CN103635848B - 显微镜 - Google Patents
显微镜 Download PDFInfo
- Publication number
- CN103635848B CN103635848B CN201180051638.2A CN201180051638A CN103635848B CN 103635848 B CN103635848 B CN 103635848B CN 201180051638 A CN201180051638 A CN 201180051638A CN 103635848 B CN103635848 B CN 103635848B
- Authority
- CN
- China
- Prior art keywords
- rotationally symmetric
- symmetric axis
- camera
- time delay
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B17/00—Details of cameras or camera bodies; Accessories therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/26—Measuring arrangements characterised by the use of optical techniques for measuring angles or tapers; for testing the alignment of axes
- G01B11/27—Measuring arrangements characterised by the use of optical techniques for measuring angles or tapers; for testing the alignment of axes for testing the alignment of axes
- G01B11/272—Measuring arrangements characterised by the use of optical techniques for measuring angles or tapers; for testing the alignment of axes for testing the alignment of axes using photoelectric detection means
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/02—Objectives
- G02B21/025—Objectives with variable magnification
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/361—Optical details, e.g. image relay to the camera or image sensor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
- G02B7/003—Alignment of optical elements
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N7/00—Television systems
- H04N7/18—Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
- H04N25/70—SSIS architectures; Circuits associated therewith
- H04N25/71—Charge-coupled device [CCD] sensors; Charge-transfer registers specially adapted for CCD sensors
- H04N25/711—Time delay and integration [TDI] registers; TDI shift registers
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Signal Processing (AREA)
- Microscoopes, Condenser (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
Claims (8)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211332719.6A CN115542529A (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN201610829165.9A CN106226978B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN202010000698.2A CN111323899B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN201610829299.0A CN106226979B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/912,641 US8175452B1 (en) | 2010-10-26 | 2010-10-26 | Method and system for imaging high density biochemical arrays with sub-pixel alignment |
US12/912,641 | 2010-10-26 | ||
PCT/US2011/056211 WO2012058014A2 (en) | 2010-10-26 | 2011-10-13 | Method and system for imaging high density biochemical arrays with sub-pixel alignment |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610829165.9A Division CN106226978B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN202010000698.2A Division CN111323899B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN201610829299.0A Division CN106226979B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN202211332719.6A Division CN115542529A (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103635848A CN103635848A (zh) | 2014-03-12 |
CN103635848B true CN103635848B (zh) | 2016-10-19 |
Family
ID=45973104
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610829299.0A Active CN106226979B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN202211332719.6A Pending CN115542529A (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN201180051638.2A Active CN103635848B (zh) | 2010-10-26 | 2011-10-13 | 显微镜 |
CN202010000698.2A Active CN111323899B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN201610829165.9A Active CN106226978B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610829299.0A Active CN106226979B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN202211332719.6A Pending CN115542529A (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010000698.2A Active CN111323899B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
CN201610829165.9A Active CN106226978B (zh) | 2010-10-26 | 2011-10-13 | 用于通过子像素对准使高密度生化阵列成像的方法和系统 |
Country Status (6)
Country | Link |
---|---|
US (5) | US8175452B1 (zh) |
EP (1) | EP2633359B1 (zh) |
CN (5) | CN106226979B (zh) |
AU (1) | AU2011320774B2 (zh) |
HK (1) | HK1195637A1 (zh) |
WO (1) | WO2012058014A2 (zh) |
Families Citing this family (48)
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JP2011501965A (ja) | 2007-10-30 | 2011-01-20 | コンプリート・ゲノミックス・インコーポレーテッド | 核酸のハイ・スループット塩基配列決定のための装置 |
US8774494B2 (en) | 2010-04-30 | 2014-07-08 | Complete Genomics, Inc. | Method and system for accurate alignment and registration of array for DNA sequencing |
US9880089B2 (en) | 2010-08-31 | 2018-01-30 | Complete Genomics, Inc. | High-density devices with synchronous tracks for quad-cell based alignment correction |
US9671344B2 (en) | 2010-08-31 | 2017-06-06 | Complete Genomics, Inc. | High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging |
US8175452B1 (en) * | 2010-10-26 | 2012-05-08 | Complete Genomics, Inc. | Method and system for imaging high density biochemical arrays with sub-pixel alignment |
FR2980628B1 (fr) | 2011-09-22 | 2014-07-25 | Schneider Electric Ind Sas | Melange d'hydrofluoroolefine et de fluorocetone pour l'utilisation comme milieu d'isolation et/ou d'extinction d'arc et appareil electrique moyenne tension a isolation gazeuse le comprenant |
EP4235254A3 (en) | 2012-05-02 | 2023-10-11 | Leica Biosystems Imaging Inc. | Real-time focusing in line scan imaging |
US9488823B2 (en) | 2012-06-07 | 2016-11-08 | Complete Genomics, Inc. | Techniques for scanned illumination |
US9628676B2 (en) * | 2012-06-07 | 2017-04-18 | Complete Genomics, Inc. | Imaging systems with movable scan mirrors |
US10829816B2 (en) | 2012-11-19 | 2020-11-10 | Apton Biosystems, Inc. | Methods of analyte detection |
ES2905265T3 (es) | 2012-11-19 | 2022-04-07 | Apton Biosystems Inc | Análisis digital de analitos moleculares mediante detección de molécula única |
KR102357894B1 (ko) | 2013-08-22 | 2022-02-03 | 앱톤 바이오시스템즈, 인코포레이티드 | 전기적 방법을 이용한 분자 분석물질의 디지털 분석 |
FR3019316B1 (fr) * | 2014-03-28 | 2017-08-11 | Sagem Defense Securite | Systeme de veille optronique a champ optique variable |
CN104407436B (zh) * | 2014-09-05 | 2019-01-11 | 北京大学 | 一种基于轴向超高速扫描的三轴数字扫描光片显微镜 |
JP6805135B2 (ja) * | 2014-10-06 | 2020-12-23 | ライカ マイクロシステムズ (シュヴァイツ) アクチエンゲゼルシャフトLeica Microsystems (Schweiz) AG | 顕微鏡 |
EP3204808B1 (de) * | 2014-10-06 | 2021-05-05 | Leica Microsystems (Schweiz) AG | Mikroskop |
US10928619B2 (en) * | 2014-10-06 | 2021-02-23 | Leica Microsystems (Schweiz) Ag | Microscope |
JP6562626B2 (ja) * | 2014-12-10 | 2019-08-21 | キヤノン株式会社 | 顕微鏡システム |
JP6562627B2 (ja) * | 2014-12-10 | 2019-08-21 | キヤノン株式会社 | 顕微鏡システム |
JP6478605B2 (ja) * | 2014-12-10 | 2019-03-06 | キヤノン株式会社 | 顕微鏡システムおよびその制御方法 |
DE102015100695A1 (de) * | 2015-01-19 | 2016-07-21 | Carl Zeiss Ag | Optische Anordnung für ein Laser-Scanner-System |
JP6266574B2 (ja) * | 2015-09-10 | 2018-01-24 | 株式会社日立ハイテクサイエンス | X線検査方法及びx線検査装置 |
CN108139650B (zh) | 2015-09-24 | 2020-10-30 | 徕卡生物系统公司 | 线扫描成像中的实时聚焦 |
TWI599793B (zh) * | 2015-11-23 | 2017-09-21 | 財團法人金屬工業研究發展中心 | 組織玻片影像掃描系統 |
JP6643071B2 (ja) | 2015-12-10 | 2020-02-12 | キヤノン株式会社 | 顕微鏡システム |
JP6609174B2 (ja) | 2015-12-10 | 2019-11-20 | キヤノン株式会社 | 顕微鏡システムおよびその制御方法 |
JP6643072B2 (ja) * | 2015-12-10 | 2020-02-12 | キヤノン株式会社 | 顕微鏡システムおよびその制御方法 |
KR102371894B1 (ko) * | 2016-10-13 | 2022-03-10 | 라이프 테크놀로지스 홀딩스 프리베이트 리미티드 | 시야 최적화를 위한 시스템, 방법 및 장치 |
JP2020502558A (ja) | 2016-11-10 | 2020-01-23 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 大型試料のための高速・高解像度イメージング方法 |
JP2020504320A (ja) * | 2016-11-18 | 2020-02-06 | ヴェンタナ メディカル システムズ, インク. | 基板配置精度を検出する方法およびシステム |
CN110140129B (zh) | 2016-12-30 | 2023-10-17 | 徕卡生物系统成像股份有限公司 | 使用双光学路径和单成像传感器的低分辨率载片成像和载片标签成像以及高分辨率载片成像 |
US10477097B2 (en) * | 2017-01-03 | 2019-11-12 | University Of Connecticut | Single-frame autofocusing using multi-LED illumination |
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US6310710B1 (en) * | 1999-04-23 | 2001-10-30 | Arie Shahar | High-resolution reading and writing using beams and lenses rotating at equal or double speed |
JP2007140322A (ja) * | 2005-11-22 | 2007-06-07 | Tohoku Univ | 光学装置 |
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2010
- 2010-10-26 US US12/912,641 patent/US8175452B1/en active Active
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2011
- 2011-10-13 AU AU2011320774A patent/AU2011320774B2/en active Active
- 2011-10-13 CN CN201610829299.0A patent/CN106226979B/zh active Active
- 2011-10-13 EP EP11836850.5A patent/EP2633359B1/en active Active
- 2011-10-13 CN CN202211332719.6A patent/CN115542529A/zh active Pending
- 2011-10-13 CN CN201180051638.2A patent/CN103635848B/zh active Active
- 2011-10-13 CN CN202010000698.2A patent/CN111323899B/zh active Active
- 2011-10-13 WO PCT/US2011/056211 patent/WO2012058014A2/en active Application Filing
- 2011-10-13 CN CN201610829165.9A patent/CN106226978B/zh active Active
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2012
- 2012-04-20 US US13/451,678 patent/US8428454B2/en active Active
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2013
- 2013-04-03 US US13/856,369 patent/US8660421B2/en active Active
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2014
- 2014-02-19 US US14/184,473 patent/US8965196B2/en active Active
- 2014-09-02 HK HK14108920.2A patent/HK1195637A1/zh unknown
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2015
- 2015-01-12 US US14/594,979 patent/US9285578B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US9285578B2 (en) | 2016-03-15 |
CN103635848A (zh) | 2014-03-12 |
CN106226979A (zh) | 2016-12-14 |
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CN115542529A (zh) | 2022-12-30 |
CN106226978A (zh) | 2016-12-14 |
US8428454B2 (en) | 2013-04-23 |
US20130222570A1 (en) | 2013-08-29 |
US20150160451A1 (en) | 2015-06-11 |
US20120099852A1 (en) | 2012-04-26 |
EP2633359B1 (en) | 2021-11-17 |
AU2011320774B2 (en) | 2014-10-09 |
CN106226979B (zh) | 2021-11-02 |
US8660421B2 (en) | 2014-02-25 |
WO2012058014A2 (en) | 2012-05-03 |
EP2633359A2 (en) | 2013-09-04 |
HK1195637A1 (zh) | 2014-11-14 |
US8965196B2 (en) | 2015-02-24 |
EP2633359A4 (en) | 2015-07-29 |
AU2011320774A1 (en) | 2013-05-02 |
CN106226978B (zh) | 2019-04-16 |
WO2012058014A3 (en) | 2014-04-03 |
CN111323899A (zh) | 2020-06-23 |
US20120200692A1 (en) | 2012-08-09 |
CN111323899B (zh) | 2022-11-22 |
US8175452B1 (en) | 2012-05-08 |
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