CN103621521A - Fungicidal composition containing benthiavalicarb-isopropyl and dimethomorph and applications thereof - Google Patents
Fungicidal composition containing benthiavalicarb-isopropyl and dimethomorph and applications thereof Download PDFInfo
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- CN103621521A CN103621521A CN201210311351.5A CN201210311351A CN103621521A CN 103621521 A CN103621521 A CN 103621521A CN 201210311351 A CN201210311351 A CN 201210311351A CN 103621521 A CN103621521 A CN 103621521A
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- dimethomorph
- benzene metsulfovax
- isopropyl
- bactericidal composition
- downy mildew
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Abstract
The invention belongs to the pesticide technology field, and concretely relates to a fungicidal composition containing benthiavalicarb-isopropyl and dimethomorph compound, and applications in controlling oomycete fungal diseases of crop downy mildew, phytophthora diseases and the like. In the composition, the weight ratio of benthiavalicarb-isopropyl to dimethomorph is 1:1-1:100. The fungicidal composition has synergistic effects through compounding, can be used for controlling diseases of downy mildew, phytophthora diseases and the like caused by fungi of oomycetes and the like on various crops of grapes, cucumbers, tomatoes, potatoes and the like, has good control effects, is safe to many crops in a dosage range in which pathogenic bacteria can be controlled effectively, and has good functions of delaying drug resistance of pathogenic bacteria.
Description
Technical field
The invention belongs to the technical field of agricultural chemicals, be specifically related to a kind ofly contain benzene metsulfovax and dimethomorph carries out composite bactericidal composition, and the application aspect control farm crop fungus disease.
Background technology
Benzene metsulfovax general (benthiavalicarb-isopropyl) by name, chemical being called [(S)-1-[(R)-1-(6-fluoro benzothiazole-2-base-) ethylamino formoxyl]-2-methyl-propyl] carbamic acid isopropyl ester, the novel bactericide of amino amino formate ester for the exploitation of Japanese combinatorial chemistry company, it is to various epidemic diseases, the tall and erect effect of downy mildew tool, with lower dosage (25-75ga.i./h ㎡), can effectively control the late blight (Phytophthora infestans) of potato and tomato, downy mildew of garpe (Plasmopara viticola), downy mildew of cucurbits (Pseudoperonospora cubensis), parasitic downy mildew (Peronospora parasitica).Benzene metsulfovax has good toxicity and the feature of environmental protection, to many vegetables and fruit nonhazardous.
Benzene metsulfovax molecular structural formula is:
Dimethomorph (dimethomorph), chemical name: (E, Z)-4-[3-(4-chlorphenyl) 3-(3,4-Dimethoxyphenyl) acryloyl] morpholine, be single-minded ovicidal Gammaproteobacteria fungi bactericide, its effect feature is to destroy the formation of cell envelope, and there is to effect in each stage of oomycetes history of life, formation stages at sporangiophore and egg spore is particularly responsive, and under extremely low concentration, (<0.25 μ g/ml) is suppressed.With phenylamide medicament without cross resistance.Be widely used in vegetables downy mildew, epidemic disease, seedling stage damping off, black shank etc. by the fungus-caused disease control of Mastigomycotina Oomycete.
Dimethomorph molecular structural formula is:
Above-mentioned two kinds of medicaments are used separately due to long-term, easily cause the drug-fast generation of germ, cause drug effect obviously to decline, thereby cause dosage greatly to rise, the sprinkling cycle shortens, and result of use is poor, increased cost, the use of a large amount of agricultural chemicals, makes germ resistance more serious, also environment is affected, the medicament residue of agricultural product also increases, have influence on health and the normal existence of the mankind, animal etc., benzene metsulfovax and dimethomorph are carried out to composite use control corps diseases, there is not yet report both at home and abroad.
Summary of the invention
The object of the invention is to provide a kind of for the problems referred to above and carry out composite bactericidal composition and application thereof by benzene metsulfovax and dimethomorph, said composition plays synergistic effect by composite, can be used to prevent and treat the diseases such as downy mildew that the fungies such as Oomycete produce in the various crop such as grape, cucumber, tomato, potato, epidemic disease, there is good control efficiency, to delaying the pesticide resistance of pathogen, have good effect simultaneously.
In the present invention, the benzene metsulfovax of mentioning, the weight of dimethomorph, the weight of active ingredient etc., all refer to the weight after folding hundred, i.e. the weight of active principle.
Bactericidal composition containing benzene metsulfovax and dimethomorph of the present invention, its active ingredient consists of benzene metsulfovax and dimethomorph, and described benzene metsulfovax and the weight ratio of dimethomorph be, benzene metsulfovax: dimethomorph=1:1～1:100.
As preferably, described benzene metsulfovax and the weight ratio of dimethomorph be, benzene metsulfovax: dimethomorph=1:1～1:5.
Wherein, in said composition, the weight percentage of active ingredient is 1%～90%.
Said composition formulation comprises wetting powder, suspending agent, water dispersible granules, adds auxiliary agent and excipient, and the production technology of all knowing according to those skilled in the art can be made into required formulation.
This bactericidal composition is for preventing and treating the lower fungus disease on crop, for prevent and treat on grape, cucumber, tomato, potato by fungus-caused downy mildew, epidemic disease disease, the fungal disease that described fungi can cause for Oomycete.
Beneficial effect of the present invention is: benzene metsulfovax is carbamate fungicide, has very strong treatment, osmotically active; Dimethomorph belongs to acid amide fungicides; there is good protection, suppress active; the two is composite; not only can have higher protection and therapeutic activity concurrently; and composite composition has synergistic effect in certain proportion, not only control efficiency is good, has reduced dosage and drug cost; reduce the harmful effect to environment, and greatly delayed the drug-fast generation of germ.
With mycelial growth rate method, studied the indoor virulence of benzene metsulfovax from the composite mixture Phytophthora infestans of the different proportionings of dimethomorph, experimental technique adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect, CTC value is greater than 120 o'clock mixtures and has synergistic effect, being less than at 80 o'clock is antagonism, has summation action in the time of between 80～120.
Concrete grammar is as follows:
Get the liquid preparing and be placed in 100ml 50-60 ℃ of PDA sterilising medium, shake up, pour in the sterilizing culture dish of diameter 60 mm, after cooled and solidified, move respectively the bacterium cake that length is consistent, diameter is 4mm of delivering a child, using and add the sterilising medium of equivalent coordinative solvent as blank, all operations all carries out sterile working at superclean bench, and 3 repetitions are established in every processing.Put into 27 ℃ of constant incubators and cultivate after 3-8 days, adopt right-angled intersection method to measure colony diameter, calculate bacteriostasis rate, EC
50, the relevant parameter such as CTC, relevant calculating formulas is as follows:
Pure amount of growth=bacterium colony average diameter-bacterium cake diameter (0.4cm)
Bacteriostasis rate=[the pure amount of growth of (contrast pure amount of growth-process pure amount of growth) * 100/ contrast] * 100%
The EC50*100 of the EC50/B agent of toxicity index TI(B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
The percentage of percentage+TI (B) the * B of theoretical toxicity index TTI (AB)=TI (A) * A in mixture in mixture
Co-toxicity coefficient CTC=ATI(AB)/TTI(AB) * 100
The toxicity test table of table 1 benzene metsulfovax and dimethomorph list mixture Phytophthora infestans
| Reagent agent | Active ingredient weight ratio | EC50（mg/L） | Co-toxicity coefficient (CTC) |
| Benzene metsulfovax | —— | 12.68 | —— |
| Dimethomorph | —— | 1.39 | —— |
| Benzene metsulfovax: dimethomorph | 1：1 | 1.48 | 220.56 |
| Benzene metsulfovax: dimethomorph | 1：2 | 1.23 | 245.92 |
| Benzene metsulfovax: dimethomorph | 1：5 | 1.30 | 223.31 |
| Benzene metsulfovax: dimethomorph | 1：10 | 1.44 | 197.34 |
| Benzene metsulfovax: dimethomorph | 1：50 | 1.61 | 174.59 |
| Benzene metsulfovax: dimethomorph | 1：100 | 1.75 | 160.27 |
| ? | ? | ? | ? |
From table 1, benzene metsulfovax and dimethomorph are composite, Phytophthora infestans has good indoor virulence, the CTC value of six proportionings is all over 120, show that these two bactericide have good synergistic function under this proportioning, also can find out that in composition, along with benzene metsulfovax is also different from different its synergistic effects of dimethomorph ratio, mixed ratio synergy between 1:1～1:5 is particularly remarkable simultaneously.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto, and the formulation preparation method in embodiment is conventional method.
Embodiment 1:16% benzene metsulfovax dimethomorph suspending agent, comprises following component by weight:
Benzene metsulfovax 8%
Dimethomorph 8%
Alkyl naphthalene formaldehyde condensate sulfonates 1%
Polyoxyethylene nonylphenol ether 1%
Xanthans 0.3%
Benzoic acid 0.1%
Organosilan defoamer 0.3%
Water surplus
By whole mixing of materials, after stirring, material is joined to sand mill and carry out sand milling, make material reach 2～5 μ m fineness, make 16% benzene metsulfovax dimethomorph suspending agent.
Embodiment 2:30% benzene metsulfovax dimethomorph water dispersion granula, comprises following component by weight:
Benzene metsulfovax 10%
Dimethomorph 20%
Sodium lignin sulfonate 6%
PO-EO block polyether 4%
Lauryl sodium sulfate 3%
Ammonium sulfate 5%
Precipitated calcium carbonate surplus
The above-mentioned ratio in formula is mixed, through air-flow crushing, become wetting powder, then add a certain amount of water mixing extruder grain, after drying screening, obtain 30% benzene metsulfovax dimethomorph water dispersion granula.
Embodiment 3:60% benzene metsulfovax dimethomorph wetting powder, comprises following component by weight:
Benzene metsulfovax 10%
Dimethomorph 50%
To methoxyl group fatty acid Sodium p-aminobenzene sulfonat 2%
Sodium methylene bis-naphthalene sulfonate 4%
White carbon 5%
Kaolin surplus
Said components is carried out to air-flow crushing, make 60% benzene metsulfovax dimethomorph wetting powder.
test example: the test of pesticide effectiveness that benzene metsulfovax is prevented and treated cucumber downy mildew from the mixture of the different proportionings of dimethomorph
3 kinds of mixtures that the embodiment of the present invention is obtained carry out the test of pesticide effectiveness, adopt greenhouse pot culture cucumber seedling, the control efficiency of single mixture of mensuration benzene metsulfovax and dimethomorph to cucumber downy mildew.When cucumber grows to 3～4 leaves, select the blade of growing way uniformity to adopt manual sprayer to carry out foliar spray processing, after 24 hours, inoculate pathogen, 7d " Invest, Then Investigate " result is cultivated in moisturizing, the results are shown in Table 2.
The control efficiency table of table 2 pair cucumber downy mildew
| Reagent agent | Dosage (μ g/mL) | Disease index | Control efficiency (%) |
| Embodiment 1 product | 100 | 12.98 | 78.79 |
| Embodiment 2 products | 100 | 13.14 | 78.53 |
| Embodiment 3 products | 100 | 15.62 | 77.48 |
| 8% benzene metsulfovax suspending agent | 100 | 23.24 | 62.03 |
| 8% dimethomorph suspending agent | 100 | 17.86 | 60.82 |
| Clear water contrast | —— | 61.21 | —— |
As can be seen from Table 2, the mixture preparation of benzene metsulfovax and dimethomorph can effectively be prevented and treated cucumber downy mildew, and is obviously better than the control efficiency of single dose.
Comprehensively above result of the test shows, microbicide compositions of the present invention has good control efficiency to Oomycete germs such as downy mildew and epidemic diseases, and uses safety, is the new formulation of environment-friendly high-efficiency.
Claims (6)
1. containing a bactericidal composition for benzene metsulfovax and dimethomorph, its active ingredient consists of benzene metsulfovax and dimethomorph, and described benzene metsulfovax and the weight ratio of dimethomorph be, benzene metsulfovax: dimethomorph=1:1～1:100.
2. bactericidal composition according to claim 1, is characterized in that, described benzene metsulfovax and the weight ratio of dimethomorph be, benzene metsulfovax: dimethomorph=1:1～1:5.
3. bactericidal composition according to claim 1 and 2, is characterized in that, the weight percentage of described active ingredient is 1%～90%.
4. bactericidal composition according to claim 1, is characterized in that, said composition formulation comprises wetting powder, suspending agent, water dispersible granules.
5. bactericidal composition as claimed in claim 1, for preventing and treating the fungal disease on crop.
6. bactericidal composition as claimed in claim 1, for prevent and treat on the fruit and vegetable crops such as grape, cucumber, tomato, potato by fungus-caused downy mildew, epidemic disease disease.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210311351.5A CN103621521A (en) | 2012-08-29 | 2012-08-29 | Fungicidal composition containing benthiavalicarb-isopropyl and dimethomorph and applications thereof |
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| CN201210311351.5A CN103621521A (en) | 2012-08-29 | 2012-08-29 | Fungicidal composition containing benthiavalicarb-isopropyl and dimethomorph and applications thereof |
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| CN103621521A true CN103621521A (en) | 2014-03-12 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719117A (en) * | 2012-10-13 | 2014-04-16 | 海利尔药业集团股份有限公司 | Sterilization composition containing benthiavalicarb-isopropyl and dimethomorph |
| CN114478132A (en) * | 2022-03-24 | 2022-05-13 | 贵州省烟草公司毕节市公司 | Biomass charcoal-based slow-release functional fertilizer and preparation method thereof |
-
2012
- 2012-08-29 CN CN201210311351.5A patent/CN103621521A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719117A (en) * | 2012-10-13 | 2014-04-16 | 海利尔药业集团股份有限公司 | Sterilization composition containing benthiavalicarb-isopropyl and dimethomorph |
| CN114478132A (en) * | 2022-03-24 | 2022-05-13 | 贵州省烟草公司毕节市公司 | Biomass charcoal-based slow-release functional fertilizer and preparation method thereof |
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Application publication date: 20140312 |