CN105853637A - Traditional Chinese medicine composition with synergetic effect on radiotherapy and chemotherapy, and preparation method thereof - Google Patents

Traditional Chinese medicine composition with synergetic effect on radiotherapy and chemotherapy, and preparation method thereof Download PDF

Info

Publication number
CN105853637A
CN105853637A CN201610197438.2A CN201610197438A CN105853637A CN 105853637 A CN105853637 A CN 105853637A CN 201610197438 A CN201610197438 A CN 201610197438A CN 105853637 A CN105853637 A CN 105853637A
Authority
CN
China
Prior art keywords
herba
crude drug
parts
drug quality
minute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610197438.2A
Other languages
Chinese (zh)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Han Changying
Original Assignee
Han Changying
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Han Changying filed Critical Han Changying
Priority to CN201610197438.2A priority Critical patent/CN105853637A/en
Publication of CN105853637A publication Critical patent/CN105853637A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention discloses a traditional Chinese medicine composition with the synergetic effect on radiotherapy and chemotherapy. The traditional Chinese medicine composition mainly comprises the following raw materials in mass part: 10-18 parts of bighead atractylodes rhizome, 9-14 parts of pyrola, 8-16 parts of the herb of birdsfoot deervetch, 5-10 parts of Galium aparine, 6-12 parts of scutellaria indica, 4-10 parts of averrhoa carambola L.root, 7-11 parts of pinellia cordata, 4-8 parts of the herb of shady groundsel, 3-6 parts of Lamium amplexicaule, 5-9 parts of bergamot, 6-10 parts of flabelate maiden hair herb, 4-9 parts of Kerria japonica, 5-12 parts of clematis glauca willd and 2-8 parts of the root of Spiraea salicifolia L. The traditional Chinese medicine composition is scientific in formula, synergistic in effect and good in synergism, which is capable of clearing away heat, removing toxicity, tonifying qi and relieving pain. Meanwhile, the recurrence is effectively prevented.

Description

Chemicotherapy is had Chinese medicine composition and the preparation method of potentiation
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition that chemicotherapy is had potentiation And preparation method.
Background technology
Hepatocarcinoma i.e. liver malignancy, Characters of Primary Malignant Tumors of Liver originates from epithelium or the mesenchymal tissue of liver, the former It is referred to as primary hepatocarcinoma, is that China is occurred frequently, very harmful malignant tumor；The latter is referred to as sarcoma, compared with primary hepatocarcinoma The most rare.Secondary cases or the malignant tumor claiming secondary liver cancer to mean that the multiple organ of whole body originates from are invaded to liver.Typically It is more common in the hepatic metastases of the organ malignant tumours such as stomach, biliary tract, pancreas, Colon and rectum, ovary, uterus, lung, mammary gland.Primary hepatocarcinoma In early days often symptom is without specificity, and the symptom of mid and late liver cancer is the most more, common clinical manifestation have hepatalgia, abdominal distention, poor appetite, Weak, become thin, Progressive symmetric erythrokeratodermia hepatomegaly or epigastrium enclosed mass etc.；Some patients has low grade fever, jaundice, diarrhoea, upper gastrointestinal hemorrhage；Hepatocarcinoma Acute abdomen performance etc. occurs after rupturing, also has symptom inconspicuous or be showed only as the symptom of metastasis.Chemotherapy is oncotherapy Conventional means, chemotherapeutic can act in the different links of cell growth and breeding, suppresses or kills tumor cell, thus reach to control The purpose treated.But overwhelming majority chemotherapeutics is " failing to differentiate between the enemy and ourselves " for patient's body, while killing cancerous cell, also Damage the normal cell of body, particularly those metabolism cell faster to some extent, mostly can cause complete after treatment , there is many untoward reaction in body symptom and various damage.
Publication No. CN 104274765 A(application number 201310291438.5) Chinese patent literature disclose a kind of right Chemotherapy of tumors has the Chinese medicine composition of attenuation synergistic, and its active component is made up of the raw material of following parts by weight: the Radix Astragali 678 Part, Radix Angelicae Sinensis 226 parts, Herba Solani Lyrati 678 parts, Herba Solani Nigri 678 parts, Radix Salviae Miltiorrhizae 226 parts, Herba Scutellariae Barbatae 678 parts, Herba Duchesneae Indicae 339 parts, Radix Curcumae 226 parts.Publication No. CN 104606580 A(application number 201510008540.9) Chinese patent literature disclose a kind of to change Treat and there is Chinese medicine preparation and the preparation method of potentiation, take off and state the primary raw material medicine of weight proportion and be prepared from: Radix Astragali 15- 25, Semen Coicis 12-20, Herba Galii Teneri 10-20, Rhizoma Polygonati 9-15, Rhizoma Chuanxiong 8-16, Herba Cirrohopetali Andersonii 8-12, Fructus Trichosanthis 6-15, Hericium erinaceus (Bull. Ex Fr.) Pers. 8-16, in vain Serpentis SHECAO 6-9, great Ye Rhizoma Curculiginis 10-15, Herba Typhonii gigantei 10-15, Radix Glycyrrhizae 9-12, cirsii japonici,radix 9-15.Publication No. CN 105148229 A(application number 201510573329.1) Chinese patent literature disclose a kind of chemotherapy of gastric cancer and combine with Chinese medicine efficacy enhancing and toxicity reducing side, Medicine form: Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Poria, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Amomi, Herba Pogostemonis, Colla Corii Asini, Folium Perillae, Rhizoma Coptidis, Caulis Spatholobi, Rhizoma Dioscoreae, raw Semen Coicis, Rhizoma Zingiberis Recens, Radix Ranunculi Ternati, Herba Salviae Chinensis, Gekko Swinhonis, Pseudobulbus Cremastrae Seu Pleiones.
Medically commonly use chemicotherapy means treatment hepatocarcinoma, typically can produce toxic and side effects, affect the quality of life of patient, for Improve standing state, the research to prescription face can be strengthened, to reach to improve curative effect, reduce untoward reaction, improve survival of patients Time and the purpose of quality.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide that a kind of curative effect is reliable, take safe to chemicotherapy There is Chinese medicine composition and the preparation method of potentiation.
The technical scheme is that
Chemicotherapy is had the Chinese medicine composition of potentiation, is mainly prepared from by following bulk drugs, be mass parts: the Rhizoma Atractylodis Macrocephalae 10-18, Herba Pyrolae 9-14, Herba Loti Corniculati 8-16, Herba Galii Teneri 5-10, Herba Scutellariae indicae 6-12, Radix Averrhoae Carambolae 4-10, Rhizoma pinelliae cordatae 7-11, Herba senecionis nemorensis 4-8, Herba Lamii Amplexicaulis 3-6, Fructus Citri Sarcodactylis 5-9, Herba Adianti Flabellulati 6-10, Flos kerriae japonicae 4-9, Herba Clematidis Glaucae 5-12, Radix spiraeae japonicae 2-8.
Preferred version is, Rhizoma Atractylodis Macrocephalae 12-16, Herba Pyrolae 10-13, Herba Loti Corniculati 10-14, Herba Galii Teneri 6-9, Herba Scutellariae indicae 8-10, sun Radix Persicae 6-8, Rhizoma pinelliae cordatae 8-10, Herba senecionis nemorensis 5-7, Herba Lamii Amplexicaulis 4-5, Fructus Citri Sarcodactylis 6-8, Herba Adianti Flabellulati 7-9, Flos kerriae japonicae 5-8, Herba Clematidis Glaucae 7- 10, Radix spiraeae japonicae 4-6.
It is more preferable that the Rhizoma Atractylodis Macrocephalae 14, Herba Pyrolae 11.5, Herba Loti Corniculati 12, Herba Galii Teneri 7.5, Herba Scutellariae indicae 9, Radix Averrhoae Carambolae 7, drip The globule 9, Herba senecionis nemorensis 6, Herba Lamii Amplexicaulis 4.5, Fructus Citri Sarcodactylis 7, Herba Adianti Flabellulati 8, Flos kerriae japonicae 6.5, Herba Clematidis Glaucae 8.5, Radix spiraeae japonicae 5.
The preparation method of the soft extract of described Chinese medicine composition, step is as follows:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, and constant temperature drying is made with step (1) Crude drug is pulverized together, makes medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, adds rice vinegar and mixes 10 minutes, continues to be heated to being dried；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add boiled crude drug quality 5-7 times Soak by water (preferably: add the soak by water of boiled crude drug quality 6 times), big fire is boiled, and continues 20-40 minute (preferably: hold Continuous 25-35 minute；More preferably: continue 30 minutes), filtrate is collected by filtration；
(5) being mixed with step (4) gained filtrate by step (2) made raw material, big fire is boiled again, filtered while hot, collects filtrate, This filtrate of concentrating under reduced pressure, to thick paste, obtains soft extract.
The preparation method of described Chinese medicine composition soft extract, step (3) adds the 0.6-1 that rice vinegar amount is crude drug quality Again (preferably: addition rice vinegar amount is 0.8 times of crude drug quality).
The preparation method of the pill of described Chinese medicine composition, step is as follows:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, and constant temperature drying is made with step (1) Crude drug is pulverized together, makes medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, and the rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to doing Dry；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add boiled crude drug quality 5-7 times Soak by water (preferably: add the soak by water of boiled crude drug quality 6 times), big fire is boiled, and continues 20-40 minute (preferably: hold Continuous 25-35 minute；More preferably: continue 30 minutes), filtrate is collected by filtration；
(5) spray drying step (4) gained filtrate, pulverizes again, and mixes with step (2) made medicated powder, adds refined honey water general Make ball, be dried, packaging, obtain pill.
The preparation method of described Chinese medicine composition pill, the weight of step (5) every pill is that 2-4g(is preferred: every The weight of grain pill is 2.5-3.5g；More preferably: the weight of every pill is 3g).
The preparation method of the decoction of described Chinese medicine composition, step is as follows:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, and constant temperature drying is made with step (1) Crude drug is pulverized together, makes medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, and the rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to doing Dry；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae being mixed with step (3) made crude drug, boiling, big fire is boiled, and turns little fire Continue to decoct 20-30 minute (preferably: continue to decoct 23-27 minute；More preferably: continue to decoct 25 minutes), filter and receive Collection filtrate；
(5) step (2) (4) gained medicated powder and filtrate are mixed, heated and boiled again, continue 10 minutes, filtering and collecting filter liquid, Obtain decoction.
The preparation method of described Chinese medicine composition decoction, step (4) amount of water is 6-9 times of boiled crude drug quality (preferably: amount of water is 7-8 times of boiled crude drug quality；More preferably: amount of water is the 7.5 of boiled crude drug quality Times).
The preparation method of the powder of described Chinese medicine composition, step is as follows:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, constant temperature drying；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, and the rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to doing Dry；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (1) (2) (3) made crude drug, add boiled crude drug quality The soak by water (preferably: add the soak by water of boiled crude drug quality 4 times) of 3-5 times, big fire is boiled, and lasting 20-40 minute (excellent Choosing: continue 25-35 minute；More preferably: continue 30 minutes), filtrate is collected by filtration；
(5) step (4) gained filtrate is spray-dried, then pulverizes and sieves, make medicated powder, obtain powder.
The preparation method of described Chinese medicine composition composition powders, step (5) pulverized 80-160 mesh sieve (preferably: pulverized 100-140 mesh sieve；More preferably: pulverized 120 mesh sieves).
The Chinese medicine composition not only scientific formula that chemicotherapy is had potentiation that the present invention provides, and preparation method letter Single, product taking convenience.In addition, the excellent results of the present invention is also manifested by:
1, good effect of the present invention, can effectively prevent recurrence, and untoward reaction is few；
2, this prescription complies fully with Chinese medicine principle, has the effect such as heat-clearing and toxic substances removing, QI invigorating pain relieving；
3, medical material selected by the present invention has no side effect safely, can long-term taking, strengthen patient body immunity.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1 has the Chinese medicine composition of potentiation to chemicotherapy, is mainly prepared from (every by following bulk drugs Part 10g): the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Pyrolae 9 parts, Herba Loti Corniculati 8 parts, Herba Galii Teneri 5 parts, Herba Scutellariae indicae 6 parts, Radix Averrhoae Carambolae 4 parts, Rhizoma pinelliae cordatae 7 parts, Herba senecionis nemorensis 4 parts, Herba Lamii Amplexicaulis 3 parts, Fructus Citri Sarcodactylis 5 parts, Herba Adianti Flabellulati 6 parts, Flos kerriae japonicae 4 parts, Herba Clematidis Glaucae 5 parts, Radix spiraeae japonicae 2 parts.Above-mentioned right The preparation method of the Chinese medicine composition soft extract that chemicotherapy has potentiation is:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, add the Sal mix homogeneously of crude drug quality 0.3 times, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 30 minutes, take Go out to rub broken, constant temperature drying, pulverize together with step (1) made crude drug, make medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 9 minutes, and taking-up is smashed to pieces, The rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to being dried；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add the water of boiled crude drug quality 6 times Decocting, big fire is boiled, and continues 30 minutes, filtrate is collected by filtration；
(5) being mixed with step (4) gained filtrate by step (2) made raw material, big fire is boiled again, filtered while hot, collects filtrate, This filtrate of concentrating under reduced pressure, to thick paste, obtains soft extract.
Embodiment 2 has the Chinese medicine composition of potentiation to chemicotherapy, is mainly prepared from (every by following bulk drugs Part 10g): the Rhizoma Atractylodis Macrocephalae 18 parts, Herba Pyrolae 14 parts, Herba Loti Corniculati 16 parts, Herba Galii Teneri 10 parts, Herba Scutellariae indicae 12 parts, Radix Averrhoae Carambolae 10 parts, Rhizoma pinelliae cordatae 11 parts, Herba senecionis nemorensis 8 parts, Herba Lamii Amplexicaulis 6 parts, Fructus Citri Sarcodactylis 9 parts, Herba Adianti Flabellulati 10 parts, Flos kerriae japonicae 9 parts, Herba Clematidis Glaucae 12 parts, Radix spiraeae japonicae 8 parts. The preparation method of the Chinese medicine composition pill to chemicotherapy with potentiation is:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, add the Sal mix homogeneously of crude drug quality 0.3 times, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 30 minutes, take Go out to rub broken, constant temperature drying, pulverize together with step (1) made crude drug, make medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 9 minutes, and taking-up is smashed to pieces, The rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to being dried；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add the water of boiled crude drug quality 6 times Decocting, big fire is boiled, and continues 30 minutes, filtrate is collected by filtration；
(5) spray drying step (4) gained filtrate, pulverizes again, and mixes with step (2) made medicated powder, adds refined honey water general Make ball, be dried, packaging, obtain pill, the weight of every pill is 3g.
Model case: xxx, female, 51 years old.Main suit: epigastrium swells and ache, body weight is decreased obviously；Medical history: nearly three months of patient, Often stomachache occur without obvious inducement, and appetite declines, stature is gradually become thin, and is admitted to hospital and is checked, and CT shows that there is lump in liver, Being diagnosed as hepatocarcinoma, use excision, after half a year, disease relapse and diffusion, patient accepts chemotherapy.
In therapeutic process, patient takes the present embodiment gained simultaneously and has the Chinese medicine composition ball of potentiation to chemicotherapy Agent, every day 2 times, each 2-3 grain, warm boiled water, 20 days courses for the treatment of.After patient takes a course for the treatment of, uncomfortable disease gradually disappears Moving back, spirit takes a turn for the better, and after adhering to taking three courses for the treatment of, focus disappears substantially, and body weight increased, and continues to strengthen a course for the treatment of, suffers from Person's self-induction is fully recovered, and follows up a case by regular visits in 1 year, and the state of an illness does not recurs.
Embodiment 3 has the Chinese medicine composition of potentiation to chemicotherapy, is mainly prepared from (every by following bulk drugs Part 10g): the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Pyrolae 10 parts, Herba Loti Corniculati 10 parts, Herba Galii Teneri 6 parts, Herba Scutellariae indicae 8 parts, Radix Averrhoae Carambolae 6 parts, Rhizoma pinelliae cordatae 8 Part, Herba senecionis nemorensis 5 parts, Herba Lamii Amplexicaulis 4 parts, Fructus Citri Sarcodactylis 6 parts, Herba Adianti Flabellulati 7 parts, Flos kerriae japonicae 5 parts, Herba Clematidis Glaucae 7 parts, Radix spiraeae japonicae 4 parts.To putting The preparation method of the Chinese medicine composition decoction that chemotherapy has potentiation is:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, add the Sal mix homogeneously of crude drug quality 0.3 times, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 30 minutes, take Go out to rub broken, constant temperature drying, pulverize together with step (1) made crude drug, make medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 9 minutes, and taking-up is smashed to pieces, The rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to being dried；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add boiled crude drug quality 7.5 times Soak by water, big fire is boiled, and turns little fire and continues to decoct 25 minutes, filtrate is collected by filtration；
(5) step (2) (4) gained medicated powder and filtrate are mixed, heated and boiled again, continue 10 minutes, filtering and collecting filter liquid, Obtain decoction.
Model case: xxx, man, 60 years old.Medical history: near the most over the past half year, patient self-induction liver dull pain, health is weak, and spirit is relatively Difference, weight loss, inappetence, once took many medicines, the state of an illness is not improved, after enter examination in hospital, show through CT, be diagnosed as former Diagnosis, uses the treatment of radiotherapy means, untoward reaction such as feeling sick, dizzy, body constitution is decreased obviously occurs.
Recommend to take the present embodiment gained through people and chemicotherapy is had the Chinese medicine composition decoction of potentiation, use every day 2 times, each 150-250ml, warm takes, 20 days courses for the treatment of.After patient takes two courses for the treatment of, hepatalgia alleviates, appetite Increasing, muscle power is basic to be recovered, and after continuing to take three courses for the treatment of, uncomfortable disease all disappears, and CT checks, and focus disappears substantially, does not expands Dissipating, follow up a case by regular visits in 1 year, the state of an illness does not recurs.
Embodiment 4 has the Chinese medicine composition of potentiation to chemicotherapy, is mainly prepared from (every by following bulk drugs Part 10g): the Rhizoma Atractylodis Macrocephalae 16 parts, Herba Pyrolae 13 parts, Herba Loti Corniculati 14 parts, Herba Galii Teneri 9 parts, Herba Scutellariae indicae 10 parts, Radix Averrhoae Carambolae 8 parts, Rhizoma pinelliae cordatae 10 Part, Herba senecionis nemorensis 7 parts, Herba Lamii Amplexicaulis 5 parts, Fructus Citri Sarcodactylis 8 parts, Herba Adianti Flabellulati 9 parts, Flos kerriae japonicae 8 parts, Herba Clematidis Glaucae 10 parts, Radix spiraeae japonicae 6 parts.Right The preparation method of the Chinese medicine composition composition powders that chemicotherapy has potentiation is:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, add the Sal mix homogeneously of crude drug quality 0.3 times, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 30 minutes, take Go out to rub broken, constant temperature drying；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 9 minutes, and taking-up is smashed to pieces, The rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to being dried；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (1) (2) (3) made crude drug, add boiled crude drug quality 4 Soak by water again, big fire is boiled, and continues 30 minutes, filtrate is collected by filtration；
(5) step (4) gained filtrate is spray-dried, then pulverized 120 mesh sieves, make medicated powder, obtain powder.
Model case: xxx, man, 48 years old.Medical history: patient Zeng get has chronic cirrhosis, often has stomachache, abdominal distention, body void weak Etc. symptom, long-time by the alleviation state of an illness of taking medicine, nearly one month, self-induction aggravation, lethargy, body weight was remarkably decreased, and is admitted to hospital Check, hepatic region lobus sinister Visible lumps, be diagnosed as hepatocarcinoma.
Patient accepts chemotherapy and takes the present embodiment gained and have the Chinese medicine composition composition powders of potentiation to chemicotherapy, adopts With every day 2 times, each 4-6g, with warm boiled water, 20 days courses for the treatment of.After patient takes two courses for the treatment of, hepatic region swells and ache, abdominal distention The symptom such as weak alleviates, and after taking five courses for the treatment of, uncomfortable disease substantially eliminates, and further consultation liver function index part is recovered, and lump is basic Disappear, consolidate drug withdrawal after the course for the treatment of, follow up a case by regular visits in two years, patient orthobiosis.
Embodiment 5 has the Chinese medicine composition of potentiation to chemicotherapy, is mainly prepared from (every by following bulk drugs Part 10g): the Rhizoma Atractylodis Macrocephalae 14 parts, Herba Pyrolae 11.5 parts, Herba Loti Corniculati 12 parts, Herba Galii Teneri 7.5 parts, Herba Scutellariae indicae 9 parts, Radix Averrhoae Carambolae 7 parts, drip 9 parts of pearl, Herba senecionis nemorensis 6 parts, Herba Lamii Amplexicaulis 4.5 parts, Fructus Citri Sarcodactylis 7 parts, Herba Adianti Flabellulati 8 parts, Flos kerriae japonicae 6.5 parts, Herba Clematidis Glaucae 8.5 parts, Ramulus et Folium Spiraeae Salicifolia Root 5 parts.The preparation method of the Chinese medicine composition soft extract to chemicotherapy with potentiation is:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, add the Sal mix homogeneously of crude drug quality 0.3 times, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 30 minutes, take Go out to rub broken, constant temperature drying, pulverize together with step (1) made crude drug, make medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 9 minutes, and taking-up is smashed to pieces, The rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to being dried；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add the water of boiled crude drug quality 6 times Decocting, big fire is boiled, and continues 30 minutes, filtrate is collected by filtration；
(5) being mixed with step (4) gained filtrate by step (2) made raw material, big fire is boiled again, filtered while hot, collects filtrate, This filtrate of concentrating under reduced pressure, to thick paste, obtains soft extract.
Used by the present invention, the pharmacology of main raw material of Chinese medicine is as follows:
The Rhizoma Atractylodis Macrocephalae: base: for the rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Nature and flavor: bitter in the mouth；Sweet；Warm in nature.Gui Jing: return spleen；Stomach warp.Function cures mainly: Invigorating the spleen and benefiting QI；Dampness diuretic；Hidroschesis；Antiabortive.Main deficiency-weakness of spleen-QI；Spiritlessness and weakness；Lack of appetite abdominal distention；Big loose stool is thin；Fluid-retention stagnating in the interior；Little The most unfavorable；Edema；Dizziness due to fluid-retention；Temperature numbness is ached；Spontaneous sweating due to deficiency of QI；Frequent fetal movement.
Herba Pyrolae: base: for Pyrolaceae plant traditional embankment, Herba pyrolae japonicae, pyrola japonicaKlenze ex Alef, Herba Pyrolae incarnatae complete Grass.Nature and flavor: sweet；Bitter；Warm in nature.Gui Jing: liver；Kidney channel.Function cures mainly: the kidney invigorating bone strengthening；Expelling wind and removing dampness；Cough-relieving；Hemostasis.Main waist of suffering from a deficiency of the kidney Bitterly；Rheumatic arthralgia；Muscles and bones flaccidity is soft；New chronic cough is coughed；Spit blood；Epistaxis；Metrorrhagia；Traumatic hemorrhage.
Herba Loti Corniculati: base: for herb and the flower of leguminous plant Radix Loti Corniculati.Chemical analysis: herb contains Kaempferol, 7-bis-Mus Lee's glucoside, violaxanthin, epoxy phylloxanthin, linamarin.Nature and flavor: sweet；Micro-hardship；Cool.Gui Jing: lung；Stomach warp.Function cures mainly: heat clearing away Removing toxic substances；Relieving cough and asthma；Dampness removing disappears painful abdominal mass.Main air heat cough；Laryngopharynx swelling and pain；Gastral cavilty feeling of fullness pain；Furuncle；Innominate toxic swelling；Eczema；Dysentery Disease；Hemorrhoidal hemorrhage.
Herba Galii Teneri: base: Rubiaceae clivers Herba Galii Teneri, with all herbal medicine.Nature and flavor: pungent, bitter are cool.Function master Control: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Flu, gingival hemorrhage, acute and chronic appendicitis, urinary system infection, edema, dysmenorrhea, metrorrhagia, in vain Band, cancer, leukemia；External controls mastitis from the beginning of, carbuncle furuncle and phyma poison, traumatic injury.
Herba Scutellariae indicae: base: for the whole herb with root of labiate Herba Scutellariae indicae.Chemical analysis: herb is containing flavone such as baicalins Class, phenolic constituent, aminoacid, organic acid.Nature and flavor: arduous are flat.Gui Jing: " Quanzhou book on Chinese herbal medicine ": " enter the heart, liver, lung three warp." function Cure mainly: dispel the wind, invigorate blood circulation, removing toxic substances, pain relieving.Control traumatic injury, spit blood, hemoptysis, carbuncle, furunculosis, acute throat trouble, toothache.
Radix Averrhoae Carambolae: base: for root or the root bark of Oxalidaceae plant Fructus Averrhoae Carambolae.Nature and flavor: sour in the mouth；Puckery；Property flat.Gui Jing: bladder； Kidney channel.Function cures mainly: expelling wind and removing dampness；Promoting the circulation of QI to relieve pain；Relieving leukorrhea by astringents.Main air pain of dampness syndrome；Joint wind；Paralysis is slow unsuccessful；Chronic wind syndrome of head； Heart peratodynia；Seminal emission；Leucorrhea.
Rhizoma pinelliae cordatae: base: for the tuber of the aroid lobus cardiacus Rhizoma Pinelliae.Nature and flavor: " Jiangxi medical herbs ": " warm in nature, acrid in the mouth, Slightly poisonous." function cures mainly: pain relieving, clots absorbing, detumescence, removing toxic substances.Control headache, stomachache, stomachache, lumbago, traumatic injury, acute mastitis, swollen Poison.
Herba senecionis nemorensis: base: for the herb of feverfew wood groundsel.Nature and flavor: bitter in the mouth；Pungent；Cold in nature.Function cures mainly: heat clearing away Removing toxic substances.Main dysentery；Enteritis；Hepatitis；Conjunctivitis；Otitis media；Carbuncle treats poison.
Herba Lamii Amplexicaulis: base: for the herb of labiate Herba Lamii Amplexicaulis.Nature and flavor: acrid in the mouth；Bitter；Slightly warm in nature.Function cures mainly: live Blood dredging collateral；Removing toxic substances and promoting subsidence of swelling.Main traumatic injury；Bones and muscles pain；Numb limbs and tense tendons；Hemiplegia；Face is completed；Jaundice；Nasal sinusitis；Scrofula；Swollen Poison；Impetigo.
Fructus Citri Sarcodactylis: base: for the fruit of rutaceae Fructus Citri Sarcodactylis.Chemical analysis: containing citropten. in dry fruit 0.007%；The also daflon containing trace and hesperidin.Nature and flavor: arduous acid, temperature.Gui Jing: enter liver, stomach warp.Function cures mainly: reason Gas, reduces phlegm.Treat for stomachache, coerce swollen, vomiting, dysphagic, phlegm retention cough with asthma, and can relieve the effect of alcohol.
Herba Adianti Flabellulati: base: for herb or the rhizome of adiantaceae plant flabellum venushair fern.Chemical analysis: herb contains flavone Glycoside, organic acid, aminoacid, phenols and saccharide.Nature and flavor: toil are cool.Function cures mainly: heat clearing away, dampness removing, repercussive, dissipates swollen.Control acute Infectious hepatitis, dysentery, diarrhoea, sand Stranguria, spit blood, have blood in stool, scrofula, traumatic injury, scald, traumatic hemorrhage, furuncle.
Flos kerriae japonicae: base: for flower or the branch and leaf of rosaceous plant kerria.Chemical analysis: flower pigment Han waxiness, is Radix Inulae Brain, lutein dipalmitate, the mixture of xanthophyll-oil acid esters.Leaf contains vitamin C _ 100～200 milligrams of %.Separately there is meaning kerria Chinese bush cherry contains linariin.Nature and flavor: bitter, puckery；Flat.Gui Jing: lung；Stomach；Spleen channel.Function cures mainly: preventing phlegm from forming and stopping coughing；Inducing diuresis to remove edema；Removing toxic substances.Main Cough, rheumatic arthralgia, puerperal impairment caused by overstrain pain, edema, dysuria, dyspepsia, swollen ulcer drug, eczema, urticaria.
Herba Clematidis Glaucae: base: for the herb of ranunculaceae plant clematis glauca.Nature and flavor: pungent；Temperature；Mild toxicity.Gui Jing: the heart；Stomach Warp.Function cures mainly: expelling wind and removing dampness, detoxicating and resolving stagnation of pathogens；Dispelling wind is antipruritic.Main rheumatic arthralgia；Enteritis；Dysentery；Carbuncle furuncle；Skin Pruritus；Snake bite and insect sting.
Radix spiraeae japonicae: base: for rosaceous plant pink blossom Ramulus et Folium Spiraeae Salicifolia or the root of light leaf Ramulus et Folium Spiraeae Salicifolia.Nature and flavor: bitter, pungent；Cool；Nothing Poison.Gui Jing: lung；Liver Channel.Function cures mainly: expelling wind and clearing away heat, improving acuity of vision and removing nebula.Main cough, headache, toothache, cataract.
Test example 1 gained of the present invention has a clinical practice of the Chinese medicine composition (embodiment 5) of potentiation to chemicotherapy:
Choose crowd: in October, 2014 in December ,-2015, according to medical case history, the liver cancer patient that screening is accepted for medical treatment in four hospitals 275 examples, age 38-65 year, 57.5 ± 0.8 years old mean age, the course of disease 1 month-8 months, wherein male patient 154 example, women Patient 121 example.All patients all make a definite diagnosis through the imaging examinations such as CT and pathological examination, it is contemplated that life span is more than 3 months, blood Liquid and health can accept chemicotherapy, and reception test voluntarily, and by regulation medication treatment.
Before test, patient being randomly divided into two groups, experimental group 150 example and matched group 125 example, two groups in sex, age, disease The aspect such as journey, the state of an illness is without significant difference.Matched group takes merely conventional chemotherapy method to treat, experimental group on the basis of chemotherapy, Taking products obtained therefrom of the present invention, each 6-8g, once a day, warm boiled water, 20 days is a course for the treatment of.To two groups during treatment Patient carries out Continuous Observation, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, 1. complete incidence graph (CR): cases of complete remission, continue 4 weeks with On.2. part alleviates (PR): tumor regression more than 50%, continues more than 4 weeks, occurs without new pathological changes.3. stable (NC): swollen Tumor reduces less than 50% or increases within 25%, continues more than 4 weeks, occurs without new pathological changes.4. (PD) is deteriorated: tumor increases More than 25%, or have new pathological changes to occur.Effective percentage=(CR+ PR)/total number of cases * 100%.
Clinical effectiveness: after the treatment of five courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
The therapeutic outcome of 1 liang of table group
As shown in Table 1, the complete incidence graph example of experimental group is 41 examples, and accounting for percentage ratio is 27.3%, and effective percentage is 78.6%, and matched group Complete incidence graph example be 26 examples, accounting for percentage ratio is 20.8%, and effective percentage is 54.4%, illustrates that products obtained therefrom of the present invention can be effectively increased The curative effect of chemicotherapy, improves life in patients.
After treatment, recurrence and the mean survival time of two groups are as shown in table 2:
As shown in Table 2, experimental group relatively matched group is compared, and relapse rate is low, and life span is long, and products obtained therefrom of the present invention can effectively reduce The relapse rate of patient, improves the survival of patients time.
Chinese medicine used in the present invention, the Rhizoma Atractylodis Macrocephalae can invigorating the spleen and benefiting QI, Herba Pyrolae can the kidney invigorating bone strengthening, Herba Loti Corniculati, Herba senecionis nemorensis can be clear Thermal detoxification, Herba Galii Teneri, Flos kerriae japonicae can inducing diuresis to remove edema, Herba Scutellariae indicae can promoting blood circulation and stopping pain, Radix Averrhoae Carambolae can promoting the circulation of QI to relieve pain, Rhizoma pinelliae cordatae can clots absorbing Detumescence, Herba Lamii Amplexicaulis can promoting blood circulation to remove obstruction in the collateral, Fructus Citri Sarcodactylis can activating QI to eliminate phlegm, Herba Adianti Flabellulati can clearing away heat-damp and promoting diuresis, Herba Clematidis Glaucae can detoxicating and resolving stagnation of pathogens, embroider line Radix Chrysanthemi can expelling wind and clearing away heat, multiple medical material synergism, play heat-clearing and toxic substances removing, effect of QI invigorating pain relieving altogether, control cancerous cell diffusion, carry High immunologic function.
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that the skill of the present invention Art scheme is not limited to above-described embodiment, it is also possible to have many variations.Those of ordinary skill in the art, the most public with present invention institute What what that open or according to file written description was undoubted obtained, all it is considered as this patent scope of the claimed.

Claims (10)

1. pair chemicotherapy has the Chinese medicine composition of potentiation, it is characterised in that be mainly prepared from by following bulk drugs, all For mass parts: Rhizoma Atractylodis Macrocephalae 10-18, Herba Pyrolae 9-14, Herba Loti Corniculati 8-16, Herba Galii Teneri 5-10, Herba Scutellariae indicae 6-12, Radix Averrhoae Carambolae 4-10, drip Globule 7-11, Herba senecionis nemorensis 4-8, Herba Lamii Amplexicaulis 3-6, Fructus Citri Sarcodactylis 5-9, Herba Adianti Flabellulati 6-10, Flos kerriae japonicae 4-9, Herba Clematidis Glaucae 5-12, Radix spiraeae japonicae 2-8。
2. the Chinese medicine composition that chemicotherapy is had potentiation as claimed in claim 1, it is characterised in that Rhizoma Atractylodis Macrocephalae 12-16, Herba Pyrolae 10-13, Herba Loti Corniculati 10-14, Herba Galii Teneri 6-9, Herba Scutellariae indicae 8-10, Radix Averrhoae Carambolae 6-8, Rhizoma pinelliae cordatae 8-10, Herba senecionis nemorensis 5-7, precious Cover grass 4-5, Fructus Citri Sarcodactylis 6-8, Herba Adianti Flabellulati 7-9, Flos kerriae japonicae 5-8, Herba Clematidis Glaucae 7-10, Radix spiraeae japonicae 4-6(preferably: the Rhizoma Atractylodis Macrocephalae 14, Herba Pyrolae 11.5, Herba Loti Corniculati 12, Herba Galii Teneri 7.5, Herba Scutellariae indicae 9, Radix Averrhoae Carambolae 7, Rhizoma pinelliae cordatae 9, Herba senecionis nemorensis 6, Herba Lamii Amplexicaulis 4.5, Fructus Citri Sarcodactylis 7, Herba Adianti Flabellulati 8, Flos kerriae japonicae 6.5, Herba Clematidis Glaucae 8.5, Radix spiraeae japonicae 5).
3. the preparation method of the soft extract of the Chinese medicine composition as described in claim 1-2 is arbitrary, it is characterised in that step is such as Under:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, and constant temperature drying is made with step (1) Crude drug is pulverized together, makes medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, adds rice vinegar and mixes 10 minutes, continues to be heated to being dried；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add boiled crude drug quality 5-7 times Soak by water (preferably: add the soak by water of boiled crude drug quality 6 times), big fire is boiled, and continues 20-40 minute (preferably: hold Continuous 25-35 minute；More preferably: continue 30 minutes), filtrate is collected by filtration；
(5) being mixed with step (4) gained filtrate by step (2) made raw material, big fire is boiled again, filtered while hot, collects filtrate, This filtrate of concentrating under reduced pressure, to thick paste, obtains soft extract.
4. the preparation method of Chinese medicine composition soft extract as claimed in claim 3, it is characterised in that step (3) adds rice vinegar 0.6-1 times (preferably: addition rice vinegar amount is 0.8 times of crude drug quality) that amount is crude drug quality.
5. the preparation method of the pill of the Chinese medicine composition as described in claim 1-2 is arbitrary, it is characterised in that step is as follows:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, and constant temperature drying is made with step (1) Crude drug is pulverized together, makes medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, and the rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to doing Dry；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (3) made crude drug, add boiled crude drug quality 5-7 times Soak by water (preferably: add the soak by water of boiled crude drug quality 6 times), big fire is boiled, and continues 20-40 minute (preferably: hold Continuous 25-35 minute；More preferably: continue 30 minutes), filtrate is collected by filtration；
(5) spray drying step (4) gained filtrate, pulverizes again, and mixes with step (2) made medicated powder, adds refined honey water general Make ball, be dried, packaging, obtain pill.
6. the preparation method of Chinese medicine composition pill as claimed in claim 5, it is characterised in that step (5) every pill Weight is that 2-4g(is preferred: the weight of every pill is 2.5-3.5g；More preferably: the weight of every pill is 3g).
7. the preparation method of the decoction of the Chinese medicine composition as described in claim 1-2 is arbitrary, it is characterised in that step is as follows:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, and constant temperature drying is made with step (1) Crude drug is pulverized together, makes medicated powder；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, and the rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to doing Dry；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae being mixed with step (3) made crude drug, boiling, big fire is boiled, and turns little fire Continue to decoct 20-30 minute (preferably: continue to decoct 23-27 minute；More preferably: continue to decoct 25 minutes), filter and receive Collection filtrate；
(5) step (2) (4) gained medicated powder and filtrate are mixed, heated and boiled again, continue 10 minutes, filtering and collecting filter liquid, Obtain decoction.
8. the preparation method of Chinese medicine composition decoction as claimed in claim 7, it is characterised in that step (4) amount of water is institute Boil 6-9 times of crude drug quality (preferably: amount of water is 7-8 times of boiled crude drug quality；More preferably: amount of water is 7.5 times of boiled crude drug quality).
9. the preparation method of the powder of the Chinese medicine composition as described in claim 1-2 is arbitrary, it is characterised in that step is as follows:
(1) taking the Rhizoma Atractylodis Macrocephalae, Radix Averrhoae Carambolae, Rhizoma pinelliae cordatae and Radix spiraeae japonicae to clean, be placed in steamer, the water adding crude drug quality 1 times steams Dry, take out chopping, the Sal (preferably: add the Sal of crude drug quality 0.3 times) adding crude drug quality 0.2-0.4 times is mixed Closing uniformly, at 60 DEG C, low temperature stir-fries to being dried, and takes out；
(2) Herba Pyrolae, Herba Loti Corniculati, Herba Galii Teneri and Flos kerriae japonicae are removed impurity, spray hydromel to uniformly, moistening 25-35 minute (preferably: moistening 28-32 minute；More preferably: moistening 30 minutes), taking-up is rubbed broken, constant temperature drying；
(3) taking Herba Scutellariae indicae, Fructus Citri Sarcodactylis and Herba Adianti Flabellulati and clean remove impurity, be placed in parch container, moderate heat stir-fries 6-12 minute (preferably : moderate heat stir-fries 9 minutes), taking-up is smashed to pieces, and the rice vinegar adding crude drug quality 0.8 times mixes 10 minutes, continues to be heated to doing Dry；
(4) Herba senecionis nemorensis, Herba Lamii Amplexicaulis and Herba Clematidis Glaucae are mixed with step (1) (2) (3) made crude drug, add boiled crude drug quality The soak by water (preferably: add the soak by water of boiled crude drug quality 4 times) of 3-5 times, big fire is boiled, and lasting 20-40 minute (excellent Choosing: continue 25-35 minute；More preferably: continue 30 minutes), filtrate is collected by filtration；
(5) step (4) gained filtrate is spray-dried, then pulverizes and sieves, make medicated powder, obtain powder.
10. the preparation method of Chinese medicine composition composition powders as claimed in claim 9, it is characterised in that step (5) pulverized 80- 160 mesh sieves are (preferably: pulverized 100-140 mesh sieve；More preferably: pulverized 120 mesh sieves).
CN201610197438.2A 2016-03-31 2016-03-31 Traditional Chinese medicine composition with synergetic effect on radiotherapy and chemotherapy, and preparation method thereof Withdrawn CN105853637A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610197438.2A CN105853637A (en) 2016-03-31 2016-03-31 Traditional Chinese medicine composition with synergetic effect on radiotherapy and chemotherapy, and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610197438.2A CN105853637A (en) 2016-03-31 2016-03-31 Traditional Chinese medicine composition with synergetic effect on radiotherapy and chemotherapy, and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105853637A true CN105853637A (en) 2016-08-17

Family

ID=56626879

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610197438.2A Withdrawn CN105853637A (en) 2016-03-31 2016-03-31 Traditional Chinese medicine composition with synergetic effect on radiotherapy and chemotherapy, and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105853637A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104606580A (en) * 2015-01-08 2015-05-13 李宏 Traditional Chinese medicine preparation with synergistic effect on chemotherapy and preparation method of traditional Chinese medicine preparation traditional Chinese medicine preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104606580A (en) * 2015-01-08 2015-05-13 李宏 Traditional Chinese medicine preparation with synergistic effect on chemotherapy and preparation method of traditional Chinese medicine preparation traditional Chinese medicine preparation

Similar Documents

Publication Publication Date Title
CN104873947A (en) Medicinal composition for treating dog acute upper gastrointestinal hemorrhage and preparation method thereof
CN103893722A (en) Traditional Chinese medicinal composition for treating solar dermatitis and preparation method thereof
CN103768398A (en) Traditional Chinese medicine composition for treating advanced lung tumors
CN103285343B (en) Medicine for treating liver cancer and preparation method thereof
CN102614466B (en) Traditional Chinese medical preparation for treatment of lung adenocarcinoma
CN104840773A (en) Traditional Chinese medicine composition for treating vertebral artery type cervical spondylopathy and method for preparing same
CN104771660A (en) Chinese traditional medicine preparation for treatment of gastric cancer and preparation method thereof
CN104984027A (en) Chinese materia medica preparation for treating myelodysplastic syndrome and preparation method thereof
CN104771553A (en) Invigorating spleen and kidney preparation for treatment of gastric cancer and preparation method thereof
CN104840629A (en) Drug composition for treating cat jaundice and preparation method thereof
CN104800764A (en) Traditional Chinese medicine preparation for treating liver cancer and preparation method
CN104083548A (en) Traditional Chinese medicinal composition for treating ovarian cyst and preparation method thereof
CN108324916A (en) Treat the Chinese medicine and preparation method thereof of tumour
CN105853637A (en) Traditional Chinese medicine composition with synergetic effect on radiotherapy and chemotherapy, and preparation method thereof
CN105012789A (en) Composition for treating cervical cancer and preparation method thereof
CN105770760A (en) Preparation for treating gastric ulcer and preparation method thereof
CN105663551A (en) Traditional Chinese medicine preparation for patient suffering from pancreatic cancer to take after operation as well as preparation method
CN105412673A (en) Drug for treating Hashimoto disease and preparing method thereof
CN104606537A (en) Qi-reinforcing and blood-nourishing medicated diet for improving chemotherapy-induced myocardial ischemic injury and preparation method
CN104998212A (en) Medicament for treating cervical cancer and preparation method thereof
CN104352872A (en) Traditional Chinese medicine for treating pulmonary asthenia due to deficiency heat
CN104306565A (en) Traditional Chinese medicine preparation for treating qi stagnation and blood stasis type angina pectoris and preparation method thereof
CN104707003B (en) The Chinese medicinal capsule for the treatment of hypertension, hyperlipidemia
WO2015149392A1 (en) Preparation of traditional chinese medicine for treating chronic colitis and preparation method therefor
CN105770340A (en) Preparation for synergizing chemotherapy and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: 336000, Jiangxi, Yichun province Yuanzhou District, Jiangxi Road, Hengda oasis, building 2, 1-401

Applicant after: Han Changying

Address before: Lixia District, Shandong city of Ji'nan Province, 250000 mountain East Road No. 23

Applicant before: Han Changying

WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20160817