CN103651408A - Bactericidal composition containing hymexazol and isoprothiolane and application thereof - Google Patents
Bactericidal composition containing hymexazol and isoprothiolane and application thereof Download PDFInfo
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- CN103651408A CN103651408A CN201210338550.5A CN201210338550A CN103651408A CN 103651408 A CN103651408 A CN 103651408A CN 201210338550 A CN201210338550 A CN 201210338550A CN 103651408 A CN103651408 A CN 103651408A
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- isoprothiolane
- hymexazo
- bactericidal composition
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Abstract
The invention belongs to the technical field of pesticides, and particularly relates to a compound bactericidal composition containing hymexazol and isoprothiolane and application thereof in preventing and treating fungus diseases of crops. The weight ratio of the isoprothiolane to the hymexazol in the composition is 1:1-1:100. The compounding of the hymexazol and isoprothiolane has a synergistic action; and thus, the composition has the advantages of wide applicability, low cost and favorable effect, can be used for preventing and treating blight, root rot, stem rot, epidemic disease, greensickness, sheath blight, rice blast and other diseases caused by fusarium, nectria, Rhizoctonia, Pythium, Seedling rot fungus, Corticium and other fungi on grapes, cucumbers, tomatoes, potatoes, various vegetables, rice, peanuts, tobacco, drugs, bananas and many other crops, and has higher resistance to low temperature, frost, drought, waterlogging, chemical injury, fertilizer injury and many other natural disasters. The composition has favorable preventing and treating effects, and has favorable actions on postponing drug resistance of pathogens.
Description
Technical field
The invention belongs to the technical field of agricultural chemicals, be specifically related to a kind of Han You hymexazo and Isoprothiolane and carry out composite bactericidal composition, and the application aspect control farm crop fungus disease.
Background technology
Hymexazo (hymexazol) chemical name 3-hydroxy-5-methyl base isoxazole, belongs to organic heterocyclic series bactericidal agent.Dislike mould spirit enter by soil, absorbed after soil and with soil in the inorganic metal salt ions binding such as iron, aluminium, the sprouting and the mycelial normal growth of disease fungus or the direct killing pathogenic bacteria that effectively suppress spore, the mechanism of action is unique, efficiently, micro-poison, nuisanceless, can effectively suppress the mycelial normal growth of disease fungus or direct killing pathogenic bacteria.The pathogens such as soil fungi, sickle-like bacteria, root shell bacterium, rhizoctonia, pythium spp, the rotten bacterium of seedling, photovoltaicing leather bacteria are had to significant control efficiency.
Isoprothiolane (isoprothiolane), chemical name 1, the sub-penta cyclic group Diisopropyl malonate of 3-bis-sulphur-2-, belongs to organic heterocyclic series bactericidal agent, and the efficient systemic fungicide of feature is the special effect agent of control rice blast.Rice blast is had to preventive and therapeutic action, can be absorbed by each position of paddy rice, and be accumulated to leaf portion tissue, thus performance drug effect, and resistance of rainwater washing against also can doublely be controlled plant hopper.
Above-mentioned two kinds of medicaments are used separately due to long-term, easily cause the drug-fast generation of germ, cause drug effect obviously to decline, thereby cause dosage greatly to rise, the sprinkling cycle shortens, and result of use is poor, increased cost, the use of a large amount of agricultural chemicals, makes germ resistance more serious, also environment is affected, the medicament residue of agricultural product also increases, the health and the normal existence ， that have influence on the mankind, animal etc. carry out composite use control corps diseases Jiang hymexazo and Isoprothiolane, there is not yet report both at home and abroad.
Summary of the invention
The object of the invention is provides a kind of You hymexazo and Isoprothiolane to carry out composite bactericidal composition and application thereof for the problems referred to above, said composition plays synergistic effect by composite, applied widely, cost is low, effective, can be used to prevent and treat sickle-like bacteria, root shell bacterium, rhizoctonia, pythium spp, the rotten bacterium of seedling, the fungies such as photovoltaicing leather bacteria are at grape, cucumber, tomato, potato, all kinds of vegetables, paddy rice, peanut, tobacco, medicinal material, the fusarium wilt producing in the various crop such as banana, root rot, stem rot, epidemic disease, verticillium wilt, banded sclerotial blight, the diseases such as rice blast, and strengthen low temperature, frost, arid, waterlogging stain, poisoning, the multiple natural calamity such as fertilizer damage resist performance.To delaying the pesticide resistance of pathogen, there is good effect simultaneously.
In the present invention, the Ti of institute, the weight of active ingredient etc., all refers to the weight after folding hundred, i.e. the weight of active principle Dao the weight of hymexazo, Isoprothiolane.
Bactericidal composition containing hymexazo and Isoprothiolane of the present invention, its active ingredient forms for hymexazo and Isoprothiolane, and the hymexazo of stating and the weight ratio of Isoprothiolane be, Isoprothiolane: hymexazo=1:1～1:100.
As preferably, the weight ratio of Suo Shu hymexazo and Isoprothiolane is, Isoprothiolane: hymexazo=1:1～1:10.
Wherein, in said composition, the weight percentage of active ingredient is 1%～99%.
Said composition formulation comprises wetting powder, missible oil and microemulsion, adds auxiliary agent and excipient, and the production technology of all knowing according to those skilled in the art can be made into required formulation.
This bactericidal composition is for preventing and treating the fungal disease on crop, for preventing and treating the diseases such as the fusarium wilt that produces in the various crop such as grape, cucumber, tomato, potato, all kinds of vegetables, paddy rice, peanut, tobacco, medicinal material, banana, root rot, stem rot, epidemic disease, verticillium wilt, banded sclerotial blight, rice blast, and strengthen the performance of resisting to multiple natural calamities such as low temperature, frost, arid, flooded stain, poisoning, fertilizer damages.To delaying the pesticide resistance of pathogen, there is good effect simultaneously.
Beneficial effect of the present invention is that: carries out composite Jiang hymexazo and two kinds of bactericide of Isoprothiolane, due to the different hymexazos of the mechanism of action between the two be enter by soil, absorbed after soil and with soil in the inorganic metal salt ions binding such as iron, aluminium, the sprouting and the mycelial normal growth of disease fungus or the direct killing pathogenic bacteria that effectively suppress spore, Isoprothiolane is affect chitin other cell wall constituents in addition synthetic.Make complex preparation have protection, interior suction conduction function concurrently; expanded fungicidal spectrum; thereby applied widely; composite composition has synergistic effect in certain proportion; not only control efficiency is good; reduce dosage and drug cost, reduced the harmful effect to environment, and greatly delayed the drug-fast generation of germ.This bactericidal composition, can be used to prevent and treat the diseases such as fusarium wilt that the fungies such as sickle-like bacteria, root shell bacterium, rhizoctonia, pythium spp, the rotten bacterium of seedling, photovoltaicing leather bacteria produce in the various crop such as grape, cucumber, tomato, potato, all kinds of vegetables, paddy rice, peanut, tobacco, medicinal material, banana, root rot, stem rot, epidemic disease, verticillium wilt, banded sclerotial blight, rice blast, and strengthen the performance of resisting to multiple natural calamities such as low temperature, frost, arid, flooded stain, poisoning, fertilizer damages.To delaying the pesticide resistance of pathogen, there is good effect simultaneously.In a word, combination sterilization composition of the present invention, has obvious economic benefit and environmental benefit.
The indoor virulence of the composite mixture of studying hymexazo and the different proportionings of Isoprothiolane with mycelial growth rate method to citrus anthracnose bacterium, experimental technique adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect, CTC value is greater than 120 o'clock mixtures and has synergistic effect, being less than at 80 o'clock is antagonism, has summation action in the time of between 80～120.
Concrete grammar is as follows:
Get the liquid preparing and be placed in 100ml 50-60 ℃ of PDA sterilising medium, shake up, pour in the sterilizing culture dish of diameter 60 mm, after cooled and solidified, move respectively the bacterium cake that length is consistent, diameter is 4mm of delivering a child, using and add the sterilising medium of equivalent coordinative solvent as blank, all operations all carries out sterile working at superclean bench, and 3 repetitions are established in every processing.Put into 27 ℃ of constant incubators and cultivate after 3-8 days, adopt right-angled intersection method to measure colony diameter, calculate bacteriostasis rate, EC
50, the relevant parameter such as CTC, relevant calculating formulas is as follows:
Pure amount of growth=bacterium colony average diameter-bacterium cake diameter (0.4cm)
Bacteriostasis rate=[the pure amount of growth of (contrast pure amount of growth-process pure amount of growth) * 100/ contrast] * 100%
The EC50*100 of the EC50/B agent of toxicity index TI(B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
The percentage of percentage+TI (B) the * B of theoretical toxicity index TTI (AB)=TI (A) * A in mixture in mixture
Co-toxicity coefficient CTC=ATI(AB)/TTI(AB) * 100
Table 1 hymexazo and the toxicity test table of Isoprothiolane list mixture to citrus anthracnose bacterium
| Reagent agent | Active ingredient weight ratio | EC50（mg/L） | Co-toxicity coefficient (CTC) |
| Hymexazo | —— | 9.08 | —— |
| Isoprothiolane | —— | 15.27 | —— |
| Hymexazo: Isoprothiolane | 1：1 | 5.35 | 243.36 |
| Hymexazo: Isoprothiolane | 1：5 | 7.29 | 220.17 |
| Hymexazo: Isoprothiolane | 1：10 | 8.23 | 201.38 |
| Hymexazo: Isoprothiolane | 1：20 | 10.26 | 186.54 |
| Hymexazo: Isoprothiolane | 1：40 | 11.58 | 179.35 |
| Hymexazo: Isoprothiolane | 1：80 | 14.88 | 170.09 |
| Hymexazo: Isoprothiolane | 1：100 | 15.03 | 163.39 |
Composite by the visible hymexazo of table 1 and Isoprothiolane, citrus anthracnose germ is had to good indoor virulence, the CTC value of seven proportionings is all over 120, show that these two bactericide have good synergistic function under this proportioning, also can find out that in composition it is also different from different its synergistic effects of Isoprothiolane ratio that Sui hymexazo, mixed ratio synergy between 1:1～1:10 is particularly remarkable simultaneously.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto, and the formulation preparation method in embodiment is conventional method.
Embodiment 1:20% hymexazo Isoprothiolane missible oil, comprises following component by weight:
Hymexazo 10%
Isoprothiolane 10%
Calcium dodecyl benzene sulfonate 4%
Polyoxyethylene nonylphenol ether 5%
Ethanol 15%
Toluene surplus
By whole mixing of materials, after stirring, make 20% hymexazo Isoprothiolane missible oil.
Embodiment 2:30% hymexazo Isoprothiolane microemulsion, comprises following component by weight:
Hymexazo 5%
Isoprothiolane 25%
Calcium dodecyl benzene sulfonate 6%
Castor oil polyoxyethylene ether 10%
Polyoxyethylene nonylphenol ether 4%
Toluene 15%
Ethanol 10%
Water is mended to 100%
Embodiment 3:66% hymexazo Isoprothiolane wetting powder, comprises following component by weight:
Hymexazo 6%
Isoprothiolane 60%
To methoxyl group fatty acid Sodium p-aminobenzene sulfonat 2%
Sodium methylene bis-naphthalene sulfonate 4%
White carbon 10%
Kaolin surplus
Said components is carried out to air-flow crushing, make 66% hymexazo Isoprothiolane wetting powder.
The test of pesticide effectiveness that test example: hymexazo is prevented and treated rice blast from the mixture of the different proportionings of Isoprothiolane
3 kinds of mixtures that the embodiment of the present invention is obtained carry out the test of pesticide effectiveness, adopt greenhouse pot culture rice seedling, and Ce is Dinged single mixture of hymexazo and Isoprothiolane control efficiency to rice blast.When paddy rice grows 3～4 young leaves, select the blade of growing way uniformity to adopt manual sprayer to carry out foliar spray processing, after 24 hours, inoculate pathogen, 7d " Invest, Then Investigate " result is cultivated in moisturizing, the results are shown in Table 2.
The control efficiency table of table 2 pair rice blast
| Reagent agent | Dosage (μ g/mL) | Disease index | Control efficiency (%) |
| Embodiment 1 product | 200 | 10.08 | 84.90 |
| Embodiment 2 products | 200 | 11.09 | 83.39 |
| Embodiment 3 products | 200 | 14.45 | 78.35 |
| 45% hymexazo aqueous emulsion | 200 | 21.33 | 68.04 |
| 45% isoprothiolane emulsion in water | 200 | 41.09 | 38.44 |
| Clear water contrast | —— | 66.75 | —— |
The mixture preparation of ， hymexazo and Isoprothiolane can effectively be prevented and treated rice blast as can be seen from Table 2, and is obviously better than the control efficiency of single dose.
Claims (6)
1. containing a bactericidal composition for hymexazo and Isoprothiolane, its active ingredient forms for hymexazo and Isoprothiolane, and the hymexazo of stating and the weight ratio of Isoprothiolane be, Isoprothiolane: hymexazo=1:1～1:100.
2. bactericidal composition according to claim 1, is characterized in that, the weight ratio of Suo Shu hymexazo and Isoprothiolane is, Isoprothiolane: hymexazo=1:1～1:10.
3. bactericidal composition according to claim 1 and 2, is characterized in that, the weight percentage of described active ingredient is 1%～99%.
4. bactericidal composition according to claim 1, is characterized in that, said composition formulation comprises wetting powder, missible oil and microemulsion.
5. bactericidal composition as claimed in claim 1, for preventing and treating the fungal disease on crop.
6. bactericidal composition as claimed in claim 1, for preventing and treating the diseases such as the fusarium wilt that produces in the various crop such as grape, cucumber, tomato, potato, all kinds of vegetables, paddy rice, peanut, tobacco, medicinal material, banana, root rot, stem rot, epidemic disease, verticillium wilt, banded sclerotial blight, rice blast.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210338550.5A CN103651408A (en) | 2012-09-14 | 2012-09-14 | Bactericidal composition containing hymexazol and isoprothiolane and application thereof |
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| CN201210338550.5A CN103651408A (en) | 2012-09-14 | 2012-09-14 | Bactericidal composition containing hymexazol and isoprothiolane and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110558343A (en) * | 2019-09-27 | 2019-12-13 | 沈阳市大光农业服务中心 | Insect-expelling and bird-repelling medicament for crop growth |
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- 2012-09-14 CN CN201210338550.5A patent/CN103651408A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110558343A (en) * | 2019-09-27 | 2019-12-13 | 沈阳市大光农业服务中心 | Insect-expelling and bird-repelling medicament for crop growth |
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Application publication date: 20140326 |