CN103649117B - Fc变体及其生成方法 - Google Patents
Fc变体及其生成方法 Download PDFInfo
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- CN103649117B CN103649117B CN201280016878.3A CN201280016878A CN103649117B CN 103649117 B CN103649117 B CN 103649117B CN 201280016878 A CN201280016878 A CN 201280016878A CN 103649117 B CN103649117 B CN 103649117B
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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| PCT/US2012/023749 WO2012106587A1 (en) | 2011-02-04 | 2012-02-03 | Fc VARIANTS AND METHODS FOR THEIR PRODUCTION |
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| CN103649117A CN103649117A (zh) | 2014-03-19 |
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| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| UA115641C2 (uk) | 2010-12-20 | 2017-11-27 | Дженентек, Інк. | Виділене антитіло, яке зв'язує мезотелін, та імунокон'югат, що його містить |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| SG11201401422VA (en) * | 2011-10-27 | 2014-09-26 | Genmab As | Production of heterodimeric proteins |
| AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| AR090903A1 (es) | 2012-05-01 | 2014-12-17 | Genentech Inc | Anticuerpos e inmunoconjugados anti-pmel17 |
| ES2882183T3 (es) * | 2013-03-14 | 2021-12-01 | Univ Duke | Moléculas biespecíficas que son inmunorreactivas con células efectoras inmunitarias que expresan un receptor activador |
| KR102190220B1 (ko) * | 2013-05-29 | 2020-12-14 | 삼성전자주식회사 | 타겟 특이적 세포막 단백질 제거용 조성물 |
| US9388243B2 (en) | 2013-05-29 | 2016-07-12 | Samsung Electronics Co., Ltd. | Method of target membrane protein depletion |
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| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| CN106459990B (zh) * | 2014-02-07 | 2021-06-01 | 麦克马斯特大学 | 三功能t细胞抗原偶联物及其制备方法和用途 |
| ME03558B (me) | 2014-03-14 | 2020-07-20 | Novartis Ag | Molekuli anti-lag-3 antiтela i njihove upotrebe |
| ES2955736T3 (es) | 2014-05-06 | 2023-12-05 | Hoffmann La Roche | Producción de proteínas heteromultiméricas usando células de mamífero |
| KR102259232B1 (ko) * | 2014-08-25 | 2021-05-31 | 삼성전자주식회사 | 항 c-Met/항 Ang2 이중 특이 항체 |
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| JP6730261B2 (ja) | 2014-09-17 | 2020-07-29 | ジェネンテック， インコーポレイテッド | 抗ｈｅｒ２抗体を含む免疫複合体 |
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- 2012-02-03 RU RU2013140685/10A patent/RU2013140685A/ru not_active Application Discontinuation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1705491A (zh) * | 2002-09-27 | 2005-12-07 | 赞科股份有限公司 | 优化的Fc变体及其产生方法 |
| CN101014619A (zh) * | 2004-07-15 | 2007-08-08 | 赞科股份有限公司 | 优化的Fc变体 |
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| Publication number | Publication date |
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| EP2670776A1 (en) | 2013-12-11 |
| RU2018108836A (ru) | 2019-03-14 |
| JP6161540B2 (ja) | 2017-07-12 |
| BR112013019499A2 (pt) | 2020-03-10 |
| KR20140043722A (ko) | 2014-04-10 |
| AR127516A2 (es) | 2024-01-31 |
| RU2013140685A (ru) | 2015-03-10 |
| CA2825064C (en) | 2022-08-30 |
| WO2012106587A1 (en) | 2012-08-09 |
| JP2017006128A (ja) | 2017-01-12 |
| CN103649117A (zh) | 2014-03-19 |
| HK1196020A1 (zh) | 2014-11-28 |
| MX355255B (es) | 2018-04-11 |
| BR112013019499B1 (pt) | 2023-01-10 |
| KR101913448B1 (ko) | 2018-10-30 |
| JP2014506790A (ja) | 2014-03-20 |
| MX2013008920A (es) | 2013-10-01 |
| AR085138A1 (es) | 2013-09-11 |
| RU2018108836A3 (enExample) | 2019-03-14 |
| EP2670776B1 (en) | 2018-11-21 |
| CA2825064A1 (en) | 2012-08-09 |
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