CN103717583B - 二苯并硫氮杂*衍生物及其在治疗中枢神经系统紊乱中的用途 - Google Patents

二苯并硫氮杂*衍生物及其在治疗中枢神经系统紊乱中的用途 Download PDF

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CN103717583B
CN103717583B CN201280023906.4A CN201280023906A CN103717583B CN 103717583 B CN103717583 B CN 103717583B CN 201280023906 A CN201280023906 A CN 201280023906A CN 103717583 B CN103717583 B CN 103717583B
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CN103717583A (zh
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D·卡瓦拉
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D. Cavalla
SerinaTis Biotech
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Numedicus Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/14—[b, e]-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CN201280023906.4A 2011-04-18 2012-04-16 二苯并硫氮杂*衍生物及其在治疗中枢神经系统紊乱中的用途 Active CN103717583B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1106520.8 2011-04-18
GBGB1106520.8A GB201106520D0 (en) 2011-04-18 2011-04-18 Pharmaceutical compounds
GBGB1113163.8A GB201113163D0 (en) 2011-04-18 2011-08-01 Pharmaceutical compounds
GB1113163.8 2011-08-01
PCT/GB2012/050831 WO2012143703A1 (en) 2011-04-18 2012-04-16 Dibenzothiazepine derivatives and their use in the treatment of cns disorders

Publications (2)

Publication Number Publication Date
CN103717583A CN103717583A (zh) 2014-04-09
CN103717583B true CN103717583B (zh) 2016-02-10

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US (1) US9487492B2 (enExample)
EP (1) EP2699559B1 (enExample)
JP (1) JP6030120B2 (enExample)
CN (1) CN103717583B (enExample)
CA (1) CA2833320C (enExample)
DK (1) DK2699559T3 (enExample)
ES (1) ES2574277T3 (enExample)
GB (2) GB201106520D0 (enExample)
WO (1) WO2012143703A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6557674B2 (ja) * 2014-03-12 2019-08-07 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 新規クラスのミュー−オピオイド受容体アゴニスト
CA2998868A1 (en) 2015-09-16 2017-03-23 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
GB201517133D0 (en) * 2015-09-28 2015-11-11 Numedicus Ltd New pharmaceutical use
WO2021222353A1 (en) 2020-04-30 2021-11-04 Gilead Sciences, Inc. Macrocyclic inhibitors of peptidylarginine deiminases
US20240092802A1 (en) * 2020-10-06 2024-03-21 Kures, Inc. Mu-opioid receptor agonists and uses therefor
WO2022074588A1 (en) * 2020-10-06 2022-04-14 Kures, Inc. Carboxylic diarylthiazepineamines and uses therefor
CN118598743A (zh) * 2024-05-29 2024-09-06 康龙化成手性医药技术(宁波)有限公司 一种2,2-二甲基环丁烷甲酸的合成方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872102A (en) * 1971-11-04 1975-03-18 En Nom Collectif Science Union Tricyclic compounds of aliphatic w-amino alcohols
CN1367782A (zh) * 1999-07-09 2002-09-04 宇部兴产株式会社 二苯并硫氮䓬衍生物的制备方法
WO2005099714A1 (en) * 2004-04-08 2005-10-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of neuropathic pain, fibromyalgia and chronic fatigue syndrome
CN1913900A (zh) * 2003-12-22 2007-02-14 阿卡蒂亚药品公司 作为毒蕈碱激动剂的氨基取代的二芳基[a,d]环庚烯类似物及神经精神疾病的治疗方法
CN101351210A (zh) * 2005-01-07 2009-01-21 阿斯利康公司 11－哌嗪－1－基二苯并[b,f][l,4]硫氮杂卓或其药学上可接受的盐的新用途及其用于口服药物组合物的新用途
US20090275541A1 (en) * 2008-05-05 2009-11-05 Sullivan Gregory M Method for treating neurocognitive dysfunction
WO2010070667A2 (en) * 2008-11-19 2010-06-24 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1269551A (en) 1969-03-27 1972-04-06 Science Union & Cie New tricyclic derivatives and process for their manufacture
EP1752143A1 (en) * 2005-08-08 2007-02-14 NewThera Novel uses for drugs targeting glutamine synthetase
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872102A (en) * 1971-11-04 1975-03-18 En Nom Collectif Science Union Tricyclic compounds of aliphatic w-amino alcohols
CN1367782A (zh) * 1999-07-09 2002-09-04 宇部兴产株式会社 二苯并硫氮䓬衍生物的制备方法
CN1913900A (zh) * 2003-12-22 2007-02-14 阿卡蒂亚药品公司 作为毒蕈碱激动剂的氨基取代的二芳基[a,d]环庚烯类似物及神经精神疾病的治疗方法
WO2005099714A1 (en) * 2004-04-08 2005-10-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of neuropathic pain, fibromyalgia and chronic fatigue syndrome
CN101351210A (zh) * 2005-01-07 2009-01-21 阿斯利康公司 11－哌嗪－1－基二苯并[b,f][l,4]硫氮杂卓或其药学上可接受的盐的新用途及其用于口服药物组合物的新用途
US20090275541A1 (en) * 2008-05-05 2009-11-05 Sullivan Gregory M Method for treating neurocognitive dysfunction
WO2010070667A2 (en) * 2008-11-19 2010-06-24 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate

Also Published As

Publication number Publication date
JP2014511897A (ja) 2014-05-19
EP2699559A1 (en) 2014-02-26
GB201113163D0 (en) 2011-09-14
US20140243317A1 (en) 2014-08-28
EP2699559B1 (en) 2016-04-06
WO2012143703A1 (en) 2012-10-26
CA2833320A1 (en) 2012-10-26
CA2833320C (en) 2019-05-21
US9487492B2 (en) 2016-11-08
CN103717583A (zh) 2014-04-09
DK2699559T3 (en) 2016-07-04
JP6030120B2 (ja) 2016-11-24
GB201106520D0 (en) 2011-06-01
ES2574277T3 (es) 2016-06-16

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