CN108651458A - A kind of bactericidal composition containing carvacrol and hexaconazole - Google Patents
A kind of bactericidal composition containing carvacrol and hexaconazole Download PDFInfo
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- CN108651458A CN108651458A CN201810674670.XA CN201810674670A CN108651458A CN 108651458 A CN108651458 A CN 108651458A CN 201810674670 A CN201810674670 A CN 201810674670A CN 108651458 A CN108651458 A CN 108651458A
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- Prior art keywords
- hexaconazole
- carvacrol
- bactericidal composition
- composition containing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of bactericidal composition containing carvacrol and hexaconazole, active ingredient are made of carvacrol and hexaconazole, and carvacrol and hexaconazole weight ratio are 1:10‑40.Bactericidal composition of the present invention can be applied to prevention crop gray mold, has higher synergistic function, overcomes and the drug resistance of germ has been delayed to generate, and sterilization speed is fast, and the lasting period is long, and control effect is substantially better than the use of its single dose.
Description
Technical field
The present invention relates to pesticides application technical fields, and in particular to a kind of bactericidal composition containing carvacrol and hexaconazole.
Background technology
Carvacrol (carvacrol), molecular formula are C10H14O, are a kind of pure plant source fungicide, have safety, ring
Protect, without poisoning the advantages of, meanwhile, carvacrol has the fungal diseases such as powdery mildew, rust, downy mildew, gray mold extremely strong anti-
Control effect.
Hexaconazole (hexaconazole), molecular formula are C14H17Cl2N3O, belong to triazole bactericidal agent, sterol demethylation
Inhibitor has disease caused by fungi especially Basidiomycota and Ascomycota the protection and therapeutic effect of broad spectrum activity.It is made
It is the biosynthesis for the cell membrane important composition ingredient ergosterol for destroying and preventing germ with mechanism, cell membrane is caused to be unable to shape
At keeping germ dead.With interior suction, protection and therapeutic activity.Suitable for crop and safety fruit tree such as apple, grape, banana, vegetable
Dish (melon and fruit, capsicum etc.), peanut, coffee, cereal crop and ornamental plant etc..
Graw mold of tomato is that heavier and common disease is endangered on tomato, and each vegetable-growing area all occurs.In addition to endangering tomato, may be used also
Endanger 20 various crop such as eggplant, capsicum, cucumber.Time harm more than low temperature, continuous rainy weather is serious.Graw mold of tomato is
The important disease of Plastic Greenhouse Tomato Cultivation In Relation, stem, leaf, flower, fruit can endanger, but main harm fruit, usually be fallen ill with Chinese olive heavier.
Therefore, prevention graw mold of tomato is for improving the yield of vegetables, ensureing that the quality of vegetables all has great influence.It is raw in agricultural
In the real process of production, the problem of controlling disease most easily produces is the generation of disease drug resistance.Different cultivars ingredient is answered
Match, is to prevent the very common method of resistance disease.It is studied by the present inventor, discovery mutually compounds carvacrol and hexaconazole,
There is good synergistic effect in a certain range.At present with carvacrol compounding related to hexaconazole at home and abroad there is not yet related report
Road.
Invention content
The technical problem to be solved by the present invention is to provide a kind of bactericidal composition containing carvacrol and hexaconazole, prevention effect
Fruit is good, germ drug resistance can be delayed to generate, for preventing graw mold of tomato.
The present invention is achieved through the following technical solutions：A kind of bactericidal composition containing carvacrol and hexaconazole, effectively at
Divide and be made of carvacrol and hexaconazole, the weight ratio of carvacrol and hexaconazole is 1:10-40.
Preferably, the weight ratio of the bactericidal composition, carvacrol and hexaconazole is 1:15、1:20 or 1:30.
The bactericidal composition, carvacrol account for the 0.2-1.0% of bactericidal composition total weight, and hexaconazole accounts for Bactericidal composite
The 5-20% of object total weight, surplus are auxiliary element pesticide-acceptable.
The bactericidal composition is added according to method known in those skilled in the art made of corresponding auxiliary element
Dosage form is suspending agent.
The auxiliary element that bactericidal composition of the present invention uses include dispersant, wetting agent, antifreezing agent, antifoaming agent, thickener,
Solvent etc. or other active ingredients that are beneficial to stablize the known substance played with drug effect in the formulation, are all in field of pesticide preparation
Commonly use or allow the various composition used.
Advantageous effect of the present invention：Bactericidal composition of the present invention can be applied to prevention graw mold of tomato, have higher collaboration
Synergistic effect overcomes and the drug resistance of germ has been delayed to generate, and sterilization speed is fast, and the lasting period is long, and control effect is substantially better than it
Single dose uses.
Specific implementation mode
Technical scheme of the present invention and technique effect are described further below in conjunction with specific embodiment, institute of the present invention
The percentage stated is weight percentage.
One, indoor toxicity determination test
Subjects：Graw mold of tomato germ
Test method：After prerun determines the effective inhibition concentration range of each medicament, each medicament is by active constituent content point
5 dose gradient processing are not set, if clear water compares.Reference《Farm-chemical indoor determination test rule fungicide》It carries out, uses
Mycelial growth rate method measures virulence of the medicament to botrytis cinerea.It is measured and is recorded everywhere using crossing method after 72h
The colony diameter of reason calculates each processing net growth, mycelial growth inhibition rate.
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm (x), with minimum
Square law acquires virulence regression equation (y=a+bx), and thus calculates the EC of each medicament50Value.Simultaneously according to Sun Yunpei's Method
Co-toxicity coefficient method (CTC) evaluate the synergistic effect of pharmacy mix, i.e. CTC≤80, composition shows as antagonism, when 80
<CTC<120, composition shows as summation action, and when CTC >=120, composition shows as synergistic effect.Test result such as table 1.
The toxicity test analysis of results table of 1 carvacrol of table, hexaconazole and its compounding to graw mold of tomato
As shown in Table 1, carvacrol is 1 in weight ratio with hexaconazole:Mixture is to the equal table of botrytis cinerea within the scope of 10-40
Reveal apparent synergistic effect.Wherein, when carvacrol and hexaconazole weight ratio are 1:15、1:20 or 1:Synergistic effect is particularly when 30
It is prominent；And when carvacrol and hexaconazole weight ratio are 1:When 5, composition shows as summation action；When carvacrol and hexaconazole weight
Amount is than being 5:1、1:Composition shows as antagonism when 45.
Two, product prepares embodiment
Embodiment 1：5.5% carvacrol hexaconazole suspending agent (1:10)
Carvacrol (active ingredient) 0.5%, hexaconazole (active ingredient) 5%, aliphatic alcohol polyoxyvinethene phosphate (dispersion
Agent) 3%, spaonin powder (wetting agent) 3%, carboxymethyl cellulose (thickener) 1%, ethylene glycol (antifreezing agent) 1%, silicone oil (disappears
Infusion) 0.1%, deionized water (solvent) complement to 100%；First other auxiliary agents are mixed, shear-mixed is uniform in cutter,
Then carvacrol and hexaconazole is added, 2h is ground in ball crusher, you can 5.5% carvacrol hexaconazole suspending agent is made.
Embodiment 2：20.5% carvacrol hexaconazole suspending agent (1:40)
Carvacrol (active ingredient) 0.5%, hexaconazole (active ingredient) 20%, aliphatic amine polyoxyethylene ether (dispersant)
2%, lignosulfonates (dispersant) 2.5%, lauryl sodium sulfate (wetting agent) 4.5%, polyvinyl alcohol (thickener)
2%, propylene glycol (antifreezing agent) 2%, C10-20 saturated fat acid compounds (antifoaming agent) 0.3%, deionized water (solvent) are mended
Enough to 100%；First other auxiliary agents are mixed, shear-mixed is uniform in cutter, and carvacrol and hexaconazole is then added, is grinding
2h is ground in ball machine, you can 20.5% carvacrol hexaconazole suspending agent is made.
Embodiment 3：16% carvacrol hexaconazole suspending agent (1:15)
Carvacrol (active ingredient) 1%, hexaconazole (active ingredient) 15%, nonylphenol polyoxyethylene ether (dispersant) 4%,
Spaonin powder (wetting agent) 3.5%, xanthans (thickener) 1.5%, glycerine (antifreezing agent) 1.5%, C8-10 aliphatic alcohols
Close object (antifoaming agent) 0.2%, deionized water (solvent) complements to 100%；First other auxiliary agents are mixed, are sheared in cutter mixed
It closes uniformly, carvacrol and hexaconazole is then added, 2h is ground in ball crusher, you can 16% carvacrol hexaconazole is made and suspends
Agent.
Embodiment 4：6.2% carvacrol hexaconazole suspending agent (1:30)
Carvacrol (active ingredient) 0.2%, hexaconazole (active ingredient) 6%, alkyl phenol polyoxyethylene ether (dispersant)
3%, silkworm excrement (wetting agent) 3%, polyvinyl alcohol (thickener) 1%, ethylene glycol (antifreezing agent) 1%, C10-20 saturated fat acids
Compound (antifoaming agent) 0.1%, deionized water (solvent) complement to 100%；First other auxiliary agents are mixed, are sheared in cutter
It is uniformly mixed, carvacrol and hexaconazole is then added, 2h is ground in ball crusher, you can 6.2% carvacrol hexaconazole is made
Suspending agent.
Comparative example 1：5% carvacrol aqua, registration card number：PD20140941, Lanzhou Shichuang Biotechnology Co., Ltd., city
Purchase.
Comparative example 2：5% hexaconazole suspending agent, registration card number：PD20150772, the limited public affairs of Hangzhou, Zhejiang province space dragon chemical industry
Department, it is purchased in market.
Three, product embodiments are applied to prevention graw mold of tomato field medicine effect test
Test method：Reference《GB/T17980.28-2000 pesticide field efficacy medicine test criterions (one) bactericidal agent for preventing and treating vegetables
Gray mold》.If clear water is blank control (CK), experiment sets 7 processing altogether, often handles 4 repetitions, per plot area 35m2, with
Machine district's groups arrange.First time spray pesticide, second of spray pesticide after 10 days, altogether dispenser 2 times are carried out in the early stages of disease.
Investigation method：Before the application, 7 days after second of dispenser, 14 days to each cell using 5 points of samplings, every investigation
3 plants, whole blades of every plant of investigation, record total number of sheets, the sick number of sheets and sick series calculate disease index and prevention preventive effect.Experiment
As a result such as table 2.
Disease index and control effect computational methods：
Formula (1)：Disease index calculation formula：In formula (1)：X- disease indexs；NiDiseases at different levels
The number of sheets；I- is with respect to value of series；N- investigates total number of sheets.
Formula (2)：Control effect calculation formula：In formula (2)：P- control effects, unit
For percentage (%)；CK0Disease index before blank district dispenser；CK1Disease index after blank district dispenser；PT0Medicine
Disease index before agent treatment region dispenser；PT1Disease index after chemicals treatment district dispenser.
2 carvacrol of table, hexaconazole and its compounding prevention graw mold of tomato field medicine effect test
As can be seen from Table 2, in bactericidal composition of the invention active ingredient hexaconazole and carvacrol in particular range
Mixture not will produce conflict, obvious synergy, and preventive effect is better than single dose, greatly improve the prevention effect to graw mold of tomato
Fruit.The two compounding has delayed the generation of disease drug resistance, lasting period long simultaneously.
Claims (4)
1. a kind of bactericidal composition containing carvacrol and hexaconazole, which is characterized in that active ingredient is by carvacrol and hexaconazole group
At the weight ratio of carvacrol and hexaconazole is 1:10-40.
2. bactericidal composition according to claim 1, which is characterized in that the weight ratio of carvacrol and hexaconazole is 1:15、
1:20 or 1:30.
3. bactericidal composition according to claim 1 or 2, which is characterized in that it is total that the carvacrol accounts for bactericidal composition
The 0.2-1.0% of weight, hexaconazole account for the 5-20% of bactericidal composition total weight, surplus be auxiliary pesticide-acceptable at
Point.
4. bactericidal composition according to claim 3, which is characterized in that the bactericidal composition is prepared into suspending agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810674670.XA CN108651458A (en) | 2018-06-27 | 2018-06-27 | A kind of bactericidal composition containing carvacrol and hexaconazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810674670.XA CN108651458A (en) | 2018-06-27 | 2018-06-27 | A kind of bactericidal composition containing carvacrol and hexaconazole |
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| Publication Number | Publication Date |
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| CN108651458A true CN108651458A (en) | 2018-10-16 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115088712A (en) * | 2022-06-23 | 2022-09-23 | 广西壮族自治区农业科学院 | Medicament for preventing and treating Pueraria thomsonii rust disease |
Citations (3)
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|---|---|---|---|---|
| CN101530088A (en) * | 2008-03-14 | 2009-09-16 | 北京绿色农华植保科技有限责任公司 | Hexaconazole suspending agent and method for preparing same |
| CN101683073A (en) * | 2009-07-30 | 2010-03-31 | 南通润鸿生物化学有限公司 | Process for producing 5 percent hexaconazole suspending agent |
| CN103999851A (en) * | 2013-02-24 | 2014-08-27 | 陈浩 | Carvacrol emulsion in water and preparation method tehreof |
-
2018
- 2018-06-27 CN CN201810674670.XA patent/CN108651458A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530088A (en) * | 2008-03-14 | 2009-09-16 | 北京绿色农华植保科技有限责任公司 | Hexaconazole suspending agent and method for preparing same |
| CN101683073A (en) * | 2009-07-30 | 2010-03-31 | 南通润鸿生物化学有限公司 | Process for producing 5 percent hexaconazole suspending agent |
| CN103999851A (en) * | 2013-02-24 | 2014-08-27 | 陈浩 | Carvacrol emulsion in water and preparation method tehreof |
Non-Patent Citations (1)
| Title |
|---|
| 俞勇权: "5%己唑醇SC防治番茄灰霉病田间药效试验", 《上海蔬菜》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115088712A (en) * | 2022-06-23 | 2022-09-23 | 广西壮族自治区农业科学院 | Medicament for preventing and treating Pueraria thomsonii rust disease |
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Application publication date: 20181016 |