 groups of treatments of table

* traditional Chinese medical science group compares P ＜ 0.05 with traditional Chinese and western medicine group, and ★ traditional Chinese medical science group compares P ＜ 0.05 with doctor trained in Western medicine group, △ traditional Chinese and western medicines group with Doctor trained in Western medicine group compares P ＜ 0.05

The 42nd day cardinal symptom pectoralgia, weak improvement degree compare after three groups of treatments, and difference has significant, and patient coughs Cough, hemoptysis, heating, shortness of breath, the improvement degree such as dry compare, difference there are no significant meaning.Symptom improves degree ratio between two groups Compared with：Traditional Chinese medical science group compares with traditional Chinese and western medicine group, and heating, weak improvement degree are variant, is traditional Chinese medical science group better than traditional Chinese and western medicine group；Traditional Chinese medical science group Compare with doctor trained in Western medicine group, pectoralgia, indigestion and loss of appetite, weak, dry improvement degree are variant, during wherein pectoralgia improvement degree is better than with doctor trained in Western medicine group Doctor's group, indigestion and loss of appetite, weak, dry is then better than doctor trained in Western medicine group with traditional Chinese medical science group；Traditional Chinese and western medicine group compares with doctor trained in Western medicine group, each symptom significant difference Property, as shown in upper table 24.

The 84th day symptom improves degree comparison sheet after 25 3 groups of treatments of table

* traditional Chinese medical science group compares P ＜ 0.05 with traditional Chinese and western medicine group, and ★ traditional Chinese medical science group compares P ＜ 0.05 with doctor trained in Western medicine group, △ traditional Chinese and western medicines group with Doctor trained in Western medicine group compares P ＜ 0.05.

Cardinal symptom shortness of breath in 84th day after three groups of treatments, stomach are received, weak, dry improves degree and compares, and difference has conspicuousness The improvement degree such as meaning, patient's cough, hemoptysis, pectoralgia compare, difference there are no significant meaning.Symptom improves degree ratio between two groups Compared with：Traditional Chinese medical science group compares with traditional Chinese and western medicine group, and shortness of breath improvement degree is variant, and traditional Chinese and western medicine group is better than traditional Chinese medical science group；Traditional Chinese medical science group and doctor trained in Western medicine group Compare, heating, stomach are received, weak, dry improvement degree is variant, and traditional Chinese medical science group is better than doctor trained in Western medicine group；Traditional Chinese and western medicine group compares with doctor trained in Western medicine group Shortness of breath, stomach are received, weak improvement degree is variant, and traditional Chinese and western medicine group is better than doctor trained in Western medicine group, as shown in upper table 25.

9.8 erythrocyte sedimentation rates and CEA situations of change

In the middle of this research, erythrocyte sedimentation rate and CEA each groups treat front and rear change comparing difference without conspicuousness, each time point Comparing difference is also without conspicuousness between group.

9.9 adverse events and adverse reaction are observed

Adverse events and adverse reaction refer to that patient signs the participation examination of patient's Informed Consent Form in this clinical test, certainly Any bad medical events and adverse reaction (reaction of acute or subacute toxicity) started to occurring between last time follow-up are tested, There are no serious adverse events in this clinical test, as shown in table 26 below and accompanying drawing 16, three groups during treating, difference occur The hematotoxicity of degree, comparing difference is statistically significant between three groups；Combined analysis, traditional Chinese medical science group, traditional Chinese and western medicine group and doctor trained in Western medicine group III, IV degree Neuroleptic Leukocytopenia incidence are respectively 2.17%, 15% and 26.32%, three groups of statistically significant P of comparing difference ＜ 0.01 (P=0.006), wherein, traditional Chinese medical science group compares with traditional Chinese and western medicine group, doctor trained in Western medicine group, and difference has (the P values point of conspicuousness P ＜ 0.05 Wei 0.031 and 0.001)；Traditional Chinese medical science group, traditional Chinese and western medicine group and doctor trained in Western medicine group III, IV degree granulocyte reduce incidence and are respectively 2.17%th, 22.5% and 31.58%, the statistically significant P ＜ 0.01 (P=0.001) of difference, traditional Chinese medical science group and traditional Chinese and western medicine group, west Doctor's group compares, and difference has conspicuousness P ＜ 0.01 (P values are respectively .0004 and .0001)；Decrease of platelet III, IV degree merges Analysis, the incidence of traditional Chinese medical science group, traditional Chinese and western medicine group and doctor trained in Western medicine group is respectively 0%, 2.5% and 10.53%, and difference is statistically significant P ＜ 0.05 (P=0.044), wherein, traditional Chinese medical science group compares with doctor trained in Western medicine group, and difference has conspicuousness P ＜ 0.05 (P=0.025)；The traditional Chinese medical science Group, traditional Chinese and western medicine group and doctor trained in Western medicine group III, IV degree hemoglobin reduction incidence are respectively 0%, 5% and 21.05%, and three groups are compared The statistically significant P ＜ 0.01 (P=0.001) of difference, wherein, doctor trained in Western medicine group compares with traditional Chinese medical science group, traditional Chinese and western medicine group, and difference has aobvious Work property P ＜ 0.05 (P values are respectively 0.001 and 0.035).

Three groups have the different degrees of appearance liver and kidney dysfunction of small number of patients, show as ATL, AST, GGT, BUN, Cr liter The elevated incidence of height, wherein AST, AKP, three groups of comparing differences have conspicuousness P ＜ 0.05, and (P values are respectively 0.004 He 0.044), hepatic and renal function indices III, IV degree combined analysis, three groups of more equal no significant differences.

26 3 groups of adverse reactions of patients comparison sheets of table

Four grades compare：* traditional Chinese medical science group compares P ＜ 0.05 with traditional Chinese and western medicine group, and ★ traditional Chinese medical science group compares P ＜ with doctor trained in Western medicine group 0.05, △ traditional Chinese and western medicine group compares P ＜ 0.05 with doctor trained in Western medicine group.

For most of lung cancer patient, particularly centering patients with terminal, " phlegm ", " void " two word are emphasized especially, it is believed that in this It is mark, simulataneous insufficiency and excessive with " phlegm " for this that the pathological characters of one moment lung cancer are with " void "." phlegm coming from spleen, lung is storage The device of phlegm ", therefore, the morbidity of lung cancer is dirty closely related with spleen, lung two.It is insufficiency of the spleen originally, to focus on " void ",《Method living is confidential》Say " without product, empty people then has it to strong people, weakness of the spleen and the stomach, and qi and blood two declines, thoughts when four, all can be into product." with " phlegm " for mark, drilled in lung cancer During change, " phlegm be thing, with gas lift drop, nowhere less than ".Lung cancer phlegm to suffer from, except seeing that cough spits, gurgling weith sputum of panting etc. has Outside the phlegm of shape, still there is the symptom of a variety of insubstantial phlegms.Shortness of breath of such as coughing is phlegm wet Kui lung, and hemoptysis pectoralgia is fought knot, lung cancer for phlegm addiction Lymphatic metastasis flees subcutaneous skin for subcutaneous nodule, and brain metastasis blind clear key for phlegm is turbid.Therefore, to the treatment of lung cancer, eliminating phlegm Necessary QI invigorating, facilitaing lung must simultaneous invigorating the spleen.Temper, the congenital kidney qi of QI invigorating, i.e., beneficial lung qi, and the beneficial day after tomorrow, work(support canonical in righting Product is imitated in eliminating evil from eliminating phlegm, i.e., the hot phlegm in warming cold phlegm, Qinghua, eliminating dampness and eliminating phlegm, moistening dryness and resolving phlegm is removed, and heresy goes then just pacifying certainly.

In clinical test, the treatment of traditional Chinese medical science group can significantly extend the life cycle of patients with lung cancer, particularly extend III, IV Phase ordinary circumstance poor gerontal patient's life cycle.Moreover, while survival rate is improved, can preferably safeguard patient's Life quality, and the toxic and side effect of antagonism chemotherapy to a certain extent.Clinical trial results fully show：Therapy of combing traditional Chinese and Western medicine There is larger advantage in terms of Tumor response, Chinese medicine is in sides such as tumor-related symptoms, performance status, holding body mass stables There is larger advantage in face.Chinese medicine is not to emphasize merely the therapeutic purpose that knurl body reduces, but patient-centered health care is controlled Cancer therapies, according to the viewpoint of evidence-based medicine EBM, are evaluated by treatment theory by endpoint of prognosis, a large amount of reliable real Test under the support of data, can produce safely, effectively, reasonably treat curative effect, can obviously improve late result and the life of patient Bioplasm amount.To extend life span, raising life quality is practical goals to Chinese medicine, payes attention to the benefited reaction of patient.

Summary data, fully show traditional Chinese medical science group treatment lung cancer these three therapeutic schemes in be the most rationally, Economical.Also fully reflect simultaneously, the composition of the specific embodiment of the invention is much excellent with effect associated with chemotherapeutant In doctor trained in Western medicine group as a comparison case, and simple traditional Chinese medical science group, with significant synergy.

Embodiment 19：Type of deficiency of both QI and YIN patient treats example

Patient Zhang, man, 71 years old, there is cough and expectoration in November, 2011 without obvious inducement in patient, and amount is few in vain for color, can cough Go out, patient does not do any treatment.2012 beginning of the years gave anti-infective, cough-relieving and symptomatic treatment, and symptom is without being clearly better.With after Show through CT examination within 03 month 2012：Upper left apex pulmonis back segment lung cancer, size 4.2cm × 4.5cm, and left hilus pulumonis and the multiple lymph of vertical diaphragm Carry down shifting, left side pneumonia, left side pleural thickening and a small amount of hydrops, left side thyroid nodule.Special treatment is not given, is coughed afterwards earlier above Without being clearly better, chest CT was checked again in June 20 then and is shown：Upper left apex pulmonis back segment occupy-place and obstructive pneumonia, size is about 6.0cm × 4.6cm, left hilus pulumonis, vertical diaphragm, knuckle inferior gluteal lymph node enlargement；Left side pleural thickening and hydrops.In July, 2012 row lung is accounted for Position puncturing tissue pathology shows：Irregular heterocyst nest infiltration is seen in tissue, partially visible angling, SABC shows：CK7 (+), CK5/6 (+), P63 (+), TTF-1 (-).Prompting：Differentiated squamous-cell carcinomas in (lung).Then in the row of in August, 2012 TCM on tumor treatment, disease See：Refreshing clear, tired spirit, weak, trachyphonia, have when afternoon hectic fever, it is even have nausea, without vomiting, double upper limbs occasionally have and tremble, double lower limb The following oedema of knee joint, prostration and feels shortness of breath when lying on the left side, dry substantially, without fever with aversion to cold, cough and expectoration, chest and back pain, chest The discomforts such as vexed palpitaition, abdominal pain and distension, dormancy of receiving is poor, and urine color is yellow, enuresis nocturna 2~3 times/late, dry and hard excrement, 2~3 days/time.From onset Come, Body weight loss about 5kg.The red tongue of tongue is few, and deeptensepulse is counted accurately.Then patient selfheal 30g, house lizard 5g, black nightshade grass 20g, Sculellaria barbata are given 10g, northern apricot 20g, ganoderma lucidum 30g, dried orange peel 15g, Radix Codonopsis 40g, one dose per day, are decocted in water for oral dose by 14 doses.Patient answers in August, 2012 afterwards Examine：Spiritual muscle power each side has improvement earlier above, and shortness of breath, dry improve, and hectic fever substantially mitigates, and the thin yellow, arteries and veins of red tongue body, tongue is thin. Prescription is stated more than continuing afterwards for basic side takes more than 3 years, patient shows in October, 2015 check chest CT：Upper left lung lung cancer is simultaneously double Intrapulmonary transfer, left hilus pulumonis and the multiple lymphatic metastasis of mediastinum, focus are in progress earlier above.Left side pleural thickening and a small amount of hydrops.First shape Gland lobus lateralis sinister tubercle is the same.To in November, 2015, morbidity 4 years adheres to being taken with the prescription for follow-up, though focus is slowly entered Exhibition, but life quality, without being decreased obviously, live such as ordinary person.

Embodiment 20：Accumulation of phlegm and heat in type patient treats example

Patient Lin, man 59 years old, patient is medical to local hospital because of " low fever companion back pain is more than January repeatedly ", 2013 September PET/CT promptings on the 18th：The upper lobe of left lung point rear end irregular strip and block hypermetabolism focus of nearly oblique segmentation pleura, considers lung first Cancer, with the multiple lymphatic metastasis of mediastinum.After the row focus pathological biopsy on the 28th of September in 2013, show：(left lung) low differentiation of primary Gland cancer；SABC：CK7, EGFR, TTF1, CK20, CK5/6, P40 (-), Ki-67 about 80% (+), P53 parts (+)；After go Quadruple pass " pemetrexed+cis-platinum ", in the treatment of in October, 2013 row TCM on tumor, symptoms include：Refreshing clear, spirit is general, fatiguability, low-heat Sweating, cough is coughed up phlegm, amount of expectoration is more, the thick color of matter is yellow, accompany the trace of blood, shortness of breath shortness of breath, it is even have pectoralgia, dry mouth with bitter taste, receive general, night and sleep Feel unwell, dreaminess, defecate 2~3 days one solve, matter is dry and hard, urine color Huang, red tongue with yellowish fur, veins is sliding.Then give radix ranunculi ternati 20g, stiff silkworm 15g, Glabrous Sarcandra Herb 10, black nightshade grass 20g, edible tulip 15g, fritillaria thunbergii 25, northern apricot 15g, ganoderma lucidum 15g, rhizoma pinellinae praeparata 20g, American Ginseng 20g, 14 Agent, one dose per day, is decocted in water for oral dose.Further consultation tells that without obvious low-heat, cough is coughed up phlegm and is clearly better, and is defecated 1 day 1 and is solved after two weeks, and night sleeps still Have and feel unwell, cape jasmine, the tuber of dwarf lilyturf each 10g are subject to original side then, after tell sleep improvement.Follow-up in January, 2016, morbidity 2 years It is remaining, adhere to being taken with the prescription, though the not regular imageological examination of rear patient, without special discomfort, life quality is good, and life is such as Ordinary person.

Embodiment 21：Asthenia of pulmonosplenic qi type patient treats example

Patient Lee, man 65 years old, double finger tips finger joint swelling, without pain and work was had found in 2010 without obvious inducement The symptom such as limited is moved, rabat is looked into and is shown：Right upper lung occupy-place；Parallel operative treatment, pathology shows：Break up gland cancer, lymphatic vessel in right upper lung Inside see cancer embolus；SABC：CK (+), TTF-1 (+), CK20 (-), SPB parts (+), CDX-2 (-).Because of patient requests, not OK Chemicotherapy, to ask TCM on tumor diagnosis and treatment, symptoms include：After refreshing clear, spiritual general, fatiguability, susceptible chill, conscious shortness of breath, activity slightly Shortness of breath, coughs up phlegm and feeling of oppression and pain in the chest without substantially cough, and dry receives general, easy abdominal distension after feed without bitter taste, matter of defecating it is rotten not into Shape, urine is adjusted, tongue nature is light red, side has that indentation, tongue be white, arteries and veins is thin.Give radix ranunculi ternati 15g, stiff silkworm 5g, house lizard 5g, Glabrous Sarcandra Herb 15g, mountain Arrowhead 30g, fritillaria thunbergii 15g, ganoderma lucidum 30g, rhizoma pinellinae praeparata 15g, American Ginseng 30g, dried orange peel 15g, one dose per day, are decocted in water for oral dose by 14 doses.It is hard The treatment that takes traditional Chinese medicine is held, the state of an illness is without repeatedly.The chest CT of on April 22nd, 2015 is checked：Right lung cancer Postoperative changes, lung and upper left lung in the right side Point limitation fiber becomes, bottom right pleural thickening, adhesion；Left pleura pulmonalis inferior thyroid tubercle slightly increases earlier above, it is proposed that checked after treatment.After The left lung neoplasm percutaneous biopsy of the row of in September, 2015+lung neoplasm radio-frequency ablation procedure, postoperative pathological：Have no cancer.Follow-up was to 2016 1 Month, morbidity more than 5 years adheres to being taken with the prescription, but without special discomfort, life such as ordinary person.

Embodiment 22：Lung yin deficiency patient treats example

Patient Zhu, female, 60 years old, there is dry cough, row CT promptings without inducement in SARS in 2003：Pulmonary shadow, after Found during annual row lung plain film physical examination, shade increases year by year.2013 beginning of the year patients start uncomfortable in chest, pectoralgia and shortness of breath occur Deng uncomfortable, do not give substantially attention, after gradually aggravated because of symptom, in November, 2013 row PET/CT, show：Under middle lobe of right lung and double lungs Tikka sheet densification shadow, and thin original mold paste shadow, however not excluded that lung cancer；Double hilus pulumonis and mediastinum have no obvious lymphatic metastasis sign； It is remaining without special.After lower pneumonectomy, postoperative pathological in the row of November 26 right side：Well-differentiated adenocarcinoma, T4N0M0IIIA phases, gene inspection Measure：EGFR (-), ALK (-), postoperative patient refusal chemicotherapy, seek medical advice in TCM on tumor treatment, symptoms include：Dry cough, night substantially, When have hectic fever, Sleep hyperhidrosis, dry substantially, when have a shortness of breath uncomfortable in chest, activity postemphasis, food of receiving is general, night sleeps feels unwell, Yi Xing, greatly Just once defecation was laborious, matter is dry, urine is yellow on 2nd, and tongue nature is light red and dry, tongue is few, thready rapid pulse.Then radix ranunculi ternati 30g, selfheal are given 10g, house lizard 15g, Glabrous Sarcandra Herb 30g, edible tulip 10g, Sculellaria barbata 20g, fritillaria thunbergii 15g, ganoderma lucidum 15g, dried orange peel 15g, American Ginseng 25g, one dose per day, is decocted in water for oral dose by 14 doses.Further consultation is told after 2 weeks：The symptoms such as dry cough, hectic fever night sweat mitigate earlier above, dry and hard excrement symptom Be not improved, Piao 15g, pockmarks benevolence 10g thickeied then, after tell the improvement of dry and hard excrement symptom.Check chest CT is shown within 2015：Lung Postoperative changes, have no obvious relapse and metastasis sign.To 2 months 2016, morbidity more than 2 years adhered to being taken with the prescription for follow-up With, but without special discomfort, life such as ordinary person.

Embodiment 23：Qi stagnation and blood stasis type patient treats example

68 years old, there is cough, does not give attention in March, 2013 without obvious inducement in patient Zheng, man, and rear progressive is aggravated, In in October, 2013 right upper lung occupy-place aspiration biopsy：Lung squamous cancer；Bone scanning, cranium brain MR and upper abdomen CT no abnormality seens；Row is purple afterwards Checked after China fir alcohol+journey of carboplatin 4, shown：Superior lobe of right lung central type carcinoma of lung and right lung door, mediastinum and right supraclavicular lymph nodes turn Move, similar earlier above, double multiple lesser tubercles of lower lung increase increase earlier above.The symptom such as heating, n and V, tired is bright during because of chemotherapy It is aobvious, refuse further chemotherapy, seek medical advice in TCM on tumor treatment, symptoms include：Chest and back pain, position are fixed, night substantially, with scorching hot Sense, cough, it is even have spitting of blood, god is tired, weak, dry be not intended to drink, it is uncomfortable in chest, sigh and then relax, receive general, night and sleep and feel unwell, stool 2~3 Day one solves, and matter shaping, urine Huang, dark tongue quality, tongue do thin yellow, stringy and hesitant pulse.Give patient radix ranunculi ternati 20g, selfheal 20g, stiff silkworm 15g, house lizard 5g, Glabrous Sarcandra Herb 10g, black nightshade grass 15g, edible tulip 15g, Sculellaria barbata 15g, fritillaria thunbergii 10g, northern apricot 15g, ganoderma lucidum 20g, Rhizoma pinellinae praeparata 5g, dried orange peel 15g, American Ginseng 10g, Radix Codonopsis 10g, one dose per day, are decocted in water for oral dose by 14 doses.The big portion of symptom is told in further consultation after one week Point mitigate, after always above side taken as substantially square, adhere to Chinese medicine more than 2 years.In December, 2015 check CT shows：Right lung Upper leaf central type carcinoma of lung and right lung door, mediastinum and right supraclavicular lymph nodes transfer, be slightly in progress earlier above, double multiple lesser tubercles of lower lung compared with It is preceding similar.The state of an illness is evaluated as stabilization.Now without special discomfort, life each side can take care of oneself, such as ordinary person.

By implement the specific embodiment of the invention describe treatment lung cancer composition and for prepare treat lung-cancer medicament Application technical scheme, following technique effect can be produced：

Each embodiment is described by the way of progressive in this specification, and what each embodiment was stressed is and other The difference of embodiment, between each embodiment identical similar part mutually referring to.

The above, is only presently preferred embodiments of the present invention, and any formal limitation is not made to the present invention.Though So the present invention is disclosed as above with preferred embodiment, but is not limited to the present invention.It is any to be familiar with those skilled in the art Member, in the case where Spirit Essence of the invention and technical scheme is not departed from, all using in the methods and techniques of the disclosure above Appearance makes many possible variations and modification, or the Equivalent embodiments for being revised as equivalent variations to technical solution of the present invention.Therefore, Every content without departing from technical solution of the present invention, according to technical spirit of the invention to made for any of the above embodiments any simple Modification, equivalent, equivalence changes and modification, still fall within the range of technical solution of the present invention protection.

Claims

1. it is used to treat the composition of lung cancer, it is characterised in that the composition includes the following components containing therapeutically effective amount：

Component A) radix ranunculi ternati, any one or two kinds in selfheal；

Component B) stiff silkworm, any one or two kinds in house lizard；

Component C) Glabrous Sarcandra Herb, any one or two kinds in black nightshade grass；

Component D) edible tulip, any one or two kinds in Sculellaria barbata；

Component E) fritillaria thunbergii, any one or two kinds in northern apricot；

Component F) ganoderma lucidum；

Component G) rhizoma pinellinae praeparata, any one or two kinds in dried orange peel；

Component H) American Ginseng, any one or two kinds in Radix Codonopsis；

The composition is provided with the component proportion less than toxic dose.

2. the composition for treating lung cancer according to claim 1, it is characterised in that the composition includes following heavy Measure the component of part：

Component F) ganoderma lucidum, 10~40 parts；

3. the composition for treating lung cancer according to claim 2, it is characterised in that the weight of the various components is matched somebody with somebody Than as follows：

Component F) ganoderma lucidum, 15~30 parts；

4. the composition for treating lung cancer according to claim 2, it is characterised in that the weight of the various components is matched somebody with somebody Than as follows：

Component F) ganoderma lucidum, 15~30 parts；

5. the composition for treating lung cancer according to claim 4, it is characterised in that the weight of the various components is matched somebody with somebody Than as follows：

Component F) ganoderma lucidum, 15~30 parts；

6. the composition for treating lung cancer according to claim 5, it is characterised in that the weight of the various components is matched somebody with somebody Than as follows：

Component F) ganoderma lucidum, 15~20 parts；

7. the composition for treating lung cancer according to claim any one of 1-5, it is characterised in that the various components Weight proportion it is as follows：

Component B) stiff silkworm, any one or two kinds, 10 parts in house lizard；

Component F) ganoderma lucidum, 30 parts；

8. the composition for treating lung cancer according to claim 1 and 2, it is characterised in that the weight of the various components Amount proportioning is as follows：

Component B) stiff silkworm, any one or two kinds, 10 parts in house lizard；

Component F) ganoderma lucidum, 40 parts；

9. the composition for treating lung cancer according to claim 1 and 2, it is characterised in that the weight of the various components Amount proportioning is as follows：

Component B) stiff silkworm, any one or two kinds, 5 parts in house lizard；

Component F) ganoderma lucidum, 15 parts；

10. the composition for treating lung cancer according to claim 1,2 or 3, it is characterised in that the various components Weight proportion is as follows：

Component B) stiff silkworm, any one or two kinds, 10 parts in house lizard；

Component F) ganoderma lucidum, 20 parts；

11. compositions for treating lung cancer according to claim 1 and 2, it is characterised in that the weight of the various components Amount proportioning is as follows：

Component B) stiff silkworm, any one or two kinds, 15 parts in house lizard；

Component F) ganoderma lucidum, 30 parts；

12. compositions for treating lung cancer according to claim 1 and 2, it is characterised in that the weight of the various components Amount proportioning is as follows：

Component B) stiff silkworm, any one or two kinds, 5 parts in house lizard；

Component F) ganoderma lucidum, 10 parts；

13. composition for treating lung cancer according to claim any one of 1-12, it is characterised in that the composition At least one pharmacy application is shown, it is selected from：Medicament for immunity enhancement, antineoplastic and/or induction lung cancer tumor cell wither The medicine died.

14. composition for treating lung cancer according to claim any one of 1-12, it is characterised in that：The composition Formulation be any one in decoction, tablet, pill, powder agent, capsule or syrup.

Composition described in 15. claim any one of 1-14 is used to prepare the application for the treatment of lung-cancer medicament.

16. applications according to claim 15, it is characterised in that：The hot water extract of the composition is preparing treatment lung Application in cancer drug.

17. applications according to claim 15, it is characterised in that：The ethanol extract of the composition is preparing treatment lung Application in cancer drug.

18. application according to claim 15,16 or 17 any one, it is characterised in that：By the composition therapeutic alliance Application of at least one chemotherapeutant or targeted drug of effective dose in treatment lung-cancer medicament is prepared.

19. applications according to claim 18, it is characterised in that：At least one chemotherapeutant or targeted drug are selected From platinum medicine, vinorelbine, taxol, gemcitabine, pemetrexed, Gefitinib, Tarceva or gram azoles in Buddhist nun Any one.

20. application according to claim 15,16,17 or 19 any one, it is characterised in that the composition possesses following At least one pharmacy application, it is selected from：Alleviate Lung Cancer Symptoms, delay tumour progression, antagonism tumor drug resistance, improve immunologic function, Improve life quality, extension patient survival and/or the effect to chemotherapeutic sensitivity attenuation.