CN104430383A - Sterilization composition containing picoxystrobin and difenoconazole and application of composition - Google Patents
Sterilization composition containing picoxystrobin and difenoconazole and application of composition Download PDFInfo
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- CN104430383A CN104430383A CN201410686815.XA CN201410686815A CN104430383A CN 104430383 A CN104430383 A CN 104430383A CN 201410686815 A CN201410686815 A CN 201410686815A CN 104430383 A CN104430383 A CN 104430383A
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Abstract
The invention relates to a sterilization composition containing picoxystrobin and difenoconazole and application of the composition. According to the composition, the weight part ratio of picoxystrobin to difenoconazole is (40 to 1) to (1 to 40) and the weight percent of active ingredients is 1-90%. The composition has a synergistic effect by compounding picoxystrobin with difenoconazole and is used for preventing and controlling various diseases such as leaf spot disease, anthracnose, downy mildew, brown blotch, gummy stem blight, rice false smut and rust disease on various crops such as bananas, apples, paddy rice, watermelons and hot peppers.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to a kind of bactericidal composition and the application thereof that contain ZEN 90160 and Difenoconazole.
Technical background
ZEN 90160 (picoxystrobin), chemical name: (E)-3-methoxy-2-[2-[6-(trifluoromethyl)-2-pyridine oxygen methyl] phenyl] methyl acrylate.Belonging to methoxy acrylic bactericide is a class low toxicity, efficient, wide spectrum, systemic fungicide, almost all there is good activity to all fungies (Oomycete, Phycomycetes, Ascomycetes and deuteromycetes) disease such as powdery mildew, rust, glume blight, net blotch, downy mildew, rice blast etc., and effectively can prevent and treat the pathogen series other bactericide being produced to resistance, bacterial strain 14-demethylation enzyme inhibitor, benzamides, dicarboxylic dihydrazides amine and benzimidazole being produced to resistance is effective.There is no cross resistance with other bactericide at home market used at present, and can degrade very soon in plant corpus, in soil and water, there is protection, treat, root out, osmosis, without carcinogenic with mutagenesis etc. feature, be the world
The extremely potential pesticide species of the another class of agricultural chemicals circle after triazole bactericidal agent.
Difenoconazole You Ming Difenoconazole, trade name generation is high, enemy withers pellet, and chemical name is: 1-(2-[4-(4-chlorobenzene oxygen)-2-chlorphenyl]-4-methyl isophthalic acid, 3-dioxin-pentane-2-ylmethyl)-H-1,2,4-triazole, its structural formula is as follows:
Difenoconazole technical material outward appearance is grayish white powdery thing, density 1.40g/cm
3(20 DEG C), fusing point 78.6 DEG C, vapour pressure 3.3 × 10
-8pa (25 DEG C), solvability (25 DEG C): water 15mg/L, ethanol 330g/L, acetone 610g/L, toluene 490g/L, normal hexane 3.4g/L, n-octyl alcohol 95g/L.Difenoconazole is a kind of interior suction wide-spectrum bactericide, to leaf spot, powdery mildew, rust, the disease such as anthracnose and scab of various vegetables and fruit tree, there is good result for the treatment of, to crop safety, all can improve crop yield to the process of seed and the spraying on blade face.Its preparation is mainly missible oil, microemulsion etc., because missible oil, microemulsion employ a large amount of organic solvents,
Easily produce residual to crop, easily cause poisoning, simultaneously comparatively large to the damage ratio of environment, along with the enhancing of people's environmental consciousness, development water-based pesticides is particularly important.
The present inventor finds ZEN 90160 and the composite use of Difenoconazole, the two has obviously synergistic effect within the scope of certain proportion, there is significance to improve to the control efficiency of corps diseases, and fungicidal spectrum can be expanded, delay the drug-fast generation of pathogen, so propose the present invention.
Summary of the invention
For the problems referred to above, the invention provides a kind of bactericidal composition of the high-efficiency low-toxicity containing ZEN 90160 and Difenoconazole for controlling disease, greatly can delay generation and the development of pathogen resistance, low-consuming, preventive effect is high, low to influence degree, be beneficial to the sustainable development of agricultural production.
The present invention is achieved through the following technical solutions:
The present invention relates to a kind of bactericidal composition containing ZEN 90160 and Difenoconazole, the ratio of weight and number of active component ZEN 90160 and Difenoconazole is 40:1 ~ 1:40.As preferably,
The ratio of weight and number of active component ZEN 90160 and Difenoconazole is 10:1 ~ 1:10.
The bactericidal composition active component weight percentage that the present invention relates to is 1 ~ 90%, add suitable known auxiliary agent and excipient, the method all known according to those skilled in the art makes the formulation being applicable to agriculturally using, and is preferably suspending agent and water dispersible granules.Described known auxiliary agent, excipient have dispersant, diffusant, defoamer, wetting agent, disintegrant etc.
The bactericidal composition that the present invention relates to can be used to prevent and treat the crop pest caused by disease fungus, especially prevents and treats the multiple diseases such as the leaf spot in the various crop such as banana, apple, paddy rice, watermelon, capsicum, anthracnose, downy mildew, brown spot, blight dis-ease, false smut, rust.
Beneficial effect of the present invention: one is by ZEN 90160 and the composite use of Difenoconazole, because the mechanism of action is different each other, action site variation, thus greatly can delay generation and the development of pathogen resistance, be conducive to the service life extending outstanding bactericide.Two is that the built agent of ZEN 90160 and Difenoconazole possesses very high prolection and treatment simultaneously, roots out activity; after composite by a certain percentage, there is obvious synergistic effect; compared with single dose; preventive effect can be significantly improved; thus save dosage, drug cost and a large amount of manpower and materials, reach thing half merit
Effect doubly.Three is because ZEN 90160 and Difenoconazole all belong to low-toxin farm chemicals, its complex preparation high-efficiency low-toxicity, consumption reduces, thus the extent of injury of environment is significantly reduced, what alleviate social environment bears pressure, there is good economic benefit, social benefit and environmental benefit, be conducive to the sustainable development of agricultural production, meet the trend of environmental protection.
Embodiment
Be described further below in conjunction with the bactericidal composition of embodiment to ZEN 90160 of the present invention and Difenoconazole, but the present invention is not limited thereto.
Raw survey embodiment 1: ZEN 90160 and the composite toxicity test to apple anthrax bacteria of Difenoconazole
The indoor virulence of mixture to apple anthrax bacteria of ZEN 90160 and Difenoconazole different ratio is have studied with mycelial growth rate method, experimental technique adopts the abundant method of Sun Yun to calculate co-toxicity coefficient (CTC) and evaluates mixed effect, think that mixture has synergistic effect when CTC value is greater than 120, think antagonism when being less than 80, time between 80 ~ 120, think that there is summation action.Concrete grammar is as follows:
Get the liquid prepared and be placed in 100ml50-60 DEG C of PDA sterilising medium, shake up, pour in the sterilizing culture dish of diameter 60mm, after cooled and solidified, move the bacterium cake that length is consistent, diameter is 4mm of delivering a child respectively, to add the sterilising medium of equivalent coordinative solvent as blank, all operations all carries out sterile working at superclean bench, and often 3 repetitions are established in process.Put into after 27 DEG C of constant incubators cultivate 3-8 days, adopt right-angled intersection method to measure colony diameter, calculate bacteriostasis rate, EC
50, the relevant parameter such as CTC, relevant calculating formulas is as follows:
Pure amount of growth=bacterium colony average diameter-bacterium cake diameter (0.4cm)
Bacteriostasis rate=[the pure amount of growth of (contrast pure amount of growth-process pure amount of growth) × 100/ contrast] × 100%
The EC50*100 of the EC50/B agent of toxicity index TI (B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
Theoretical toxicity index TTI (AB)=percentage+TI (B) the * B percentage in mixture of TI (A) * A in mixture
Co-toxicity coefficient CTC=ATI (AB)/TTI (AB) * 100
Result of the test shows, ZEN 90160 and Difenoconazole composite, to Colletotrichum capsici, there is good indoor virulence, the CTC value of all proportionings is all more than 120, show that these two bactericide have good synergistic function under this proportioning, and when mixed ratio is between 10: 1 ~ 1: 10, synergy is particularly remarkable.Experimental data sees the following form 1.
Table 1 ZEN 90160 and the composite toxicity test table of comparisons to Colletotrichum capsici of Difenoconazole
| Reagent agent | Active ingredient ratio | EC50(ppm) | Co-toxicity coefficient (CTC) |
| ZEN 90160 | —— | 28.3 | —— |
| Difenoconazole | —— | 21.9 | —— |
| ZEN 90160: Difenoconazole | 40:1 | 18.6 | 120.5 |
| ZEN 90160: Difenoconazole | 20:1 | 13.4 | 148.7 |
| ZEN 90160: Difenoconazole | 10:1 | 9.8 | 189.4 |
| ZEN 90160: Difenoconazole | 1:1 | 10.6 | 201.8 |
| ZEN 90160: Difenoconazole | 1:10 | 10.2 | 190.3 |
| ZEN 90160: Difenoconazole | 1:20 | 14.3 | 152.3 |
| ZEN 90160: Difenoconazole | 1:40 | 17.2 | 146.9 |
Application Example 1 prevents and treats the test of pesticide effectiveness of pepper anthracnose
22% ZEN 90160 Difenoconazole floats the preparation of agent
Above-mentioned each component is mixed by formula rate, after sand milling grinds, then mixes, namely obtain the preparation that 22% ZEN 90160 Difenoconazole floats agent.
In the control efficiency of field test mixture to pepper anthracnose.In the 1st dispenser of pepper anthracnose initial stage of origination, connect spray medicine 3 times, 7 days, interval, using clear water as blank, 7 days investigation preventive effects after the 3rd dispenser, result is as follows:
The control efficiency of table 2 pair pepper anthracnose
ZEN 90160 Difenoconazole mixture preparation has good control efficiency to pepper anthracnose as seen from the above table, and is better than the preventive effect of single dose.
Application Example 2 prevents and treats the test of pesticide effectiveness of sigatoka
The preparation of 30% ZEN 90160 difenoconazole water dispersible granule:
Above-mentioned active component, dispersant, disintegrant and filler etc. are mixed by formula rate, becoming through air-flow crushing can wet-milling, then adds a certain amount of water mixing extruder grain, and drying obtains 30% ZEN 90160 difenoconazole water dispersible granule after sieving.
In the control efficiency of field test mixture to sigatoka.In the 1st dispenser of sigatoka initial stage of origination, be advisable to squirt leave dual sides, using clear water as blank, spray medicine 3 times altogether, 10 days, interval, 10 days investigation preventive effects after the 3rd dispenser, result is as follows:
The control efficiency of table 7 pair sigatoka
ZEN 90160 Difenoconazole mixture preparation has good control efficiency to sigatoka as seen from the above table, and is better than the preventive effect of single dose.
Claims (4)
1., containing ZEN 90160 and a Difenoconazole bactericidal composition, it is characterized in that, described bactericidal composition comprises, and the ratio of weight and number of ZEN 90160 and Difenoconazole is 40:1 to 1:40.
2., according to bactericidal composition according to claim 1, it is characterized in that the ratio of weight and number of described ZEN 90160 and Difenoconazole is 10:1 ~ 1:10.
3., according to bactericidal composition according to claim 1, it is characterized in that described ZEN 90160 can become suspending agent and water dispersible granules with known auxiliary agent with excipient with Difenoconazole.
4. according to the application of microbicide compositions according to claim 1, it is characterized in that, this bactericidal composition is used for preventing and treating leaf spot, anthracnose, downy mildew, brown spot, blight dis-ease, false smut, the rust diseases on banana, apple, paddy rice, watermelon, Pepper crops.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410686815.XA CN104430383A (en) | 2014-11-25 | 2014-11-25 | Sterilization composition containing picoxystrobin and difenoconazole and application of composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410686815.XA CN104430383A (en) | 2014-11-25 | 2014-11-25 | Sterilization composition containing picoxystrobin and difenoconazole and application of composition |
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| CN104430383A true CN104430383A (en) | 2015-03-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107006462A (en) * | 2017-04-12 | 2017-08-04 | 江苏金凤凰农化有限公司 | A kind of composition and application process that pepper anthracnose is treated based on guaiacol |
-
2014
- 2014-11-25 CN CN201410686815.XA patent/CN104430383A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107006462A (en) * | 2017-04-12 | 2017-08-04 | 江苏金凤凰农化有限公司 | A kind of composition and application process that pepper anthracnose is treated based on guaiacol |
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