CN103518743B - Sterilizing composition containing boscalid and dimethomorph - Google Patents
Sterilizing composition containing boscalid and dimethomorph Download PDFInfo
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- CN103518743B CN103518743B CN201310476330.3A CN201310476330A CN103518743B CN 103518743 B CN103518743 B CN 103518743B CN 201310476330 A CN201310476330 A CN 201310476330A CN 103518743 B CN103518743 B CN 103518743B
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Abstract
The invention discloses a sterilizing composition containing boscalid and dimethomorph. Boscalid and dimethomorph are active components, and the weight ratio of boscalid to dimethomorph is 1:10-6:1. Due to the fact that boscalid and dimethomorph which respectively possess different action mechanisms are compounded, the sterilizing composition has obvious synergy effect; the composition has relatively wide sterilization spectrum, and is used to control common diseases such as downy mildew, late blight, botrytis and the like during crop plantation; the composition helps to reduce pesticide application amount, so that the cost and the pollution to environment are reduced; and the composition is beneficial for resistance treatment on diseases, and the popularization and the application of the composition have relatively large economical benefit and social benefit.
Description
Technical field
The present invention relates to a kind of bactericidal composition, be specifically related to a kind of bactericidal composition containing Boscalid and dimethomorph.
Background technology
Boscalid, English name: Boscalid, the chloro-N-of chemical name: 2-(4 '-chlorodiphenyl-2-base) vitamin PP.Boscalid is Novel tobacco acid amide fungicides, fungicidal spectrum is wider, almost there is activity to all types of fungal disease, to preventing and treating, powdery mildew, gray mold, stalk break and various rots etc. are very effective, and also effective to the resistance bacterium of other medicaments, be mainly used in the control comprising the diseases such as rape, grape, fruit tree, vegetables and field crop.With carbendazim, Sukeling etc. without cross resistance.
Dimethomorph, English common name: dimethomorph, chemical name: (E, Z)-4-[3-(4-chlorphenyl) 3-(3,4-Dimethoxyphenyl) acryloyl] morpholine.Dimethomorph belongs to single-minded control Oomycete fungal venereal disease evil medicament, all has good control efficiency to lower fungus venereal disease evils such as downy mildew, peronospora tabacina, late blight, epidemic disease (mould) disease, phytophthora rot, rotten mildew, balck shanks.Can be applicable to grape, lichee, cucumber, muskmelon, balsam pear, tomato, capsicum, potato, brassicaceous vegetable.
Need enough dosage just can play control efficiency for the use of Boscalid and dimethomorph single dose in prior art, and can there is higher resistance risk in a large amount of use, cause use cost to increase.At present report is had no for Boscalid and the composite of dimethomorph.
Summary of the invention
The object of this invention is to provide a kind of bactericidal composition containing Boscalid and dimethomorph of efficient, low toxicity, low-residual, Boscalids different for the mechanism of action and dimethomorph are carried out composite, there is obvious synergistic effect, fungicidal spectrum is comparatively wide, for preventing and treating Common Diseases in the crop-planting processes such as downy mildew, late blight, gray mold; This bactericidal composition reduces Pesticide use amount, thus reduces cost and decrease the pollution to environment, and be conducive to the resistance management of disease, it is applied has larger economic benefit and social benefit.
Bactericidal composition containing Boscalid and dimethomorph of the present invention, with Boscalid and dimethomorph for active ingredient, the weight ratio of described Boscalid and dimethomorph is 1:10 ~ 6:1, preferably 1:6 ~ 1:1.In such proportion, there is not cross resistance in described active ingredient Boscalid and dimethomorph, reduces Pesticide use amount, and then reduce cost, decrease the pollution to environment simultaneously, be conducive to the resistance management of disease, there is larger economic benefit and social benefit.
When the weight ratio of described active ingredient Boscalid and dimethomorph is 1:6, its co-toxicity coefficient is 230.52, and synergy is the most obvious.
Described Boscalid suppresses spore germination, the extension of bacterium pipe, mycelial growth and spore mother cell to form the Main Stage of conk and breeding, and bactericidal action is directly caused by parent active agent, does not have corresponding metabolic activity; The formation of described dimethomorph chief destructive germ cell envelope, causes the decomposition of spore cyst wall, and makes germ dead, and in it, absorption is strong.Boscalids different for the mechanism of action and dimethomorph are carried out composite, help avoid fungi produce resistance and delay the drug-fast generation speed of fungi, and the two is composite has obvious synergistic effect, for preventing and treating Common Diseases in the crop-planting processes such as downy mildew, late blight, gray mold.
The described percetage by weight containing active ingredient in the bactericidal composition of Boscalid and dimethomorph is 10% ~ 54%, all the other are allow in pesticidal preparations to use and acceptable auxiliary element, and such as used auxiliary agent comprises surfactant, dispersant, filler, filler etc. and other are of value to the conventional material of active ingredient stable and performance drug effect in the formulation.
Described bactericidal composition is prepared from according to the method for conventional pesticide preparation in prior art, and the formulation of described bactericidal composition is the one of water dispersible granules or wetting powder or suspending agent.
Boscalid and dimethomorph carry out composite as active ingredient with certain weight ratio by the present invention, and its beneficial effect is:
(1) described bactericidal composition fungicidal spectrum is comparatively wide, avoiding fungi produce resistance and delay the drug-fast generation speed of fungi, having obvious synergistic effect, for preventing and treating Common Diseases in the crop-planting processes such as downy mildew, late blight, gray mold;
(2) there is not cross resistance in described active ingredient Boscalid and dimethomorph, reduces Pesticide use amount, and then reduce cost, decreases the pollution to environment simultaneously, is conducive to the resistance management of disease, has larger economic benefit and social benefit.
Embodiment
In order to technique effect of the present invention is described better; effectively prevent and treat the diseases such as downy mildew, late blight, gray mold; inventor has carried out respective chambers pot experiment with reference to Wu Wenjun " chemical protection of plant experimental technique introduction " (1993); be studied according to Toxicity Determination test, test data is in table 1:
Table 1 benzene metsulfovax and dimethomorph indoor pot experiment data.
| Weight ratio | EC 50（μg/ml） | Co-toxicity coefficient (CTC) |
| Boscalid | 5.62 | - |
| Dimethomorph | 10.16 | - |
| Boscalid: dimethomorph (1:10) | 7.53 | 159.62 |
| Boscalid: dimethomorph (1:8) | 6.75 | 183.71 |
| Boscalid: dimethomorph (1:6) | 5.42 | 230.52 |
| Boscalid: dimethomorph (1:4) | 5.67 | 229.33 |
| Boscalid: dimethomorph (1:3) | 5.85 | 226.12 |
| Boscalid: dimethomorph (1:2) | 6.01 | 215.50 |
| Boscalid: dimethomorph (1:1) | 6.32 | 201.46 |
| Boscalid: dimethomorph (6:1) | 7.14 | 162.35 |
Calculate the toxicity index of each medicament and the co-toxicity coefficient (CTC value) of mixture according to the abundant method of Sun Yun, when CTC≤80 are antagonism, 80 ﹤ CTC ﹤ 120 are summation action, and CTC>=120 are synergistic effect; EC
50represent medium effective concentration, having guided 50% individual effective dosage, is Drug safety index.
Shown by table 1 data: carry out composite by weight the ratio for 1:10,1:8,1:6,1:4,1:3,1:2,1:1,6:1 respectively by active ingredient Boscalid and dimethomorph, produce synergistic effect, co-toxicity coefficient is between 159.62-230.52; When the weight ratio of Boscalid and dimethomorph is 1:6 ~ 1:1, synergistic effect is obvious, and its co-toxicity coefficient is 201.46 ~ 230.52; When the weight ratio of Boscalid and dimethomorph is 1:6, co-toxicity coefficient is up to 230.52, and its synergistic effect is the most remarkable, and its EC
50minimum, safety is good.
Be described in further detail content of the present invention below in conjunction with embodiment, content mentioned in embodiment is not limitation of the invention, and unless otherwise indicated, all percentage is all weight percentage, and is raw materials usedly commercially available prod.
Embodiment 1
24% Boscalid dimethomorph water dispersion granula
Its pulp furnish is: Boscalid 6%, dimethomorph 18%, lauryl sodium sulfate (surfactant) 2%, white carbon (filler) 4%, sodium lignin sulfonate (dispersant) 5%, and bentonite (filler) complements to 100%.By above-mentioned formula dry pulverization process, granulation, drying, screening i.e. obtained 24% Boscalid dimethomorph water dispersion granula in proportion.
This formula control cucumber downy mildew is by 1500 times of dilution sprayings, and after medicine, 7 days control efficiency are 92.1%.50% Boscalid water dispersible granules is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 81.2%, 40% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 69.7%.Test shows: 24% Boscalid dimethomorph water dispersion granula has good control efficiency to cucumber downy mildew, is better than corresponding single dose.
Embodiment 2
42% Boscalid dimethomorph water dispersion granula
Its pulp furnish is: Boscalid 6%, dimethomorph 36%, lauryl sodium sulfate (surfactant) 2%, sodium carboxymethyl starch (filler) 2%, sodium lignin sulfonate (dispersant) 5%, and bentonite (filler) complements to 100%.By the ultra-fine grinding in proportion of above-mentioned formula, granulation, drying, screening i.e. obtained 42% Boscalid dimethomorph water dispersion granula.
This formula control late blight of tomato is by 2000 times of dilution sprayings, and after medicine, 7 days control efficiency are 93.7%.70% Boscalid water dispersible granules is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 83.2%, 40% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 69.7%.Test shows: 42% Boscalid dimethomorph water dispersion granula has good control efficiency to late blight of tomato, is better than corresponding single dose.
Embodiment 3
18% Boscalid dimethomorph suspending agent
Its pulp furnish is: Boscalid 6%, dimethomorph 12%, sodium lignin sulfonate (dispersant) 5%, ethylene glycol 5%(antifreezing agent), white carbon 2%(filler), sodium alginate 1%(suspending agent) and, deionized water complements to 100%.Above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 32% Boscalid dimethomorph suspending agent of allotment after high shear mixing.
This formula control gray mold of cucumber is by 1500 times of dilution sprayings, and after medicine, 7 days control efficiency are 91.7%.20% Boscalid suspending agent is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 80.7%, 20% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 68.9%.Test shows: 18% Boscalid dimethomorph water dispersion granula has good control efficiency to gray mold of cucumber, is better than corresponding single dose.
Embodiment 4
10% Boscalid dimethomorph suspending agent
Its pulp furnish is: Boscalid 5%, dimethomorph 5%, aliphatic alcohol polyoxyvinethene phosphate (surfactant) 5%, ethylene glycol 5%(antifreezing agent), white carbon 2%(filler), xanthans 0.5%(thickener) and, deionized water complements to 100%.Above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 32% Boscalid dimethomorph suspending agent of allotment after high shear mixing.
This formula prevents and treats potato late blight by 1500 times of dilution sprayings, and after medicine, 7 days control efficiency are 91.5%.20% Boscalid suspending agent is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 81.2%, 40% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 69.7%.Test shows: 10% Boscalid dimethomorph water dispersion granula has good control efficiency to potato late blight, is better than corresponding single dose.
Embodiment 5
20% Boscalid dimethomorph suspending agent
Its pulp furnish is: Boscalid 4%, dimethomorph 16%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 5%, 0203B(surfactant) 6%, white carbon (filler) 5%, aluminium-magnesium silicate (suspending agent) 0.4%, ethylene glycol (antifreezing agent) 3%, tributyl phosphate (defoamer) 1.5%, deionized water complements to 100%.Above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 20% Boscalid dimethomorph suspending agent of allotment after high shear mixing.
This formula prevents and treats downy mildew of garpe by 1500 times of dilution sprayings, and after medicine, 7 days control efficiency are 92.5%.20% Boscalid suspending agent is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 81.2%, 50% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 77.3%.Test shows that 20% Boscalid dimethomorph suspending agent has good control efficiency to downy mildew of garpe, is better than corresponding single dose.
Embodiment 6
44% Boscalid dimethomorph wetting powder
Its pulp furnish is: Boscalid 4%, dimethomorph 40%, tea withered powder 5%(dispersant), sodium lignin sulfonate 5%(dispersant), lauryl sodium sulfate 0.5%(wetting agent), bentonite 10%, attapulgite (filler) complements to 100%.By above-mentioned formula by than the abundant mixing of row, after ultra-fine pulverizer disintegrating, obtain wetting powder.
This formula control graw mold of tomato is by 2000 times of dilution sprayings, and after medicine, 7 days control efficiency are 90.1%.50% Boscalid suspending agent is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 81.6%, 40% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 71.7%.Test shows that 44% Boscalid dimethomorph suspending agent has good control efficiency to graw mold of tomato, is better than corresponding single dose.
Embodiment 7
54% Boscalid dimethomorph wetting powder
Its pulp furnish is: Boscalid 6%, dimethomorph 48%, NNO5%(dispersant), sodium lignin sulfonate 5%(dispersant), pull open powder 0.5%(wetting agent) and, kaolin (filler) complements to 100%.By above-mentioned formula by than the abundant mixing of row, after ultra-fine pulverizer disintegrating, obtain wetting powder.
This formula control tomato late blight is by 2000 times of dilution sprayings, and after medicine, 7 days control efficiency are 90.7%.20% Boscalid suspending agent is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 83.5%, 40% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 73.5%.Test shows that 54% Boscalid dimethomorph suspending agent has good control efficiency to tomato late blight, is better than corresponding single dose.
Embodiment 8
35% Boscalid dimethomorph wetting powder
Its pulp furnish is: Boscalid 30%, dimethomorph 5%, NNO5%(dispersant), sodium lignin sulfonate 5%(dispersant), pull open powder 0.5%(wetting agent) and, white carbon 3%, kaolin (filler) complements to 100%.By above-mentioned formula by than the abundant mixing of row, after ultra-fine pulverizer disintegrating, obtain wetting powder.
This formula control cucumber downy mildew is by 2000 times of dilution sprayings, and after medicine, 7 days control efficiency are 90.2%.50% Boscalid suspending agent is by 1000 times of dilution sprayings, and after medicine, 7 days control efficiency are that 81.2%, 40% dimethomorph water dispersion granula dilutes spraying by 1000 times, and after medicine, 7 days control efficiency are 69.7%.Test shows that 35% Boscalid dimethomorph suspending agent has good control efficiency to cucumber downy mildew, is better than corresponding single dose.
As can be seen from embodiment 1-8, adopt bactericidal composition of the present invention, for preventing and treating Common Diseases in the crop-planting processes such as downy mildew, late blight, gray mold, its preventive effect is more than 90%, when the weight ratio of Boscalid and dimethomorph is 1:6 ~ 1:1, its preventive effect is more than 91.5%, and when the weight ratio of Boscalid and dimethomorph is 1:6, its preventive effect is up to 93.7%.
Claims (1)
1. a 42% Boscalid dimethomorph water dispersion granula, its pulp furnish is: Boscalid 6%, dimethomorph 36%, lauryl sodium sulfate 2%, sodium carboxymethyl starch 2%, sodium lignin sulfonate 5%, and bentonite complements to 100%;
The preparation method of described 42% Boscalid dimethomorph water dispersion granula is: by the ultra-fine grinding in proportion of above-mentioned formula, granulation, drying, screening i.e. obtained 42% Boscalid dimethomorph water dispersion granula.
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| CA2312993C (en) * | 1997-12-18 | 2010-06-22 | Basf Aktiengesellschaft | Fungicide mixtures based on pyridine carboxamides |
| DK1041883T3 (en) * | 1997-12-18 | 2002-10-14 | Basf Ag | Fungicidal mixtures based on pyridinamides and morpholine and piperidine derivatives respectively |
| AR075573A1 (en) * | 2009-02-11 | 2011-04-20 | Basf Se | DIMETHOMORPH AS A PESTICIDE PROTECTOR WITH PHYTO-TOXIC EFFECTS |
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Address after: 256500 Boxing County Economic Development Zone, Binzhou, Shandong Patentee after: JINGBO AGROCHEMICALS TECHNOLOGY Co.,Ltd. Address before: 256500 Boxing County Economic Development Zone, Binzhou, Shandong Patentee before: JINGBO AGROCHEMICALS TECHNOLOGY Co.,Ltd. |
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Address after: 256500 Boxing Economic Development Zone, Shandong, Binzhou Patentee after: Shandong Jingbo Agrochemical Technology Co.,Ltd. Address before: 256500 Boxing Economic Development Zone, Shandong, Binzhou Patentee before: JINGBO AGROCHEMICALS TECHNOLOGY Co.,Ltd. |