CA2833320C - Dibenzothiazepine derivatives and their use in the treatment of cns disorders - Google Patents

Dibenzothiazepine derivatives and their use in the treatment of cns disorders Download PDF

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Publication number
CA2833320C
CA2833320C CA2833320A CA2833320A CA2833320C CA 2833320 C CA2833320 C CA 2833320C CA 2833320 A CA2833320 A CA 2833320A CA 2833320 A CA2833320 A CA 2833320A CA 2833320 C CA2833320 C CA 2833320C
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CA
Canada
Prior art keywords
compound
alkyl
independently represent
formula
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2833320A
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English (en)
French (fr)
Other versions
CA2833320A1 (en
Inventor
David Cavalla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Numedicus Ltd
Original Assignee
Numedicus Ltd
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Filing date
Publication date
Application filed by Numedicus Ltd filed Critical Numedicus Ltd
Publication of CA2833320A1 publication Critical patent/CA2833320A1/en
Application granted granted Critical
Publication of CA2833320C publication Critical patent/CA2833320C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/14—[b, e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CA2833320A 2011-04-18 2012-04-16 Dibenzothiazepine derivatives and their use in the treatment of cns disorders Active CA2833320C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1106520.8A GB201106520D0 (en) 2011-04-18 2011-04-18 Pharmaceutical compounds
GB1106520.8 2011-04-18
GBGB1113163.8A GB201113163D0 (en) 2011-04-18 2011-08-01 Pharmaceutical compounds
GB1113163.8 2011-08-01
PCT/GB2012/050831 WO2012143703A1 (en) 2011-04-18 2012-04-16 Dibenzothiazepine derivatives and their use in the treatment of cns disorders

Publications (2)

Publication Number Publication Date
CA2833320A1 CA2833320A1 (en) 2012-10-26
CA2833320C true CA2833320C (en) 2019-05-21

Family

ID=44147160

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2833320A Active CA2833320C (en) 2011-04-18 2012-04-16 Dibenzothiazepine derivatives and their use in the treatment of cns disorders

Country Status (9)

Country Link
US (1) US9487492B2 (enExample)
EP (1) EP2699559B1 (enExample)
JP (1) JP6030120B2 (enExample)
CN (1) CN103717583B (enExample)
CA (1) CA2833320C (enExample)
DK (1) DK2699559T3 (enExample)
ES (1) ES2574277T3 (enExample)
GB (2) GB201106520D0 (enExample)
WO (1) WO2012143703A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015138791A1 (en) * 2014-03-12 2015-09-17 The Trustees Of Columbia University In The City Of New York A new class of mu-opioid receptor agonists
AU2016323977B9 (en) 2015-09-16 2021-03-04 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
GB201517133D0 (en) * 2015-09-28 2015-11-11 Numedicus Ltd New pharmaceutical use
MX2022013615A (es) 2020-04-30 2022-11-16 Gilead Sciences Inc Inhibidores de macrociclo de peptidilarginina deiminasas.
US20240092802A1 (en) * 2020-10-06 2024-03-21 Kures, Inc. Mu-opioid receptor agonists and uses therefor
US20230365519A1 (en) * 2020-10-06 2023-11-16 Kures, Inc. Carboxylic diarylthiazepineamines and uses thereof
CN118598743A (zh) * 2024-05-29 2024-09-06 康龙化成手性医药技术(宁波)有限公司 一种2,2-二甲基环丁烷甲酸的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1269551A (en) 1969-03-27 1972-04-06 Science Union & Cie New tricyclic derivatives and process for their manufacture
US3872102A (en) * 1971-11-04 1975-03-18 En Nom Collectif Science Union Tricyclic compounds of aliphatic w-amino alcohols
NZ516851A (en) * 1999-07-09 2004-02-27 Astrazeneca Uk Ltd Process for producing dibenzothiazepine derivatives
CN1913900B (zh) * 2003-12-22 2010-11-24 阿卡蒂亚药品公司 作为毒蕈碱激动剂的氨基取代的二芳基[a，d]环庚烯类似物及神经精神疾病的治疗方法
US20050227961A1 (en) * 2004-04-08 2005-10-13 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of neuropathic pain, fibromyalgia and chronic fatigue syndrome
CN101351210A (zh) * 2005-01-07 2009-01-21 阿斯利康公司 11－哌嗪－1－基二苯并[b,f][l,4]硫氮杂卓或其药学上可接受的盐的新用途及其用于口服药物组合物的新用途
EP1752143A1 (en) * 2005-08-08 2007-02-14 NewThera Novel uses for drugs targeting glutamine synthetase
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
US9314469B2 (en) * 2008-05-05 2016-04-19 Tonix Pharma Holdings Limited Method for treating neurocognitive dysfunction
WO2010070667A2 (en) * 2008-11-19 2010-06-24 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate

Also Published As

Publication number Publication date
CN103717583A (zh) 2014-04-09
CN103717583B (zh) 2016-02-10
ES2574277T3 (es) 2016-06-16
JP6030120B2 (ja) 2016-11-24
JP2014511897A (ja) 2014-05-19
CA2833320A1 (en) 2012-10-26
US20140243317A1 (en) 2014-08-28
EP2699559B1 (en) 2016-04-06
EP2699559A1 (en) 2014-02-26
DK2699559T3 (en) 2016-07-04
US9487492B2 (en) 2016-11-08
GB201106520D0 (en) 2011-06-01
WO2012143703A1 (en) 2012-10-26
GB201113163D0 (en) 2011-09-14

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