CN103719119A - Sterilizing combination containing benthiavalicarb-isopropyl and metalaxyl and application thereof - Google Patents
Sterilizing combination containing benthiavalicarb-isopropyl and metalaxyl and application thereof Download PDFInfo
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- CN103719119A CN103719119A CN201310700928.6A CN201310700928A CN103719119A CN 103719119 A CN103719119 A CN 103719119A CN 201310700928 A CN201310700928 A CN 201310700928A CN 103719119 A CN103719119 A CN 103719119A
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- metalaxyl
- isoprothiolane
- hymexazo
- bactericidal composition
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Abstract
The invention belongs to the technical field of pesticide, and particularly relates to a compound sterilizing combination containing benthiavalicarb-isopropyl and metalaxyl and the application thereof in field of prevention and treatment of crop fungus disease. According to the combination, the weight ratio of benthiavalicarb-isopropyl to metalaxyl is 1:1 to 1:100, the combination has the effect of efficacy enhancement through compounding, has wide application range, low cost and good effect, can be used for preventing and treating diseases, such as wilt, root rot, stem rot, epidemic disease, greensickness, banded sclerotial blight, rice blast and the like, produced on various crops, such as grapes, cucumbers, tomatoes, potatoes, various vegetables, rice, peanuts, tobacco, medicinal materials, bananas and the like, by funguses, such as fusarium, radicicol, rhizoctonia, pythium, fusoma, corticium and the like, enhances the resistance properties to various natural disasters, such as low temperature, frost, drought, waterlogging disaster, chemical injury, fertilizer damage and the like, has good prevention and treatment effect, and meanwhile has good effect on delaying the drug resistance of pathogenic bacteria.
Description
Technical field
The invention belongs to the technical field of agricultural chemicals, be specifically related to a kind of Han You hymexazo and Isoprothiolane and carry out composite bactericidal composition, and the application aspect control farm crop fungus disease.
Background technology
Benzene metsulfovax (benthiavalicarb-isopropyl) chemical name [[(6-fluoro benzothiazole-2-yl)-ethylamino formoxyl]-2-methyl-propyl] carbamic acid isopropyl ester CAS accession number [177406-68-7]; new type bactericide-benzene metsulfovax of being developed jointly by combinatorial chemistry industrial group and Ihara company, has good activity to Oomycete mycosis.Its chemical structural formula is
Metalaxyl-M (metalaxyl-M); chemical name N-(2,6-xylyl)-N-(methoxyl group acetyl group)-D-alanine methyl esters, phenylamide systemic fungicide; Metalaxyl-M is the R isomer of common metalaxyl; be efficient systemic fungicide, have protection and therapeutic action, drug effect is high; residual low; having good environment compatibility, is a kind of systematic, has the bactericide of prevention and therapeutic efficiency.To Pseudoperonospora cubensis, phytophthora root rot bacterium, the vegetables due to rotten mildew fungus, fruit tree, tobacco, oil plant, cotton, the crop pests such as grain have efficiently, and the anxious effect of toxicity is fast, but transaction develops immunity to drugs, the use that is mixed of normal and other medicament, its structural formula is
Above-mentioned two kinds of medicaments are used separately due to long-term, easily cause the drug-fast generation of germ, cause drug effect obviously to decline, thereby cause dosage greatly to rise, the sprinkling cycle shortens, and result of use is poor, increased cost, the use of a large amount of agricultural chemicals, makes germ resistance more serious, also environment is affected, the medicament residue of agricultural product also increases, have influence on health and the normal existence of the mankind, animal etc., benzene metsulfovax and Metalaxyl-M are carried out to composite use control corps diseases, there is not yet report both at home and abroad.
Summary of the invention
The object of the invention is to provide a kind of for the problems referred to above and carry out composite bactericidal composition and application thereof by benzene metsulfovax and metalaxyl, said composition plays synergistic effect by composite, applied widely, cost is low, effective, can be used to prevent and treat Pseudoperonospora cubensis, phytophthora root rot bacterium, the downy mildew that the fungies such as rotten mildew fungus produce in the various crop such as grape, cucumber, tomato, potato, all kinds of vegetables, phytophthora root rot, the diseases such as rotten mildew, the pesticide resistance that delays pathogen has good effect.
In the present invention, the benzene metsulfovax of mentioning, the weight of Metalaxyl-M, the weight of active ingredient etc., all refer to the weight after folding hundred, i.e. the weight of active principle.
Bactericidal composition containing benzene metsulfovax and Metalaxyl-M of the present invention, its active ingredient consists of benzene metsulfovax and Metalaxyl-M, and described benzene metsulfovax and the weight ratio of Metalaxyl-M be, benzene metsulfovax: Metalaxyl-M=1:1～1:100.
As preferably, described benzene metsulfovax and the weight ratio of Metalaxyl-M be, benzene metsulfovax: Metalaxyl-M=1:1～1:10.
Wherein, in said composition, the weight percentage of active ingredient is 1%～99%.
Said composition formulation comprises wetting powder, suspending agent, water dispersible granules, granule, aqueous emulsion, missible oil and microemulsion, adds auxiliary agent and excipient, and the production technology of all knowing according to those skilled in the art can be made into required formulation.
This bactericidal composition is for preventing and treating the fungal disease on crop, for preventing and treating the downy mildew producing in the various crop such as grape, cucumber, tomato, potato, all kinds of vegetables, phytophthora root rot, the diseases such as rotten mildew, have good effect to delaying the pesticide resistance of pathogen.
Beneficial effect of the present invention is: benzene metsulfovax and two kinds of bactericide of Metalaxyl-M are carried out composite, because the mechanism of action between the two is different, Metalaxyl-M is the synthetic inhibitor of rRNA.Interior absorption special efficacy bactericide, has protection and therapeutic action, can be absorbed by the root, stem and leaf of plant, and Water Transportation in object thereupon, and transfer to each organ of plant.There is Bidirectional Conduction performance, lasting period 10-14 days, the soil treatment lasting period can period of greater than two months.The benzene metsulfovax mechanism of action is still not clear, but completely different with electron transfer inhibitor or rna synthesis inhibitor, is estimated as Cell wall synthesis inhibitor.By bactericide compounded protection, the interior suction conduction function of having concurrently of both different modes of action; expanded fungicidal spectrum; thereby applied widely; composite composition has synergistic effect in certain proportion; not only control efficiency is good; reduce dosage and drug cost, reduced the harmful effect to environment, and greatly delayed the drug-fast generation of germ.This bactericidal composition, can be used to prevent and treat Pseudoperonospora cubensis, phytophthora root rot bacterium, the disease that the fungies such as rotten mildew fungus produce on grape, cucumber, tomato, potato, all kinds of vegetables.In a word, combination sterilization composition of the present invention, has obvious economic benefit and environmental benefit.
With mycelial growth rate method, studied the indoor virulence of the composite mixture Phytophthora infestans of benzene metsulfovax and the different proportionings of Metalaxyl-M, experimental technique adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect, CTC value is greater than 120 o'clock mixtures and has synergistic effect, being less than at 80 o'clock is antagonism, has summation action in the time of between 80～120.
Concrete grammar is as follows:
Get the liquid preparing and be placed in 100ml50-60 ℃ of PDA sterilising medium, shake up, pour in the sterilizing culture dish of diameter 60mm, after cooled and solidified, move respectively the bacterium cake that length is consistent, diameter is 4mm of delivering a child, using and add the sterilising medium of equivalent coordinative solvent as blank, all operations all carries out sterile working at superclean bench, and 3 repetitions are established in every processing.Put into 27 ℃ of constant incubators and cultivate after 3-8 days, adopt right-angled intersection method to measure colony diameter, calculate the relevant parameters such as bacteriostasis rate, EC50, CTC, relevant calculating formulas is as follows:
Pure amount of growth=bacterium colony average diameter-bacterium cake diameter (0.4cm)
Bacteriostasis rate=[the pure amount of growth of (contrast pure amount of growth-process pure amount of growth) * 100/ contrast] * 100%
The EC50*100 of the EC50/B agent of toxicity index TI(B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
The percentage of percentage+TI (B) the * B of theoretical toxicity index TTI (AB)=TI (A) * A in mixture in mixture
Co-toxicity coefficient CTC=ATI(AB)/TTI(AB) * 100
Table 1 benzene metsulfovax and the Metalaxyl-M mixture toxicity test table to rice blast fungus
From table 1, benzene metsulfovax and Metalaxyl-M are composite, Phytophthora infestans has good indoor virulence, the CTC value of seven proportionings is all over 120, show that these two bactericide have good synergistic function under this proportioning, also can find out that in composition it is also different from different its synergistic effects of Isoprothiolane ratio that Sui hymexazo, mixed ratio synergy between 1:1～1:10 is particularly remarkable simultaneously.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto, and the formulation preparation method in embodiment is conventional method.
Embodiment 1:20% benzene metsulfovax Metalaxyl-M missible oil, comprises following component by weight:
By whole mixing of materials, after stirring, make 20% benzene metsulfovax Metalaxyl-M missible oil.
Embodiment 2:30% benzene metsulfovax Metalaxyl-M microemulsion, comprises following component by weight:
Embodiment 3:66% benzene metsulfovax Metalaxyl-M wetting powder, comprises following component by weight:
Said components is carried out to air-flow crushing, make 66% benzene metsulfovax Metalaxyl-M wetting powder.
Test example: benzene metsulfovax and the mixture of the different proportionings of Metalaxyl-M are prevented and treated the test of pesticide effectiveness of potato late blight
3 kinds of mixtures that the embodiment of the present invention is obtained carry out the test of pesticide effectiveness, adopt greenhouse pot culture seedling, the control efficiency of single mixture of mensuration benzene metsulfovax and Metalaxyl-M to potato late blight.When growing 3～4 young leaves, select the blade of growing way uniformity to adopt manual sprayer to carry out foliar spray processing, after 24 hours, inoculate pathogen, 7d " Invest, Then Investigate " result is cultivated in moisturizing, the results are shown in Table 2.
The control efficiency table of table 2 pair potato late blight
| Reagent agent | Dosage (μ g/mL) | Disease index | Control efficiency (%) |
| Embodiment 1 product | 200 | 10.08 | 84.90 |
| Embodiment 2 products | 200 | 11.09 | 83.39 |
| Embodiment 3 products | 200 | 14.45 | 78.35 |
| 25% Metalaxyl-M WP | 200 | 21.33 | 68.04 |
| 25% benzene metsulfovax SC | 200 | 41.09 | 38.44 |
| Clear water contrast | —— | 66.75 | —— |
As can be seen from Table 2, the mixture preparation of benzene metsulfovax and Metalaxyl-M can effectively be prevented and treated potato late blight, and is obviously better than the control efficiency of single dose.
Claims (6)
1. containing a bactericidal composition for hymexazo and Isoprothiolane, its active ingredient forms for hymexazo and Isoprothiolane, and the hymexazo of stating and the weight ratio of Isoprothiolane be, Isoprothiolane: hymexazo=1:1～1:100.
2. bactericidal composition according to claim 1, is characterized in that, the weight ratio of Suo Shu hymexazo and Isoprothiolane is, Isoprothiolane: hymexazo=1:1～1:10.
3. bactericidal composition according to claim 1 and 2, is characterized in that, the weight percentage of described active ingredient is 1%～99%.
4. bactericidal composition according to claim 1, is characterized in that, said composition formulation comprises wetting powder, missible oil and microemulsion.
5. bactericidal composition as claimed in claim 1, for preventing and treating the fungal disease on crop.
6. bactericidal composition as claimed in claim 1, for preventing and treating the diseases such as the fusarium wilt that produces in the various crop such as grape, cucumber, tomato, potato, all kinds of vegetables, paddy rice, peanut, tobacco, medicinal material, banana, root rot, stem rot, epidemic disease, verticillium wilt, banded sclerotial blight, rice blast.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310700928.6A CN103719119A (en) | 2013-12-18 | 2013-12-18 | Sterilizing combination containing benthiavalicarb-isopropyl and metalaxyl and application thereof |
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| CN201310700928.6A CN103719119A (en) | 2013-12-18 | 2013-12-18 | Sterilizing combination containing benthiavalicarb-isopropyl and metalaxyl and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108293700A (en) * | 2018-01-26 | 2018-07-20 | 四川省农业科学院植物保护研究所 | A method of for preventing eggplant root rot class disease |
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2013
- 2013-12-18 CN CN201310700928.6A patent/CN103719119A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108293700A (en) * | 2018-01-26 | 2018-07-20 | 四川省农业科学院植物保护研究所 | A method of for preventing eggplant root rot class disease |
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